SF-1/NR5A1/Steroidogenic Factor 1 Antibody (N1665) [Unconjugated]

Product Discontinued

SF-1/NR5A1/Steroidogenic Factor 1 Antibody (N1665) [Unconjugated] Summary

• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: NR5A1

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5-15 ug/mL
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Buffer: A liquid formulation in physiologic saline with 0.1% NaN₃.
• Preservative: 0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SF-1/NR5A1/Steroidogenic Factor 1 Antibody (N1665) [Unconjugated]

• AD4BP
• AD4BPSTF-1
• Adrenal 4-binding protein
• ELP
• FTZ1adrenal 4 binding protein
• FTZF1
• FTZF1nuclear receptor AdBP4
• Fushi tarazu factor homolog 1
• NR5A1
• Nuclear receptor subfamily 5 group A member 1
• nuclear receptor subfamily 5, group A, member 1
• SF1
• SF-1
• SF-1POF7
• SF1steroidogenic factor 1
• Steroid hormone receptor Ad4BP
• steroidogenic factor-1

Background

Streroidogenic Factor 1 (SF-1, AD4BP, FTZ-F1; NR5A1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of steroidogenic enzyme gene expression. Oxysterols are suggested as its ligands. It is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 plays an important role in adrenal and gonadal development, including the hypothalamic-pituitary-gonadal axis and sex determination.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SF-1/NR5A1/Steroidogenic Factor 1 Antibody (PP-N1665-00)(2)

Publications using PP-N1665-00

• M Cools, P Hoebeke, K P Wolffenbuttel, H Stoop, R Hersmus, M Barbaro et al. Pubertal androgenization and gonadal histology in two 46,XY adolescents with NR5A1 mutations and predominantly female phenotype at birth European Journal of Endocrinology 2012-02-01 [PMID: 22080441] (Immunohistochemistry, Human)
• Guo G, Smith A A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development, 2010-10-01;137(19):3185-92. 2010-10-01 [PMID: 20823062] (Western Blot, Mouse)

Reviews for SF-1/NR5A1/Steroidogenic Factor 1 Antibody (PP-N1665-00) (2)

Average Rating: 5

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Mouse.

reviewed by: Verified Customer IHC-P Mouse 02/25/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 23874227
• Species: Mouse

reviewed by: Verified Customer IF Mouse 02/25/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23874227
• Species: Mouse

Bioinformatics

• Gene Symbol: NR5A1