Recombinant Mouse CXCL13/BLC/BCA-1 Protein

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity

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Recombinant Mouse CXCL13/BLC/BCA-1 Protein Summary

Details of Functionality
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR5. The ED50 for this effect is 0.5‑2 µg/mL.
Source
E. coli-derived mouse CXCL13/BLC/BCA-1 protein
Ile22-Ala109
Accession #
N-terminal Sequence
Ile22
Protein/Peptide Type
Recombinant Proteins
Gene
Cxcl13
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
9.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
470-BC in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse CXCL13/BLC/BCA-1 Protein

  • ANGIE
  • ANGIE2
  • B cell-attracting chemokine 1
  • B lymphocyte chemoattractant
  • BCA1
  • BCA-1
  • BCA1B-cell chemoattractant
  • BCA-1CXC chemokine BLC
  • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
  • BLC
  • BLCSmall-inducible cytokine B13
  • BLR1L
  • B-lymphocyte chemoattractant
  • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
  • chemokine (C-X-C motif) ligand 13
  • C-X-C motif chemokine 13
  • CXCL13
  • SCYB13
  • SCYB13B-cell-attracting chemokine 1
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

Background

CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse BCA-1 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse BCA-1 shares 64% amino acid sequence similarity with the human protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.

  1. Gunn, M.D. et al. (1998) Nature, 391:799.
  2. Legler, D.F. et al. (1998) J. Exp. Med. 187:655.
  3. Forster, R. et al. (1996) Cell 87:1037.

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470-BC
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Applications: Bioactivity

Publications for CXCL13/BLC/BCA-1 (470-BC)(15)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Bioassay.


Filter By Application
Bioassay
(15)
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Filter By Species
Mouse
(15)
All Species
Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using 470-BC Applications Species
A Ardain, R Domingo-Go, S Das, SW Kazer, NC Howard, A Singh, M Ahmed, S Nhamoyebon, J Rangel-Mor, P Ogongo, L Lu, D Ramsuran, M de la Luz, T K Ulland, M Darby, E Park, F Karim, L Melocchi, R Madansein, KJ Dullabh, M Dunlap, N Marin-Agud, T Ebihara, T Ndung'u, D Kaushal, AS Pym, JK Kolls, A Steyn, J Zúñiga, W Horsnell, WM Yokoyama, AK Shalek, HN Kløverpris, M Colonna, A Leslie, SA Khader Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis Nature, 2019;570(7762):528-532. 2019 [PMID: 31168092] (Bioassay, Mouse) Bioassay Mouse
R Mashud, A Nomachi, A Hayakawa, K Kubouchi, S Danno, T Hirata, K Matsuo, T Nakayama, R Satoh, R Sugiura, M Abe, K Sakimura, S Wakana, H Ohsaki, S Kamoshida, H Mukai Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1 Sci Rep, 2017;7(1):7663. 2017 [PMID: 28794483] (Bioassay, Mouse) Bioassay Mouse
M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista The Small Rho GTPase TC10 Modulates B Cell Immune Responses J. Immunol., 2017;0(0):. 2017 [PMID: 28747344] (Bioassay, Mouse) Bioassay Mouse
R Garg, JM Blando, CJ Perez, MC Abba, F Benavides, MG Kazanietz Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway Cell Rep, 2017;19(2):375-388. 2017 [PMID: 28402859] (Bioassay, Mouse) Bioassay Mouse
Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization Cell Rep, 2016;17(1):193-205. 2016 [PMID: 27681431] (Bioassay, Mouse) Bioassay Mouse
SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin J. Immunol, 2016;196(6):2514-25. 2016 [PMID: 26851219] (Bioassay, Mouse) Bioassay Mouse
Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK. PLoS ONE, 2015;10(4):e0125340. 2015 [PMID: 25909640] (Bioassay, Mouse) Bioassay Mouse
Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking. J Immunol, 2015;194(5):2128-39. 2015 [PMID: 25617475] (Bioassay, Mouse) Bioassay Mouse
Graham K, Zhang J, Lewen S, Burke T, Dang T, Zoudilova M, Sobel R, Butcher E, Zabel B A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS ONE, 2014;9(12):e112925. 2014 [PMID: 25437209] (Bioassay, Mouse) Bioassay Mouse
Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K Control of lymphocyte egress from lymph nodes through beta2-adrenergic receptors. J Exp Med, 2014;211(13):2583-98. 2014 [PMID: 25422496] (Bioassay, Mouse) Bioassay Mouse
Show All 15 Publications.

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Bioinformatics

Gene Symbol Cxcl13
Uniprot