Renin Products

Description

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.

Bioinformatics

Entrez	5972 Human
Uniprot	AAH47752 Human NM_000537 Human P00797 Human Q99665 Human
Product By Gene ID	5972
Alternate Names	angiotensin-forming enzyme Angiotensinogenase angiotensinogenase EC 3.4.23 EC 3.4.23.15 FLJ10761 HNFJ2 Prorenin renin precursor, renal renin