SLC1A5 Antibody (1085750) [Alexa Fluor® 750]

• Applications: WB, IHC, ICC/IF
• Clone: 1085750
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

SLC1A5 Antibody (1085750) [Alexa Fluor® 750] Summary

• Immunogen: Synthetic Peptide
  Accession # Q15758
• Specificity: Detects a synthetic peptide corresponding to residues near amino acid 500 of human SLC1A5 protein by Direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

SLC1A5 is a sodium dependent antiporter also known as ASCT2 (ASC amino acid Transporter2).  It is a member of the solute carrier (SLC) superfamily of transporters and plays an important role in tumors.  It is one of the 3 proteins, including SLC7A5 and SLC3A2, that are among the highest differentially expressed genes in activated lymphocytes and cancerous cells.  Pharmacological inhibition of SLC1A5 was found to abrogate the effector functions of NK cells.  In a pancancer analysis of SLC1A5, it has been demonstrated to be a prognostic biomarker in cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.