SIGIRR Antibody

Product Discontinued

SIGIRR Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human SIGIRR. The exact sequence is proprietary.
• Localization: Membrane; Single-pass type III membrane protein
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SIGIRR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 46 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Expected cross reactivity based on sequence homology: Mouse (86%), Rat (87%), Bovine (88%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7), 20% Glycerol, 1% BSA
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for SIGIRR Antibody

• IL-1R8
• SIGIRR
• single Ig IL-1-related receptor
• Single Ig IL-1R-related molecule
• single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
• single immunoglobulin domain IL1R1 related
• Single immunoglobulin domain-containing IL1R-related protein
• TIR8
• TIR8MGC110992
• Toll/interleukin-1 receptor 8

Background

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: SIGIRR
• Uniprot:
  • Q6IA17()