SH2D1A Products

Description

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Bioinformatics

Entrez	20400 Mouse 4068 Human 501502 Rat
Uniprot	AAH20732 Human NM_002351 Human NP_002342 Human NP_002342.1 Human
Product By Gene ID	4068
Alternate Names	DSHPLYP Duncan disease SH2-protein EBVS FLJ92177 IMD5 MTCP1 SAP/SH2D1A SAPlymphoproliferative syndrome SH2 domain containing 1A SH2 domain-containing protein 1A signaling lymphocyte activation molecule-associated protein Signaling lymphocytic activation molecule-associated protein SLAM associated protein/SH2 domain protein 1A SLAM-associated protein T cell signal transduction molecule SAP T-cell signal transduction molecule SAP XLPDFLJ18687 XLPSH2 domain protein 1A

Research Areas for SH2D1A

Find related products by research area and learn more about each of the different research areas below.

Immune System Diseases
Immunology