Recombinant Mouse IL-23 Protein, CF

Product Discontinued

Recombinant Mouse IL-23 Protein, CF Summary

• Details of Functionality: Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910. The ED₅₀ for this effect is 0.05-0.25 ng/mL.
• Source: Spodoptera frugiperda, Sf 21 (stably transfected)-derived mouse IL-23 protein
  

  Mouse IL-23 p40 (Met23-Ser335) Accession # P43432	IGSGSSRGGSGSGGSGGGGSK	Mouse IL-23 p19 (Leu20-Ala196) Accession # Q9EQ14
  N-terminus		C-terminus

• Accession #: P43432 (p40) & Q9EQ14 (p19)
• N-terminal Sequence: Met23
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il23a
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 57 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: (58-71) kDa, non-reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-23 Protein, CF

• IL-23 p19/IL-12 p40
• IL23
• IL-23
• IL-23A
• IL-23-A
• IL-23p19
• IL-23p19/IL-12p40
• IL23P19P19
• interleukin 23 p19 subunit
• interleukin 23, alpha subunit p19
• interleukin-23 subunit alpha
• Interleukin-23 subunit p19
• JKA3 induced upon T-cell activation
• MGC79388
• SGRF
• SGRFIL-23 subunit alpha

Background

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human Tnbsp;cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8^- and CD8⁺ subtypes, however only IL-23 can act directly on CD8⁺ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.

1. Oppmann, B. et al. (2000) Immunity 13:715.
2. Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.
3. Parham, C. et al. (2002) J. Immunol. 168:5699.
4. Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.
5. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

Publications for IL-23A/IL-23 P19 (1887-ML/CF)(180)

Publications using 1887-ML/CF

• Ruchti, F;Tuor, M;Mathew, L;McCarthy, NE;LeibundGut-Landmann, S; ?? T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control PLoS pathogens 2024-01-01 [PMID: 38215167] (Bioassay, Mouse)
• WL Yang, W Qiu, T Zhang, K Xu, ZJ Gu, Y Zhou, HJ Xu, ZZ Yang, B Shen, YL Zhao, Q Zhou, Y Yang, W Li, PY Yang, YG Yang Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis Nature Communications, 2023-02-16;14(1):863. 2023-02-16 [PMID: 36792629] (Bioassay, Mouse)
• T Huu Hoang, M Sato-Matsu, H Yuasa, T Matsubara, LTT Thuy, H Ikenaga, DM Phuong, NV Hanh, VN Hieu, DV Hoang, H Hai, Y Okina, M Enomoto, A Tamori, A Daikoku, H Urushima, K Ikeda, NQ Dat, Y Yasui, H Shinkawa, S Kubo, R Yamagishi, N Ohtani, K Yoshizato, J Gracia-San, N Kawada Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms Science Advances, 2022-09-28;8(39):eabo5525. 2022-09-28 [PMID: 36170363] (Bioassay, Mouse)
• N Millet, NV Solis, D Aguilar, MS Lionakis, RT Wheeler, N Jendzjowsk, M Swidergall IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis Nature Communications, 2022-09-22;13(1):5545. 2022-09-22 [PMID: 36138043] (In Vivo, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• K Nishida-Ta, A Kimura, T Tsubata, S Takahashi, H Suzuki Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels PLoS ONE, 2022-07-29;17(7):e0272090. 2022-07-29 [PMID: 35905076] (Bioassay, Mouse)
• X Chen, A Jaiswal, Z Costliow, P Herbst, EA Creasey, N Oshiro-Rap, MJ Daly, KL Carey, DB Graham, RJ Xavier pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells Nature Immunology, 2022-06-06;0(0):. 2022-06-06 [PMID: 35668320] (Bioassay, Mouse)
• YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614130] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
• Q Zhang, W Liu, H Wang, H Zhou, K Bulek, X Chen, CJ Zhang, J Zhao, R Zhang, C Liu, Z Kang, RA Bermel, G Dubyak, DW Abbott, TS Xiao, LE Nagy, X Li TH17 cells promote CNS inflammation by sensing danger signals via Mincle Nature Communications, 2022-05-03;13(1):2406. 2022-05-03 [PMID: 35504893] (Bioassay, Mouse)
• HW Cheng, U Mörbe, M Lütge, C Engetschwi, L Onder, M Novkovic, C Gil-Cruz, C Perez-Shib, T Hehlgans, E Scandella, B Ludewig Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function Nature Communications, 2022-04-19;13(1):2027. 2022-04-19 [PMID: 35440118] (Bioassay, Mouse)
• N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival Cell Reports, 2022-03-29;38(13):110565. 2022-03-29 [PMID: 35354043] (Bioassay, Mouse)
• M Wakai, R Hayashi, Y Ueno, K Onishi, T Takasago, T Uchida, H Takigawa, R Yuge, Y Urabe, S Oka, Y Kitadai, S Tanaka Promoting mechanism of serum amyloid a family expression in mouse intestinal epithelial cells PLoS ONE, 2022-03-18;17(3):e0264836. 2022-03-18 [PMID: 35303008] (Organoid Culture, Mouse)
• S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)
• V Patel, A Jayaraman, S Jayaraman Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells International immunopharmacology, 2021-12-23;103(0):108490. 2021-12-23 [PMID: 34954557] (Bioassay, Mouse)
• Y Zhu, Z Wu, W Yan, F Shao, B Ke, X Jiang, J Gao, W Guo, Y Lai, H Ma, D Chen, Q Xu, Y Sun Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis Embo Molecular Medicine, 2021-12-22;0(0):e14455. 2021-12-22 [PMID: 34936223] (Bioassay, Mouse)
• M Gurusamy, D Tischner, J Shao, S Klatt, S Zukunft, R Bonnavion, S Günther, K Siebenbrod, RI Kestner, T Kuhlmann, I Fleming, S Offermanns, N Wettschure G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators Nature Communications, 2021-11-23;12(1):6798. 2021-11-23 [PMID: 34815397] (Bioassay, Mouse)
• X Chi, W Jin, X Bai, X Zhao, J Shao, J Li, Q Sun, B Su, X Wang, XO Yang, C Dong RORalpha is critical for mTORC1 activity in T�cell-mediated colitis Cell Reports, 2021-09-14;36(11):109682. 2021-09-14 [PMID: 34525365] (Bioassay, Mouse)
• A Agasing, JL Quinn, G Kumar, RC Axtell Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease Cells, 2021-08-20;10(8):. 2021-08-20 [PMID: 34440908] (Bioassay, Mouse)
• J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 2021-06-16;7(25):. 2021-06-16 [PMID: 34134995] (Bioassay, Mouse)
• ELY Chen, CR Lee, PK Thompson, DL Wiest, MK Anderson, JC Zúñiga-Pfl Ontogenic timing, T�cell receptor signal strength, and Notch signaling direct &amp;gamma&amp;delta T�cell functional differentiation in�vivo Cell Reports, 2021-06-08;35(10):109227. 2021-06-08 [PMID: 34107257] (Bioassay, Mouse)
• FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Cell Reports, 2021-05-25;35(8):109176. 2021-05-25 [PMID: 34038731] (Bioassay, Mouse)
• Z Maria, E Turner, A Agasing, G Kumar, RC Axtell Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE International Journal of Molecular Sciences, 2021-03-13;22(6):. 2021-03-13 [PMID: 33805762] (Bioassay, Mouse)
• H Tao, Y Pan, S Chu, L Li, J Xie, P Wang, S Zhang, S Reddy, JW Sleasman, XP Zhong Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals Nature Communications, 2021-04-01;12(1):2029. 2021-04-01 [PMID: 33795689] (Bioassay, Mouse)
• PMIA Doss, M Umair, J Baillargeo, R Fazazi, N Fudge, I Akbar, AP Yeola, JB Williams, M Leclercq, C Joly-Beaup, P Beauchemin, GF Ruda, M Alpaugh, AC Anderson, PE Brennan, A Droit, H Lassmann, CS Moore, M Rangachari Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity Cell Reports, 2021-03-09;34(10):108833. 2021-03-09 [PMID: 33691111] (Bioassay, Mouse)
• R Yabe, SH Chung, MA Murayama, S Kubo, K Shimizu, Y Akahori, T Maruhashi, A Seno, T Kaifu, S Saijo, Y Iwakura TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens Nature Communications, 2021-01-04;12(1):94. 2021-01-04 [PMID: 33397982] (Bioassay, Mouse)
• H Zhang, A Madi, N Yosef, N Chihara, A Awasthi, C Pot, C Lambden, A Srivastava, PR Burkett, J Nyman, E Christian, Y Etminan, A Lee, H Stroh, J Xia, K Karwacz, PI Thakore, N Acharya, A Schnell, C Wang, L Apetoh, O Rozenblatt, AC Anderson, A Regev, VK Kuchroo An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets Cell Rep, 2020-11-24;33(8):108433. 2020-11-24 [PMID: 33238123] (Cell Culture, Mouse)
• A Baniahmad, K Birkner, J Görg, J Loos, F Zipp, B Wasser, S Bittner The frequency of follicular T helper cells differs in acute and chronic neuroinflammation Sci Rep, 2020-11-24;10(1):20485. 2020-11-24 [PMID: 33235306] (Bioassay, Transgenic Mouse)
• R Kajino-Sak, T Fujishita, MM Taketo, M Aoki Synthetic lethality between MyD88 loss and mutations in Wnt/&amp;beta-catenin pathway in intestinal tumor epithelial cells Oncogene, 2020-11-12;0(0):. 2020-11-12 [PMID: 33177648] (Bioassay, Mouse)
• I Mizoguchi, M Ohashi, H Hasegawa, Y Chiba, N Orii, S Inoue, C Kawana, M Xu, K Sudo, K Fujita, M Kuroda, SI Hashimoto, K Matsushima, T Yoshimoto EBV-induced gene 3 augments IL-23R&amp;alpha protein expression through a chaperone calnexin J. Clin. Invest., 2020-11-02;0(0):. 2020-11-02 [PMID: 32809973] (Bioassay, Mouse)
• Y Liu, R Bockermann, M Hadi, I Safari, B Carrion, M Kveiborg, S Issazadeh- ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation Cell. Mol. Immunol., 2020-06-22;0(0):. 2020-06-22 [PMID: 32572163] (Bioassay, Mouse)
• AM Agasing, Q Wu, B Khatri, N Borisow, K Ruprecht, AU Brandt, S Gawde, G Kumar, JL Quinn, RM Ko, Y Mao-Draaye, CJ Lessard, F Paul, RC Axtell Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica Nat Commun, 2020-06-05;11(1):2856. 2020-06-05 [PMID: 32503977] (Bioassay, Mouse)
• KM Lee, Z Zhang, A Achuthan, AJ Fleetwood, JE Smith, JA Hamilton, AD Cook IL-23 in arthritic and inflammatory pain development in mice Arthritis Res. Ther., 2020-05-29;22(1):123. 2020-05-29 [PMID: 32471485] (In Vivo, Mouse)
• P Mamareli, F Kruse, CW Lu, M Guderian, S Floess, K Rox, DSJ Allan, JR Carlyle, M Brönstrup, R Müller, L Berod, T Sparwasser, M Lochner Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection Mucosal Immunol, 2020-04-30;0(0):. 2020-04-30 [PMID: 32355319] (Bioassay, Mouse)
• AE Morelli, TL Sumpter, DM Rojas-Cana, M Bandyopadh, Z Chen, O Tkacheva, WJ Shufesky, CT Wallace, SC Watkins, A Berger, CJ Paige, LD Falo, AT Larregina Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells Cell Rep, 2020-03-10;30(10):3448-3465.e8. 2020-03-10 [PMID: 32160549] (Bioassay, Mouse)
• A Singh, M Dashnyam, B Chim, TM Escobar, AE Dulcey, X Hu, KM Wilson, PP Koganti, CA Spinner, X Xu, A Jadhav, N Southall, J Marugan, V Selvaraj, V Lazarevic, SA Muljo, M Ferrer Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells Sci Rep, 2020-02-28;10(1):3766. 2020-02-28 [PMID: 32111885] (Cell Culture, Mouse)
• D Liu, S Xing, W Wang, X Huang, H Lin, Y Chen, K Lan, L Chen, F Luo, S Qin, R Liang, C Bai, J Xu, W Liu Prognostic value of serum soluble interleukin-23 receptor and related T-helper 17 cell cytokines in non-small cell lung carcinoma Cancer Sci., 2020-03-04;111(4):1093-1102. 2020-03-04 [PMID: 32020720] (ELISA Developmet)
• I Raphael, F Gomez-Rive, RA Raphael, RR Robinson, S Nalawade, TG Forsthuber TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells JCI Insight, 2019-12-19;4(24):. 2019-12-19 [PMID: 31852844] (Cell Culture, Mouse)
• W Razawy, PS Asmawidjaj, AM Mus, N Salioska, N Davelaar, N Kops, M Oukka, CH Alves, E Lubberts CD4+ CCR6+ T�cells, but not gammadelta T�cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice Eur. J. Immunol., 2019-11-28;50(2):245-255. 2019-11-28 [PMID: 31778214] (Bioassay, Transgenic Mouse)
• HG Lee, LK Kim, JM Choi NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17 Mol Ther Methods Clin Dev, 2019-10-23;16(0):32-41. 2019-10-23 [PMID: 31737742] (Cell Culture, Mouse)
• K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death J. Immunol., 2019-05-31;0(0):. 2019-05-31 [PMID: 31152078] (Bioassay, Mouse)
• JZ Kawalkowsk, J Ogbechi, PJ Venables, RO Williams cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs Sci Adv, 2019-05-01;5(5):eaaw5422. 2019-05-01 [PMID: 31049403] (Bioassay, Mouse)
• A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis PLoS ONE, 2019-04-26;14(4):e0215981. 2019-04-26 [PMID: 31026283] (Bioassay, Mouse)
• Y Okunuki, R Mukai, T Nakao, SJ Tabor, O Butovsky, R Dana, BR Ksander, KM Connor Retinal microglia initiate neuroinflammation in ocular autoimmunity Proc. Natl. Acad. Sci. U.S.A., 2019-04-25;0(0):. 2019-04-25 [PMID: 31023885] (Bioassay, Mouse)
• H Katsura, Y Kobayashi, PR Tata, BLM Hogan IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration Stem Cell Reports, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930244] (Bioassay, Mouse)
• Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development EBioMedicine, 2019-03-01;0(0):. 2019-03-01 [PMID: 30827928] (Mouse)
• HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Mouse)
• KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis Proc. Natl. Acad. Sci. U.S.A., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718413] (Bioassay, Mouse)
• K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)
• M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018-12-26;25(13):3733-3749.e8. 2018-12-26 [PMID: 30590045] (Bioassay, Mouse)
• AO Bamidele, PA Svingen, MR Sagstetter, OF Sarmento, M Gonzalez, MB Braga Neto, S Kugathasan, G Lomberk, RA Urrutia, WA Faubion Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation Cell Mol Gastroenterol Hepatol, 2018-09-14;7(1):55-71. 2018-09-14 [PMID: 30510991] (Bioassay, Mouse)
• KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism Cell Death Dis, 2018-11-13;9(11):1130. 2018-11-13 [PMID: 30425241] (Bioassay, Mouse)
• CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, X Chen, J Xiao, A Fisher, WJ Kaiser, MA Murayama, Y Iwakura, J Gao, J Carman, A Dongre, G Dubyak, DW Abbott, FD Shi, RM Ransohoff, X Li TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation J. Clin. Invest., 2018-10-29;0(0):. 2018-10-29 [PMID: 30372424] (Bioassay, Mouse)
• CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses PLoS Pathog., 2018-10-26;14(10):e1007406. 2018-10-26 [PMID: 30365535] (Bioassay, Mouse)
• HC Chuang, CY Tsai, CH Hsueh, TH Tan GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease Sci Adv, 2018-09-12;4(9):eaat5401. 2018-09-12 [PMID: 30214937] (Bioassay, Mouse)
• J Breuer, E Korpos, MJ Hannocks, T Schneider-, J Song, L Zondler, S Herich, K Flanagan, T Korn, A Zarbock, T Kuhlmann, L Sorokin, H Wiendl, N Schwab Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus J Neuroinflammation, 2018-08-22;15(1):236. 2018-08-22 [PMID: 30134924] (Bioassay, Mouse)
• L Bouchareyc, EM Grössinger, M Kang, IE Adamopoulo ??TCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis Sci Rep, 2018-05-15;8(1):7590. 2018-05-15 [PMID: 29765156] (Bioassay, Mouse)
• VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Con, D Merlin, AT Gewirtz, A Nusrat, TL Denning A cytokine network involving IL-36?, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage Proc. Natl. Acad. Sci. U.S.A., 2018-05-14;0(0):. 2018-05-14 [PMID: 29760082] (Bioassay, Mouse)
• R Wu, J Zeng, J Yuan, X Deng, Y Huang, L Chen, P Zhang, H Feng, Z Liu, Z Wang, X Gao, H Wu, H Wang, Y Su, M Zhao, Q Lu MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation J. Clin. Invest., 2018-05-14;0(0):. 2018-05-14 [PMID: 29757188] (Bioassay, In Vivo, Mouse)
• Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 Nat Commun, 2018-04-12;9(1):1424. 2018-04-12 [PMID: 29651155] (Bioassay, Mouse)
• G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 2018-03-20;48(3):556-569.e7. 2018-03-20 [PMID: 29562202] (Bioassay, Mouse)
• Y Mikami, G Scarno, B Zitti, HY Shih, Y Kanno, A Santoni, JJ O'Shea, G Sciumè NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice Eur. J. Immunol., 2018-04-16;0(0):. 2018-04-16 [PMID: 29524223] (Bioassay, Mouse)
• H Suto, A Nambu, H Morita, S Yamaguchi, T Numata, T Yoshizaki, E Shimura, K Arae, Y Asada, K Motomura, M Kaneko, T Abe, A Matsuda, Y Iwakura, K Okumura, H Saito, K Matsumoto, K Sudo, S Nakae IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1? production by dermal dendritic cells J. Allergy Clin. Immunol., 2018-03-06;0(0):. 2018-03-06 [PMID: 29522843] (Bioassay, Mouse)
• Y Hou, L Zhu, H Tian, HX Sun, R Wang, L Zhang, Y Zhao IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis Protein Cell, 2018-03-05;0(0):. 2018-03-05 [PMID: 29508278] (Bioassay, Mouse)
• B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao Characterization and allergic role of IL-33-induced neutrophil polarization Cell. Mol. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29503441] (Bioassay, Mouse)
• AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection J. Exp. Med., 2018-02-28;0(0):. 2018-02-28 [PMID: 29490936] (Bioassay, Mouse)
• J Emgård, H Kammoun, B García-Cas, J Chesné, SM Parigi, JM Jacob, HW Cheng, E Evren, S Das, P Czarnewski, N Sleiers, F Melo-Gonza, E Kvedaraite, M Svensson, E Scandella, MR Hepworth, S Huber, B Ludewig, L Peduto, EJ Villablanc, H Veiga-Fern, JP Pereira, RA Flavell, T Willinger Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation Immunity, 2018-01-16;48(1):120-132.e8. 2018-01-16 [PMID: 29343433] (Bioassay, Mouse)
• PC Duncker, JS Stoolman, AK Huber, BM Segal GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction J. Immunol., 2017-12-29;0(0):. 2017-12-29 [PMID: 29288202] (Bioassay, Mouse)
• T He, Y Huang, C Zhang, D Liu, C Cheng, W Xu, X Zhang Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis Oncotarget, 2017-09-11;8(57):96993-97008. 2017-09-11 [PMID: 29228588] (Bioassay, Mouse)
• HA Purvis, F Clarke, CK Jordan, CS Blanco, GH Cornish, X Dai, DJ Rawlings, R Zamoyska, AP Cope Protein Tyrosine Phosphatase PTPN22 regulates IL-1? dependent Th17 responses by modulating dectin-1 signaling in mice Eur. J. Immunol., 2017-10-20;0(0):. 2017-10-20 [PMID: 28948613] (Bioassay, Mouse)
• A Muschaweck, F Petermann, T Korn IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855314] (Bioassay, Mouse)
• Y Arima, T Ohki, N Nishikawa, K Higuchi, M Ota, Y Tanaka, J Nio-Kobaya, M Elfeky, R Sakai, Y Mori, T Kawamoto, A Stofkova, Y Sakashita, Y Morimoto, M Kuwatani, T Iwanaga, Y Yoshioka, N Sakamoto, A Yoshimura, M Takiguchi, S Sakoda, M Prinz, D Kamimura, M Murakami Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit Elife, 2017-08-15;6(0):. 2017-08-15 [PMID: 28809157] (Bioassay, Mouse)
• AK Savage, HE Liang, RM Locksley The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747343] (In Vivo, Mouse)
• WF Carson, KA Cavassani, EM Soares, S Hirai, NA Kittan, MA Schaller, MM Scola, A Joshi, A Matsukawa, DM Aronoff, CN Johnson, Y Dou, KA Gallagher, SL Kunkel The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages J. Immunol., 2017-07-21;0(0):. 2017-07-21 [PMID: 28733487] (Bioassay, Mouse)
• W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 2017-07-21;10(1):348. 2017-07-21 [PMID: 28732522] (Bioassay, Mouse)
• A Aki, M Nagasaki, BA Malynn, A Ma, T Kagari Hypomorphic A20 expression confers susceptibility to psoriasis PLoS ONE, 2017-06-28;12(6):e0180481. 2017-06-28 [PMID: 28658319] (In Vivo, Mouse)
• H Dai, F He, GC Tsokos, VC Kyttaris IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus J. Immunol., 2017-06-23;0(0):. 2017-06-23 [PMID: 28646040] (Bioassay, Mouse)
• SH Kim, BH Cho, H Kiyono, YS Jang Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer&#039;s patches Sci Rep, 2017-06-21;7(1):3980. 2017-06-21 [PMID: 28638068] (Bioassay, Mouse)
• HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity Biochem. Biophys. Res. Commun., 2017-06-12;0(0):. 2017-06-12 [PMID: 28619514] (Bioassay, Mouse)
• MM Montoya, J Maul, PB Singh, HH Pua, F Dahlström, N Wu, X Huang, KM Ansel, D Baumjohann A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation J. Immunol., 2017-06-12;0(0):. 2017-06-12 [PMID: 28607111] (Bioassay, Mouse)
• H Yang, HZ Guo, XY Li, J Lin, W Zhang, JM Zhao, HX Zhang, SJ Chen, Z Chen, J Zhu Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance J. Immunol., 2017-05-26;0(0):. 2017-05-26 [PMID: 28550197] (Bioassay, Mouse)
• Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539431] (Bioassay, Mouse)
• ER Pierson, JM Goverman GM-CSF is not essential for experimental autoimmune encephalomyelitis but promotes brain-targeted disease JCI Insight, 2017-04-06;2(7):e92362. 2017-04-06 [PMID: 28405624] (Bioassay, Mouse)
• G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1 J. Exp. Med., 2017-04-11;0(0):. 2017-04-11 [PMID: 28400474] (Bioassay, Mouse)
• CN Lino, J Barros-Mar, L Oberdörfer, T Walzer, I Prinz Eomes expression reports the progressive differentiation of IFN-?-producing Th1-like ?? T cells Eur. J. Immunol., 2017-04-24;0(0):. 2017-04-24 [PMID: 28386934] (Bioassay, Mouse)
• H Zhu, F Lou, Q Yin, Y Gao, Y Sun, J Bai, Z Xu, Z Liu, W Cai, F Ke, L Zhang, H Zhou, H Wang, G Wang, X Chen, H Zhang, Z Wang, F Ginhoux, C Lu, B Su, H Wang RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease EMBO Mol Med, 2017-05-01;9(5):589-604. 2017-05-01 [PMID: 28377495] (In Vivo, Mouse)
• S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells Nat Commun, 2017-03-14;8(0):14649. 2017-03-14 [PMID: 28290453] (Bioassay, Mouse)
• L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis J. Immunol, 2017-02-27;0(0):. 2017-02-27 [PMID: 28242647] (Bioassay, Mouse)
• Z Hao, Y Sheng, GS Duncan, WY Li, C Dominguez, J Sylvester, YW Su, GH Lin, BE Snow, D Brenner, A You-Ten, J Haight, S Inoue, A Wakeham, A Elford, S Hamilton, Y Liang, JC Z£¤iga-Pfl, HH He, PS Ohashi, TW Mak K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression Nat Commun, 2017-01-13;8(0):14003. 2017-01-13 [PMID: 28084302] (Bioassay, Mouse)
• MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis Proc. Natl. Acad. Sci. U.S.A, 2017-01-09;114(4):E524-E533. 2017-01-09 [PMID: 28069965] (Bioassay, Mouse)
• AA Kesewa Lay, S L Sprout, D Phillips, PM Oliver Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production Sci Rep, 2017-01-04;7(0):39649. 2017-01-04 [PMID: 28051111] (Bioassay, Mouse)
• Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 2016-12-01;6(0):37977. 2016-12-01 [PMID: 27905482] (Bioassay, In Vivo, Mouse)
• Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function Proc Natl Acad Sci USA, 2016-09-26;0(0):. 2016-09-26 [PMID: 27671649] (In Vivo, Mouse)
• Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor Sci Rep, 2016-07-27;6(0):30384. 2016-07-27 [PMID: 27461849] (Bioassay, Mouse)
• Marie-Laure Michel SLAM-associated protein favours the development of iNKT2 over iNKT17 cells Eur J Immunol, 2016-07-22;0(0):. 2016-07-22 [PMID: 27338553] (Bioassay, Mouse)
• LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses J. Biol. Chem., 2016-05-23;291(30):15830-40. 2016-05-23 [PMID: 27226638] (Bioassay, Mouse)
• Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU) PLoS ONE, 2016-05-19;11(5):e0155953. 2016-05-19 [PMID: 27196432] (Bioassay, Mouse)
• Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells J Immunol, 2016-04-22;196(11):4731-8. 2016-04-22 [PMID: 27183613] (Bioassay, Mouse)
• CM Larabee, Y Hu, S Desai, C Georgescu, JD Wren, RC Axtell, SM Plafker Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice Mol Vis, 2016-04-11;22(0):332-41. 2016-04-11 [PMID: 27122964] (Bioassay, Mouse)
• CE O'Leary, CR Riling, LA Spruce, H Ding, S Kumar, G Deng, Y Liu, SH Seeholzer, PM Oliver Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells Nat Commun, 2016-04-18;7(0):11226. 2016-04-18 [PMID: 27088444] (Bioassay, Mouse)
• Shweta Pasi Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response J Biol Chem, 2016-03-28;291(23):12358-69. 2016-03-28 [PMID: 27022030] (Bioassay, Mouse)
• Chih-Chung Lin, Tara R Bradstree, Elizabeth A Schwarzko, Nicholas N Jarjour, Chun Chou, Angela S Archambau, Julia Sim, Bernd H Zinselmey, Javier A Carrero, Gregory F Wu, Reshma Taneja, Maxim N Artyomov, John H Russell, Brian T Edelson IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. The Journal of Experimental Medicine, 2016-02-01;0(0):1540-9538. 2016-02-01 [PMID: 26834156] (Bioassay, Mouse)
• Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis. J Neuroinflammation, 2016-02-01;13(1):24. 2016-02-01 [PMID: 26831924] (Bioassay, Mouse)
• Velazquez F, Grodecki-Pena A, Knapp A, Salvador A, Nevers T, Croce K, Alcaide P CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol, 2015-12-23;196(3):1305-16. 2015-12-23 [PMID: 26700769] (Bioassay, Mouse)
• Bozoyan L, Dumas A, Patenaude A, Vallieres L Interleukin-36gamma is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis. J Neuroinflammation, 2015-09-17;12(0):173. 2015-09-17 [PMID: 26377915] (Bioassay, Mouse)
• Doisne J, Balmas E, Boulenouar S, Gaynor L, Kieckbusch J, Gardner L, Hawkes D, Barbara C, Sharkey A, Brady H, Brosens J, Moffett A, Colucci F Composition, Development, and Function of Uterine Innate Lymphoid Cells. J Immunol, 2015-09-14;195(8):3937-45. 2015-09-14 [PMID: 26371244] (Bioassay, Mouse)
• Chen M, Liang D, Zuo A, Shao H, Kaplan H, Sun D An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation. PLoS ONE, 2015-07-06;10(7):e0132348. 2015-07-06 [PMID: 26147733] (Bioassay, Mouse)
• Lombes A, Durand A, Charvet C, Riviere M, Bonilla N, Auffray C, Lucas B, Martin B Adaptive Immune-like gamma/delta T Lymphocytes Share Many Common Features with Their alpha/beta T Cell Counterparts. J Immunol, 2015-06-29;195(4):1449-58. 2015-06-29 [PMID: 26123353] (Bioassay, Mouse)
• Russi A, Walker-Caulfield M, Ebel M, Brown M Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice. J Immunol, 2015-05-13;194(12):5609-13. 2015-05-13 [PMID: 25972476] (Bioassay, Mouse)
• Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol, 2015-02-12;16(0):6. 2015-02-12 [PMID: 25879435] (Bioassay, Mouse)
• Kim Y, Lim H, Jung H, Wetsel R, Chung Y Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE, 2015-03-13;10(3):e0120294. 2015-03-13 [PMID: 25768299] (Bioassay, Mouse)
• de Andrade Pereira B, Ackermann M, Chaudhary S, Vogel R, Vogt B, Dresch C, Fraefel C Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells. Gene Ther, 2015-03-05;22(5):382-90. 2015-03-05 [PMID: 25739989] (Bioassay, Mouse)
• Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun, 2015-02-19;6(0):6329. 2015-02-19 [PMID: 25695838] (Bioassay, Mouse)
• Munoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kuhl A, Wang X, Manzanillo P, Li Y, Rutz S, Zheng Y, Diehl L, Kayagaki N, van Lookeren-Campagne M, Liesenfeld O, Heimesaat M, Ouyang W Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity, 2015-02-10;42(2):321-31. 2015-02-10 [PMID: 25680273] (Bioassay, Mouse)
• Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol, 2015-02-11;194(6):2522-30. 2015-02-11 [PMID: 25672751] (Bioassay, Mouse)
• Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol, 2015-02-02;16(3):286-95. 2015-02-02 [PMID: 25642823] (Bioassay, Mouse)
• Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol, 2015-01-28;8(5):1099-109. 2015-01-28 [PMID: 25627812] (Bioassay, Mouse)
• Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol, 2015-01-02;194(3):1039-46. 2015-01-02 [PMID: 25556244] (Bioassay, Mouse)
• Abadier M, Haghayegh Jahromi N, Cardoso Alves L, Boscacci R, Vestweber D, Barnum S, Deutsch U, Engelhardt B, Lyck R Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. Eur J Immunol, 2015-01-23;45(4):1043-58. 2015-01-23 [PMID: 25545837] (Bioassay, Mouse)
• Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol, 2015-01-22;45(4):1192-205. 2015-01-22 [PMID: 25486906] (Bioassay, Mouse)
• Chen J, Waddell A, Lin Y, Cantorna M Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells. Mucosal Immunol, 2014-10-15;8(3):618-26. 2014-10-15 [PMID: 25315967] (Bioassay, Mouse)
• Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, Higgins S, Mills K A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine. Mucosal Immunol, 2014-10-15;8(3):607-17. 2014-10-15 [PMID: 25315966] (Bioassay, Mouse)
• Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 2014-07-29;211(9):1807-19. 2014-07-29 [PMID: 25073792] (Bioassay, Mouse)
• Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature, 2014-07-16;513(7519):564-8. 2014-07-16 [PMID: 25043027] (Bioassay, Mouse)
• Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, Georas S Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS ONE, 2014-07-08;9(7):e101655. 2014-07-08 [PMID: 25003200] (Bioassay, Mouse)
• Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci, 2014-06-18;34(25):8646-58. 2014-06-18 [PMID: 24948818] (Bioassay, Mouse)
• Glenn J, Smith M, Calabresi P, Whartenby K Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis. Stem Cells, 2014-10-01;32(10):2744-55. 2014-10-01 [PMID: 24911892] (Bioassay, Mouse)
• Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, Yang T, Shi X, Guo H, Tan X, Zhang L, Wang Q, Li Z, Zhao Y The inhibitory effect of IFN-gamma on protease HTRA1 expression in rheumatoid arthritis. J Immunol, 2014-06-06;193(1):130-8. 2014-06-06 [PMID: 24907345] (Bioassay, Mouse)
• Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile. BMC Biol, 2014-05-09;12(0):32. 2014-05-09 [PMID: 24886643] (Bioassay, Mouse)
• Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3. J Immunol, 2014-05-19;192(12):5599-609. 2014-05-19 [PMID: 24842756] (Bioassay, Mouse)
• Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F IL-21 induces IL-22 production in CD4+ T cells. Nat Commun, 2014-05-06;5(0):3753. 2014-05-06 [PMID: 24796415] (Bioassay, Mouse)
• Sriskantharajah S, Guckel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis P, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley S Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. J Immunol, 2014-03-17;192(8):3518-29. 2014-03-17 [PMID: 24639351] (Bioassay, Mouse)
• Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek A, Lee Y, Weaver C, Yagi R, Lazarevic V The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells. Immunity, 2014-02-13;40(3):355-66. 2014-02-13 [PMID: 24530058] (Bioassay, Mouse)
• Zhou H, Wang Y, Lian Q, Yang B, Ma Y, Wu X, Sun S, Liu Y, Sun B Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction. Eur J Immunol, 2014-03-07;44(5):1352-62. 2014-03-07 [PMID: 24496948] (Bioassay, Mouse)
• Ikeda S, Saijo S, Murayama M, Shimizu K, Akitsu A, Iwakura Y Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-beta-induced Foxp3 expression. J Immunol, 2014-01-15;192(4):1449-58. 2014-01-15 [PMID: 24431229] (Bioassay, Mouse)
• Guo X, Qiu J, Tu T, Yang X, Deng L, Anders R, Zhou L, Fu Y Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity, 2014-01-09;40(1):25-39. 2014-01-09 [PMID: 24412612] (Bioassay, Mouse)
• Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, Huang C, Tan T Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol, 2014-01-08;192(4):1547-57. 2014-01-08 [PMID: 24403530] (Bioassay, Mouse)
• Pierson E, Stromnes I, Goverman J B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system. J Immunol, 2013-12-23;192(3):929-39. 2013-12-23 [PMID: 24367024] (Bioassay, Mouse)
• Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol, 2013-12-22;133(4):1162-74. 2013-12-22 [PMID: 24365136] (Bioassay, Mouse)
• Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol, 2013-12-09;192(1):59-72. 2013-12-09 [PMID: 24323580] (Bioassay, Mouse)
• Fisher Y, Strominger I, Biton S, Nemirovsky A, Baron R, Monsonego A Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance. J Immunol, 2013-12-04;192(1):92-102. 2013-12-04 [PMID: 24307730] (Bioassay, Mouse)
• Chen J, Cascio J, Magee J, Techasintana P, Gubin M, Dahm G, Calaluce R, Yu S, Atasoy U Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis. J Immunol, 2013-10-28;191(11):5441-50. 2013-10-28 [PMID: 24166976] (Bioassay, Mouse)
• Chen Y, Peng H, Chen Y, Wei H, Sun R, Tian Z CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology, 2014-03-01;141(3):388-400. 2014-03-01 [PMID: 24164540] (Bioassay, Mouse)
• Mascanfroni , Ivan D, Yeste , Ada, Vieira , Silvio M, Burns , Evan J, Patel , Bonny, Sloma , Ido, Wu , Yan, Mayo , Lior, Ben-Hamo , Rotem, Efroni , Sol, Kuchroo , Vijay K, Robson , Simon C, Quintana , Francisc IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol, 2013-09-01;14(10):1054-63. 2013-09-01 [PMID: 23995234] (Bioassay, Mouse)
• Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, Hisaeda H IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages. Eur J Immunol, 2013-08-19;43(10):2696-706. 2013-08-19 [PMID: 23843079] (Bioassay, Mouse)
• Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder T, Sato S Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol, 2013-04-29;94(4):563-73. 2013-04-29 [PMID: 23630391] (Bioassay, Mouse)
• Matsumoto A, Kanai T, Mikami Y, Chu P, Nakamoto N, Ebinuma H, Saito H, Sato T, Yagita H, Hibi T IL-22-producing RORgammat-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis. PLoS ONE, 2013-04-23;8(4):e62853. 2013-04-23 [PMID: 23626860] (Bioassay, Mouse)
• Liu H, Yao S, Dann S, Qin H, Elson C, Cong Y ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis. Eur J Immunol, 2013-06-03;43(7):1716-26. 2013-06-03 [PMID: 23620016] (Cell Culture, Mouse)
• Simons D, Oh S, Kropf E, Aitken M, Garcia V, Basehoar A, Caton A Autoreactive Th1 cells activate monocytes to support regional Th17 responses in inflammatory arthritis. J Immunol, 2013-02-18;190(7):3134-41. 2013-02-18 [PMID: 23420889] (Bioassay, Mouse)
• Flanagan K, Fitzgerald K, Baker J Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. PLoS ONE, 2012-07-06;7(7):e40443. 2012-07-06 [PMID: 22792325] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J. Immunol., 2012-04-13;188(10):4866-75. 2012-04-13 [PMID: 22504644] (Bioassay, Mouse)
• Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J. Immunol., 2012-01-04;188(3):1421-30. 2012-01-04 [PMID: 22219321] (Bioassay, Mouse)
• Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect. Immun., 2011-10-28;80(1):410-7. 2011-10-28 [PMID: 22038916] (Bioassay, Mouse)
• Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection. Infect. Immun., 2011-10-24;80(1):398-409. 2011-10-24 [PMID: 22025517] (In Vivo, Mouse)
• Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Bioassay, Mouse)
• Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation. J. Invest. Dermatol., 2011-06-16;131(9):1838-44. 2011-06-16 [PMID: 21677670] (In Vivo, Mouse)
• Breslow JM, Meissler JJ, Hartzell RR Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Infect. Immun., 2011-05-16;79(8):3317-27. 2011-05-16 [PMID: 21576323] (Bioassay, Mouse)
• Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J. Exp. Med., 2011-03-07;208(3):491-503. 2011-03-07 [PMID: 21383056] (Bioassay, Mouse)
• Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model. J. Immunol., 2011-02-23;186(7):4481-9. 2011-02-23 [PMID: 21346238] (In Vivo, Mouse)
• Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Berard M, Kleinschek M, Cua D, Di Santo JP, Eberl G RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat. Immunol., 2011-02-20;12(4):320-6. 2011-02-20 [PMID: 21336274] (Bioassay, In Vivo, Mouse)
• DePaolo RW, Abadie V, Tang F Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature, 2011-02-09;471(7337):220-4. 2011-02-09 [PMID: 21307853] (Bioassay, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J., 2010-09-08;25(1):409-19. 2010-09-08 [PMID: 20826539] (Bioassay, Mouse)
• De Luca A, Zelante T, D'Angelo C IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol, 2010-05-05;3(4):361-73. 2010-05-05 [PMID: 20445503] (Bioassay, Mouse)
• Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J. Clin. Invest., 2010-04-01;120(5):1762-73. 2010-04-01 [PMID: 20364087] (Bioassay, Mouse)
• Meeks KD, Sieve AN, Kolls JK, Ghilardi N, Berg RE IL-23 is required for protection against systemic infection with Listeria monocytogenes. J. Immunol., 2009-12-15;183(12):8026-34. 2009-12-15 [PMID: 19923464] (Cell Culture, Mouse)
• Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9. 2009-03-16 [PMID: 19289819] (ELISA (Standard), In Vivo, Mouse)
• Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J. Immunol., 2009-03-15;182(6):3469-81. 2009-03-15 [PMID: 19265125] (Bioassay, Mouse)
• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008-09-15;181(6):4089-97. 2008-09-15 [PMID: 18768865] (Bioassay, Mouse)
• Shinohara ML, Kim JH, Garcia VA, Cantor H Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity, 2008-07-18;29(1):68-78. 2008-07-18 [PMID: 18619869] (Bioassay, Mouse)
• Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse)
• Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, Foley P, Ley K IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J. Immunol., 2007-12-15;179(12):8274-9. 2007-12-15 [PMID: 18056371] (In Vivo, Mouse)
• Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol., 2007-11-11;8(12):1372-9. 2007-11-11 [PMID: 17994023] (Bioassay, Mouse)
• Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol., 2007-10-01;37(10):2695-706. 2007-10-01 [PMID: 17899546] (Bioassay, Mouse)
• Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol., 2007-08-05;8(9):958-66. 2007-08-05 [PMID: 17676043] (Bioassay, Mouse)
• Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood, 2007-02-08;109(11):4846-55. 2007-02-08 [PMID: 17289816] (In Vivo, Mouse)
• Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am. J. Respir. Cell Mol. Biol., 2006-12-01;36(4):442-51. 2006-12-01 [PMID: 17142310] (Bioassay, Mouse)
• Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 2006-04-30;441(7090):235-8. 2006-04-30 [PMID: 16648838] (Bioassay, Mouse)
• Harrington , Laurie E, Hatton , Robin D, Mangan , Paul R, Turner , Henriett, Murphy , Theresa, Murphy , Kenneth, Weaver , Casey T Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 2005-10-02;6(11):1123-32. 2005-10-02 [PMID: 16200070] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Il23a
• Uniprot:
  • P43432 (p40) & Q9EQ14 (p19)()