Recombinant Mouse IL-23 Protein

Product Discontinued

Recombinant Mouse IL-23 Protein Summary

• Additional Information: This product is in the process of being discontinued.
• Details of Functionality: Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910. The ED₅₀ for this effect is 0.05-0.25 ng/mL.
• Source: Spodoptera frugiperda, Sf 21 (stably transfected)-derived mouse IL-23 protein
  

  Mouse IL-23 p40 (Met23-Ser335) Accession # P43432	IGSGSSRGGSGSGGSGGGGSK	Mouse IL-23 p19 (Leu20-Ala196) Accession # Q9EQ14
  N-terminus		C-terminus

• Accession #: P43432 (p40) & Q9EQ14 (p19)
• N-terminal Sequence: Met23
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il23a
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 57 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: (58-71) kDa, non-reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-23 Protein

• IL-23 p19/IL-12 p40
• IL23
• IL-23
• IL-23A
• IL-23-A
• IL-23p19
• IL-23p19/IL-12p40
• IL23P19P19
• interleukin 23 p19 subunit
• interleukin 23, alpha subunit p19
• interleukin-23 subunit alpha
• Interleukin-23 subunit p19
• JKA3 induced upon T-cell activation
• MGC79388
• SGRF
• SGRFIL-23 subunit alpha

Background

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human Tnbsp;cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8^- and CD8⁺ subtypes, however only IL-23 can act directly on CD8⁺ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.

1. Oppmann, B. et al. (2000) Immunity 13:715.
2. Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.
3. Parham, C. et al. (2002) J. Immunol. 168:5699.
4. Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.
5. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

Publications for IL-23A/IL-23 P19 (1887-ML)(183)

Publications using 1887-ML

• Hao, J;Liu, C;Gu, Z;Yang, X;Lan, X;Guo, X; Dysregulation of Wnt/?-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells Nature communications 2024-04-01 [PMID: 38561332] (Mouse)
• Chen, S;Wang, J;Zhang, K;Ma, B;Li, X;Wei, R;Nian, H; LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation Cell death & disease 2023-09-16 [PMID: 37716986] (Bioassay, Mouse)
• van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E; CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1 European journal of immunology 2023-09-08 [PMID: 37683186] (Bioassay, Mouse)
• Gao, Y;Wang, Y;Chauss, D;Villarino, AV;Link, VM;Nagashima, H;Spinner, CA;Koparde, VN;Bouladoux, N;Abers, MS;Break, TJ;Chopp, LB;Park, JH;Zhu, J;Wiest, DL;Leonard, WJ;Lionakis, MS;O'Shea, JJ;Afzali, B;Belkaid, Y;Lazarevic, V; Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system Nature immunology 2023-07-13 [PMID: 37443284] (Bioassay, Mouse)
• WL Yang, W Qiu, T Zhang, K Xu, ZJ Gu, Y Zhou, HJ Xu, ZZ Yang, B Shen, YL Zhao, Q Zhou, Y Yang, W Li, PY Yang, YG Yang Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis Nature Communications, 2023-02-16;14(1):863. 2023-02-16 [PMID: 36792629] (Bioassay, Mouse)
• T Huu Hoang, M Sato-Matsu, H Yuasa, T Matsubara, LTT Thuy, H Ikenaga, DM Phuong, NV Hanh, VN Hieu, DV Hoang, H Hai, Y Okina, M Enomoto, A Tamori, A Daikoku, H Urushima, K Ikeda, NQ Dat, Y Yasui, H Shinkawa, S Kubo, R Yamagishi, N Ohtani, K Yoshizato, J Gracia-San, N Kawada Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms Science Advances, 2022-09-28;8(39):eabo5525. 2022-09-28 [PMID: 36170363] (Bioassay, Mouse)
• N Millet, NV Solis, D Aguilar, MS Lionakis, RT Wheeler, N Jendzjowsk, M Swidergall IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis Nature Communications, 2022-09-22;13(1):5545. 2022-09-22 [PMID: 36138043] (In Vivo, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• K Nishida-Ta, A Kimura, T Tsubata, S Takahashi, H Suzuki Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels PLoS ONE, 2022-07-29;17(7):e0272090. 2022-07-29 [PMID: 35905076] (Bioassay, Mouse)
• X Chen, A Jaiswal, Z Costliow, P Herbst, EA Creasey, N Oshiro-Rap, MJ Daly, KL Carey, DB Graham, RJ Xavier pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells Nature Immunology, 2022-06-06;0(0):. 2022-06-06 [PMID: 35668320] (Bioassay, Mouse)
• YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614130] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
• Q Zhang, W Liu, H Wang, H Zhou, K Bulek, X Chen, CJ Zhang, J Zhao, R Zhang, C Liu, Z Kang, RA Bermel, G Dubyak, DW Abbott, TS Xiao, LE Nagy, X Li TH17 cells promote CNS inflammation by sensing danger signals via Mincle Nature Communications, 2022-05-03;13(1):2406. 2022-05-03 [PMID: 35504893] (Bioassay, Mouse)
• HW Cheng, U Mörbe, M Lütge, C Engetschwi, L Onder, M Novkovic, C Gil-Cruz, C Perez-Shib, T Hehlgans, E Scandella, B Ludewig Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function Nature Communications, 2022-04-19;13(1):2027. 2022-04-19 [PMID: 35440118] (Bioassay, Mouse)
• N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival Cell Reports, 2022-03-29;38(13):110565. 2022-03-29 [PMID: 35354043] (Bioassay, Mouse)
• M Wakai, R Hayashi, Y Ueno, K Onishi, T Takasago, T Uchida, H Takigawa, R Yuge, Y Urabe, S Oka, Y Kitadai, S Tanaka Promoting mechanism of serum amyloid a family expression in mouse intestinal epithelial cells PLoS ONE, 2022-03-18;17(3):e0264836. 2022-03-18 [PMID: 35303008] (Organoid Culture, Mouse)
• S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)
• V Patel, A Jayaraman, S Jayaraman Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells International immunopharmacology, 2021-12-23;103(0):108490. 2021-12-23 [PMID: 34954557] (Bioassay, Mouse)
• Y Zhu, Z Wu, W Yan, F Shao, B Ke, X Jiang, J Gao, W Guo, Y Lai, H Ma, D Chen, Q Xu, Y Sun Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis Embo Molecular Medicine, 2021-12-22;0(0):e14455. 2021-12-22 [PMID: 34936223] (Bioassay, Mouse)
• M Gurusamy, D Tischner, J Shao, S Klatt, S Zukunft, R Bonnavion, S Günther, K Siebenbrod, RI Kestner, T Kuhlmann, I Fleming, S Offermanns, N Wettschure G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators Nature Communications, 2021-11-23;12(1):6798. 2021-11-23 [PMID: 34815397] (Bioassay, Mouse)
• X Chi, W Jin, X Bai, X Zhao, J Shao, J Li, Q Sun, B Su, X Wang, XO Yang, C Dong RORalpha is critical for mTORC1 activity in T�cell-mediated colitis Cell Reports, 2021-09-14;36(11):109682. 2021-09-14 [PMID: 34525365] (Bioassay, Mouse)
• A Agasing, JL Quinn, G Kumar, RC Axtell Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease Cells, 2021-08-20;10(8):. 2021-08-20 [PMID: 34440908] (Bioassay, Mouse)
• J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 2021-06-16;7(25):. 2021-06-16 [PMID: 34134995] (Bioassay, Mouse)
• ELY Chen, CR Lee, PK Thompson, DL Wiest, MK Anderson, JC Zúñiga-Pfl Ontogenic timing, T�cell receptor signal strength, and Notch signaling direct &amp;gamma&amp;delta T�cell functional differentiation in�vivo Cell Reports, 2021-06-08;35(10):109227. 2021-06-08 [PMID: 34107257] (Bioassay, Mouse)
• FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Cell Reports, 2021-05-25;35(8):109176. 2021-05-25 [PMID: 34038731] (Bioassay, Mouse)
• Z Maria, E Turner, A Agasing, G Kumar, RC Axtell Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE International Journal of Molecular Sciences, 2021-03-13;22(6):. 2021-03-13 [PMID: 33805762] (Bioassay, Mouse)
• H Tao, Y Pan, S Chu, L Li, J Xie, P Wang, S Zhang, S Reddy, JW Sleasman, XP Zhong Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals Nature Communications, 2021-04-01;12(1):2029. 2021-04-01 [PMID: 33795689] (Bioassay, Mouse)
• PMIA Doss, M Umair, J Baillargeo, R Fazazi, N Fudge, I Akbar, AP Yeola, JB Williams, M Leclercq, C Joly-Beaup, P Beauchemin, GF Ruda, M Alpaugh, AC Anderson, PE Brennan, A Droit, H Lassmann, CS Moore, M Rangachari Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity Cell Reports, 2021-03-09;34(10):108833. 2021-03-09 [PMID: 33691111] (Bioassay, Mouse)
• R Yabe, SH Chung, MA Murayama, S Kubo, K Shimizu, Y Akahori, T Maruhashi, A Seno, T Kaifu, S Saijo, Y Iwakura TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens Nature Communications, 2021-01-04;12(1):94. 2021-01-04 [PMID: 33397982] (Bioassay, Mouse)
• H Zhang, A Madi, N Yosef, N Chihara, A Awasthi, C Pot, C Lambden, A Srivastava, PR Burkett, J Nyman, E Christian, Y Etminan, A Lee, H Stroh, J Xia, K Karwacz, PI Thakore, N Acharya, A Schnell, C Wang, L Apetoh, O Rozenblatt, AC Anderson, A Regev, VK Kuchroo An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets Cell Rep, 2020-11-24;33(8):108433. 2020-11-24 [PMID: 33238123] (Cell Culture, Mouse)
• A Baniahmad, K Birkner, J Görg, J Loos, F Zipp, B Wasser, S Bittner The frequency of follicular T helper cells differs in acute and chronic neuroinflammation Sci Rep, 2020-11-24;10(1):20485. 2020-11-24 [PMID: 33235306] (Bioassay, Transgenic Mouse)
• R Kajino-Sak, T Fujishita, MM Taketo, M Aoki Synthetic lethality between MyD88 loss and mutations in Wnt/&amp;beta-catenin pathway in intestinal tumor epithelial cells Oncogene, 2020-11-12;0(0):. 2020-11-12 [PMID: 33177648] (Bioassay, Mouse)
• I Mizoguchi, M Ohashi, H Hasegawa, Y Chiba, N Orii, S Inoue, C Kawana, M Xu, K Sudo, K Fujita, M Kuroda, SI Hashimoto, K Matsushima, T Yoshimoto EBV-induced gene 3 augments IL-23R&amp;alpha protein expression through a chaperone calnexin J. Clin. Invest., 2020-11-02;0(0):. 2020-11-02 [PMID: 32809973] (Bioassay, Mouse)
• Y Liu, R Bockermann, M Hadi, I Safari, B Carrion, M Kveiborg, S Issazadeh- ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation Cell. Mol. Immunol., 2020-06-22;0(0):. 2020-06-22 [PMID: 32572163] (Bioassay, Mouse)
• AM Agasing, Q Wu, B Khatri, N Borisow, K Ruprecht, AU Brandt, S Gawde, G Kumar, JL Quinn, RM Ko, Y Mao-Draaye, CJ Lessard, F Paul, RC Axtell Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica Nat Commun, 2020-06-05;11(1):2856. 2020-06-05 [PMID: 32503977] (Bioassay, Mouse)
• KM Lee, Z Zhang, A Achuthan, AJ Fleetwood, JE Smith, JA Hamilton, AD Cook IL-23 in arthritic and inflammatory pain development in mice Arthritis Res. Ther., 2020-05-29;22(1):123. 2020-05-29 [PMID: 32471485] (In Vivo, Mouse)
• P Mamareli, F Kruse, CW Lu, M Guderian, S Floess, K Rox, DSJ Allan, JR Carlyle, M Brönstrup, R Müller, L Berod, T Sparwasser, M Lochner Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection Mucosal Immunol, 2020-04-30;0(0):. 2020-04-30 [PMID: 32355319] (Bioassay, Mouse)
• AE Morelli, TL Sumpter, DM Rojas-Cana, M Bandyopadh, Z Chen, O Tkacheva, WJ Shufesky, CT Wallace, SC Watkins, A Berger, CJ Paige, LD Falo, AT Larregina Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells Cell Rep, 2020-03-10;30(10):3448-3465.e8. 2020-03-10 [PMID: 32160549] (Bioassay, Mouse)
• A Singh, M Dashnyam, B Chim, TM Escobar, AE Dulcey, X Hu, KM Wilson, PP Koganti, CA Spinner, X Xu, A Jadhav, N Southall, J Marugan, V Selvaraj, V Lazarevic, SA Muljo, M Ferrer Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells Sci Rep, 2020-02-28;10(1):3766. 2020-02-28 [PMID: 32111885] (Cell Culture, Mouse)
• D Liu, S Xing, W Wang, X Huang, H Lin, Y Chen, K Lan, L Chen, F Luo, S Qin, R Liang, C Bai, J Xu, W Liu Prognostic value of serum soluble interleukin-23 receptor and related T-helper 17 cell cytokines in non-small cell lung carcinoma Cancer Sci., 2020-03-04;111(4):1093-1102. 2020-03-04 [PMID: 32020720] (ELISA Developmet)
• I Raphael, F Gomez-Rive, RA Raphael, RR Robinson, S Nalawade, TG Forsthuber TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells JCI Insight, 2019-12-19;4(24):. 2019-12-19 [PMID: 31852844] (Cell Culture, Mouse)
• W Razawy, PS Asmawidjaj, AM Mus, N Salioska, N Davelaar, N Kops, M Oukka, CH Alves, E Lubberts CD4+ CCR6+ T�cells, but not gammadelta T�cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice Eur. J. Immunol., 2019-11-28;50(2):245-255. 2019-11-28 [PMID: 31778214] (Bioassay, Transgenic Mouse)
• HG Lee, LK Kim, JM Choi NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17 Mol Ther Methods Clin Dev, 2019-10-23;16(0):32-41. 2019-10-23 [PMID: 31737742] (Cell Culture, Mouse)
• K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death J. Immunol., 2019-05-31;0(0):. 2019-05-31 [PMID: 31152078] (Bioassay, Mouse)
• JZ Kawalkowsk, J Ogbechi, PJ Venables, RO Williams cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs Sci Adv, 2019-05-01;5(5):eaaw5422. 2019-05-01 [PMID: 31049403] (Bioassay, Mouse)
• A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis PLoS ONE, 2019-04-26;14(4):e0215981. 2019-04-26 [PMID: 31026283] (Bioassay, Mouse)
• Y Okunuki, R Mukai, T Nakao, SJ Tabor, O Butovsky, R Dana, BR Ksander, KM Connor Retinal microglia initiate neuroinflammation in ocular autoimmunity Proc. Natl. Acad. Sci. U.S.A., 2019-04-25;0(0):. 2019-04-25 [PMID: 31023885] (Bioassay, Mouse)
• H Katsura, Y Kobayashi, PR Tata, BLM Hogan IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration Stem Cell Reports, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930244] (Bioassay, Mouse)
• Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development EBioMedicine, 2019-03-01;0(0):. 2019-03-01 [PMID: 30827928] (Mouse)
• HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Mouse)
• KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis Proc. Natl. Acad. Sci. U.S.A., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718413] (Bioassay, Mouse)
• K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)
• M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018-12-26;25(13):3733-3749.e8. 2018-12-26 [PMID: 30590045] (Bioassay, Mouse)
• AO Bamidele, PA Svingen, MR Sagstetter, OF Sarmento, M Gonzalez, MB Braga Neto, S Kugathasan, G Lomberk, RA Urrutia, WA Faubion Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation Cell Mol Gastroenterol Hepatol, 2018-09-14;7(1):55-71. 2018-09-14 [PMID: 30510991] (Bioassay, Mouse)
• KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism Cell Death Dis, 2018-11-13;9(11):1130. 2018-11-13 [PMID: 30425241] (Bioassay, Mouse)
• CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, X Chen, J Xiao, A Fisher, WJ Kaiser, MA Murayama, Y Iwakura, J Gao, J Carman, A Dongre, G Dubyak, DW Abbott, FD Shi, RM Ransohoff, X Li TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation J. Clin. Invest., 2018-10-29;0(0):. 2018-10-29 [PMID: 30372424] (Bioassay, Mouse)
• CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses PLoS Pathog., 2018-10-26;14(10):e1007406. 2018-10-26 [PMID: 30365535] (Bioassay, Mouse)
• HC Chuang, CY Tsai, CH Hsueh, TH Tan GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease Sci Adv, 2018-09-12;4(9):eaat5401. 2018-09-12 [PMID: 30214937] (Bioassay, Mouse)
• J Breuer, E Korpos, MJ Hannocks, T Schneider-, J Song, L Zondler, S Herich, K Flanagan, T Korn, A Zarbock, T Kuhlmann, L Sorokin, H Wiendl, N Schwab Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus J Neuroinflammation, 2018-08-22;15(1):236. 2018-08-22 [PMID: 30134924] (Bioassay, Mouse)
• L Bouchareyc, EM Grössinger, M Kang, IE Adamopoulo ??TCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis Sci Rep, 2018-05-15;8(1):7590. 2018-05-15 [PMID: 29765156] (Bioassay, Mouse)
• VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Con, D Merlin, AT Gewirtz, A Nusrat, TL Denning A cytokine network involving IL-36?, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage Proc. Natl. Acad. Sci. U.S.A., 2018-05-14;0(0):. 2018-05-14 [PMID: 29760082] (Bioassay, Mouse)
• R Wu, J Zeng, J Yuan, X Deng, Y Huang, L Chen, P Zhang, H Feng, Z Liu, Z Wang, X Gao, H Wu, H Wang, Y Su, M Zhao, Q Lu MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation J. Clin. Invest., 2018-05-14;0(0):. 2018-05-14 [PMID: 29757188] (Bioassay, In Vivo, Mouse)
• Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 Nat Commun, 2018-04-12;9(1):1424. 2018-04-12 [PMID: 29651155] (Bioassay, Mouse)
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Review for IL-23A/IL-23 P19 (1887-ML) (1)

Average Rating: 5

(Based on 1 review)

reviewed by: Sweta Ghosh Stem/Immune cell maintenance or differentiation 05/10/2024

Summary

• Application: Stem/Immune cell maintenance or differentiation
• Lot: DFXU1323101

Bioinformatics

• Gene Symbol: Il23a
• Uniprot:
  • P43432 (p40) & Q9EQ14 (p19)()