Renin Antibody

Product Discontinued

Renin Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human Renin. The exact sequence is proprietary.
• Localization: Secreted, Membrane
• Predicted Species: Primate (100%), Rhesus Macaque (98%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: REN
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
• Application Notes: Renin antibody validated for ICC/IF from a verified customer review.
• Theoretical MW: 45 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Chimpanzee (100%). Reactivity to mouse reported in verified customer review.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for Renin Antibody

• angiotensin-forming enzyme
• Angiotensinogenase
• EC 3.4.23
• EC 3.4.23.15
• FLJ10761
• HNFJ2
• Prorenin
• REN
• renin precursor, renal
• Renin

Background

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Renin also occurs in other organs than the kidney, e.g., in the brain, where it is implicated in the regulation of numerous activities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for Renin Antibody (NBP1-31559)(1)

Publication using NBP1-31559

• Gunawardhana KL, Hong L, Rugira T et al. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension The Journal of clinical investigation 2023-01-05 [PMID: 36602864] (IHC-Fr, WB, Mouse)
  
  Details:
  Dilution for IHC-Fr - 1:300

Review for Renin Antibody (NBP1-31559) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Verified Customer IHC-Fr Mouse 03/07/2019

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: Embryonic kidney
• Species: Mouse
• Lot: 39946

Comments

• Comments: Embryonic mouse kidney sections (E17.5)

Bioinformatics

• Gene Symbol: REN