Recombinant Mouse IL-4 Protein

Recombinant Mouse IL-4 (Catalog # 404-ML) has a molecular weight (MW) of 13.2 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Recombinant Mouse IL-4 (Catalog # 404-ML) stimulates cell proliferation of the HT‑2 mouse T cell line. The ED50 for this effect is 0.300-3.00 ng/mL.

1 μg/lane of Recombinant Mouse IL-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 12 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-4 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using HT‑2 mouse T cells. The ED₅₀ for this effect is 0.300‑3.00 ng/mL.
• Source: E. coli-derived mouse IL-4 protein
  His23-Ser140, with an N-terminal Met
• Accession #: P07750
• N-terminal Sequence: His23
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il4
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 14 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-4 Protein

• B cell growth factor 1
• BCDF
• B-cell stimulatory factor 1
• BCGF1
• BCGF-1
• binetrakin
• BSF1
• BSF-1
• IL4
• IL-4
• IL-4B_cell stimulatory factor 1
• IL4E12
• interleukin 4
• interleukin-4
• Lymphocyte stimulatory factor 1
• MGC79402
• pitrakinra

Background

Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1-4). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (5). Mouse IL-4 is synthesized with a 24 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (6-8). IL-4 exerts its effects through two receptor complexes (9, 10). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and
-21). The type II receptor on nonhematopoietic cells consists of IL‑4 R alpha and IL‑13 R alpha 1. The type II receptor also transduces IL‑13 mediated signals. IL-4 is primarily expressed by Th2‑biased CD4⁺ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4⁺ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (11 ‑ 14). IL-4 plays a dominant role in the development of allergic inflammation and asthma (13, 15).

1. Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109.
2. Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1.
3. Lee, F. et al. (1986) Proc. Natl. Acad. Sci. 83:2061.
4. Noma, Y. et al. (1986) Nature 319:640.
5. Redfield, C. et al. (1991) Biochemistry 30:11029.
6. Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141.
7. Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451.
8. Mosman, T.R. et al. (1987) J. Immunol. 138:1813.
9. Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237.
10. Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701.
11. Paludan, S.R. (1998) Scand. J. Immunol. 48:459.
12. Corthay, A. (2006) Scand. J. Immunol. 64:93.
13. Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15.
14. Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1.
15. Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303.

Publications for IL-4 (404-ML)(479)

Publications using 404-ML

• Kadariswantiningsih, IN;Okunaga, I;Yamasaki, K;Empitu, MA;Yamada, H;Makino, SI;Hotta, A;Yagita, H;Aizawa, M;Koyama-Nasu, R;Kimura, MY;Tatsumoto, N;Asanuma, K; CCL5 paradoxically regulates glomerular injury by skewing macrophage polarization JCI insight 2025-09-23 [PMID: 40986444] (Bioassay, Mouse)
• Lenoel, I;Ribon, M;Lorenc, F;Diebold, A;Philibert, CE;Robaldo, D;Badsi, M;Perronnet, J;Lameth, J;Berriat, F;Misawa, H;Coutelier, M;Cassel, R;Sarrazin, N;Jost-Mousseau, C;Bohl, D;Millecamps, S;Mallat, M;Brenner, D;Weishaupt, JH;Boillée, S;Lobsiger, CS; ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice Nature communications 2025-08-26 [PMID: 40858618] (Bioassay, Mouse)
• Horii, Y;Ino, H;Sasaki, F;Ishibashi, M;Koike, E;Kawamoto, Y;Flavell, RA;Ohashi, R;Suzuki, S;Negishi, Y;Morita, R; Inflammatory cytokine interleukin-18 prevents murine miscarriage by inducing appropriate inflammation Scientific reports 2025-08-21 [PMID: 40841464] (In vivo assay, Mouse)
• Sharma, B;Lu, X;Rehman, H;Figueiredo, VC;Davis, C;Van Remmen, H;Kuang, S;Brooks, SV;Maddipati, KR;Markworth, JF; Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury Molecular metabolism 2025-08-05 [PMID: 40769490] (Bioassay, Mouse, Transgenic Mouse)
• Kim, DS;Park, Y;Tsokos, GC;Cho, ML;Kwok, SK; The ubiquitin E3 ligase TRIM21 suppresses type I interferon signaling via STING degradation and ameliorates systemic autoimmunity Experimental & molecular medicine 2025-07-03 [PMID: 40610751] (Bioassay, Mouse)
• Zhu, X;Yu, Y;Li, Y;Wang, P;Li, Y;McCabe, C;Chen, S;Langenfeld, HE;Hanson, AC;Sharp, BE;Woltzen, A;Crowson, CS;Markovic, SN;Davis, JM;Dong, H;Thanarajasingam, U;Zeng, H; Inflammatory arthritis immune related adverse events represent a unique autoimmune disease entity primarily driven by T cells, but likely not autoantibodies medRxiv : the preprint server for health sciences 2025-06-06 [PMID: 40502578] (Bioassay, Mouse)
• Zhang, J;Tang, H;Wu, H;Pang, X;Jin, R;Zhang, Y; Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-? production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms eLife 2025-05-14 [PMID: 40366856] (Bioassay, Mouse)
• Bakadlag, R;Chou, H;Guilbert, C;Luo, VM;Orthwein, A;Mann, KK; The role of tungsten in modulating DNA double-strand break repair and class switch recombination Toxicology and applied pharmacology 2025-05-11 [PMID: 40360058] (Bioassay, Mouse)
• Szczepan, M;Llorián-Salvador, M;Yi, C;Hughes, D;Mack, M;Chen, M;Xu, H; Differential Roles of Macrophages and Microglia in Subretinal Fibrosis Secondary to Neovascular Age-Related Macular Degeneration Investigative ophthalmology & visual science 2025-03-03 [PMID: 40111356] (Bioassay, Mouse)
• Picco, F;Zeboudj, L;Oggero, S;Prato, V;Burgoyne, T;Gamper, N;Malcangio, M; Macrophage to neuron communication via extracellular vesicles in neuropathic pain conditions Heliyon 2025-01-15 [PMID: 39811367] (Bioassay, Mouse)
• Kim, JY;Cho, DW;Choi, JY;Jeong, S;Kang, M;Kim, WJ;Hong, IS;Song, H;Chang, H;Yang, SR;Lee, SJ;Park, M;Hong, SH; CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice Cell & bioscience 2024-11-15 [PMID: 39548525] (Bioassay, Mouse)
• Zhao, Q;Wang, Q;Yao, Q;Yang, Z;Li, W;Cheng, X;Wen, Y;Chen, R;Xu, J;Wang, X;Qin, D;Zhu, S;He, L;Li, N;Wu, Y;Yu, Y;Cao, X;Wang, P; Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses Cell research 2025-01-06 [PMID: 39757301] (Bioassay, Mouse)
• Oberholtzer, N;Chakraborty, P;Kassir, MF;Dressman, J;Das, S;Mills, S;Comte-Walters, S;Gooz, M;Choi, S;Parikh, RY;Hedley, Z;Vaena, S;DeMass, R;Scurti, G;Romeo, M;Gangaraju, VK;Berto, S;Hill, E;Ball, LE;Mehta, AS;Maldonado, EN;Nishimura, MI;Ogretmen, B;Mehrotra, S; H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response Science advances 2024-11-15 [PMID: 39546607] (Bioassay, Mouse)
• Shan, X;Ji, Z;Wang, B;Zhang, Y;Dong, H;Jing, W;Zhou, Y;Hu, P;Cui, Y;Li, Z;Yu, S;Zhou, J;Wang, T;Shen, L;Liu, Y;Yu, Q; Riboflavin kinase binds and activates inducible nitric oxide synthase to reprogram macrophage polarization Redox biology 2024-10-30 [PMID: 39536592] (Bioassay, Mouse)
• Shen, Q;Murakami, K;Sotov, V;Butler, M;Ohashi, PS;Reedijk, M; Inhibition of Notch enhances efficacy of immune checkpoint blockade in triple-negative breast cancer Science advances 2024-11-01 [PMID: 39475614] (Bioassay, Mouse)
• Hou, Y;Sun, L;LaFleur, MW;Huang, L;Lambden, C;Thakore, PI;Geiger-Schuller, K;Kimura, K;Yan, L;Zang, Y;Tang, R;Shi, J;Barilla, R;Deng, L;Subramanian, A;Wallrapp, A;Choi, HS;Kye, YC;Ashenberg, O;Schiebinger, G;Doench, JG;Chiu, IM;Regev, A;Sharpe, AH;Kuchroo, VK; Neuropeptide signalling orchestrates T cell differentiation Nature 2024-10-16 [PMID: 39415015] (Bioassay, Mouse)
• Koksalar Alkan, F;Caglayan, AB;Alkan, HK;Benson, E; Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironment Scientific Reports 2024-01-01 [PMID: 39341857] (Bioassay, Mouse)
• Cho, HH;Rhee, S;Cho, DI;Jun, JH;Heo, H;Cho, SH;Kim, D;Wang, M;Kang, BG;Yoo, SJ;Cho, M;Lim, SY;Cho, JY;Jeong, IS;Kim, YS;Ahn, Y; IKK?-deficient macrophages impede cardiac repair after myocardial infarction by enhancing the macrophage-myofibroblast transition Experimental & molecular medicine 2024-09-01 [PMID: 39261656] (Bioassay, Mouse)
• Pena Calderin, EH;Zheng, JJ;Boyd, NL;Lynch, W;Sansbury, BE;Spite, M;Hill, BG;Hellmann, J; Exercise-stimulated Resolvin Biosynthesis in Adipose Tissue is Abrogated by High Fat Diet-induced Adrenergic Deficiency bioRxiv : the preprint server for biology 2024-08-19 [PMID: 39229191] (Bioassay, Mouse)
• Shan, L;Matloubi, M;Okwor, I;Kung, S;Almiski, MS;Basu, S;Halayko, A;Koussih, L;Gounni, AS; CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma PloS one 2024-08-30 [PMID: 39213301] (Bioassay, Transgenic Mouse)
• Singh, SS;Calvo, R;Kumari, A;Sable, RV;Fang, Y;Tao, D;Hu, X;Castle, SG;Nahar, S;Li, D;Major, E;Sanchez, TW;Kato, R;Xu, X;Zhou, J;Liu, L;LeClair, CA;Simeonov, A;Baljinnyam, B;Henderson, MJ;Marugan, J;Rudloff, U; Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity Molecular cancer therapeutics 2024-08-30 [PMID: 39212669] (Bioassay, Mouse)
• Lim, YJ;Park, SA;Wang, D;Jin, W;Ku, WL;Zhang, D;Xu, J;Patiño, LC;Liu, N;Chen, W;Kazmi, R;Zhao, K;Zhang, YE;Sun, L;Chen, W; MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells Cell reports 2024-07-30 [PMID: 39083380] (Bioassay, Human, Mouse)
• Kim, Y;Manara, F;Grassmann, S;Belcheva, KT;Reyes, K;Kim, H;Downs-Canner, S;Yewdell, WT;Sun, JC;Chaudhuri, J; IL-21 Shapes the B Cell Response in a Context-Dependent Manner bioRxiv : the preprint server for biology 2024-07-13 [PMID: 39026745] (Bioassay, Mouse)
• Zewdie, EY;Edwards, GM;Hunter, DM;Earp, HS;Holtzhausen, A; MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming Cancer immunology research 2024-07-08 [PMID: 38976507] (Bioassay, Mouse)
• Tedeschi, G;Navarro, MX;Scipioni, L;Sondhi, TK;Prescher, JA;Digman, MA; Monitoring macrophage polarization with gene expression reporters and bioluminescence phasor analysis bioRxiv : the preprint server for biology 2024-06-12 [PMID: 38915606] (Bioassay, Mouse)
• Wright, NE;Kennedy, DE;Ai, J;Veselits, ML;Attaway, M;Yoon, YM;Durkee, MS;Veselits, J;Maienschein-Cline, M;Mandal, M;Clark, MR; BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function bioRxiv : the preprint server for biology 2024-04-28 [PMID: 38712068] (Bioassay, Mouse)
• Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B; Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice Nature communications 2024-02-26 [PMID: 38409097] (Bioassay, Mouse)
• Hardaker, EL;Sanseviero, E;Karmokar, A;Taylor, D;Milo, M;Michaloglou, C;Hughes, A;Mai, M;King, M;Solanki, A;Magiera, L;Miragaia, R;Kar, G;Standifer, N;Surace, M;Gill, S;Peter, A;Talbot, S;Tohumeken, S;Fryer, H;Mostafa, A;Mulgrew, K;Lam, C;Hoffmann, S;Sutton, D;Carnevalli, L;Calero-Nieto, FJ;Jones, GN;Pierce, AJ;Wilson, Z;Campbell, D;Nyoni, L;Martins, CP;Baker, T;Serrano de Almeida, G;Ramlaoui, Z;Bidar, A;Phillips, B;Boland, J;Iyer, S;Barrett, JC;Loembé, AB;Fuchs, SY;Duvvuri, U;Lou, PJ;Nance, MA;Gomez Roca, CA;Cadogan, E;Critichlow, SE;Fawell, S;Cobbold, M;Dean, E;Valge-Archer, V;Lau, A;Gabrilovich, DI;Barry, ST; The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment Nature communications 2024-02-24 [PMID: 38402224] (Bioassay, Mouse)
• Bekkat, F;Seradj, M;Lengagne, R;Fiore, F;Kato, M;Lucas, B;Castellano, F;Molinier-Frenkel, V;Richard, Y;Prévost-Blondel, A; Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties European journal of immunology 2024-02-24 [PMID: 38400692] (Bioassay, Mouse)
• Guo, HL;Liang, XS;Zeng, XP;Liu, Y;Li, ZS;Wang, LJ;Hu, LH; Pirfenidone alleviates chronic pancreatitis via suppressing the activation of pancreatic stellate cells and the M1 polarization of macrophages International immunopharmacology 2024-02-16 [PMID: 38367466] (Bioassay, Mouse)
• Zhang, Z;Zhao, C;Sun, L;Cheng, C;Tian, Q;Wu, C;Xu, Y;Dong, X;Zhang, B;Zhang, L;Zhao, Y; Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice European journal of immunology 2024-01-17 [PMID: 38234007] (Bioassay, Mouse, Transgenic Mouse)
• King, A;Reichl, P;Metson, JS;Parker, R;Munro, D;Oliveira, C;Becker, JR;Biggs, D;Preece, C;Davies, B;Chapman, JR; Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice bioRxiv : the preprint server for biology 2023-12-21 [PMID: 38187711] (Bioassay, Mouse)
• Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L; Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity Nature communications 2024-01-04 [PMID: 38177117] (Bioassay, Mouse)
• Hou, Y;Wei, D;Zhang, Z;Lei, T;Li, S;Bao, J;Guo, H;Tan, L;Xie, X;Zhuang, Y;Lu, Z;Zhao, Y; Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes Cell reports 2024-01-03 [PMID: 38175755] (Bioassay, Mouse, Transgenic Mouse)
• Lin, YL;Cheng, PY;Chin, CL;Chuang, KT;Lin, JY;Chang, N;Pan, CK;Lin, CS;Pan, SC;Chiang, BL; A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge Journal of biomedical science 2023-12-18 [PMID: 38110940] (Bioassay, Mouse)
• Rosell-Mases, E;Santiago, A;Corral-Pujol, M;Yáñez, F;Varela, E;Egia-Mendikute, L;Arpa, B;Cosovanu, C;Panosa, A;Serrano-Gómez, G;Mora, C;Verdaguer, J;Manichanh, C; Mutual modulation of gut microbiota and the immune system in type 1 diabetes models Nature communications 2023-11-27 [PMID: 38012160] (Bioassay, Mouse)
• Lima Teixeira, JF;Henning, P;Cintra Magalhães, FA;Coletto-Nunes, G;Floriano-Marcelino, T;Westerlund, A;Movérare-Skrtic, S;Oliveira, GJPL;Lerner, UH;Souza, PPC; Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis Cytokine 2023-10-26 [PMID: 37898012] (In vivo assay, Mouse)
• Alexander, ET;Fahey, E;Phanstiel, O;Gilmour, SK; Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice Biomedicines 2023-10-05 [PMID: 37893077] (Bioassay, Transgenic Mouse, Mouse)
• Wang, Y;Chen, X;Zhou, L;Chinn, E;Yue, J; The mechanism underlying the inverse proportion between serum IgE concentration and Stat3 transcriptional activity depends on Stat3 mutation type International immunopharmacology 2023-10-10 [PMID: 37827058] (Bioassay, Mouse)
• Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC; Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release Nature communications 2023-10-09 [PMID: 37813836] (Bioassay, Mouse)
• Cao, Y;Wu, Y;Tu, H;Gu, Z;Yu, F;Huang, W;Shen, L;Wang, L;Li, Y; (-)-Guaiol inhibit epithelial-mesenchymal transition in lung cancer via suppressing M2 macrophages mediated STAT3 signaling pathway Heliyon 2023-09-01 [PMID: 37809930] (Bioassay, Mouse)
• Chen, S;Wang, J;Zhang, K;Ma, B;Li, X;Wei, R;Nian, H; LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation Cell death & disease 2023-09-16 [PMID: 37716986] (Bioassay, Mouse)
• van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E; CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1 European journal of immunology 2023-09-08 [PMID: 37683186] (Bioassay, Human)
• Zhang, J;Koolmeister, C;Han, J;Filograna, R;Hanke, L;Àdori, M;Sheward, DJ;Teifel, S;Gopalakrishna, S;Shao, Q;Liu, Y;Zhu, K;Harris, RA;McInerney, G;Murrell, B;Aoun, M;Bäckdahl, L;Holmdahl, R;Pekalski, M;Wedell, A;Engvall, M;Wredenberg, A;Karlsson Hedestam, GB;Castro Dopico, X;Rorbach, J; Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations JCI insight 2023-09-08 [PMID: 37681412] (Bioassay, Mouse)
• Wu, J;Hu, Y;Song, J;Xu, J;Zhang, Q;Chai, Y;Wang, X;Wang, B;Zhao, Y;Cao, X;Xu, X; Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation Cell death & disease 2023-09-06 [PMID: 37673879] (Bioassay, Mouse)
• Genetta, TL;Hurwitz, JC;Clark, EA;Herold, BT;Khalil, S;Abbas, T;Larner, JM; ZEB1 promotes non-homologous end joining double-strand break repair Nucleic acids research 2023-09-04 [PMID: 37665026] (Bioassay, Mouse)
• Hirano, Y;Nakagomi, T;Nakano-Doi, A;Kubo, S;Minato, Y;Sawano, T;Sakagami, M;Tsuzuki, K; Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains Cells 2023-08-10 [PMID: 37626850] (Bioassay, Mouse)
• Lee, JY;Chou, NL;Yu, YR;Shih, HA;Lin, HW;Lee, CK;Chang, MS; PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells PloS one 2023-08-04 [PMID: 37540725] (Bioassay, Mouse)
• Li, Y;Li, L;Wang, M;Yang, B;Huang, B;Bai, S;Zhang, X;Hou, N;Wang, H;Yang, Z;Tang, C;Li, Y;Yuk-Wai Lee, W;Feng, L;Tortorella, MD;Li, G; O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair Bioactive materials 2023-10-01 [PMID: 37303853] (Bioassay, Rat)
• Colombo, E;De Angelis, A;Bassani, C;Ruffini, F;Ottoboni, L;Garzetti, L;Finardi, A;Martino, G;Furlan, R;Farina, C; iAstrocytes do not restrain T cell proliferation in vitro BMC neuroscience 2023-06-07 [PMID: 37286983] (Bioassay, Mouse)
• Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D; Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages Journal of translational medicine 2023-05-22 [PMID: 37217897] (Bioassay, Mouse)
• Arpa, L;Batlle, C;Jiang, P;Caelles, C;Lloberas, J;Celada, A; Distinct Responses to IL4 in Macrophages Mediated by JNK Cells 2023-04-11 [PMID: 37190036] (Bioassay, Mouse)
• Kurosaka, M;Hung, YL;Machida, S;Kohda, K; IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger Cells 2023-04-29 [PMID: 37174683] (Bioassay, Mouse)
• Shang, M;Ni, L;Shan, X;Cui, Y;Hu, P;Ji, Z;Shen, L;Zhang, Y;Zhou, J;Bing Chen, ;Wang, T;Yu, Q; MTHFD2 reprograms macrophage polarization by inhibiting PTEN Cell reports 2023-05-05 [PMID: 37149861] (Bioassay, Mouse)
• Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC; Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development Science advances 2023-05-05 [PMID: 37146141] (Bioassay, Mouse)
• CE Rivera, Y Zhou, DP Chupp, H Yan, AD Fisher, R Simon, H Zan, Z Xu, P Casali Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells Science Advances, 2023-04-28;9(17):eade8928. 2023-04-28 [PMID: 37115935] (Bioassay, Mouse)
• H Huang, Y Li, G Zhang, GX Ruan, Z Zhu, W Chen, J Zou, R Zhang, J Wang, Y Ouyang, S Xu, X Ou The RNA-binding protein hnRNP F is required for the germinal center B cell response Nature Communications, 2023-03-30;14(1):1731. 2023-03-30 [PMID: 36997512] (Bioassay, Mouse)
• KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity Nature Communications, 2023-03-24;14(1):1652. 2023-03-24 [PMID: 36964178] (Bioassay, Mouse)
• Y Zhang, W Gao, J Yuan, X Zhong, K Yao, R Luo, H Liu CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction Pharmaceutics, 2023-01-30;15(2):. 2023-01-30 [PMID: 36839783] (Bioassay, Mouse)
• WL Yang, W Qiu, T Zhang, K Xu, ZJ Gu, Y Zhou, HJ Xu, ZZ Yang, B Shen, YL Zhao, Q Zhou, Y Yang, W Li, PY Yang, YG Yang Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis Nature Communications, 2023-02-16;14(1):863. 2023-02-16 [PMID: 36792629] (Bioassay, Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768873] (Bioassay, Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768873] (Bioassay, Mouse)
• N Beckmann, A Neuhaus, S Zurbruegg, P Volkmer, C Patino, S Joller, D Feuerbach, A Doelemeyer, T Schweizer, S Rudin, U Neumann, R Berth, W Frieauff, F Gasparini, DR Shimshek Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model Journal of Neuroinflammation, 2023-02-08;20(1):29. 2023-02-08 [PMID: 36755323] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• Z Li, K Chen, Q Shao, H Lu, X Zhang, Y Pu, X Sun, H He, L Cao Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress Journal of Neuroinflammation, 2023-01-30;20(1):16. 2023-01-30 [PMID: 36710351] (Bioassay, Mouse)
• MK Park, HK Park, HS Yu Toll-like receptor 2 mediates Acanthamoeba-induced allergic airway inflammatory response in mice PloS Neglected Tropical Diseases, 2023-01-27;17(1):e0011085. 2023-01-27 [PMID: 36706056] (Bioassay, Mouse)
• A Mironov, M Fisher, P Narayanan, R Elsayed, M Karabuluto, N Akhtar Rac1 controls cell turnover and reversibility of the involution process in postpartum mammary glands PloS Biology, 2023-01-19;21(1):e3001583. 2023-01-19 [PMID: 36656812] (Bioassay, Mouse)
• J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports, 2023-01-18;42(1):111991. 2023-01-18 [PMID: 36656709] (Bioassay, Mouse)
• Y Hu, RA Hill, M Yoshimura Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia International Journal of Molecular Sciences, 2022-12-25;24(1):. 2022-12-25 [PMID: 36613790] (Bioassay, Mouse)
• BE Clausen, L Amon, RA Backer, L Berod, T Bopp, A Brand, S Burgdorf, L Chen, M Da, U Distler, RJ Dress, D Dudziak, CA Dutertre, C Eich, A Gabele, M Geiger, F Ginhoux, L Giusiano, GJ Godoy, AEI Hamouda, L Hatscher, L Heger, GF Heidkamp, LC Hernandez, L Jacobi, T Kaszubowsk, WT Kong, CHK Lehmann, T López-Lópe, K Mahnke, D Nitsche, J Renkawitz, RA Reza, PJ Sáez, L Schlautman, MT Schmitt, A Seichter, M Sielaff, T Sparwasser, P Stoitzner, G Tchitashvi, S Tenzer, NR Tochoedo, D Vurnek, F Zink, T Hieronymus Guidelines for mouse and human DC functional assays European Journal of Immunology, 2022-12-23;0(0):. 2022-12-23 [PMID: 36563126] (Mouse)
• Y Hou, D Wei, Z Zhang, H Guo, S Li, J Zhang, P Zhang, L Zhang, Y Zhao FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism Cell Reports, 2022-11-15;41(7):111668. 2022-11-15 [PMID: 36384126] (Bioassay, Mouse, Transgenic Mouse)
• CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Science Advances, 2022-11-16;8(46):eabq0615. 2022-11-16 [PMID: 36383649] (Bioassay, Transgenic Mouse)
• KC Huang, CY Lai, WZ Hong, HY Chang, PC Lin, SF Chiang, TW Ke, JA Liang, AC Shiau, PC Yang, WT Chen, KSC Chao A Novel Engineered AAV-based Neoantigen Vaccine in Combination with Radiotherapy Eradicates Tumors Cancer Immunology Research, 2023-01-03;0(0):. 2023-01-03 [PMID: 36315960] (Bioassay, Mouse)
• AP Shaik, AS Shaik, M Abudawood, A Al Faraj Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses BioMed Research International, 2022-10-06;2022(0):9470845. 2022-10-06 [PMID: 36246991] (Bioassay, Mouse)
• SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Mouse)
• H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target Nature Communications, 2022-10-10;13(1):5974. 2022-10-10 [PMID: 36216803] (Bioassay, Mouse)
• J Liu, L Shi, W Huang, Z Zheng, X Huang, Y Su Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB Signaling Mediators of Inflammation, 2022-09-29;2022(0):3441357. 2022-09-29 [PMID: 36211988] (Bioassay, Mouse)
• KC Fernandez, L Feeney, RM Smolkin, WF Yen, AJ Matthews, W Alread, JHJ Petrini, J Chaudhuri The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes Elife, 2022-10-03;11(0):. 2022-10-03 [PMID: 36190107] (Bioassay, Mouse)
• Y Inoue, CW Liao, Y Tsunakawa, IL Tsai, S Takahashi, M Hamada Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing International Journal of Molecular Sciences, 2022-08-19;23(16):. 2022-08-19 [PMID: 36012611] (Cell Culture, Mouse)
• SI Tsukumo, PG Subramani, N Seija, M Tabata, Y Maekawa, Y Mori, C Ishifune, Y Itoh, M Ota, K Fujio, JM Di Noia, K Yasutomo AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination Science Advances, 2022-08-24;8(34):eabq0008. 2022-08-24 [PMID: 36001653] (Cell Culture, Mouse)
• C Vasavda, R Xu, J Liew, R Kothari, RS Dhindsa, ER Semenza, BD Paul, DP Green, MF Sabbagh, JY Shin, W Yang, AM Snowman, LK Albacarys, A Moghekar, CA Pardo-Vill, M Luciano, J Huang, C Bettegowda, SG Kwatra, X Dong, M Lim, SH Snyder Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain Science Advances, 2022-08-03;8(31):eabo5633. 2022-08-03 [PMID: 35921423] (Western Blot, Mouse)
• Maša Filipović, Darja Flegar, Alan Šućur, Dino Šisl, Inga Kavazović, Mariastefania Antica et al. Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions Frontiers in Immunology 2022-07-05 [PMID: 35865541] (Bioassay, Mouse)
• R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 2022-07-04;12(11):5220-5236. 2022-07-04 [PMID: 35836819] (Bioassay, Mouse)
• Y Mo, H Kang, JY Bang, JW Shin, HY Kim, SH Cho, HR Kang Intratracheal administration of mesenchymal stem cells modulates lung macrophage polarization and exerts anti-asthmatic effects Scientific Reports, 2022-07-11;12(1):11728. 2022-07-11 [PMID: 35821386] (Bioassay, Mouse)
• MK Ameka, WN Beavers, CM Shaver, LB Ware, VE Kerchberge, KQ Schoenfelt, L Sun, T Koyama, EP Skaar, L Becker, AH Hasty An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload International Journal of Molecular Sciences, 2022-07-03;23(13):. 2022-07-03 [PMID: 35806422] (Bioassay, Mouse)
• J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu, Z Yao, L Liu, H Zhang, B Luo, X Wang, C Zeng, X Bai, H Zhang, D Cai Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32 Cell Death & Disease, 2022-06-24;13(6):567. 2022-06-24 [PMID: 35739102] (Bioassay, Mouse)
• EA Kowalski, E Soliman, C Kelly, EK Gudenschwa, J Leonard, KJ Pridham, J Ju, AM Cash, A Hazy, C de Jager, AM Kaloss, H Ding, RD Hernandez, GM Coleman, X Wang, ML Olsen, AM Pickrell, MH Theus Monocyte pro-inflammatory phenotypic control by Ephrin type-A receptor 4 mediates neural tissue damage JCI Insight, 2022-08-08;0(0):. 2022-08-08 [PMID: 35737458] (Bioassay, Mouse)
• JH Lee, SH Lee, EH Lee, JY Cho, DK Song, YJ Lee, TK Kwon, BC Oh, KW Cho, TF Osborne, TI Jeon, SS Im SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization Journal of advanced research, 2022-05-31;0(0):. 2022-05-31 [PMID: 35659922] (Bioassay, Mouse)
• Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis Cell Death & Disease, 2022-05-31;13(5):512. 2022-05-31 [PMID: 35641492] (Bioassay, Mouse)
• R Mary, F Chalmin, T Accogli, M Bruchard, C Hibos, J Melin, C Truntzer, E Limagne, V Derangère, M Thibaudin, E Humblin, R Boidot, S Chevrier, L Arnould, C Richard, Q Klopfenste, A Bernard, Y Urade, JA Harker, L Apetoh, F Ghiringhel, F Végran Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects Cancer Immunology Research, 2022-07-01;0(0):OF1-OF17. 2022-07-01 [PMID: 35612500] (Bioassay, Mouse)
• AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 2022-05-10;39(6):110785. 2022-05-10 [PMID: 35545045] (Bioassay, Mouse)
• K Ming-Chin, AA Achuthan, DP De Souza, TJ Lupancu, KJ Binger, MKS Lee, Y Xu, MJ McConville, NA de Weerd, D Dragoljevi, PJ Hertzog, AJ Murphy, JA Hamilton, AJ Fleetwood Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization Cell Reports, 2022-04-19;39(3):110719. 2022-04-19 [PMID: 35443173] (Bioassay, Mouse)
• MM LaRue, S Parker, J Puccini, M Cammer, AC Kimmelman, D Bar-Sagi Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer Proceedings of the National Academy of Sciences of the United States of America, 2022-04-11;119(16):e2119168119. 2022-04-11 [PMID: 35412885] (Cell Culture, Mouse)
• Z Qu, M Li, R An, H Dai, Y Yu, C Li, C Cao, Y Meng, J Wang, M Gao Self-assembled BPIV3 nanoparticles can induce comprehensive immune responses and protection against BPIV3 challenge by inducing dendritic cell maturation in mice Veterinary Microbiology, 2022-03-31;268(0):109415. 2022-03-31 [PMID: 35395543] (Bioassay, Mouse)
• CJ Ortiz-Boni, TP Uccello, SA Gerber, EM Lord, EM Messing, YF Lee Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity International Journal of Molecular Sciences, 2022-03-08;23(6):. 2022-03-08 [PMID: 35328324] (Bioassay, Mouse)
• JD Hathaway-S, JD Aartun, NA Poulides, MB Kuhn, BE McCormick, ME Chew, E Huang, RP Darveau, C Westwater, CM Novince Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 35077397] (Bioassay, Mouse)
• Z Mirman, NK Sasi, A King, JR Chapman, T de Lange 53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polalpha-primase fill-in synthesis Nature Cell Biology, 2022-01-13;24(1):51-61. 2022-01-13 [PMID: 35027730] (Bioassay, Mouse)
• D Zhao, C Wang, X Liu, N Liu, S Zhuang, Q Zhang, X Bao, S Xu, X Zhou, Q Meng, S Li, L Tang CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis Mediators of Inflammation, 2021-12-30;2021(0):7858746. 2021-12-30 [PMID: 35002536] (Bioassay, Mouse)
• X Xiao, Y Li, Y Wang, Y Zhang, J Chen, W Liu, J Tang, F Yue, J Yang Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway International immunopharmacology, 2021-12-15;103(0):108427. 2021-12-15 [PMID: 34922249] (Polarization, Mouse)
• S Chen, Y Bai, Y Wang, C Liang, K Du, S Wang, J Li, YX Chang Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-alpha induced dendritic cells Journal of ethnopharmacology, 2021-12-14;285(0):114918. 2021-12-14 [PMID: 34919989] (Bioassay, Mouse)
• A Di Pietro, J Polmear, L Cooper, T Damelang, T Hussain, L Hailes, K O'Donnell, V Udupa, T Mi, S Preston, A Shtewe, U Hershberg, SJ Turner, NL La Gruta, AW Chung, DM Tarlinton, CD Scharer, KL Good-Jacob Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection Nature Immunology, 2021-11-29;0(0):. 2021-11-29 [PMID: 34845392] (Bioassay, Mouse)
• KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang Deleterious Role of Th9 Cells in Pulmonary Fibrosis Cells, 2021-11-17;10(11):. 2021-11-17 [PMID: 34831433] (Bioassay, Mouse)
• Y Feng, C Li, JA Stewart, P Barbulescu, NS Desivo, A Álvarez-Qu, RC Pezo, MLW Perera, K Chan, AHY Tong, R Mohamad-Ra, M Berru, D Nakib, G Li, GA Kardar, JR Carlyle, J Moffat, D Durocher, JM Di Noia, AS Bhagwat, A Martin FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Nature, 2021-11-24;0(0):. 2021-11-24 [PMID: 34819670] (Bioassay, Mouse)
• HM Shen, R Wuerffel, JF Cantillo, S Priyadarsh, X Lei, J Liang, YL Wu, AL Kenter Loop extrusion promotes an alternate pathway for isotype switching Cell Reports, 2021-11-23;37(8):110059. 2021-11-23 [PMID: 34818547] (Bioassay, Mouse)
• L Long, J Wei, SA Lim, JL Raynor, H Shi, JP Connelly, H Wang, C Guy, B Xie, NM Chapman, G Fu, Y Wang, H Huang, W Su, J Saravia, I Risch, YD Wang, Y Li, M Niu, Y Dhungana, A Kc, P Zhou, P Vogel, J Yu, SM Pruett-Mil, J Peng, H Chi CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity Nature, 2021-11-18;0(0):. 2021-11-18 [PMID: 34795452] (Bioassay, Mouse)
• Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons Journal of Neuroinflammation, 2021-11-08;18(1):261. 2021-11-08 [PMID: 34749758] (Bioassay, Mouse)
• JM Motta, VM Rumjanek, A Mantovani, M Locati Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation Biomedicines, 2021-10-04;9(10):. 2021-10-04 [PMID: 34680504] (Differentiation, Differentiation, Mouse)
• J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, 2021-09-21;36(12):109726. 2021-09-21 [PMID: 34551302] (Bioassay, Mouse)
• H Muto, T Ito, T Tanaka, S Yokoyama, K Yamamoto, N Imai, Y Ishizu, K Maeda, T Honda, T Ishikawa, A Kato, T Ohshiro, F Kano, A Yamamoto, K Sakai, H Hibi, M Ishigami, M Fujishiro Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Scientific Reports, 2021-09-21;11(1):18778. 2021-09-21 [PMID: 34548598] (Bioassay, Mouse)
• M Qadri, GD Jay, LX Zhang, TA Schmidt, J Totonchy, KA Elsaid Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration Arthritis Research & Therapy, 2021-09-14;23(1):241. 2021-09-14 [PMID: 34521469] (Bioassay, Mouse)
• L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer&#039;s disease Brain, Behavior, and Immunity, 2021-09-06;98(0):337-348. 2021-09-06 [PMID: 34500034] (Bioassay, Mouse)
• Qiuju Li, Ming Yuan, Xue Jiao, Yufei Huang, Jing Li, Dong Li et al. M1 Macrophage-Derived Nanovesicles Repolarize M2 Macrophages for Inhibiting the Development of Endometriosis Frontiers in Immunology 2021-07-20 [PMID: 34354711] (Bioassay, Mouse)
• F Zhao, W Kim, H Gao, C Liu, Y Zhang, Y Chen, M Deng, Q Zhou, J Huang, Q Hu, SH Chen, S Nowsheen, JA Kloeber, B Qin, P Yin, X Tu, G Guo, S Qin, C Zhang, M Gao, K Luo, Y Liu, Z Lou, J Yuan ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection Nature Cell Biology, 2021-08-05;23(8):894-904. 2021-08-05 [PMID: 34354233] (Bioassay, Mouse)
• NR Nabar, CN Heijjer, CS Shi, IY Hwang, S Ganesan, MCI Karlsson, JH Kehrl LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells Autophagy, 2021-07-27;0(0):19-Jan. 2021-07-27 [PMID: 34313548] (Bioassay, Mouse)
• Y Wu, Q Yu, M Zhang, Y Zhou, X Su, M Wu, J Lv, Z Xia Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles Journal of leukocyte biology, 2021-07-23;0(0):. 2021-07-23 [PMID: 34296788] (Bioassay, Mouse)
• A Ortega-Mol, C Lebrero-Fe, A Sanz, N Deleyto-Se, AB Plata-Góme, C Menéndez, O Graña-Cast, E Caleiras, A Efeyan Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs Cell Reports, 2021-07-13;36(2):109372. 2021-07-13 [PMID: 34260908] (Bioassay, Mouse)
• SS Yerneni, S Werner, JH Azambuja, N Ludwig, R Eutsey, SD Aggarwal, PC Lucas, N Bailey, TL Whiteside, PG Campbell, NL Hiller Pneumococcal Extracellular Vesicles Modulate Host Immunity MBio, 2021-07-13;0(0):e0165721. 2021-07-13 [PMID: 34253061] (Bioassay, Mouse)
• D Wang, J Ma, MV Botuyan, G Cui, Y Yan, D Ding, Y Zhou, EW Krueger, J Pei, X Wu, L Wang, H Pei, MA McNiven, D Ye, G Mer, H Huang ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication Science Advances, 2021-06-18;7(25):. 2021-06-18 [PMID: 34144977] (Bioassay, Mouse)
• J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 2021-06-16;7(25):. 2021-06-16 [PMID: 34134995] (Bioassay, Mouse)
• M Kurosaka, Y Ogura, S Sato, K Kohda, T Funabashi Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis Skeletal Muscle, 2021-05-29;11(1):14. 2021-05-29 [PMID: 34051858] (Bioassay, Mouse)
• Y Lu, L Liu, J Pan, B Luo, H Zeng, Y Shao, H Zhang, H Guan, D Guo, C Zeng, R Zhang, X Bai, H Zhang, D Cai MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-&amp;kappaB pathway Cell Death & Disease, 2021-05-25;12(6):533. 2021-05-25 [PMID: 34031369] (Cell Culture, Mouse)
• Y Luo, X Zheng, P Yuan, X Ye, L Ma Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes Bioactive materials, 2021-04-21;6(11):4065-4072. 2021-04-21 [PMID: 33997493] (Bioassay, Mouse)
• C Feng, L Li, Q Li, K Switzer, M Liu, S Han, B Zheng Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells International immunopharmacology, 2021-04-28;97(0):107698. 2021-04-28 [PMID: 33932699] (Bioassay, Mouse)
• D Wan, S Ai, H Ouyang, L Cheng Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice Experimental & Molecular Medicine, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859350] (Bioassay, Mouse)
• Y Zhang, Y Yan, J Meng, M Girotra, S Ramakrishn, S Roy Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids Mucosal Immunology, 2021-04-14;0(0):. 2021-04-14 [PMID: 33854193] (Bioassay, Mouse)
• Y Wang, M Song, M Liu, G Zhang, X Zhang, MO Li, X Ma, JJ Zhang, XY Huang Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity Cell Reports, 2021-04-06;35(1):108948. 2021-04-06 [PMID: 33826900] (Bioassay, Mouse)
• TJ Kopper, B Zhang, WM Bailey, KE Bethel, JC Gensel The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation Scientific Reports, 2021-03-18;11(1):6341. 2021-03-18 [PMID: 33737707] (Bioassay, Mouse)
• A Sripada, K Sirohi, L Michalec, L Guo, JT McKay, S Yadav, M Verma, J Good, D Rollins, MM Gorska, R Alam Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases PloS Biology, 2021-03-08;19(3):e3001063. 2021-03-08 [PMID: 33684096] (Bioassay, Mouse)
• RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-01-01;296(0):100129. 2020-01-01 [PMID: 33460921] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• VK Rangasami, S Samanta, VS Parihar, K Asawa, K Zhu, OP Varghese, Y Teramura, B Nilsson, J Hilborn, RA Harris, OP Oommen Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization Carbohydrate polymers, 2020-10-27;254(0):117291. 2020-10-27 [PMID: 33357860] (Bioassay, Mouse)
• Jukka Pajarinen, Tzuhua Lin, Akira Nabeshima, Taishi Sato, Emmanuel Gibon, Eemeli Jämsen et al. Interleukin‐4 repairs wear particle induced osteolysis by modulating macrophage polarization and bone turnover Journal of Biomedical Materials Research Part A 2021-08-01 [PMID: 33340244] (Bioassay, Mouse)
• L Kealy, A Di Pietro, L Hailes, S Scheer, L Dalit, JR Groom, C Zaph, KL Good-Jacob The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses Cell Reports, 2020-12-15;33(11):108504. 2020-12-15 [PMID: 33326791] (Bioassay, Transgenic Mouse)
• RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-12-04;0(0):. 2020-12-04 [PMID: 33262217] (Cell Culture, Mouse)
• A Baniahmad, K Birkner, J Görg, J Loos, F Zipp, B Wasser, S Bittner The frequency of follicular T helper cells differs in acute and chronic neuroinflammation Sci Rep, 2020-11-24;10(1):20485. 2020-11-24 [PMID: 33235306] (Bioassay, Transgenic Mouse)
• R Yang, G Wang, L Li, H He, M Zheng, L Lu, S Wu Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway J Transl Med, 2020-11-23;18(1):444. 2020-11-23 [PMID: 33228696] (Cell Culture, Mouse)
• SH Shin, HY Kim, HS Yoon, WJ Park, DR Adams, NJ Pyne, S Pyne, JW Park A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Na�ve CD4 T Lymphocytes Int J Mol Sci, 2020-11-08;21(21):. 2020-11-08 [PMID: 33171607] (Bioassay, Mouse)
• DM de Graaf, RJA Maas, SP Smeekens, E Eisenmesse, JS Redzic, MM Helsen, NE Powers, S Li, V Kalabokis, MS Gresnigt, LAB Joosten, CA Dinarello, FL van de Vee Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease Cytokine, 2020-10-28;137(0):155334. 2020-10-28 [PMID: 33128926] (Bioassay, Mouse)
• Huan Yang, Ting Zhou, Christine M. Sorenson, Nader Sheibani, Bo Liu Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1 Arteriosclerosis, Thrombosis, and Vascular Biology 2020-12-01 [PMID: 33028100] (Bioassay, Mouse)
• CY Han, I Kang, M Omer, S Wang, T Wietecha, TN Wight, A Chait Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its anti-inflammatory properties JCI Insight, 2020-09-24;0(0):. 2020-09-24 [PMID: 32970631] (Bioassay, Mouse)
• J Tur, S Pereira-Lo, T Vico, EA Marín, JP Muñoz, M Hernández-, PJ Cardona, A Zorzano, J Lloberas, A Celada Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity Cell Rep, 2020-08-25;32(8):108079. 2020-08-25 [PMID: 32846136] (Bioassay, Mouse)
• P Francica, M Mutlu, VA Blomen, C Oliveira, Z Nowicka, A Trenner, NM Gerhards, P Bouwman, E Stickel, ML Hekkelman, L Lingg, I Klebic, M van de Ven, R de Korte-G, D Howald, J Jonkers, AA Sartori, W Fendler, JR Chapman, T Brummelkam, S Rottenberg Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining Cell Rep, 2020-08-25;32(8):108068. 2020-08-25 [PMID: 32846126] (Bioassay, Mouse)
• AJ Nelson, DJ Stephenson, RN Bone, CL Cardona, MA Park, YG Tusing, X Lei, G Kokotos, CL Graves, CE Mathews, J Kramer, MJ Hessner, CE Chalfant, S Ramanadham Lipid mediators and biomarkers associated with type 1 diabetes development JCI Insight, 2020-08-20;5(16):. 2020-08-20 [PMID: 32814707] (Bioassay, Mouse)
• MA Maqbool, L Pioger, AZ El Aabidin, N Karasu, AM Molitor, LTM Dao, G Charbonnie, F van Laethe, R Fenouil, F Koch, G Lacaud, I Gut, M Gut, S Amigorena, O Joffre, T Sexton, S Spicuglia, JC Andrau Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation Cell Rep, 2020-08-18;32(7):108048. 2020-08-18 [PMID: 32814051] (Bioassay, Cell Culture, Human, Mouse)
• JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32807943] (Bioassay, Mouse)
• L Tu, X Sun, L Yang, T Zhang, X Zhang, X Li, B Dong, Y Liu, M Yang, L Wang, Y Yu TGF-beta2 interfering oligonucleotides used as adjuvants for microbial vaccines J. Leukoc. Biol., 2020-08-13;0(0):. 2020-08-13 [PMID: 32794350] (Bioassay, Mouse)
• M Koide, T Yamashita, K Murakami, S Uehara, K Nakamura, M Nakamura, M Matsushita, T Ara, H Yasuda, JM Penninger, N Takahashi, N Udagawa, Y Kobayashi Sclerostin expression in trabecular bone is downregulated by osteoclasts Sci Rep, 2020-08-13;10(1):13751. 2020-08-13 [PMID: 32792620] (Bioassay, Cell Culture, Mouse)
• JPM Luiz, JE Toller-Kaw, PR Viacava, DC Nascimento, PT Pereira, AL Saraiva, DS Prado, M LeBert, E Giurisato, C Tournier, TM Cunha, FQ Cunha, V Quesniaux, B Ryffel, JC Alves-Filh MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression J. Leukoc. Biol., 2020-08-03;0(0):. 2020-08-03 [PMID: 32745297] (Bioassay, Mouse)
• A Jandke, D Melandri, L Monin, DS Ushakov, AG Laing, P Vantourout, P East, T Nitta, T Narita, H Takayanagi, R Feederle, A Hayday Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial &amp;gamma&amp;delta T cell compartments Nat Commun, 2020-07-28;11(1):3769. 2020-07-28 [PMID: 32724083] (Cell Culture, Mouse)
• B Mahata, J Pramanik, L van der We, K Polanski, G Kar, A Riedel, X Chen, NA Fonseca, K Kundu, LS Campos, E Ryder, G Duddy, I Walczak, K Okkenhaug, DJ Adams, JD Shields, SA Teichmann Tumors induce de novo steroid biosynthesis in T cells to evade immunity Nat Commun, 2020-07-17;11(1):3588. 2020-07-17 [PMID: 32680985] (Bioassay, Mouse)
• D Prantner, S Nallar, K Richard, D Spiegel, KD Collins, SN Vogel Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response J. Leukoc. Biol., 2020-07-17;0(0):. 2020-07-17 [PMID: 32678947] (Cell Culture, Mouse)
• LJ Wang, L He, L Hao, HL Guo, XP Zeng, YW Bi, GT Lu, ZS Li, LH Hu Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages J. Cell. Mol. Med., 2020-07-17;0(0):. 2020-07-17 [PMID: 32678498] (Cell Culture, Human)
• J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (Bioassay, Mouse)
• CY Han, I Kang, IA Harten, JA Gebe, CK Chan, M Omer, KM Alonge, LJ den Hartig, D Gomes Kjer, L Goodspeed, S Subramania, S Wang, F Kim, DE Birk, TN Wight, A Chait Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity Cell Rep, 2020-06-30;31(13):107818. 2020-06-30 [PMID: 32610121] (Bioassay, Mouse)
• AP Ng, HD Coughlan, S Hediyeh-Za, K Behrens, TM Johanson, MSY Low, CC Bell, O Gilan, YC Chan, AJ Kueh, T Boudier, R Feltham, A Gabrielyan, L DiRago, CD Hyland, H Ierino, S Mifsud, E Viney, T Willson, MA Dawson, RS Allan, MJ Herold, K Rogers, DM Tarlinton, GK Smyth, MJ Davis, SL Nutt, WS Alexander An Erg-driven transcriptional program controls B cell lymphopoiesis Nat Commun, 2020-06-15;11(1):3013. 2020-06-15 [PMID: 32541654] (Bioassay, Mouse)
• A Kim, L Han, K Yu Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions Mol. Cell. Biol., 2020-07-29;0(0):. 2020-07-29 [PMID: 32513818] (Bioassay, Mouse)
• M Kubota, E Iizasa, Y Chuuma, H Kiyohara, H Hara, H Yoshida Adjuvant activity of Mycobacteria-derived mycolic acids Heliyon, 2020-05-27;6(5):e04064. 2020-05-27 [PMID: 32490252] (Bioassay, Mouse)
• IS Kang, JS Jang, C Kim Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation Sci Rep, 2020-04-27;10(1):7024. 2020-04-27 [PMID: 32341385] (Flow Cytometry, Human)
• W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice Sci Rep, 2020-04-24;10(1):7004. 2020-04-24 [PMID: 32332865] (Bioassay, Human, Mouse)
• D Zhu, TK Johnson, Y Wang, M Thomas, K Huynh, Q Yang, VC Bond, YE Chen, D Liu Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb Stem Cell Res Ther, 2020-04-22;11(1):162. 2020-04-22 [PMID: 32321589] (Bioassay, Mouse)
• J Lv, ZL Wu, Z Gan, P Gui, SL Yao CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production Mediators Inflamm., 2020-03-31;2020(0):2431705. 2020-03-31 [PMID: 32317861] (Bioassay, Mouse)
• W Lin, Y Xu, X Chen, J Liu, Y Weng, Q Zhuang, F Lin, Z Huang, S Wu, J Ding, L Chen, X Qiu, L Zhang, J Wu, D Lin, S Qiu Radiation-induced small extracellular vesicles as &quot;carriages&quot; promote tumor antigen release and trigger antitumor immunity Theranostics, 2020-03-26;10(11):4871-4884. 2020-03-26 [PMID: 32308755] (Cell Culture, Mouse)
• H Gan, T Shen, DP Chupp, JR Taylor, HN Sanchez, X Li, Z Xu, H Zan, P Casali B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response Sci Adv, 2020-04-01;6(14):eaay2793. 2020-04-01 [PMID: 32270032] (Cell Culture, Mouse)
• Y Zhao, J Wang, Z Min, L Peng, S Qi, W Lin I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis Mediators Inflamm., 2020-03-10;2020(0):6947482. 2020-03-10 [PMID: 32256194] (Bioassay, Mouse)
• D Kazadi, J Lim, G Rothschild, V Grinstein, B Laffleur, O Becherel, MJ Lavin, U Basu Effects of senataxin and RNA exosome on B-cell chromosomal integrity Heliyon, 2020-03-12;6(3):e03442. 2020-03-12 [PMID: 32195383] (Cell Culture, Mouse)
• X Zhuang, Y Qi, M Wang, N Yu, F Nan, H Zhang, M Tian, C Li, H Lu, N Jin mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice Vaccines (Basel), 2020-03-10;8(1):. 2020-03-10 [PMID: 32164372] (Cell Culture, Mouse)
• E Meidan, H Li, W Pan, M Kono, S Yu, VC Kyttaris, C Ioannidis, N Rodriguez, JC Crispin, SA Apostolidi, P Lee, J Manis, A Sharabi, MG Tsokos, GC Tsokos Serine/threonine phosphatase PP2A is essential for optimal B cell function JCI Insight, 2020-03-12;5(5):. 2020-03-12 [PMID: 32161189] (Cell Culture, Mouse)
• Chanju Lee, Hyunju Jeong, Hyunji Lee, Minwoo Hong, Seon-young Park, Hyunsu Bae Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation Frontiers in Immunology 2020-02-07 [PMID: 32117241] (Bioassay, Mouse)
• ML Li, XM Su, Y Ren, X Zhao, LF Kong, J Kang HDAC8 inhibitor attenuates airway responses to antigen stimulus through synchronously suppressing galectin-3 expression and reducing macrophage-2 polarization Respir. Res., 2020-02-28;21(1):62. 2020-02-28 [PMID: 32111211] (Cell Culture, Mouse)
• CB Lee, IH Seo, MW Chae, JW Park, EH Choi, HS Uhm, KY Baik Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation Oxid Med Cell Longev, 2020-01-31;2020(0):2946820. 2020-01-31 [PMID: 32089766] (Cell Culture, Mouse)
• FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair Nat Commun, 2020-01-30;11(1):600. 2020-01-30 [PMID: 32001677] (Bioassay, Mouse)
• JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun, 2020-01-22;11(1):431. 2020-01-22 [PMID: 31969567] (Cell Culture, Mouse)
• DA Girón-Pére, E Vadillo, M Schnoor, L Santos-Arg Myo1e modulates the recruitment of activated B cells to inguinal lymph nodes J. Cell. Sci., 2020-03-02;0(0):. 2020-03-02 [PMID: 31964710] (Bioassay, Mouse)
• H Yan, M Fernandez, J Wang, S Wu, R Wang, Z Lou, JB Moroney, CE Rivera, JR Taylor, H Gan, H Zan, D Kolvaskyy, D Liu, P Casali, Z Xu B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-kappaB Activation for Antibody Class-Switching J. Immunol., 2020-01-13;204(5):1146-1157. 2020-01-13 [PMID: 31932498] (Bioassay, Transgenic Mouse)
• X Han, S Huang, P Xue, J Fu, L Liu, C Zhang, L Yang, L Xia, L Sun, SK Huang, Y Zhou LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE Sci Adv, 2019-12-11;5(12):eaax9230. 2019-12-11 [PMID: 31844669] (Cell Culture, Mouse)
• E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy Nat Commun, 2019-12-13;10(1):5349. 2019-12-13 [PMID: 31836706] (Bioassay, Mouse)
• MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo Impact of aging on transition of acute kidney injury to chronic kidney disease Sci Rep, 2019-12-05;9(1):18445. 2019-12-05 [PMID: 31804508] (Bioassay, Mouse)
• P Haase, L Mokada-Gop, D Radtke, D Voehringer Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells Eur. J. Immunol., 2019-12-15;0(0):. 2019-12-15 [PMID: 31803941] (Stimulation, Mouse)
• Y Mu, J Zhang, Y Liu, J Ma, D Jiang, X Zhang, X Yi, K Cheng, S Shen, Y Yang, R Zhuang, Y Zhang CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340 J. Leukoc. Biol., 2019-12-04;0(0):. 2019-12-04 [PMID: 31802539] (Bioassay, Mouse)
• S McLaughlin, B McNeill, J Podrebarac, K Hosoyama, V Sedlakova, G Cron, D Smyth, R Seymour, K Goel, W Liang, KJ Rayner, M Ruel, EJ Suuronen, EI Alarcon Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction Nat Commun, 2019-10-25;10(1):4866. 2019-10-25 [PMID: 31653830] (Cell Culture, Mouse)
• S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing Nature, 2019-10-23;574(7779):553-558. 2019-10-23 [PMID: 31645721] (Cell Culture, Mouse)
• GR Martin, CM Blomquist, KL Henare, FR Jirik Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice Sci Rep, 2019-10-03;9(1):14281. 2019-10-03 [PMID: 31582793] (Cell Culture, Mouse)
• SS Dykes, HO Fasanya, DW Siemann Cathepsin L secretion by host and neoplastic cells potentiates invasion Oncotarget, 2019-09-17;10(53):5560-5568. 2019-09-17 [PMID: 31565189] (Bioassay, Mouse)
• LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity Cell Rep, 2019-09-24;28(13):3353-3366.e5. 2019-09-24 [PMID: 31553906] (Cell Culture, Mouse)
• A El-Kenawi, C Gatenbee, M Robertson-, R Bravo, J Dhillon, Y Balaguruna, A Berglund, N Visvakarma, A Ibrahim-Ha, J Choi, K Luddy, R Gatenby, S Pilon-Thom, A Anderson, B Ruffell, R Gillies Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer Br. J. Cancer, 2019-08-16;121(7):556-566. 2019-08-16 [PMID: 31417189] (Bioassay, Mouse)
• PAM Cavalcante, N Alenina, A Budu, LC Freitas-Li, T Alves-Silv, JSH Agudelo, F Qadri, NOS Camara, M Bader, RC Araújo Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein Mediators Inflamm., 2019-07-10;2019(0):9086758. 2019-07-10 [PMID: 31360120] (Cell Culture, Mouse)
• KS Cho, SA Kang, SD Kim, SJ Mun, HS Yu, HJ Roh Dendritic cells and M2 macrophage play an important role in suppression of Th2-mediated inflammation by adipose stem cells-derived extracellular vesicles Stem Cell Res, 2019-07-12;39(0):101500. 2019-07-12 [PMID: 31344653] (Bioassay, Mouse)
• R Zhao, X Shao, G Jia, Y Huang, Z Liu, B Song, J Hou Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells BMC Complement Altern Med, 2019-07-05;19(1):161. 2019-07-05 [PMID: 31277622] (Bioassay, Mouse)
• JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31260596] (Bioassay, Mouse)
• J Liu, L Zhu, J Wang, L Qiu, Y Chen, RE Davis, G Cheng Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism PLoS Pathog., 2019-06-04;15(6):e1007817. 2019-06-04 [PMID: 31163079] (Bioassay, Mouse)
• LR Waters, FM Ahsan, J Ten Hoeve, JS Hong, DNH Kim, A Minasyan, D Braas, TG Graeber, TA Zangle, MA Teitell Ampk regulates IgD expression but not energy stress with B cell activation Sci Rep, 2019-06-03;9(1):8176. 2019-06-03 [PMID: 31160601] (Bioassay, Mouse)
• M Bolger-Mun, K Choi, JM Scurll, L Abraham, RS Chappell, D Sheen, M Dang-Lawso, X Wu, JJ Priatel, D Coombs, JA Hammer, MR Gold Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation Elife, 2019-06-03;8(0):. 2019-06-03 [PMID: 31157616] (Bioassay, Complex Species Category)
• VV Kurilin, JN Khantakova, VP Tereschenk, JA Lopatnikov, IA Obleukhova, SV Sennikov The Effects of Immunosuppressive Factors on Primary Dendritic Cells from C57BL/6 and CBA Mice J Immunol Res, 2019-04-18;2019(0):7029726. 2019-04-18 [PMID: 31143783] (Bioassay, Mouse)
• CP Hans, N Sharma, S Sen, S Zeng, R Dev, Y Jiang, A Mahajan, T Joshi Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization Sci Rep, 2019-05-29;9(1):7999. 2019-05-29 [PMID: 31142802] (Bioassay, Mouse)
• B Maurer, H Nivarthi, B Wingelhofe, HTT Pham, M Schlederer, T Suske, R Grausenbur, AI Schiefer, M Prchal-Mur, D Chen, S Winkler, O Merkel, C Kornauth, M Hofbauer, B Hochgatter, G Hoermann, A Hoelbl-Kov, J Prochazkov, C Lobello, AA Cumaraswam, J Latzka, M Kitzwögere, A Chott, A Janikova, Š Pospíšilov, JI Loizou, S Kubicek, P Valent, T Kolbe, F Grebien, L Kenner, PT Gunning, R Kralovics, M Herling, M Müller, T Rülicke, V Sexl, R Moriggl High activation of STAT5A drives peripheral T-cell lymphoma and leukemia Haematologica, 2020-01-31;0(0):. 2020-01-31 [PMID: 31123029] (Bioassay, Mouse)
• MB Jones, CA Alvarez, JL Johnson, JY Zhou, N Morris, BA Cobb CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation PLoS ONE, 2019-05-23;14(5):e0216893. 2019-05-23 [PMID: 31120919] (Bioassay, Mouse)
• C Ballester-, TM Conlon, Z Ertüz, FR Greiffo, M Irmler, SE Verleden, J Beckers, IE Fernandez, O Eickelberg, AÖ Yildirim The Notch ligand DNER regulates macrophage IFN? release in chronic obstructive pulmonary disease EBioMedicine, 2019-05-04;0(0):. 2019-05-04 [PMID: 31060902] (Bioassay, Mouse)
• WF Yen, R Sharma, M Cols, CM Lau, A Chaudhry, P Chowdhury, WT Yewdell, B Vaidyanath, A Sun, M Coffre, JN Pucella, CC Chen, M Jasin, JC Sun, AY Rudensky, SB Koralov, J Chaudhuri Distinct Requirements of CHD4 during B Cell Development and Antibody Response Cell Rep, 2019-04-30;27(5):1472-1486.e5. 2019-04-30 [PMID: 31042474] (Bioassay, Mouse)
• L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri Cutting Edge: ATM Influences Germinal Center Integrity J. Immunol., 2019-04-26;0(0):. 2019-04-26 [PMID: 31028119] (Bioassay, Mouse)
• YB Kim, YH Ahn, JH Jung, YJ Lee, JH Lee, JL Kang Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis Cell. Mol. Immunol., 2019-03-06;0(0):. 2019-03-06 [PMID: 30842627] (Bioassay, Mouse)
• P Handa, S Thomas, V Morgan-Ste, BD Maliken, E Gochanour, S Boukhar, MM Yeh, KV Kowdley Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis J. Leukoc. Biol., 2019-03-05;0(0):. 2019-03-05 [PMID: 30835899] (Bioassay, Mouse)
• PM Ryan, EH Stolte, LEE London, JM Wells, SL Long, SA Joyce, CGM Gahan, GF Fitzgerald, RP Ross, NM Caplice, C Stanton Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe BMC Microbiol., 2019-02-08;19(1):33. 2019-02-08 [PMID: 30736731] (Bioassay, Mouse)
• K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)
• JN Pucella, M Cols, WF Yen, S Xu, J Chaudhuri The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses J. Immunol., 2019-01-25;0(0):. 2019-01-25 [PMID: 30683701] (Bioassay, Mouse)
• K Paduch, A Debus, B Rai, U Schleicher, C Bogdan Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1 J. Immunol., 2019-01-21;0(0):. 2019-01-21 [PMID: 30665936] (Mouse)
• LM Das, AM Binko, ZP Traylor, H Peng, KQ Lu Vitamin D improves sunburns by increasing autophagy in M2 macrophages Autophagy, 2019-01-24;0(0):1-14. 2019-01-24 [PMID: 30661440] (Bioassay, Mouse)
• AJ Freemerman, L Zhao, AK Pingili, B Teng, AJ Cozzo, AM Fuller, AR Johnson, JJ Milner, MF Lim, JA Galanko, MA Beck, JE Bear, JD Rotty, L Bezavada, HS Smallwood, MA Puchowicz, J Liu, JW Locasale, DP Lee, BJ Bennett, ED Abel, JC Rathmell, L Makowski Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1 J. Immunol., 2019-01-18;0(0):. 2019-01-18 [PMID: 30659108] (Mouse)
• W Fonseca, AJ Rasky, C Ptaschinsk, SH Morris, SKK Best, M Phillips, CA Malinczak, NW Lukacs Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease Mucosal Immunol, 2019-01-07;12(2):445-456. 2019-01-07 [PMID: 30617299] (Bioassay, Mouse)
• JD Jones, BP Sinder, D Paige, FN Soki, AJ Koh, S Thiele, Y Shiozawa, LC Hofbauer, S Daignault, H Roca, LK McCauley Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis Neoplasia, 2018-12-31;21(2):172-184. 2018-12-31 [PMID: 30591422] (Bioassay, Mouse)
• M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018-12-26;25(13):3733-3749.e8. 2018-12-26 [PMID: 30590045] (Bioassay, Mouse)
• D Menolfi, W Jiang, BJ Lee, T Moiseeva, Z Shao, V Estes, MG Frattini, CJ Bakkenist, S Zha Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA Nat Commun, 2018-12-17;9(1):5351. 2018-12-17 [PMID: 30559436] (Bioassay, Mouse)
• R Sugamata, A Donko, Y Murakami, HE Boudreau, CF Qi, J Kwon, TL Leto Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide J. Immunol., 2018-12-17;0(0):. 2018-12-17 [PMID: 30559322] (Bioassay, Mouse)
• MT Rached, SJ Millership, SMA Pedroni, AI Choudhury, ASH Costa, DG Hardy, JA Glegola, EE Irvine, C Selman, MC Woodberry, VK Yadav, S Khadayate, A Vidal-Puig, S Virtue, C Frezza, DJ Withers Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity Mol Metab, 2018-11-28;20(0):38-50. 2018-11-28 [PMID: 30553769] (Bioassay, Mouse)
• L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming Cell Rep, 2018-12-11;25(11):3059-3073.e10. 2018-12-11 [PMID: 30540939] (Bioassay, Mouse)
• H Chiu, LV Jackson, KI Oh, A Mai, ZA Ronai, D Ruggero, DA Fruman The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes J. Immunol., 2018-12-10;0(0):. 2018-12-10 [PMID: 30530594] (Bioassay, Mouse)
• X Liu, P Zhang, Y Zhang, Z Wang, S Xu, Y Li, W Huai, Q Zhou, X Chen, X Chen, N Li, P Wang, Y Li, X Cao Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling Cell Res., 2018-12-04;0(0):. 2018-12-04 [PMID: 30514903] (Bioassay, Mouse)
• W Sun, N Meednu, A Rosenberg, J Rangel-Mor, V Wang, J Glanzman, T Owen, X Zhou, H Zhang, BF Boyce, JH Anolik, L Xing B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation Nat Commun, 2018-12-03;9(1):5127. 2018-12-03 [PMID: 30510188] (Bioassay, Mouse)
• C Skon-Hegg, J Zhang, X Wu, M Sagolla, N Ota, A Wuster, J Tom, E Doran, N Ramamoorth, P Caplazi, J Monroe, WP Lee, TW Behrens LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation J. Immunol., 2018-12-03;0(0):. 2018-12-03 [PMID: 30510070] (Bioassay, Mouse)
• G Juban, M Saclier, H Yacoub-You, A Kernou, L Arnold, C Boisson, S Ben Larbi, M Magnan, S Cuvellier, M Théret, BJ Petrof, I Desguerre, J Gondin, R Mounier, B Chazaud AMPK Activation Regulates LTBP4-Dependent TGF-?1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy Cell Rep, 2018-11-20;25(8):2163-2176.e6. 2018-11-20 [PMID: 30463013] (Bioassay, Mouse)
• AN Billin, SE Honeycutt, AV McDougal, JP Kerr, Z Chen, JM Freudenber, DK Rajpal, G Luo, HF Kramer, RS Geske, F Fang, B Yao, RV Clark, J Lepore, A Cobitz, R Miller, K Nosaka, AC Hinken, AJ Russell HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury Skelet Muscle, 2018-11-13;8(1):35. 2018-11-13 [PMID: 30424786] (Bioassay, Mouse)
• C Farruggia, MB Kim, M Bae, Y Lee, TX Pham, Y Yang, MJ Han, YK Park, JY Lee Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners J. Nutr. Biochem., 2018-09-19;62(0):202-209. 2018-09-19 [PMID: 30308382] (Bioassay, Mouse)
• M Becerra-Dí, AB Strickland, A Keselman, NM Heller Androgen and Androgen Receptor as Enhancers of M2 Macrophage Polarization in Allergic Lung Inflammation J. Immunol., 2018-10-10;0(0):. 2018-10-10 [PMID: 30305328] (Bioassay, Mouse)
• Y Wang, S Lv, Q Wang, C Wang, M Zhu, Z Ma, W Zhao Mechanisms underlying immune tolerance caused by recombinant Echinococcus granulosus antigens Eg mMDH and Eg10 in dendritic cells PLoS ONE, 2018-09-27;13(9):e0204868. 2018-09-27 [PMID: 30261049] (Bioassay, Mouse)
• S Trezise, A Karnowski, PL Fedele, S Mithraprab, Y Liao, K D'Costa, AJ Kueh, MP Hardy, CM Owczarek, MJ Herold, A Spencer, W Shi, SN Willis, SL Nutt, LM Corcoran Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins Int J Mol Sci, 2018-07-24;19(8):. 2018-07-24 [PMID: 30042348] (Bioassay, Mouse)
• HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection Mucosal Immunol, 2018-07-23;0(0):. 2018-07-23 [PMID: 30038214] (Bioassay, Mouse)
• SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher The shieldin complex mediates 53BP1-dependent DNA repair Nature, 2018-07-18;560(7716):117-121. 2018-07-18 [PMID: 30022168] (Bioassay, Mouse)
• S Nowsheen, K Aziz, K Luo, M Deng, B Qin, J Yuan, KB Jeganathan, J Yu, H Zhang, W Ding, JM van Deurse, Z Lou ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage Nat Commun, 2018-07-16;9(1):2736. 2018-07-16 [PMID: 30013081] (Bioassay, Mouse)
• L Garcia-Bon, D Brea, C Benakis, D Lane, M Murphy, J Moore, G Racchumi, X Jiang, C Iadecola, J Anrather Endogenous protection from ischemic brain injury by preconditioned monocytes J. Neurosci., 2018-06-26;0(0):. 2018-06-26 [PMID: 29946039] (Bioassay, Mouse)
• C Youssif, M Cubillos-R, M Comalada, E Llonch, C Perna, N Djouder, AR Nebreda Myeloid p38? signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis EMBO Mol Med, 2018-07-01;0(0):. 2018-07-01 [PMID: 29907597] (Bioassay, Mouse)
• BG Barwick, CD Scharer, RJ Martinez, MJ Price, AN Wein, RR Haines, APR Bally, JE Kohlmeier, JM Boss B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation Nat Commun, 2018-05-15;9(1):1900. 2018-05-15 [PMID: 29765016] (Bioassay, Mouse)
• CD Scharer, BG Barwick, M Guo, APR Bally, JM Boss Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs Nat Commun, 2018-04-27;9(1):1698. 2018-04-27 [PMID: 29703886] (Bioassay, Mouse)
• N Chia, RK Kumar, PS Foster, C Herbert Enhanced Pro-Inflammatory Response of Macrophages to Interleukin-33 in an Allergic Environment Int. Arch. Allergy Immunol., 2018-04-05;0(0):. 2018-04-05 [PMID: 29621782] (Bioassay, Mouse)
• Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression Cell, 2018-03-29;0(0):. 2018-03-29 [PMID: 29606356] (Bioassay, Mouse)
• S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage Nat. Cell Biol., 2018-03-26;20(4):455-464. 2018-03-26 [PMID: 29581593] (Bioassay, Mouse)
• G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 2018-03-20;48(3):556-569.e7. 2018-03-20 [PMID: 29562202] (Bioassay, Mouse)
• Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes Cell Mol Gastroenterol Hepatol, 2018-01-03;5(3):333-352. 2018-01-03 [PMID: 29552622] (Bioassay, Mouse)
• S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects Front Immunol, 2018-03-02;9(0):405. 2018-03-02 [PMID: 29552013] (Bioassay, Mouse)
• C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining Nat Commun, 2018-03-08;9(1):1006. 2018-03-08 [PMID: 29520062] (Bioassay, Mouse)
• B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao Characterization and allergic role of IL-33-induced neutrophil polarization Cell. Mol. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29503441] (Bioassay, Mouse)
• N Andreas, M Riemann, CN Castro, M Groth, I Koliesnik, C Engelmann, T Sparwasser, T Kamradt, R Haenold, F Weih A new RelB-dependent CD117+CD172a+murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo Eur. J. Immunol., 2018-04-06;0(0):. 2018-04-06 [PMID: 29485182] (Bioassay, Mouse)
• K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist PLoS ONE, 2018-02-26;13(2):e0193086. 2018-02-26 [PMID: 29481574] (Bioassay, Mouse)
• D Szpak, L Izem, D Verbovetsk, DA Soloviev, VP Yakubenko, E Pluskota ?M?2Is Antiatherogenic in Female but Not Male Mice J. Immunol., 2018-02-19;0(0):. 2018-02-19 [PMID: 29459405] (Bioassay, Mouse)
• MJ Tol, MJC van der Li, TL Gabriel, JJ Hagen, S Scheij, T Veenendaal, J Klumperman, WE Donker-Koo, AJ Verhoeven, H Overkleeft, JM Aerts, CA Argmann, M van Eijk HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution Autophagy, 2018-02-17;0(0):1-13. 2018-02-17 [PMID: 29455584] (Bioassay, Mouse)
• L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84 Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454750] (Mouse)
• M Chen, J Zhao, IH Ali, S Marry, J Augustine, M Bhuckory, A Lynch, A Kissenpfen, H Xu SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis Am. J. Pathol., 2018-02-13;0(0):. 2018-02-13 [PMID: 29452101] (Bioassay, Mouse)
• C Rossi, M Cusimano, M Zambito, A Finardi, A Capotondo, JM Garcia-Man, G Comi, R Furlan, G Martino, L Muzio Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis Cell Death Dis, 2018-02-14;9(2):250. 2018-02-14 [PMID: 29445154] (Bioassay, Mouse)
• R Ritzel, S Doran, J Barrett, R Henry, E Ma, A Faden, DJ Loane Chronic Alterations in Systemic Immune Function After Traumatic Brain Injury J. Neurotrauma, 2018-05-03;0(0):. 2018-05-03 [PMID: 29421977] (Cell Culture, Mouse)
• A Das, CS Yang, S Arifuzzama, S Kim, SY Kim, KH Jung, YS Lee, YG Chai High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages Front Immunol, 2018-01-18;9(0):22. 2018-01-18 [PMID: 29403501] (Cell Culture, Mouse)
• A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice Immun Inflamm Dis, 2018-02-01;0(0):. 2018-02-01 [PMID: 29388365] (Bioassay, Mouse)
• YS Kim, MN Kim, KE Lee, JY Hong, MS Oh, SY Kim, KW Kim, MH Sohn Activated leukocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy Clin. Exp. Immunol., 2018-02-20;0(0):. 2018-02-20 [PMID: 29363753] (Bioassay, Mouse)
• W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang Crucial role of OX40/OX40L signaling in a murine model of asthma Mol Med Rep, 2018-01-18;0(0):. 2018-01-18 [PMID: 29344664] (Bioassay, Mouse)
• X Xiao, Y Fan, J Li, X Zhang, X Lou, Y Dou, X Shi, P Lan, Y Xiao, L Minze, XC Li Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation J. Exp. Med., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339447] (Cell Culture, Mouse)
• T Kerrinnes, MG Winter, BM Young, VE Diaz-Ochoa, SE Winter, RM Tsolis Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus Infect. Immun., 2018-02-20;0(0):. 2018-02-20 [PMID: 29203548] (Bioassay, Mouse)
• SN Willis, J Tellier, Y Liao, S Trezise, A Light, K O'Donnell, LA Garrett-Si, W Shi, DM Tarlinton, SL Nutt Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB Nat Commun, 2017-11-10;8(1):1426. 2017-11-10 [PMID: 29127283] (Bioassay, Mouse)
• R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis Cardiovasc Diabetol, 2017-11-06;16(1):143. 2017-11-06 [PMID: 29110715] (Bioassay, Mouse)
• RM Valanparam, M Tam, PP Gros, JP Auger, M Segura, P Gros, A Jardim, TG Geary, K Ozato, MM Stevenson IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection PLoS Pathog., 2017-10-02;13(10):e1006647. 2017-10-02 [PMID: 28968468] (ELISA (Standard), Mouse)
• S Mroczek, J Chlebowska, TM Kuli?ski, O Gewartowsk, J Gruchota, D Cysewski, V Liudkovska, E Borsuk, D Nowis, A Dziembowsk The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma Nat Commun, 2017-09-20;8(1):619. 2017-09-20 [PMID: 28931820] (Bioassay, Mouse)
• T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells Nat Commun, 2017-09-15;8(1):559. 2017-09-15 [PMID: 28916785] (Bioassay, Mouse)
• DK Chiu, AP Tse, IM Xu, J Di Cui, RK Lai, LL Li, HY Koh, FH Tsang, LL Wei, CM Wong, IO Ng, CC Wong Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma Nat Commun, 2017-09-11;8(1):517. 2017-09-11 [PMID: 28894087] (Bioassay, Mouse)
• N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction JCI Insight, 2017-09-07;2(17):. 2017-09-07 [PMID: 28878126] (Bioassay, Mouse)
• SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity Mol. Cancer Ther., 2017-09-06;0(0):. 2017-09-06 [PMID: 28878029] (Bioassay, Mouse)
• JP Antonios, H Soto, RG Everson, DL Moughon, AC Wang, J Orpilla, C Radu, BM Ellingson, JT Lee, T Cloughesy, ME Phelps, J Czernin, LM Liau, RM Prins Detection of immune responses after immunotherapy in glioblastoma using PET and MRI Proc. Natl. Acad. Sci. U.S.A., 2017-09-05;0(0):. 2017-09-05 [PMID: 28874539] (Bioassay, Mouse)
• MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855208] (Bioassay, Mouse)
• KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells J. Immunol., 2017-08-28;0(0):. 2017-08-28 [PMID: 28848064] (Bioassay, Mouse)
• T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768723] (Bioassay, Mouse)
• RD Vicetti Mi, NE Quispe Cal, D Dixon, RA Foster, A Gambotto, SD Pavelko, L Hall-Stood, TL Cherpes IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage Proc. Natl. Acad. Sci. U.S.A., 2017-08-01;0(0):. 2017-08-01 [PMID: 28765368] (Bioassay, Mouse)
• M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista The Small Rho GTPase TC10 Modulates B Cell Immune Responses J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747344] (Bioassay, Mouse)
• X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis Sci Rep, 2017-07-11;7(1):5107. 2017-07-11 [PMID: 28698550] (Bioassay, Mouse)
• H Huang, J Liu, H Hao, D Chen, L Zhizhong, M Li, H Song, R Xiang, C Jiang, X Fu, W Han Preferred M2 Polarization by ASC-Based Hydrogel Accelerated Angiogenesis and Myogenesis in Volumetric Muscle Loss Rats Stem Cells Int, 2017-06-14;2017(0):2896874. 2017-06-14 [PMID: 28694827] (Bioassay, Mouse)
• AE Shay, BT Diwakar, BJ Guan, V Narayan, JF Urban, KS Prabhu IL-4 upregulates cyclooxygenase-1 expression in macrophages J. Biol. Chem., 2017-07-06;0(0):. 2017-07-06 [PMID: 28684424] (Bioassay, Mouse)
• J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy J. Immunol., 2017-06-26;0(0):. 2017-06-26 [PMID: 28652396] (Bioassay, Mouse)
• IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells Eur. J. Immunol., 2017-06-29;0(0):. 2017-06-29 [PMID: 28598502] (Bioassay, Mouse)
• J Zhu, K Yao, J Guo, H Shi, L Ma, Q Wang, H Liu, W Gao, A Sun, Y Zou, J Ge miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway J. Cell. Mol. Med., 2017-06-09;0(0):. 2017-06-09 [PMID: 28597963] (Bioassay, Mouse)
• YY Sin, PR Price, LL Ballantyne, CD Funk Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency Sci Rep, 2017-05-31;7(1):2585. 2017-05-31 [PMID: 28566761] (Bioassay, Mouse)
• J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs Theranostics, 2017-03-24;7(6):1407-1421. 2017-03-24 [PMID: 28529626] (Bioassay, Mouse)
• CH Son, J Bae, HR Lee, K Yang, YS Park Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs Oncol Lett, 2017-03-28;13(5):3781-3786. 2017-03-28 [PMID: 28521478] (Bioassay, Mouse)
• J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells Nat. Immunol., 2017-05-15;0(0):. 2017-05-15 [PMID: 28504697] (Bioassay, Mouse)
• A Rialdi, J Hultquist, D Jimenez-Mo, Z Peralta, L Campisi, R Fenouil, N Moshkina, ZZ Wang, B Laffleur, RM Kaake, MJ McGregor, K Haas, E Pefanis, RA Albrecht, L Pache, S Chanda, J Jen, J Ochando, M Byun, U Basu, A García-Sas, N Krogan, H van Bakel, I Marazzi The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity Cell, 2017-05-04;169(4):679-692.e14. 2017-05-04 [PMID: 28475896] (Bioassay, Mouse)
• J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry Cell, 2017-04-20;169(3):523-537.e15. 2017-04-20 [PMID: 28431250] (Bioassay, Mouse)
• S Park, H Sim, HI Kim, D Jeong, G Wu, SY Cho, YS Lee, HJ Kwon, K Lee CD11b regulates antibody class switching via induction of AID Mol. Immunol., 2017-04-11;87(0):47-59. 2017-04-11 [PMID: 28407558] (Bioassay, Mouse)
• G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1 J. Exp. Med., 2017-04-11;0(0):. 2017-04-11 [PMID: 28400474] (Bioassay, Mouse)
• DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Nat Commun, 2017-04-04;8(0):14919. 2017-04-04 [PMID: 28374774] (Bioassay, Mouse)
• T Minamitani, Y Ma, H Zhou, H Kida, CY Tsai, M Obana, D Okuzaki, Y Fujio, A Kumanogoh, B Zhao, H Kikutani, E Kieff, BE Gewurz, T Yasui Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease Proc. Natl. Acad. Sci. U.S.A, 2017-03-28;0(0):. 2017-03-28 [PMID: 28351978] (Bioassay, Mouse)
• L Mokada-Gop, A Boeser, CH Lehmann, F Drepper, D Dudziak, B Warscheid, D Voehringer Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis J. Immunol, 2017-03-27;0(0):. 2017-03-27 [PMID: 28348271] (Bioassay, Mouse)
• V Piccolo, A Curina, M Genua, S Ghisletti, M Simonatto, A Sabò, B Amati, R Ostuni, G Natoli Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk Nat. Immunol, 2017-03-13;0(0):. 2017-03-13 [PMID: 28288101] (Bioassay, Mouse)
• DC Cockrell, CM Long, SJ Robertson, JG Shannon, HE Miller, L Myers, CL Larson, T Starr, PA Beare, RA Heinzen Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages PLoS ONE, 2017-03-09;12(3):e0173528. 2017-03-09 [PMID: 28278296] (Bioassay, Mouse)
• W Dawicki, C Li, J Town, X Zhang, JR Gordon Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells J. Allergy Clin. Immunol., 2016-10-26;139(5):1608-1620.e3. 2016-10-26 [PMID: 28277274] (ELISA (Standard), Mouse)
• H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao mTORC2 controls Th9 polarization and allergic airway inflammation Allergy, 2017-03-29;0(0):. 2017-03-29 [PMID: 28273354] (Bioassay, Mouse)
• LY Lu, F Loi, K Nathan, TH Lin, J Pajarinen, E Gibon, A Nabeshima, L Cordova, E Jämsen, Z Yao, SB Goodman Pro-inflammatory M1 macrophages promote osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway J. Orthop. Res, 2017-03-13;0(0):. 2017-03-13 [PMID: 28248001] (Bioassay, Mouse)
• P Drané, ME Brault, G Cui, K Meghani, S Chaubey, A Detappe, N Parnandi, Y He, XF Zheng, MV Botuyan, A Kalousi, WT Yewdell, C Münch, JW Harper, J Chaudhuri, E Soutoglou, G Mer, D Chowdhury TIRR regulates 53BP1 by masking its histone methyl-lysine binding function Nature, 2017-02-27;543(7644):211-216. 2017-02-27 [PMID: 28241136] (Bioassay, Mouse)
• S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy Sci Rep, 2017-02-17;7(0):42846. 2017-02-17 [PMID: 28211523] (Bioassay, Mouse)
• N Ng Kuet Le, F Brombacher, AH Dalpke, M Weitnauer Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells Immunobiology, 2017-02-09;0(0):. 2017-02-09 [PMID: 28209270] (Bioassay, Mouse)
• H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination Nat Commun, 2017-02-08;8(0):14244. 2017-02-08 [PMID: 28176781] (Bioassay, Mouse)
• J Zhang, S Vlasevska, VA Wells, S Nataraj, AB Holmes, R Duval, SN Meyer, T Mo, K Basso, PK Brindle, S Hussein, R Dalla-Fave, L Pasqualucc The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma Cancer Discov, 2017-01-09;0(0):. 2017-01-09 [PMID: 28069569] (Bioassay, Mouse)
• Bharat Vaidyanath The aryl hydrocarbon receptor controls cell-fate decisions in B cells J. Exp. Med, 2016-12-23;0(0):. 2016-12-23 [PMID: 28011866] (Bioassay, Mouse)
• Yee Ling Wu Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE J. Exp. Med, 2016-12-19;0(0):. 2016-12-19 [PMID: 27994069] (Bioassay, Mouse)
• Sabrina Ceeraz VISTA deficiency accelerates the development of fatal murine lupus nephritis Arthritis & rheumatology (Hoboken, N.J.), 2017-04-01;0(0):. 2017-04-01 [PMID: 27992697] (Bioassay, Mouse)
• Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy J. Immunol., 2016-11-09;197(12):4750-4761. 2016-11-09 [PMID: 27913649] (Bioassay, Mouse)
• Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-?3 production Proc. Natl. Acad. Sci. U.S.A., 2016-11-30;113(50):E8131-E8140. 2016-11-30 [PMID: 27911796] (Bioassay, Mouse)
• Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 2016-12-01;6(0):37977. 2016-12-01 [PMID: 27905482] (Bioassay, Mouse)
• Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching Sci Rep, 2016-11-17;6(0):37215. 2016-11-17 [PMID: 27853268] (Bioassay, Mouse)
• L Ge, NL Vujanovic Soluble TNF Regulates TACE via AP-2? Transcription Factor in Mouse Dendritic Cells J. Immunol., 2016-11-16;198(1):417-427. 2016-11-16 [PMID: 27852742] (Bioassay, Mouse)
• Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections Sci Rep, 2016-11-15;6(0):37211. 2016-11-15 [PMID: 27845414] (Bioassay, Mouse)
• Kazumi Taguchi, Atsushi Okada, Shuzo Hamamoto, Rei Unno, Yoshinobu Moritoki, Ryosuke Ando, Kentaro Mizuno, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development. Scientific Reports, 2016-10-12;0(0):2045-2322. 2016-10-12 [PMID: 27731368] (Bioassay, Mouse)
• Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2? J Biol Chem, 2016-09-20;0(0):. 2016-09-20 [PMID: 27650501] (Bioassay, Mouse)
• Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function J Leukoc Biol, 2016-09-06;0(0):. 2016-09-06 [PMID: 27601624] (Bioassay, Mouse)
• Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21 J Immunol, 2016-08-15;0(0):. 2016-08-15 [PMID: 27527595] (Bioassay, Mouse)
• Role of interleukin-4, the chemokine CCL3 and its receptor CCR5 in neuropathic pain Mol Immunol, 2016-08-11;77(0):184-192. 2016-08-11 [PMID: 27522478] (In Vivo, Mouse)
• Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status Circ Res, 2016-07-14;0(0):. 2016-07-14 [PMID: 27418629] (Bioassay, Mouse)
• Makiko Okubo M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation Sci Rep, 2016-06-08;6(0):27548. 2016-06-08 [PMID: 27271009] (Bioassay, Mouse)
• Mithun Maji A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8(+) T Cells Sci Rep, 2016-06-02;6(0):27206. 2016-06-02 [PMID: 27251373] (Bioassay, Mouse)
• Ahmed S Elshikha Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus PLoS ONE, 2016-05-27;11(5):e0156583. 2016-05-27 [PMID: 27232337] (Bioassay, Mouse)
• Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription Nat Commun, 2016-05-23;7(0):11624. 2016-05-23 [PMID: 27211851] (Bioassay, Mouse)
• Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU) PLoS ONE, 2016-05-19;11(5):e0155953. 2016-05-19 [PMID: 27196432] (Bioassay, Mouse)
• Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization J Immunol, 2016-05-04;196(11):4536-43. 2016-05-04 [PMID: 27183603] (Bioassay, Mouse)
• Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Biol, 2016-05-10;94(8):747-62. 2016-05-10 [PMID: 27075967] (Bioassay, Human)
• D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection PLoS Pathog, 2016-04-13;12(4):e1005561. 2016-04-13 [PMID: 27074026] (Bioassay, Mouse)
• C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis J Immunol, 2016-04-06;0(0):. 2016-04-06 [PMID: 27053763] (Bioassay, Mouse)
• Shweta Pasi Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response J Biol Chem, 2016-03-28;291(23):12358-69. 2016-03-28 [PMID: 27022030] (Bioassay, Mouse)
• E Naik, VM Dixit Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC? Kinase Activity J Immunol, 2016-03-02;196(8):3438-51. 2016-03-02 [PMID: 26936881] (Bioassay, Mouse)
• Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A, 2016-01-19;113(5):1256-60. 2016-01-19 [PMID: 26787905] (Bioassay, Mouse)
• Masani S, Han L, Meek K, Yu K Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A, 2016-01-19;113(5):1261-6. 2016-01-19 [PMID: 26787901] (Bioassay, Mouse)
• Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol, 2015-11-19;46(1):212-22. 2015-11-19 [PMID: 26514620] (Bioassay, Mouse)
• Agrawal K, Kale S, Arora N Protease activity of Per a 10 potentiates Th2 polarization by increasing IL-23 and OX40L. Eur J Immunol, 2015-10-16;45(12):3375-85. 2015-10-16 [PMID: 26417883] (Bioassay, Mouse)
• Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol, 2015-08-31;16(10):1077-84. 2015-08-31 [PMID: 26322481] (Bioassay, Mouse)
• DeMicco A, Naradikian M, Sindhava V, Yoon J, Gorospe M, Wertheim G, Cancro M, Bassing C B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo. J Immunol, 2015-08-28;195(7):3449-62. 2015-08-28 [PMID: 26320247] (Bioassay, Mouse)
• Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling. J Leukoc Biol, 2015-06-05;98(3):395-407. 2015-06-05 [PMID: 26048978] (Bioassay, Mouse)
• Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer. Sci Rep, 2015-04-29;5(0):9613. 2015-04-29 [PMID: 25923834] (Bioassay, Mouse)
• Olsan E, Matsushita T, Rezaei M, Weimbs T Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease. J Biol Chem, 2015-04-28;290(25):15679-86. 2015-04-28 [PMID: 25922073] (Bioassay, Mouse)
• Walsh N, Waters L, Fowler J, Lin M, Cunningham C, Brooks D, Rehg J, Morse H, Teitell M LKB1 inhibition of NF-kappaB in B cells prevents T follicular helper cell differentiation and germinal center formation. EMBO Rep, 2015-04-26;16(6):753-68. 2015-04-26 [PMID: 25916856] (Bioassay, Mouse)
• Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice. J Neuroinflammation, 2015-03-04;12(0):41. 2015-03-04 [PMID: 25885682] (Bioassay, Mouse)
• Chen , Yan, Zhang , Jin, Lu , Yong, Wang , Libo Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice. PLoS ONE, 2015-04-10;10(4):e0122990. 2015-04-10 [PMID: 25860995] (Bioassay, Mouse)
• Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. J Immunol, 2015-04-03;194(10):4767-76. 2015-04-03 [PMID: 25840913] (Bioassay, Mouse)
• Liu X, Ren S, Ge C, Cheng K, Zenke M, Keating A, Zhao R Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling. J Immunol, 2015-03-30;194(9):4298-308. 2015-03-30 [PMID: 25825436] (Bioassay, Mouse)
• Noh K, Son K, Jung I, Kang T, Choi C, Park Y Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression. J Biol Chem, 2015-03-26;290(19):12394-402. 2015-03-26 [PMID: 25814664] (Bioassay, Mouse)
• Shan , Chan-Cha, Shi , Liang-Ro, Ding , Mei-Qian, Zhu , Yi-Bei, Li , Xiao-Don, Xu , Bin, Jiang , Jing-Tin, Wu , Chang-Pi Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response. Oncol Lett, 2015-02-17;9(4):1549-1556. 2015-02-17 [PMID: 25788999] (Bioassay, Mouse)
• Wakasa Y, Takagi H, Watanabe N, Kitamura N, Fujiwara Y, Ogo Y, Hayashi S, Yang L, Ohta M, Thet Tin W, Sekikawa K, Takano M, Ozawa K, Hiroi T, Takaiwa F Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy. PLoS ONE, 2015-03-16;10(3):e0120209. 2015-03-16 [PMID: 25774686] (Mouse)
• Sag D, Cekic C, Wu R, Linden J, Hedrick C The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun, 2015-02-27;6(0):6354. 2015-02-27 [PMID: 25724068] (Bioassay, Mouse)
• Khairnar V, Duhan V, Maney S, Honke N, Shaabani N, Pandyra A, Seifert M, Pozdeev V, Xu H, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf A, Haussinger D, Lang F, Dittmer U, Kuppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Gothert J, Singer B, Lang P, Lang K CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun, 2015-02-18;6(0):6217. 2015-02-18 [PMID: 25692415] (Bioassay, Mouse)
• Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy, 2015-01-01;11(2):271-84. 2015-01-01 [PMID: 25650776] (Bioassay, Mouse)
• Freeman S, Jaumouille V, Choi K, Hsu B, Wong H, Abraham L, Graves M, Coombs D, Roskelley C, Das R, Grinstein S, Gold M Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nat Commun, 2015-02-03;6(0):6168. 2015-02-03 [PMID: 25644899] (Bioassay, Mouse)
• Kim J, Kang M, Kim W, Han S, Kim H, Kim H, Kwon K, Kim S, Cha S, Eum S, Koh W, Cho S, Park J, Shin S Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus. Infect Immun, 2015-02-02;83(4):1556-67. 2015-02-02 [PMID: 25644006] (Bioassay, Mouse)
• Brachman R, Lehmann M, Maric D, Herkenham M Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice. J Neurosci, 2015-01-28;35(4):1530-8. 2015-01-28 [PMID: 25632130] (Bioassay, Mouse)
• Feldman S, Achour I, Wuerffel R, Kumar S, Gerasimova T, Sen R, Kenter A Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination. J Immunol, 2015-01-26;194(5):2380-9. 2015-01-26 [PMID: 25624452] (Bioassay, Mouse)
• Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking. J Immunol, 2015-01-23;194(5):2128-39. 2015-01-23 [PMID: 25617475] (Bioassay, Mouse)
• Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, Moore B, Flavell R, Christman J, Standiford T IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. J Immunol, 2015-01-16;194(4):1894-904. 2015-01-16 [PMID: 25595781] (Bioassay, Mouse)
• Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Cancer Res, 2014-12-09;75(2):306-15. 2014-12-09 [PMID: 25492861] (Bioassay, Mouse)
• Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature, 2014-12-03;518(7539):417-21. 2014-12-03 [PMID: 25470037] (Bioassay, Mouse)
• Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, Abughazleh M, Mansy M, Naura A, Boulares A DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency. J Allergy Clin Immunol, 2014-10-19;135(2):425-40. 2014-10-19 [PMID: 25441643] (Bioassay, Mouse)
• Oeser K, Schwartz C, Voehringer D Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths. Mucosal Immunol, 2014-10-22;8(3):672-82. 2014-10-22 [PMID: 25336167] (Bioassay, Mouse)
• Bone R, Gai Y, Magrioti V, Kokotou M, Ali T, Lei X, Tse H, Kokotos G, Ramanadham S Inhibition of Ca2+-independent phospholipase A2beta (iPLA2beta) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes, 2014-09-11;64(2):541-54. 2014-09-11 [PMID: 25213337] (Bioassay, Mouse)
• Heise N, De Silva N, Silva K, Carette A, Simonetti G, Pasparakis M, Klein U Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappaB transcription factor subunits. J Exp Med, 2014-09-01;211(10):2103-18. 2014-09-01 [PMID: 25180063] (Bioassay, Mouse)
• Pefanis , Evangelo, Wang , Jiguang, Rothschild , Gerson, Lim , Junghyun, Chao , Jaime, Rabadan , Raul, Economides , Aris N, Basu , Uttiya Noncoding RNA transcription targets AID to divergently transcribed loci in B cells. Nature, 2014-08-06;514(7522):389-93. 2014-08-06 [PMID: 25119026] (Bioassay, Mouse)
• Lee S, Shin S, Lee M, Lee M, Kang T, Park W, Soh B, Park J, Shin Y, Kim H, Yun C, Jung I, Park Y A potential protein adjuvant derived from Mycobacterium tuberculosis Rv0652 enhances dendritic cells-based tumor immunotherapy. PLoS ONE, 2014-08-07;9(8):e104351. 2014-08-07 [PMID: 25102137] (Bioassay, Mouse)
• Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 2014-07-29;211(9):1807-19. 2014-07-29 [PMID: 25073792] (Bioassay, Mouse)
• Colegio O, Chu N, Szabo A, Chu T, Rhebergen A, Jairam V, Cyrus N, Brokowski C, Eisenbarth S, Phillips G, Cline G, Phillips A, Medzhitov R Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature, 2014-07-13;513(7519):559-63. 2014-07-13 [PMID: 25043024] (Bioassay, Mouse)
• Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral J, Schrottmaier W, Thell K, Saferding V, Bluml S, Schabbauer G Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol, 2014-07-11;193(4):1717-27. 2014-07-11 [PMID: 25015834] (Bioassay, Mouse)
• Jung I, Shin S, Lee M, Kang T, Han H, Lee S, Kim W, Kim H, Park W, Kim H, Yun C, Lee E, Wu T, Park Y Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X. J Immunol, 2014-07-02;193(3):1233-45. 2014-07-02 [PMID: 24990079] (Bioassay, Mouse)
• Hu , Jiazhi, Tepsuporn , Suprawee, Meyers , Robin M, Gostissa , Monica, Alt , Frederic Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci U S A, 2014-06-30;111(28):10269-74. 2014-06-30 [PMID: 24982162] (Bioassay, Mouse)
• Stouch A, Zaynagetdinov R, Barham W, Stinnett A, Slaughter J, Yull F, Hoffman H, Blackwell T, Prince L IkappaB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol, 2014-06-30;193(3):1184-93. 2014-06-30 [PMID: 24981452] (Bioassay, Mouse)
• Downey C, Aghaei M, Schwendener R, Jirik F DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2&#039;3&#039;-cGAMP, induces M2 macrophage repolarization. PLoS ONE, 2014-06-18;9(6):e99988. 2014-06-18 [PMID: 24940883] (Bioassay, Mouse)
• Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile. BMC Biol, 2014-05-09;12(0):32. 2014-05-09 [PMID: 24886643] (Bioassay, Mouse)
• Matthews A, Husain S, Chaudhuri J Binding of AID to DNA does not correlate with mutator activity. J Immunol, 2014-05-30;193(1):252-7. 2014-05-30 [PMID: 24879790] (Bioassay, Mouse)
• Gabriel T, Tol M, Ottenhof R, van Roomen C, Aten J, Claessen N, Hooibrink B, de Weijer B, Serlie M, Argmann C, van Elsenburg L, Aerts J, van Eijk M Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction. Diabetes, 2014-05-01;63(10):3310-23. 2014-05-01 [PMID: 24789918] (Bioassay, Mouse)
• Dingler F, Kemmerich K, Neuberger M, Rada C Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation. Eur J Immunol, 2014-05-27;44(7):1925-35. 2014-05-27 [PMID: 24771041] (Bioassay, Mouse)
• Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol, 2014-04-15;44(7):2175-87. 2014-04-15 [PMID: 24668151] (Bioassay, Mouse)
• Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol, 2014-03-21;192(8):3569-81. 2014-03-21 [PMID: 24659691] (ELISA (Standard), Mouse)
• Park , Mi Kyung, Cho , Min Kyou, Kang , Shin Ae, Park , Hye-Kyun, Kim , Dong-Hee, Yu , Hak Sun Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2. PLoS ONE, 2014-03-21;9(3):e92726. 2014-03-21 [PMID: 24658532] (Bioassay, Mouse)
• van Solingen C, Araldi E, Chamorro-Jorganes A, Fernandez-Hernando C, Suarez Y Improved repair of dermal wounds in mice lacking microRNA-155. J Cell Mol Med, 2014-03-17;18(6):1104-12. 2014-03-17 [PMID: 24636235] (Bioassay, Mouse)
• Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R A role for the ITAM signaling module in specifying cytokine-receptor functions. Nat Immunol, 2014-03-09;15(4):333-42. 2014-03-09 [PMID: 24608040] (Bioassay, Mouse)
• Al Faraj , Achraf, Sultana Shaik , Asma, Pureza , Mary Ang, Alnafea , Mohammad, Halwani , Rabih Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI. PLoS ONE, 2014-03-05;9(3):e90829. 2014-03-05 [PMID: 24598763] (Bioassay, Mouse)
• Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med, 2014-03-02;20(4):377-84. 2014-03-02 [PMID: 24584118] (Bioassay, Mouse)
• Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K Colony-stimulating factor-1 signaling suppresses renal crystal formation. J Am Soc Nephrol, 2014-02-27;25(8):1680-97. 2014-02-27 [PMID: 24578130] (Bioassay, Mouse)
• Srivastava , Leena, Tundup , Smanla, Choi , Beak-San, Norberg , Thomas, Harn , Donald Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells. Infect Immun, 2014-02-24;82(5):1891-903. 2014-02-24 [PMID: 24566617] (Bioassay, Mouse)
• Tatano Y, Shimizu T, Tomioka H Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep, 2014-02-20;4(0):4146. 2014-02-20 [PMID: 24553452] (Bioassay, Mouse)
• Hiroshima Y, Hsu K, Tedla N, Chung Y, Chow S, Herbert C, Geczy C S100A8 induces IL-10 and protects against acute lung injury. J Immunol, 2014-02-14;192(6):2800-11. 2014-02-14 [PMID: 24532576] (Bioassay, Mouse)
• Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga C, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models. J Invest Dermatol, 2014-03-02;134(8):2122-30. 2014-03-02 [PMID: 24480880] (Bioassay, Mouse)
• Dufort , Fay J, Gumina , Maria R, Ta , Nathan L, Tao , Yongzhen, Heyse , Shannon, Scott , David A, Richardson , Adam D, Seyfried , Thomas N, Chiles , Thomas C Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem, 2014-01-27;289(10):7011-24. 2014-01-27 [PMID: 24469453] (Bioassay, Mouse)
• Han , Ji Eun, Wui , Seo Ri, Kim , Kwang Su, Cho , Yang Je, Cho , Wan Je, Lee , Na Gyong Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide. PLoS ONE, 2014-01-22;9(1):e85838. 2014-01-22 [PMID: 24465739] (Bioassay, Mouse)
• Asai H, Ikezu S, Woodbury M, Yonemoto G, Cui L, Ikezu T Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. Am J Pathol, 2014-01-10;184(3):808-18. 2014-01-10 [PMID: 24418258] (Bioassay, Mouse)
• Terra R, Wang X, Hu Y, Charpentier T, Lamarre A, Zhong M, Sun H, Mao J, Qi S, Luo H, Wu J To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses. PLoS ONE, 2013-12-31;8(12):e82808. 2013-12-31 [PMID: 24391722] (Bioassay, Mouse)
• Date D, Das R, Narla G, Simon D, Jain M, Mahabeleshwar G Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization. J Biol Chem, 2014-01-02;289(15):10318-29. 2014-01-02 [PMID: 24385430] (Bioassay, Mouse)
• Garzetti , Livia, Menon , Ramesh, Finardi , Annamari, Bergami , Alessand, Sica , Antonio, Martino , Gianvito, Comi , Giancarl, Verderio , Claudia, Farina , Cinthia, Furlan , Roberto Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs. J Leukoc Biol, 2013-12-30;0(0):. 2013-12-30 [PMID: 24379213] (Bioassay, Mouse)
• Veremeyko , Tatyana, Siddiqui , Shafiudd, Sotnikov , Ilya, Yung , Amanda, Ponomarev , Eugene D IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE, 2013-12-16;8(12):e81774. 2013-12-16 [PMID: 24358127] (Bioassay, Mouse)
• Garg S, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R Aging is associated with increased regulatory T-cell function. Aging Cell, 2014-02-25;13(3):441-8. 2014-02-25 [PMID: 24325345] (Bioassay, Mouse)
• Lam T, Thomas L, White C, Li G, Pone E, Xu Z, Casali P Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS ONE, 2013-11-25;8(11):e80414. 2013-11-25 [PMID: 24282540] (Bioassay, Mouse)
• Buchta C, Bishop G TRAF5 negatively regulates TLR signaling in B lymphocytes. J Immunol, 2013-11-20;192(1):145-50. 2013-11-20 [PMID: 24259503] (Bioassay, Mouse)
• Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, Jasin M, Keeney S Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS Genet, 2013-11-07;9(11):e1003945. 2013-11-07 [PMID: 24244200] (Bioassay, Mouse)
• Chattopadhyay , Gouri, Shevach , Ethan M Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism. J Immunol, 2013-11-11;191(12):5875-84. 2013-11-11 [PMID: 24218453] (Bioassay, Mouse)
• Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A The exonuclease Trex1 restrains macrophage proinflammatory activation. J Immunol, 2013-11-11;191(12):6128-35. 2013-11-11 [PMID: 24218451] (Bioassay, Mouse)
• Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity, 2013-10-24;39(5):976-85. 2013-10-24 [PMID: 24210353] (Bioassay, Mouse)
• Leslie K, Song G, Barrick S, Wehbi V, Vilardaga J, Bauer P, Bisello A Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-kappaB (NF-kappaB): a feed-forward loop for systemic and vascular inflammation. J Biol Chem, 2013-11-06;288(51):36426-36. 2013-11-06 [PMID: 24196963] (Bioassay, Mouse)
• Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol, 2013-10-18;191(11):5420-9. 2013-10-18 [PMID: 24140642] (Bioassay, Mouse)
• Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity, 2013-09-26;39(4):722-32. 2013-09-26 [PMID: 24076050] (Bioassay, Mouse)
• Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang X, Lee V, Wang Y, Zheng G, Tan T, Wang Y, Alexander S, Harris D Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo. Kidney Int, 2013-09-18;85(4):794-806. 2013-09-18 [PMID: 24048378] (Bioassay, Mouse)
• Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari N, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity. J Bone Miner Res, 2014-02-01;29(2):290-303. 2014-02-01 [PMID: 24038328] (Bioassay, Mouse)
• Kim J, Kim W, Choi H, Jang B, Lee K, Park J, Kim H, Cho S, Shin S Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells. J Leukoc Biol, 2013-07-03;94(4):733-49. 2013-07-03 [PMID: 23825389] (Bioassay, Mouse)
• Nundel K, Busto P, Debatis M, Marshak-Rothstein A The role of Bruton&#039;s tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells. J Leukoc Biol, 2013-06-26;94(5):865-75. 2013-06-26 [PMID: 23804807] (Bioassay, Mouse)
• Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech S, Weaver C, Flavell R, Zhao L, Yao Z, Yin Z IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol, 2013-06-14;94(6):1103-12. 2013-06-14 [PMID: 23772040] (Bioassay, Mouse)
• Jachetti , Elena, Mazzoleni , Stefania, Grioni , Matteo, Ricupito , Alessia, Brambillasca , Chiara, Generoso , Luca, Calcinotto , Arianna, Freschi , Massimo, Mondino , Anna, Galli , Rossella, Bellone , Matteo Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses. Oncoimmunology, 2013-04-16;2(5):e24520. 2013-04-16 [PMID: 23762811] (Bioassay, Mouse)
• Chen M, Hombrebueno J, Luo C, Penalva R, Zhao J, Colhoun L, Pandi S, Forrester J, Xu H Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. PLoS ONE, 2013-04-18;8(4):e61381. 2013-04-18 [PMID: 23637822] (Bioassay, Mouse)
• Rajaiah R, Perkins D, Polumuri S, Zhao A, Keegan A, Vogel S Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages. J Immunol, 2013-03-29;190(9):4763-72. 2013-03-29 [PMID: 23543762] (Bioassay, Mouse)
• Hwang I, Hwang K, Park C, Harrison K, Kehrl J Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS ONE, 2013-03-22;8(3):e60139. 2013-03-22 [PMID: 23533672] (Bioassay, Mouse)
• Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. Sci Rep, 2013-01-01;3(0):1540. 2013-01-01 [PMID: 23528921] (Bioassay, Mouse)
• Knosp C, Schiering C, Spence S, Carroll H, Nel H, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald D, Powrie F, Fallon P, Johnston J, Kissenpfennig A Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2. J Immunol, 2013-03-01;190(7):3235-45. 2013-03-01 [PMID: 23455506] (Bioassay, Mouse)
• Napolitano , Anna, Pittoni , Paola, Beaudoin , Lucie, Lehuen , Agnes, Voehringer , David, MacDonald , H Robson, Dellabona , Paolo, Casorati , Giulia Functional education of invariant NKT cells by dendritic cell tuning of SHP-1. J Immunol, 2013-02-20;190(7):3299-308. 2013-02-20 [PMID: 23427253] (Bioassay, Mouse)
• Gartlan K, Wee J, Demaria M, Nastovska R, Chang T, Jones E, Apostolopoulos V, Pietersz G, Hickey M, van Spriel A, Wright M Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. Eur J Immunol, 2013-03-25;43(5):1208-19. 2013-03-25 [PMID: 23420539] (Bioassay, Mouse)
• Masani , Shahnaz, Han , Li, Yu , Kefei Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination. Mol Cell Biol, 2013-02-04;33(7):1468-73. 2013-02-04 [PMID: 23382073] (Bioassay, Mouse)
• Kumar M, Roe K, Orillo B, Muruve D, Nerurkar V, Gale M, Verma S Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. J Virol, 2013-01-09;87(7):3655-67. 2013-01-09 [PMID: 23302887] (Bioassay, Mouse)
• Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum, 2013-04-01;65(4):949-59. 2013-04-01 [PMID: 23280308] (Bioassay, Mouse)
• Xu Q, Chai S, Qian Y, Zhang M, Wang K Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma. Acta Pharmacol Sin, 2012-11-26;33(12):1525-32. 2012-11-26 [PMID: 23178461] (Cell Culture, Mouse)
• Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology, 2012-10-01;1(7):1074-1083. 2012-10-01 [PMID: 23170255] (Bioassay, Mouse)
• Jacome-Galarza C, Lee S, Lorenzo J, Aguila H Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. J Bone Miner Res, 2013-05-01;28(5):1203-13. 2013-05-01 [PMID: 23165930] (Bioassay, Mouse)
• Umeshappa C, Nanjundappa R, Xie Y, Freywald A, Xu Q, Xiang J Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency. Immunology, 2013-04-01;138(4):298-306. 2013-04-01 [PMID: 23113741] (Bioassay, Mouse)
• Hou J, Liu Y, Liu Y, Shao Y The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity. PLoS ONE, 2012-10-15;7(10):e47724. 2012-10-15 [PMID: 23077664] (Bioassay, Mouse)
• Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat. Med., 2012-07-08;1248(0):18. 2012-07-08 [PMID: 22772464] (Bioassay, Mouse)
• Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature, 2012-07-12;487(7406):249-53. 2012-07-12 [PMID: 22763435] (Bioassay, Mouse)
• Perez-Chacon G, Llobet D, Pardo C, Pindado J, Choi Y, Reed JC, Zapata JM TNFR-Associated Factor 2 Deficiency in B Lymphocytes Predisposes to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Mice. J. Immunol., 2012-06-18;189(2):1053-61. 2012-06-18 [PMID: 22711886] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction. Eur. J. Immunol., 2012-05-01;42(5):1250-60. 2012-05-01 [PMID: 22539297] (Bioassay, Mouse)
• Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J. Biol. Chem., 2012-03-05;287(17):14226-33. 2012-03-05 [PMID: 22393041] (Bioassay, Mouse)
• Jin W, Qi S, Luo H The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol., 2011-12-19;12(0):68. 2011-12-19 [PMID: 22182253] (Bioassay, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 2010-07-21;185(4):2044-50. 2010-07-21 [PMID: 20660352] (Bioassay, Mouse)
• Yoshizaki A, Yanaba K, Iwata Y Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol., 2010-07-12;185(4):2502-15. 2010-07-12 [PMID: 20624949] (Bioassay, Mouse)
• Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol., 2010-05-02;11(6):527-34. 2010-05-02 [PMID: 20431622] (Bioassay, Mouse)
• Perona-Wright G, Mohrs K, Mohrs M Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat. Immunol., 2010-04-25;11(6):520-6. 2010-04-25 [PMID: 20418876] (In Vivo, Mouse)
• Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem. Biophys. Res. Commun., 2010-03-04;394(2):272-8. 2010-03-04 [PMID: 20206608] (Cell Culture, Mouse)
• Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa. Mucosal Immunol, 2009-10-07;3(1):40-8. 2009-10-07 [PMID: 19812544] (Bioassay, Mouse)
• Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A, 2010-06-01;93(3):1169-79. 2010-06-01 [PMID: 19768789] (Bioassay, Mouse)
• Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 2009-03-13;11(4):524-30. 2009-03-13 [PMID: 19286469] (ELISA (Standard))
• Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J. Immunol., 2009-02-01;182(3):1617-30. 2009-02-01 [PMID: 19155511] (Bioassay, Mouse)
• Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 2009-01-12;206(1):69-78. 2009-01-12 [PMID: 19139170] (Bioassay, Mouse)
• Richez C, Yasuda K, Watkins AA TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J. Immunol., 2009-01-15;182(2):820-8. 2009-01-15 [PMID: 19124725] (Bioassay, Mouse)
• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008-09-15;181(6):4089-97. 2008-09-15 [PMID: 18768865] (Bioassay, Mouse)
• Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 2008-06-17;112(5):1822-31. 2008-06-17 [PMID: 18559975] (Bioassay, Mouse)
• Wan S, Zhou Z, Duan B, Morel L Direct B cell stimulation by dendritic cells in a mouse model of lupus. Arthritis Rheum., 2008-06-01;8(0):1741-50. 2008-06-01 [PMID: 18512810] (Bioassay, Mouse)
• Norman MU, Zbytnuik L, Kubes P Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism. Eur. J. Immunol., 2008-05-01;38(5):1368-80. 2008-05-01 [PMID: 18412158] (Bioassay, In Vivo, Mouse)
• Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA (Standard))
• Sokol CL, Barton GM, Farr AG, Medzhitov R A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol., 2008-03-01;9(3):310-8. 2008-03-01 [PMID: 18300366] (Bioassay, Mouse)
• Nakamura M, Jo J, Tabata Y, Ishikawa O Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model. Am. J. Pathol., 2008-02-02;172(3):650-8. 2008-02-02 [PMID: 18245811] (In Vivo, Mouse)
• Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol., 2007-12-28;582(1):154-61. 2007-12-28 [PMID: 18242596] (Bioassay, Mouse)
• Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 2007-12-01;117(12):3868-3878. 2007-12-01 [PMID: 18060034] (Bioassay, Mouse)
• King VL, Cassis LA, Daugherty A Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am. J. Pathol., 2007-11-30;171(6):2040-7. 2007-11-30 [PMID: 18055554] (In Vivo, Mouse)
• Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M Liposomal retinoic acids modulate asthma manifestations in mice. J. Nutr., 2007-12-01;137(12):2730-6. 2007-12-01 [PMID: 18029491] (ELISA (Standard))
• Franki SN, Steward KK, Betting DJ, Kafi K, Yamada RE, Timmerman JM Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo. Blood, 2007-11-09;111(3):1504-11. 2007-11-09 [PMID: 17993615] (Bioassay, Mouse)
• Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol., 2007-10-01;37(10):2695-706. 2007-10-01 [PMID: 17899546] (Bioassay, Mouse)
• Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. J. Immunol., 2007-09-15;179(6):3742-51. 2007-09-15 [PMID: 17785811] (Bioassay, Mouse)
• Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, Sprigg N, McKenzie AN, Watson CJ The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development, 2007-07-04;134(15):2739-50. 2007-07-04 [PMID: 17611223] (Bioassay, Mouse)
• Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity, 2007-04-12;26(4):445-59. 2007-04-12 [PMID: 17433730] (Bioassay, Mouse)
• Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J. Invest. Dermatol., 2007-03-29;127(8):1964-72. 2007-03-29 [PMID: 17392823] (Bioassay, Mouse)
• Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol. Ther., 2007-03-20;15(5):971-80. 2007-03-20 [PMID: 17375074] (Bioassay, Mouse)
• Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J. Allergy Clin. Immunol., 2007-03-01;119(3):662-70. 2007-03-01 [PMID: 17336616] (Bioassay, Mouse)
• Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007-02-15;178(4):2018-27. 2007-02-15 [PMID: 17277105] (Bioassay, Mouse)
• Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J. Immunol., 2007-01-01;178(1):480-8. 2007-01-01 [PMID: 17182587] (Bioassay, Mouse)
• Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. J Ethnopharmacol, 2006-10-19;110(3):532-8. 2006-10-19 [PMID: 17101254] (Bioassay, Mouse)
• Ogawa K, Funaba M, Chen Y, Tsujimoto M Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol., 2006-11-15;177(10):6787-94. 2006-11-15 [PMID: 17082592] (Bioassay, Mouse)
• de la Fuente MA, Kumar L, Lu B, Geha RS 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol. Cell. Biol., 2006-07-01;26(14):5214-25. 2006-07-01 [PMID: 16809760] (Bioassay, Mouse)
• Wen H, Hogaboam CM, Gauldie J, Kunkel SL Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am. J. Pathol., 2006-06-01;168(6):1940-50. 2006-06-01 [PMID: 16723709] (ELISA (Standard))
• Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Bioassay, Mouse)
• Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J. Clin. Invest., 2006-03-23;116(4):905-15. 2006-03-23 [PMID: 16557302] (Bioassay, Mouse)
• Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity, 2006-03-01;24(3):341-8. 2006-03-01 [PMID: 16546102] (In Vivo, Mouse)
• Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci., 2005-11-16;31(1):149-60. 2005-11-16 [PMID: 16297637] (Bioassay, Mouse)
• Harrington , Laurie E, Hatton , Robin D, Mangan , Paul R, Turner , Henriett, Murphy , Theresa, Murphy , Kenneth, Weaver , Casey T Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 2005-10-02;6(11):1123-32. 2005-10-02 [PMID: 16200070] (Bioassay, Mouse)
• Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines. Anticancer Res., 2005-01-01;25(1):299-303. 2005-01-01 [PMID: 15816551] (Bioassay, Mouse)
• Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest., 2005-02-01;115(2):282-90. 2005-02-01 [PMID: 15668736] (Bioassay, Human, Mouse)
• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Bioassay, Mouse)
• Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood, 2004-07-08;104(10):3267-75. 2004-07-08 [PMID: 15242871] (Bioassay, Mouse)
• Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J. Immunol., 2004-06-15;172(12):7408-16. 2004-06-15 [PMID: 15187118] (Bioassay, Mouse)
• Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C Control of Leishmania major in the absence of Tyk2 kinase. Eur. J. Immunol., 2004-02-01;34(2):519-29. 2004-02-01 [PMID: 14768057] (Bioassay, Mouse)
• Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J. Immunol., 2003-11-15;171(10):5107-15. 2003-11-15 [PMID: 14607909] (Bioassay, Mouse)
• Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Bioassay, Mouse)
• Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J. Leukoc. Biol., 2003-01-01;73(1):65-73. 2003-01-01 [PMID: 12525563] (In Vivo, Mouse)
• Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am. J. Pathol., 2002-04-01;160(4):1353-60. 2002-04-01 [PMID: 11943720] (ELISA (Standard))
• Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 2001-11-01;293(10):508-14. 2001-11-01 [PMID: 11820727] (Bioassay, Mouse)
• Morelli AE, Zahorchak AF, Larregina AT Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood, 2001-09-01;98(5):1512-23. 2001-09-01 [PMID: 11520802] (Bioassay, Mouse)
• Gabrilovich DI, 2018, Ishida T, Nadaf S, Ohm JE, Carbone DP Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. 1537, 1999-10-01;5(10):2963-70. 1999-10-01 [PMID: 10537366] (Bioassay, Mouse)

Review for IL-4 (404-ML) (1)

Average Rating: 5

(Based on 1 review)

reviewed by: Verified Customer CellProlif 02/26/2021

Summary

• Application: Cell Proliferation
• Lot: BC1918101
• Comments: It worked well in the polarization and differentiation of mouse M0 macrophages into M2 macrophages in vitro.

Bioinformatics

• Gene Symbol: Il4
• Uniprot:
  • P07750()