Siglec-7/CD328 Antibody (OTI1A1) [CoraFluor™ 1]

• Reactivity: Hu
• Applications: WB
• Clone: OTI1A1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: CoraFluor 1

Siglec-7/CD328 Antibody (OTI1A1) [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
• Immunogen: Full length human recombinant protein of human SIGLEC7(NP_057627) produced in HEK293T cell.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SIGLEC7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Siglec-7/CD328 Antibody (OTI1A1) [CoraFluor™ 1]

• Adhesion inhibitory receptor molecule 1
• adhesion inhibitory receptor molecule 1, siglec-7
• AIRM1
• AIRM-1
• AIRM1QA79 membrane protein
• CD328 antigen
• CD328
• CDw328
• D-siglec
• p75
• p75/AIRM1
• QA79
• sialic acid binding Ig-like lectin 7
• sialic acid binding immunoglobulin-like lectin 7
• sialic acid-binding Ig-like lectin 7
• Siglec7
• Siglec-7

Background

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyllactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked bycis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptorupon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) thatblock signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killercells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towardsmyelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SIGLEC7