SIT1 Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SIT1 Antibody Summary

Immunogen
Peptide with sequence C-HLSQWTRGRSRSH corresponding to internal region according to NP_055265.1.
Epitope
C-HLSQWTRGRSRSH
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SIT1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:2000
Application Notes
WB: Preliminary experiments in human lymph node, spleen, tonsil and thymus lysates gave no specific signal but low background.
Publications
Read Publication using NBP1-52153.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for SIT1 Antibody

  • gp30/40
  • MGC125908
  • MGC125909
  • RP11-331F9.5
  • SHP2 interacting transmembrane adaptor
  • SHP2-interacting transmembrane adapter protein
  • SHP2-interacting transmembrane adaptor protein
  • signaling threshold regulating transmembrane adaptor 1
  • signaling threshold-regulating transmembrane adapter 1
  • SIT1
  • SITMGC125910
  • suppression inducing transmembrane adaptor 1
  • Suppression-inducing transmembrane adapter 1

Background

SIT is a nbsp40 kD disulfide-linked protein also known as SHP2-interacting transmembrane adaptor protein. SIT is a membrane protein containing a very short extracellular domain (18 amino acids). SIT is expressed in T cells, but is not expressed in monocytes. SIT is a signaling adaptor molecule that negatively regulates T cell activation through SHP-2 interactions. The SIT protein is phosphorylated by Src kinases and has been shown to associate with SHP2, Csk, Zap70, Syk, Fyn, Lck, and Grb2. SIT is also heavily glycosylated and treatment with endoglycosidase has been shown to reduce the apprarent molecular weight to approximately 20 kD. The SIT-40 antibody recognizes the intracellular region of human SIT and has been shown to be useful for Western blotting.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SIT1 Antibody (NBP1-52153)(1)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for SIT1 Antibody (NBP1-52153)

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Bioinformatics

Gene Symbol SIT1
Entrez
Uniprot