ROR beta Antibody

Immunocytochemistry/Immunofluorescence: ROR beta Antibody [NBP1-82532] - Staining of human cell line SH-SY5Y shows localization to nucleus. Antibody staining is shown in green.

Product Discontinued

ROR beta Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: QRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLE
• Predicted Species: Mouse (96%), Rat (97%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RORB
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
• Application Notes: ICC/IF Fixation Permeabilization, Use PFA/Triton X-100.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ROR beta Antibody

• NR1F2
• NR1F2nuclear receptor ROR-beta
• Nuclear receptor RZR-beta
• Nuclear receptor subfamily 1 group F member 2
• RAR-related orphan receptor B
• RAR-related orphan receptor beta
• retinoic acid-binding receptor beta
• retinoid-related orphan receptor beta
• Retinoid-related orphan receptor-beta
• ROR beta
• RORB
• ROR-BETA
• RZRB
• RZRBbA133M9.1
• RZR-BETA

Background

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain. ESTs have been isolated from human tissue libraries, including cancerous human kidney and normal brain, pineal and eye.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ROR beta Antibody (NBP1-82532)(2)

Publications using NBP1-82532

• Shibata M, Pattabiraman K, Lorente-Galdos B Et al. Regulation of prefrontal patterning and connectivity by retinoic acid Nature 2021-10-01 [PMID: 34599305] (IF/IHC, Mouse)
• Wen Z, Chen M, Guo W et al. ROR beta suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathway Oncology reports 2021-08-01 [PMID: 34278502] (IF/IHC)

Bioinformatics

• Gene Symbol: RORB