Senataxin Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

Senataxin Antibody [DyLight 550] Summary

Immunogen
A genomic peptide made to an internal portion of the human Senataxin protein (between residues 600-750) [UniProt Q7Z333]
Localization
Nucleus, nucleoplasm, nucleolus. Cytoplasm.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SETX
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Senataxin antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, and Western Blot. In ICC/IF, nuclear staining was observed in HeLa cells. In IP and Western Blot a band is seen ~300kDa.

Reactivity Notes

Human. Mouse reactivity reported in scientific literature (PMID: 28245518).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Senataxin Antibody [DyLight 550]

  • ALS4recessive, non-Friedreich type 1
  • AOA2FLJ43459
  • DKFZp781B151
  • KIAA0625FLJ12840
  • senataxin
  • SETX

Background

Senataxin (SETX, ALS4, AOA2, SCAR1) belongs to the DNA/NAM7 helicase family. The protein encoded for by Senataxin has a DNA/RNA helicase domain at its C-terminal end. Senataxin may play a role in RNA maturation. It may also be involved in DNA double-strand breaks damage response caused by oxidative stress. Cellular localization of Senataxin is limited to the nucleus and cytoplasm. Senataxin is abundantly expressed in skeletal muscle. Expression of Senataxin is also seen in heart, fibroblast, placenta, liver, and weakly in brain and lung. Post translational modifications of Senataxin include acetylation and phosphorylation. There are 3 known isoforms (302.9, 299.4 and 306.3 kDa).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Senataxin Antibody (NBP1-94712R) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Senataxin Antibody (NBP1-94712R)

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Bioinformatics

Gene Symbol SETX