Recombinant Mouse IL-23 Protein


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Reactivity MuSpecies Glossary
Applications BA

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Recombinant Mouse IL-23 Protein Summary

Details of Functionality
Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910. The ED50 for this effect is 0.05-0.25 ng/mL.
Spodoptera frugiperda, Sf 21 (stably transfected)-derived
Mouse IL-23 p40
Accession # P43432
Accession # Q9EQ14
N-terminus C-terminus
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.


Theoretical MW
57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
66 kDa, reducing conditions
Read Publications using
1887-ML in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-23 Protein

  • IL23
  • IL-23
  • IL23A
  • IL-23A
  • IL-23-A
  • IL-23p19
  • IL23P19P19
  • interleukin 23 p19 subunit
  • interleukin 23, alpha subunit p19
  • interleukin-23 subunit alpha
  • Interleukin-23 subunit p19
  • JKA3 induced upon T-cell activation
  • MGC79388
  • SGRF
  • SGRFIL-23 subunit alpha


Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8- and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.

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Publications for (108)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture Substrate, In Vivo, cell culture.

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Showing Publications 1 - 10 of 108. Show All 108 Publications.
Publications using 1887-ML Applications Species
HA Purvis, F Clarke, CK Jordan, CS Blanco, GH Cornish, X Dai, DJ Rawlings, R Zamoyska, AP Cope Protein Tyrosine Phosphatase PTPN22 regulates IL-1? dependent Th17 responses by modulating dectin-1 signaling in mice Eur. J. Immunol., 2017;0(0):. 2017 [PMID: 28948613] (Bioassay, Mouse) Bioassay Mouse
A Muschaweck, F Petermann, T Korn IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 2017;0(0):. 2017 [PMID: 28855314] (Bioassay, Mouse) Bioassay Mouse
Y Arima, T Ohki, N Nishikawa, K Higuchi, M Ota, Y Tanaka, J Nio-Kobaya, M Elfeky, R Sakai, Y Mori, T Kawamoto, A Stofkova, Y Sakashita, Y Morimoto, M Kuwatani, T Iwanaga, Y Yoshioka, N Sakamoto, A Yoshimura, M Takiguchi, S Sakoda, M Prinz, D Kamimura, M Murakami Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit Elife, 2017;6(0):. 2017 [PMID: 28809157] (Bioassay, Mouse) Bioassay Mouse
AK Savage, HE Liang, RM Locksley The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine J. Immunol., 2017;0(0):. 2017 [PMID: 28747343] (In Vivo, Mouse) In Vivo Mouse
WF Carson, KA Cavassani, EM Soares, S Hirai, NA Kittan, MA Schaller, MM Scola, A Joshi, A Matsukawa, DM Aronoff, CN Johnson, Y Dou, KA Gallagher, SL Kunkel The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages J. Immunol., 2017;0(0):. 2017 [PMID: 28733487] (Bioassay, Mouse) Bioassay Mouse
W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 2017;10(1):348. 2017 [PMID: 28732522] (Bioassay, Mouse) Bioassay Mouse
A Aki, M Nagasaki, BA Malynn, A Ma, T Kagari Hypomorphic A20 expression confers susceptibility to psoriasis PLoS ONE, 2017;12(6):e0180481. 2017 [PMID: 28658319] (In Vivo, Mouse) In Vivo Mouse
H Dai, F He, GC Tsokos, VC Kyttaris IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus J. Immunol., 2017;0(0):. 2017 [PMID: 28646040] (Bioassay, Mouse) Bioassay Mouse
SH Kim, BH Cho, H Kiyono, YS Jang Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer&#039;s patches Sci Rep, 2017;7(1):3980. 2017 [PMID: 28638068] (Bioassay, Mouse) Bioassay Mouse
MM Montoya, J Maul, PB Singh, HH Pua, F Dahlström, N Wu, X Huang, KM Ansel, D Baumjohann A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation J. Immunol., 2017;0(0):. 2017 [PMID: 28607111] (Bioassay, Mouse) Bioassay Mouse
Show All 108 Publications.

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Gene Symbol Il23a