SH2D1A Recombinant Protein Antigen

• Reactivity: Hu
• Applications: AC

SH2D1A Recombinant Protein Antigen Summary

• Description: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human SH2D1A
  
  

  Source: E.coli

  Amino Acid Sequence: AVAVYHGKISRETGEKLLLATGLDGSY

  Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)

• Protein/Peptide Type: Recombinant Protein Antigen
• Gene: SH2D1A
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • Antibody Competition 10-100 molar excess
• Application Notes: This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP3-25134It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS and 1M Urea, pH 7.4.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Alternate Names for SH2D1A Recombinant Protein Antigen

• DSHP
• DSHPLYP
• Duncan disease SH2-protein
• EBVS
• FLJ92177
• IMD5
• LYP
• MTCP1
• SAP/SH2D1A
• SAPlymphoproliferative syndrome
• SH2 domain containing 1A
• SH2 domain-containing protein 1A
• SH2D1A
• signaling lymphocyte activation molecule-associated protein
• Signaling lymphocytic activation molecule-associated protein
• SLAM associated protein/SH2 domain protein 1A
• SLAM-associated protein
• T cell signal transduction molecule SAP
• T-cell signal transduction molecule SAP
• XLP
• XLPD
• XLPDFLJ18687
• XLPSH2 domain protein 1A

Background

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SH2D1A