SF-1/NR5A1/Steroidogenic Factor 1 Products

Description

Steroidogenic factor 1 (SF-1), a NR5 Fushi Tarazu-Like Receptor, has been shown to affect sexual differentiation, steroid metabolism, and neural development. SF-1 binds as a monomer and regulates all steroidogenic p450 genes, Mullerian inhibiting substance, the gonadotrophins, the ACTH receptor, oxytocin, nuclear receptor DAX-1, and several other genes. Four alternatively spliced isoforms of SF-1 have been isolated in mice, and they differ at the N and C termini but are identical in the DNA-binding domain. SF-1 expression has been documented in human brain, adrenal, spleen, liver, heart, ovary, testis, and placenta. ESTs have been isolated from human tissue libraries, including cancerous adrenal and normal lung and testis.

Bioinformatics

Entrez	2516 Human
Uniprot	NM_004959 Human NP_004950.2 Human Q13285 Human
Product By Gene ID	2516
Alternate Names	AD4BPSTF-1 Adrenal 4-binding protein ELP FTZ1adrenal 4 binding protein FTZF1nuclear receptor AdBP4 Fushi tarazu factor homolog 1 Nuclear receptor subfamily 5 group A member 1 nuclear receptor subfamily 5, group A, member 1 SF-1POF7 SF1steroidogenic factor 1 Steroid hormone receptor Ad4BP steroidogenic factor-1

Research Areas for SF-1/NR5A1/Steroidogenic Factor 1

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GPCR