SH2D1A Antibody

Western Blot: SH2D1A Antibody [H00004068-D01P] - Analysis of SH2D1A expression in Jurkat.

Western Blot: SH2D1A Antibody [H00004068-D01P] - Analysis of SH2D1A expression in transfected 293T cell line by SH2D1A polyclonal antibody.Lane 1: SH2D1A transfected lysate(14.20 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

SH2D1A Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: SH2D1A (NP_002342.1, 1 a.a. - 128 a.a.) full-length human protein. MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP
• Specificity: SH2D1A - SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome),
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SH2D1A
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for SH2D1A Antibody

• DSHP
• DSHPLYP
• Duncan disease SH2-protein
• EBVS
• FLJ92177
• IMD5
• LYP
• MTCP1
• SAP/SH2D1A
• SAPlymphoproliferative syndrome
• SH2 domain containing 1A
• SH2 domain-containing protein 1A
• SH2D1A
• signaling lymphocyte activation molecule-associated protein
• Signaling lymphocytic activation molecule-associated protein
• SLAM associated protein/SH2 domain protein 1A
• SLAM-associated protein
• T cell signal transduction molecule SAP
• T-cell signal transduction molecule SAP
• XLP
• XLPD
• XLPDFLJ18687
• XLPSH2 domain protein 1A

Background

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SH2D1A
• Entrez:
  • 4068(Human)
• Uniprot:
  • NP_002342.1(Human)