Siglec-7/CD328 Products

Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyllactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked bycis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptorupon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) thatblock signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killercells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towardsmyelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

Bioinformatics

Entrez	27036 Human
Uniprot	AAF12759 Human AAH28150 Human NM_014385 Human NP_055200 Human NP_055200.1 Human NP_057627 Human Q9NZQ1 Human Q9Y286 Human
Product By Gene ID	27036
Alternate Names	Adhesion inhibitory receptor molecule 1 adhesion inhibitory receptor molecule 1, siglec-7 AIRM-1 AIRM1QA79 membrane protein CD328 antigen CD328 CDw328 D-siglec p75 p75/AIRM1 QA79 sialic acid binding Ig-like lectin 7 sialic acid binding immunoglobulin-like lectin 7 sialic acid-binding Ig-like lectin 7 SIGLEC-7 Siglec-7