Recombinant Mouse IL-6 Protein, CF

Recombinant Mouse IL-6 (Catalog # 406‑ML/CF) stimulates cell proliferation of the T1165.85.2.1 mouse plasmacytoma cell line. The ED50 for this effect is 0.02‑0.06 ng/mL.

1 μg/lane of Recombinant Mouse IL-6 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 24 kDa.

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse IL-6 Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED₅₀ for this effect is 10.0-100 pg/mL.
• Source: E. coli-derived mouse IL-6 protein
  Phe25-Thr211, with an N-terminal Met
• Accession #: P08505
• N-terminal Sequence: Phe25
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il6
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 21.8 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Do not freeze.
  • 6 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied as a 0.2 μm filtered solution in Sodium Acetate and EDTA.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-6 Protein, CF

• B-cell differentiation factor
• B-cell stimulatory factor 2
• BSF2
• BSF-2
• CDF
• CTL differentiation factor
• HSF
• hybridoma growth factor
• IFNB2
• IFN-beta-2
• IL6
• IL-6
• Interferon beta-2
• interleukin 6 (interferon, beta 2)
• interleukin BSF-2
• interleukin-6
• MGI-2A

Background

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22 - 28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1 - 5). Mature mouse IL-6 is 187 amino acids (aa) in length and shares 39% and 85% aa sequence identity with human and rat IL-6, respectively (6 - 8). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha , triggering IL-6 R alpha association with gp130 and gp130 dimerization (9). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (10). Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor (5, 11). IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1 - 5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 12).

1. Mansell, A. and B.J. Jenkins (2013) Cytokine Growth Factor Rev. 24:249.
2. Schuett, H. et al. (2009) Thromb. Haemost. 102:215.
3. Erta, M. et al. (2012) Int. J. Biol. Sci. 8:1254.
4. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.
5. Mihara, M. et al. (2012) Clin. Sci. (Lond.) 122:143.
6. Chiu, C.P. et al. (1988) Proc. Natl. Acad. Sci. USA 85:7099.
7. Simpson, R.J. et al. (1988) Eur. J. Biochem. 176:187.
8. Van Snick, J. et al. (1988) Eur. J. Immunol. 18:193.
9. Murakami, M. et al. (1993) Science 260:1808.
10. Muller-Newen, G. (2003) Sci. STKE 2003:PE40.
11. Mitsuyama, K. et al. (2006) Clin. Exp. Immunol. 143:125.
12. Cerutti, A. et al. (1998) J. Immunol. 160:2145.

Publications for IL-6 (406-ML/CF)(335)

Publications using 406-ML/CF

• O Anannya, W Huang, A August ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066370] (Bioassay, Mouse)
• H Huang, Y Li, G Zhang, GX Ruan, Z Zhu, W Chen, J Zou, R Zhang, J Wang, Y Ouyang, S Xu, X Ou The RNA-binding protein hnRNP F is required for the germinal center B cell response Nature Communications, 2023-03-30;14(1):1731. 2023-03-30 [PMID: 36997512] (Bioassay, Mouse)
• KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity Nature Communications, 2023-03-24;14(1):1652. 2023-03-24 [PMID: 36964178] (Bioassay, Mouse)
• X Cui, C Zhang, F Wang, X Zhao, S Wang, J Liu, D He, C Wang, FC Yang, S Tong, Y Liang Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 Cell Reports, 2023-03-16;42(3):112274. 2023-03-16 [PMID: 36933218] (Bioassay, Mouse)
• H Koizumi, W Fujii, C Sanjoba, Y Goto BAFF induces CXCR5 expression during B cell differentiation in bone marrow Biochemistry and Biophysics Reports, 2023-03-07;34(0):101451. 2023-03-07 [PMID: 36926279] (Bioassay, Mouse)
• Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)
• AT Obi, SB Sharma, MA Elfline, CE Luke, AR Dowling, Q Cai, AS Kimball, M Hollinstat, L Stanger, BB Moore, FA Jaffer, PK Henke Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions Scientific Reports, 2023-02-24;13(1):3253. 2023-02-24 [PMID: 36828892] (Bioassay, Mouse)
• S Ma, Q Yang, N Chen, A Zheng, N Abbasi, G Wang, PR Patel, BS Cho, BA Yee, L Zhang, H Chu, SM Evans, GW Yeo, Y Zheng, WJM Huang RNA binding protein DDX5 restricts RORgammat+ Treg suppressor function to promote intestine inflammation Science Advances, 2023-02-01;9(5):eadd6165. 2023-02-01 [PMID: 36724232] (Bioassay, Mouse)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Mouse)
• M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 2022-11-30;8(48):eadc9657. 2022-11-30 [PMID: 36449620] (Bioassay, Transgenic Mouse)
• R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 2022-11-29;13(1):7345. 2022-11-29 [PMID: 36446858] (Bioassay, Mouse)
• JS Park, SC Yang, HY Jeong, SY Lee, JG Ryu, JW Choi, HY Kang, SM Kim, SH Hwang, ML Cho, SH Park EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis Arthritis Research & Therapy, 2022-11-17;24(1):254. 2022-11-17 [PMID: 36397156] (Bioassay, Mouse)
• X Hu, Y Zou, DA Copland, LP Schewitz-B, Y Li, PJP Lait, M Stimpson, Z Zhang, S Guo, J Liang, T Chen, JJ Li, S Yuan, S Li, P Zhou, Y Liu, AD Dick, X Wen, RWJ Lee, L Wei Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2 EBioMedicine, 2022-11-03;86(0):104333. 2022-11-03 [PMID: 36335665] (Bioassay, Mouse, Transgenic Mouse)
• SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Mouse)
• EC Freckmann, E Sandilands, E Cumming, M Neilson, A Román-Fern, K Nikolatou, M Nacke, TRM Lannagan, A Hedley, D Strachan, M Salji, JP Morton, L McGarry, HY Leung, OJ Sansom, CJ Miller, DM Bryant Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging Nature Communications, 2022-09-09;13(1):5317. 2022-09-09 [PMID: 36085324] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• M Plana-Carm, G Stik, R Bulteau, C Segura-Mor, N Alcázar, CDR Wyatt, A Klonizakis, L de Andrés-, M Gasnier, TV Tian, G Torcal Gar, M Vila-Casad, N Plachta, M Serrano, M Francescon, T Graf The trophectoderm acts as a niche for the inner cell mass through C/EBPalpha-regulated IL-6 signaling Stem Cell Reports, 2022-08-11;0(0):. 2022-08-11 [PMID: 35961310] (Cell Culture, Mouse)
• Y Su, X Sun, X Liu, Q Qu, L Yang, Q Chen, F Liu, Y Li, Q Wang, B Huang, XJ Huang, XH Zhang hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype Journal of hematology & oncology, 2022-07-21;15(1):99. 2022-07-21 [PMID: 35864538] (Bioassay, Mouse)
• C Navarrete, A García-Mar, A Correa-Sáe, ME Prados, F Fernández, R Pineda, M Mazzone, M Álvarez-Be, MA Calzado, E Muñoz A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury Journal of Neuroinflammation, 2022-07-09;19(1):177. 2022-07-09 [PMID: 35810304] (Bioassay, Mouse)
• LM Fan, YQ Zhang, YP Chen, LL Chen, WH Xu, LH Nan, W Xu, B Lu, Y Wang, KD Chu, JP Zhang Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation Oncogene, 2022-05-31;108(0):108894. 2022-05-31 [PMID: 35729830] (Bioassay, Mouse)
• HZ Yu, BQ Zhu, L Zhu, S Li, LM Wang NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis Oncogene, 2022-12-01;17(12):2765-2770. 2022-12-01 [PMID: 35662227] (Bioassay, Mouse)
• H Kamei, T Ishii, Y Nishii Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 2022-06-02;12(1):9243. 2022-06-02 [PMID: 35654941] (Bioassay, Mouse)
• YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614130] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
• R Mary, F Chalmin, T Accogli, M Bruchard, C Hibos, J Melin, C Truntzer, E Limagne, V Derangère, M Thibaudin, E Humblin, R Boidot, S Chevrier, L Arnould, C Richard, Q Klopfenste, A Bernard, Y Urade, JA Harker, L Apetoh, F Ghiringhel, F Végran Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects Cancer Immunology Research, 2022-07-01;0(0):OF1-OF17. 2022-07-01 [PMID: 35612500] (Bioassay, Mouse)
• Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Mouse)
• FA Graca, M Rai, LC Hunt, A Stephan, YD Wang, B Gordon, R Wang, G Quarato, B Xu, Y Fan, M Labelle, F Demontis The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy Nature Communications, 2022-05-02;13(1):2370. 2022-05-02 [PMID: 35501350] (Bioassay, Mouse)
• N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival Cell Reports, 2022-03-29;38(13):110565. 2022-03-29 [PMID: 35354043] (Bioassay, Mouse)
• B Czaya, K Heitman, I Campos, C Yanucil, D Kentrup, D Westbrook, O Gutierrez, JL Babitt, G Jung, IB Salusky, M Hanudel, C Faul Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling Elife, 2022-03-18;11(0):. 2022-03-18 [PMID: 35302487] (Cell Culture, Mouse)
• S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)
• Q Zhang, L Zhao, Y Yang, S Li, Y Liu, C Chen Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132955]
• A Okubo, Y Uchida, Y Higashi, T Sato, Y Ogawa, A Ryuge, K Kadomatsu, T Kanekura CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation International Journal of Molecular Sciences, 2021-12-24;23(1):. 2021-12-24 [PMID: 35008603] (Bioassay, Mouse)
• V Patel, A Jayaraman, S Jayaraman Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells International immunopharmacology, 2021-12-23;103(0):108490. 2021-12-23 [PMID: 34954557] (Bioassay, Mouse)
• FJ Velloso, A Wadhwa, E Kumari, I Carcea, O Gunal, SW Levison Modestly increasing systemic interleukin-6 perinatally disturbs secondary germinal zone neurogenesis and gliogenesis and produces sociability deficits Brain, Behavior, and Immunity, 2021-12-23;101(0):23-36. 2021-12-23 [PMID: 34954074] (Bioassay, Mouse)
• P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 2021-11-10;11(11):. 2021-11-10 [PMID: 34827481] (Bioassay, Mouse)
• X Liu, E Zu, X Chang, X Ma, Z Wang, X Song, X Li, Q Yu, KI Kamei, T Hayashi, K Mizuno, S Hattori, H Fujisaki, T Ikejima, DO Wang Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration Disease Models & Mechanisms, 2021-12-24;14(12):. 2021-12-24 [PMID: 34821368] (Bioassay, Mouse)
• Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons Journal of Neuroinflammation, 2021-11-08;18(1):261. 2021-11-08 [PMID: 34749758] (Bioassay, Mouse)
• HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 2021-10-08;7(41):eabg4167. 2021-10-08 [PMID: 34623912] (Bioassay, Mouse)
• S Droho, CM Cuda, H Perlman, JA Lavine Macrophage-derived interleukin-6 is necessary and sufficient for choroidal angiogenesis Scientific Reports, 2021-09-10;11(1):18084. 2021-09-10 [PMID: 34508129] (Bioassay, Mouse)
• L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer&#039;s disease Brain, Behavior, and Immunity, 2021-09-06;98(0):337-348. 2021-09-06 [PMID: 34500034] (Bioassay, Mouse)
• A Agasing, JL Quinn, G Kumar, RC Axtell Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease Cells, 2021-08-20;10(8):. 2021-08-20 [PMID: 34440908] (Bioassay, Mouse)
• K Yamamoto, S Goyama, S Asada, T Fujino, T Yonezawa, N Sato, R Takeda, A Tsuchiya, T Fukuyama, Y Tanaka, A Yokoyama, H Toya, A Kon, Y Nannya, R Onoguchi-M, S Nakagawa, T Hirose, S Ogawa, N Akimitsu, T Kitamura A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells Cell Reports, 2021-08-24;36(8):109576. 2021-08-24 [PMID: 34433054] (Bioassay, Mouse)
• A Osman, B Yan, Y Li, KD Pavelko, J Quandt, A Saadalla, MP Singh, M Kazemian, F Gounari, K Khazaie TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer Nature Immunology, 2021-08-12;0(0):. 2021-08-12 [PMID: 34385712] (Bioassay, Mouse)
• J Basu, BS Reis, S Peri, J Zha, X Hua, L Ge, K Ferchen, E Nicolas, P Czyzewicz, KQ Cai, Y Tan, JI Fuxman Bas, AJM Walhout, HL Grimes, SI Grivenniko, D Mucida, DJ Kappes Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function Nature Immunology, 2021-07-26;22(8):969-982. 2021-07-26 [PMID: 34312548] (Bioassay, Mouse)
• N Ohashi, T Terashima, M Katagi, Y Nakae, J Okano, Y Suzuki, H Kojima GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS Scientific Reports, 2021-06-17;11(1):12803. 2021-06-17 [PMID: 34140581] (Cell Culture, Mouse)
• J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 2021-06-16;7(25):. 2021-06-16 [PMID: 34134995] (Bioassay, Mouse)
• X Wang, U Ros, D Agrawal, EC Keller, J Slotta-Hus, V Dill, B Shen, R Shi, T Herold, C Belka, R Misra, F Bassermann, AJ Garcia-Sae, PJ Jost MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF Cell Death and Differentiation, 2021-06-02;0(0):. 2021-06-02 [PMID: 34079078] (Bioassay, Mouse)
• A Singh, M Dashynam, B Chim, TM Escobar, X Liu, X Hu, S Patnaik, X Xu, N Southall, J Marugan, A Jadhav, V Lazarevic, SA Muljo, M Ferrer Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells Scientific Reports, 2021-06-01;11(1):11498. 2021-06-01 [PMID: 34075120] (Bioassay, Mouse)
• FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Cell Reports, 2021-05-25;35(8):109176. 2021-05-25 [PMID: 34038731] (Bioassay, Mouse)
• Z Zheng, X Zheng, Y Zhu, Z Yao, W Zhao, Y Zhu, F Sun, X Mu, Y Wang, W He, Z Liu, K Wu, J Zheng IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer BioMed Research International, 2021-04-23;2021(0):5535578. 2021-04-23 [PMID: 33981768] (In Vivo, Mouse)
• J Zhou, N Zhang, W Zhang, C Lu, F Xu The YAP/HIF-1&amp;alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation Cell & bioscience, 2021-05-12;11(1):84. 2021-05-12 [PMID: 33980319] (Bioassay, Mouse)
• ML Chen, X Huang, H Wang, C Hegner, Y Liu, J Shang, A Eliason, H Diao, H Park, B Frey, G Wang, SA Mosure, LA Solt, DJ Kojetin, A Rodriguez-, DA Schady, CT Weaver, ME Pipkin, DD Moore, MS Sundrud CAR directs T cell adaptation to bile acids in the small intestine Nature, 2021-04-07;0(0):. 2021-04-07 [PMID: 33828301] (Bioassay, Mouse)
• C Trilleaud, V Gauttier, K Biteau, I Girault, L Belarif, C Mary, S Pengam, G Teppaz, V Thepenier, R Danger, G Robert-Sie, M Néel, S Bruneau, A Glémain, A Néel, A Poupon, JF Mosnier, G Chêne, M Dubourdeau, G Blancho, B Vanhove, N Poirier Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution Science Advances, 2021-04-02;7(14):. 2021-04-02 [PMID: 33811066] (Bioassay, Mouse)
• A Sripada, K Sirohi, L Michalec, L Guo, JT McKay, S Yadav, M Verma, J Good, D Rollins, MM Gorska, R Alam Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases PloS Biology, 2021-03-08;19(3):e3001063. 2021-03-08 [PMID: 33684096] (Bioassay, Mouse)
• S Takashima, S Usui, O Inoue, C Goten, K Yamaguchi, Y Takeda, S Cui, Y Sakai, K Hayashi, K Sakata, MA Kawashiri, M Takamura Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells Scientific Reports, 2021-01-15;11(1):1520. 2021-01-15 [PMID: 33452355] (Bioassay, Mouse)
• J Mwirigi, M Kume, SN Hassler, A Ahmad, PR Ray, C Jiang, A Chamessian, N Mseeh, BP Ludwig, BD Rivera, MT Nieman, TV de Ven, RR Ji, G Dussor, S Boitano, J Vagner, TJ Price A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist The journal of pain, 2021-01-09;0(0):. 2021-01-09 [PMID: 33429107] (In Vivo, Mouse)
• S Yoshizaki, T Tamaru, M Hara, K Kijima, M Tanaka, DJ Konno, Y Matsumoto, Y Nakashima, S Okada Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/&amp;beta1 integrin pathway Journal of Neuroinflammation, 2021-01-06;18(1):12. 2021-01-06 [PMID: 33407620] (Bioassay, Mouse)
• R Contreras-, R Elizondo-V, N Luque-Camp, MJ Torres, C Pradenas, G Tejedor, MJ Paredes-Ma, AM Vega-Lette, M Campos-Mor, Y Rigual-Gon, K Oyarce, M Salgado, C Jorgensen, M Khoury, MLÁ Garcia-Rob, C Altamirano, F Djouad, P Luz-Crawfo The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential Theranostics, 2021-01-01;11(1):445-460. 2021-01-01 [PMID: 33391485] (Bioassay, Mouse)
• MJ Park, JA Baek, SY Kim, KA Jung, JW Choi, SH Park, SK Kwok, ML Cho Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells Journal of Translational Medicine, 2020-12-14;18(1):483. 2020-12-14 [PMID: 33317573] (Bioassay, Mouse)
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• Yoshizaki A, Yanaba K, Iwata Y Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol., 2010-07-12;185(4):2502-15. 2010-07-12 [PMID: 20624949] (Bioassay, Mouse)
• Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol., 2010-01-18;184(4):2130-9. 2010-01-18 [PMID: 20083667] (Bioassay, Mouse)
• Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. J. Immunol., 2009-10-19;183(10):6135-44. 2009-10-19 [PMID: 19841165] (Bioassay, Mouse)
• Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat. Med., 2009-09-20;15(10):1170-8. 2009-09-20 [PMID: 19767732] (Bioassay, Mouse)
• Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J. Immunol., 2009-08-28;183(6):4021-30. 2009-08-28 [PMID: 19717513] (Western Blot, Mouse)
• Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE Disruption of interleukin-1 signaling improves the quality of wound healing. Am. J. Pathol., 2009-04-23;174(6):2129-36. 2009-04-23 [PMID: 19389930] (In Vivo, Mouse)
• Osuchowski MF, Connett J, Welch K, Granger J, Remick DG Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit. Care Med., 2009-05-01;37(5):1567-73. 2009-05-01 [PMID: 19325479] (ELISA (Standard))
• Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 2009-03-13;11(4):524-30. 2009-03-13 [PMID: 19286469] (ELISA (Standard))
• Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J. Immunol., 2009-03-01;182(5):3191-201. 2009-03-01 [PMID: 19234217] (Bioassay, Mouse)
• Banerjee I, Fuseler JW, Intwala AR, Baudino TA IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart. Am. J. Physiol. Heart Circ. Physiol., 2009-02-20;296(5):H1694-704. 2009-02-20 [PMID: 19234091] (Bioassay, Mouse)
• Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 2009-01-12;206(1):69-78. 2009-01-12 [PMID: 19139170] (Bioassay, In Vivo, Mouse)
• Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2. Endocrinology, 2008-11-20;150(4):1850-60. 2008-11-20 [PMID: 19022895] (In Vivo, Mouse)
• Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008-11-01;58(11):3510-9. 2008-11-01 [PMID: 18975342] (Bioassay, Mouse)
• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008-09-15;181(6):4089-97. 2008-09-15 [PMID: 18768865] (Bioassay, Mouse)
• Shinohara ML, Kim JH, Garcia VA, Cantor H Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity, 2008-07-18;29(1):68-78. 2008-07-18 [PMID: 18619869] (Bioassay, Mouse)
• Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol., 2008-06-01;180(11):7414-22. 2008-06-01 [PMID: 18490741] (Bioassay, Mouse)
• Kida H, Mucenski ML, Thitoff AR, Le Cras TD, Park KS, Ikegami M, Muller W, Whitsett JA GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am. J. Pathol., 2008-05-08;172(6):1542-54. 2008-05-08 [PMID: 18467707] (In Vivo, Mouse)
• Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA (Standard))
• Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer&#039;s patches for intestinal IgA responses. J. Immunol., 2008-04-15;180(8):5335-43. 2008-04-15 [PMID: 18390715] (Bioassay, Mouse)
• Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse)
• Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood, 2008-03-19;112(2):362-73. 2008-03-19 [PMID: 18354038] (Bioassay, Mouse)
• Fenton JI, Birmingham JM, Hursting SD, Hord NG Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells. Int. J. Cancer, 2008-06-01;122(11):2437-45. 2008-06-01 [PMID: 18338750] (Bioassay, Mouse)
• Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study. J. Neurochem., 2007-12-15;105(3):904-9. 2007-12-15 [PMID: 18088370] (In Vivo, Mouse)
• McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol., 2007-11-11;8(12):1390-7. 2007-11-11 [PMID: 17994024] (Bioassay, Mouse)
• Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J. Immunol., 2007-11-15;179(10):7128-36. 2007-11-15 [PMID: 17982105] (Bioassay, Mouse)
• Smith SE, Li J, Garbett K, Mirnics K, Patterson PH Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci., 2007-10-03;27(40):10695-702. 2007-10-03 [PMID: 17913903] (In Vivo, Mouse)
• Meagher MW, Johnson RR, Young EE, Vichaya EG, Lunt S, Hardin EA, Connor MA, Welsh CJ Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection. Brain Behav. Immun., 2007-06-25;21(8):1083-95. 2007-06-25 [PMID: 17591434] (In Vivo, Mouse)
• Boesen EI, Pollock DM Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice. Am. J. Physiol. Heart Circ. Physiol., 2007-06-08;293(3):H1745-9. 2007-06-08 [PMID: 17557918] (In Vivo, Mouse)
• Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J. Leukoc. Biol., 2007-05-15;82(2):354-60. 2007-05-15 [PMID: 17505023] (Bioassay, Mouse)
• Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S High pressure promotes monocyte adhesion to the vascular wall. Circ. Res., 2007-03-29;100(8):1226-33. 2007-03-29 [PMID: 17395876] (Bioassay, Mouse)
• Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood, 2007-01-16;109(9):3706-12. 2007-01-16 [PMID: 17227831] (Bioassay, Mouse)
• Kurooka M, Kaneda Y Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res., 2007-01-01;67(1):227-36. 2007-01-01 [PMID: 17210703] (Bioassay, Mouse)
• Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA (Standard))
• Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J. Immunol., 2006-07-01;177(1):612-20. 2006-07-01 [PMID: 16785559] (In Vivo, Mouse)
• Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 2006-05-23;108(6):2041-4. 2006-05-23 [PMID: 16720837] (Bioassay, Mouse)
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• An HJ, Jeong HJ, Um JY, Kim HM, Hong SH Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. J Ethnopharmacol, 2006-03-10;106(3):418-24. 2006-03-10 [PMID: 16530364] (ELISA (Standard))
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• Costa SK, Yshii LM, Poston RN, Muscara MN, Brain SD Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature. J. Neuroimmunol., 2005-11-02;171(1):99-109. 2005-11-02 [PMID: 16269189] (In Vivo, Mouse)
• Yilmaz OH, Kiel MJ, Morrison SJ SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood, 2005-10-11;107(3):924-30. 2005-10-11 [PMID: 16219798] (Bioassay, Mouse)
• Niederkofler V, Salie R, Arber S Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest., 2005-08-01;115(8):2180-6. 2005-08-01 [PMID: 16075058] (In Vivo, Mouse)
• Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA (Standard))
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• Fredj S, Bescond J, Louault C, Delwail A, Potreau D Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation. J. Cell. Physiol., 2005-08-01;204(2):428-36. 2005-08-01 [PMID: 15717324] (ELISA (Standard))
• Gard AL, Gavin E, Solodushko V, Pennica D Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience, 2004-01-01;127(1):43-52. 2004-01-01 [PMID: 15219667] (Western Blot)
• Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization. J. Immunol., 2004-01-15;172(2):1237-45. 2004-01-15 [PMID: 14707102] (In Vivo, Mouse)
• Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 2001-11-01;293(10):508-14. 2001-11-01 [PMID: 11820727] (Bioassay, Mouse)
• Liu F, Poursine-Laurent J, Wu HY, Link DC Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood, 1997-10-01;90(7):2583-90. 1997-10-01 [PMID: 9326224] (Bioassay, In Vivo, Mouse)

FAQs for IL-6 (406-ML/CF). (Showing 1 - 1 of 1 FAQs).

1. I was wondering if you know of any blocking antibodies against IL-6 or VEGF-C that can be used in cell culture to quench these cytokines?
   • We have no antibodies that are currently known to show blocking antibodies to VEGF-C. Please see this link to our IL-6 antibodies with blocking/neutralizing activity can be found at this link.

Bioinformatics

• Gene Symbol: Il6
• Uniprot:
  • P08505()