SerpinB2 Antibody

Images

 
Western Blot: SerpinB2 Antibody [NBP1-77964] - 2 in 50 ug of HeLa whole cell lysates. The band at ~42 kDa (arrowhead) corresponds to SerpinB2 . Faint non-specific bands are also noted at lower and higher molecular ...read more
Immunohistochemistry: SerpinB2 Antibody [NBP1-77964] - Tissue: heart. Fixation: formalin fixed paraffin embedded. Primary antibody: Anti-Plasminogen Activator 2 at 10 ug/mL for 1 h at RT. Staining: Plasminogen Activator ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

SerpinB2 Antibody Summary

Immunogen
This affinity purified SerpinB2 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal area of human SerpinB2 protein. (Uniprot: P05120)
Specificity
This affinity-purified antibody is directed against human SerpinB2 protein. Reactivity occurs against human SerpinB2 protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SERPINB2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100000-150000
  • Immunohistochemistry 10ug/ml
  • Western Blot 1:500-1:2000
Application Notes
Specific conditions for reactivity should be optimized by the end user. Expect a band 42-46.6 kDa in size corresponding to SerpinB2 protein by western blotting in the appropriate cell lysate or extract.
Theoretical MW
46.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

A BLAST analysis was used to suggest cross reactivity with SerpinB2 proteins from several primates based on 94% homology with the immunizing sequence. Reactivity against homologues from other sources is not known

Packaging, Storage & Formulations

Storage
Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% Sodium Azide
Purity
Immunogen affinity purified

Notes

This affinity-purified antibody is directed against human PAI-2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification

Store vial at -20C prior to opening. Aliquot contents and freeze at -20C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4C as an undiluted liquid. Dilute only prior to immediate use.

Alternate Names for SerpinB2 Antibody

  • HsT1201
  • Monocyte Arg-serpin
  • PAI
  • PAI2
  • PAI2Urokinase inhibitor
  • Placental plasminogen activator inhibitor
  • PLANH2
  • PLANH2PAI-2
  • plasminogen activator inhibitor 2
  • plasminogen activator inhibitor, type II (arginine-serpin)
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
  • Serpin B2
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2
  • Urokinase Inhibitor

Background

Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor; Monocyte Arg-serpin; Urokinase inhibitor; SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60-kDa, secreted, extracellular, glycosylated form and a 43-kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SERPINB2
Uniprot