Recombinant Mouse IL-23 Protein


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Recombinant Mouse IL-23 Protein Summary

Details of Functionality
Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910. The ED50 for this effect is 0.05-0.25 ng/mL.
Spodoptera frugiperda, Sf 21 (stably transfected)-derived mouse IL-23 protein
Mouse IL-23 p40
Accession # P43432
Accession # Q9EQ14
N-terminus C-terminus
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.


Theoretical MW
57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
(58-71) kDa, non-reducing conditions
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1887-ML in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-23 Protein

  • IL-23 p19/IL-12 p40
  • IL23
  • IL-23
  • IL-23A
  • IL-23-A
  • IL-23p19
  • IL-23p19/IL-12p40
  • IL23P19P19
  • interleukin 23 p19 subunit
  • interleukin 23, alpha subunit p19
  • interleukin-23 subunit alpha
  • Interleukin-23 subunit p19
  • JKA3 induced upon T-cell activation
  • MGC79388
  • SGRF
  • SGRFIL-23 subunit alpha


Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human Tnbsp;cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8- and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.
  1. Oppmann, B. et al. (2000) Immunity 13:715.
  2. Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.
  3. Parham, C. et al. (2002) J. Immunol. 168:5699.
  4. Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.
  5. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

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Publications for IL-23A/IL-23 P19 (1887-ML)(123)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture Substrate, In Vivo, cell culture.

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Showing Publications 1 - 10 of 123. Show All 123 Publications.
Publications using 1887-ML Applications Species
AO Bamidele, PA Svingen, MR Sagstetter, OF Sarmento, M Gonzalez, MB Braga Neto, S Kugathasan, G Lomberk, RA Urrutia, WA Faubion Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation Cell Mol Gastroenterol Hepatol, 2019;7(1):55-71. 2019 [PMID: 30510991] (Bioassay, Mouse) Bioassay Mouse
CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses PLoS Pathog., 2018;14(10):e1007406. 2018 [PMID: 30365535] (Bioassay, Mouse) Bioassay Mouse
HC Chuang, CY Tsai, CH Hsueh, TH Tan GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease Sci Adv, 2018;4(9):eaat5401. 2018 [PMID: 30214937] (Bioassay, Mouse) Bioassay Mouse
J Breuer, E Korpos, MJ Hannocks, T Schneider-, J Song, L Zondler, S Herich, K Flanagan, T Korn, A Zarbock, T Kuhlmann, L Sorokin, H Wiendl, N Schwab Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus J Neuroinflammation, 2018;15(1):236. 2018 [PMID: 30134924] (Bioassay, Mouse) Bioassay Mouse
L Bouchareyc, EM Grössinger, M Kang, IE Adamopoulo ??TCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis Sci Rep, 2018;8(1):7590. 2018 [PMID: 29765156] (Bioassay, Mouse) Bioassay Mouse
VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Con, D Merlin, AT Gewirtz, A Nusrat, TL Denning A cytokine network involving IL-36?, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 29760082] (Bioassay, Mouse) Bioassay Mouse
R Wu, J Zeng, J Yuan, X Deng, Y Huang, L Chen, P Zhang, H Feng, Z Liu, Z Wang, X Gao, H Wu, H Wang, Y Su, M Zhao, Q Lu MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation J. Clin. Invest., 2018;0(0):. 2018 [PMID: 29757188] (In Vivo, Mouse) In Vivo Mouse
Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 Nat Commun, 2018;9(1):1424. 2018 [PMID: 29651155] (Bioassay, Mouse) Bioassay Mouse
Y Mikami, G Scarno, B Zitti, HY Shih, Y Kanno, A Santoni, JJ O'Shea, G Sciumè NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice Eur. J. Immunol., 2018;0(0):. 2018 [PMID: 29524223] (Bioassay, Mouse) Bioassay Mouse
B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao Characterization and allergic role of IL-33-induced neutrophil polarization Cell. Mol. Immunol., 2018;0(0):. 2018 [PMID: 29503441] (Bioassay, Mouse) Bioassay Mouse
Show All 123 Publications.

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Gene Symbol Il23a