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402-ML), Recombinant Mouse IL-23 (Catalog # 1887-ML) stimulates IL-17 secretion in mouse splenocytes in a dose-dependent manner (orange line), as measured by the Mouse IL-17 Quantikine ELISA Kit (Catalog # M1700). Under these conditions, IL-17 secretion elicited by Recombinant Mouse IL-23 (0.75 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL-23 p19 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1619). The ND50 is typically 0.07-0.35 µg/mL." class="big_lightbox" target="_blank">
402-ML), Recombinant Human IL-23 (Catalog # 1290-IL) stim-ulates IL-17 secretion in mouse splenocytes in a dose-dependent manner (orange line), as measured by the Mouse IL-17 Quantikine ELISA Kit (Catalog # M1700). Under these conditions, IL-17 secretion elicited by Recombinant Human IL-23 (0.75 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-23 p19 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1716). The ND50 is typically 0.2-0.8 µg/mL." class="big_lightbox" target="_blank">
HAF109). A specific band was detected for IL-23 p19 at approximately 21 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
The IL23 P19 gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific su