Recombinant Human Endostatin Protein, CF


There are currently no images for Endostatin (1098-ES).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human Endostatin Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit the FGF basic-dependent proliferation of HUVEC human umbilical vein endothelial cells. Dhanabal, M. et al. (1999) Biochem. Biophys. Res. Commun. 258:345. The ED50 for this effect is 0.4-2 μg/mL in the presence of 20 μg/mL of Goat Anti-Human Endostatin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1098).
E. coli-derived human Endostatin protein
His1154-Ser1335, with an N-terminal Met and 8-His tag
Accession #
N-terminal Sequence
Met-His tag
Structure / Form
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
21.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
21 kDa, reducing conditions
Read Publication using
1098-ES in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 200 μg/mL in PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Endostatin Protein, CF

  • antiangiogenic agent
  • COL18A1
  • collagen alpha-1(XVIII) chain
  • collagen, type XVIII, alpha 1
  • Endostatin
  • FLJ27325
  • FLJ34914
  • human type XVIII collagen10endostatin
  • KNO
  • KNO1MGC74745
  • Knobloch syndrome, type 1
  • KS
  • multi-functional protein MFP


Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis, is an approximately 181 amino acid (aa), 20 kDa proteolytic fragment of the C‑terminal non‑collagenous domain of type XVIII collagen (1, 2). It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L (3, 4). The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity (4, 5). This region contains three zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity (4, 5). Human Endostatin shares 84‑87% aa sequence identity with mouse, rat, bovine and equine Endostatin. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis (1, 2). It is also thought to down‑regulate angiogenesis by blocking VEGF‑induced endothelial cell migration (6, 7). It alters the effect of FGF basic on adhesion and cell motility (8). Endostatin can interact with Transglutaminase 2, heparin, and integrins alpha 5 beta 1 and alpha v beta 3, all of which may be secreted by, or expressed on, endothelial cells, and can influence adhesion or migration (9, 10). Endostatin may also be involved with down‑regulation of angiogenesis after establishment of placental circulation in the pregnant uterus (11). Over‑expression in keratinocytes causes delay in healing of excisional wounds, while exogenous systemic Endostatin promotes endothelial and smooth muscle nitric oxide production and decreases blood pressure (12, 13). Since tumor growth and metastasis relies on angiogenesis to provide blood supply, Endostatin is inhibitory for a wide variety of primary and metastatic tumors (5‑8).

  1. Dhanabal, M. et al. (1999) Biochem. Biophys. Res. Commun. 10:345.
  2. O’Reilly, M.S. et al. (1997) Cell 88:277.
  3. Nilsson, U.W. et al. (2006) Cancer Res. 66:4789.
  4. Veillard, F. et al. (2011) J. Biol. Chem. 286:37158.
  5. Folkman, J. (2006) Exp. Cell Res. 312:594.
  6. Yamaguchi, N. et al. (2001) EMBO J. 18:4414.
  7. Ling, Y. et al. (2007) Biochem. Biophys. Res. Commun. 361:79.
  8. Dixelius, J. et al. (2002) Cancer Res. 62:1944.
  9. Faye, C. et al. (2010) Biochem. J. 427:467.
  10. Rehn, M. et al. (2001) Proc. Natl. Acad. Sci. USA 98:1024.
  11. Pollheimer, J. et al. (2011) Endocrinol. 152:4431.
  12. Seppinen, L. et al. (2008) Matrix Biol. 27:535.
  13. Sunshine, S.B. et al. (2012) Proc. Natl. Acad. Sci. USA 109:11306.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt, Ha
Applications: WB, ICC/IF, IHC, IHC-P, IP, MiAr
Species: Hu, Rt, Ca, Gp, Pm
Applications: WB, ELISA, ICC/IF, RNAi, S-ELISA
Species: Hu
Applications: WB
Species: Hu
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt, Ze
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu, Mu, Rt, Bv, Ca, Ch, Pm, Rb, Re, Ze
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, Dual ISH-IHC, Flow-IC, Single-Cell Western
Species: Hu, Mu, Rt, Po, Bv, Ca
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Rt
Applications: WB, ELISA
Species: Hu, Mu, Rt, Po, Ca
Species: Mu, Rt
Applications: WB, Flow, IHC, CyTOF-ready, ICC
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu
Applications: WB, ChIP, ELISA, ICC/IF
Species: Hu
Applications: Bioactivity

Publications for Endostatin (1098-ES)(1)

We have publications tested in 1 confirmed species: Chicken.

We have publications tested in 1 application: Bioassay.

Filter By Application
All Applications
Filter By Species
All Species

Reviews for Endostatin (1098-ES) (0)

There are no reviews for Endostatin (1098-ES). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for Endostatin (1098-ES) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Other Available Formats

Additional Endostatin Products

Bioinformatics Tool for Endostatin (1098-ES)

Discover related pathways, diseases and genes to Endostatin (1098-ES). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Endostatin (1098-ES)

Discover more about diseases related to Endostatin (1098-ES).

Pathways for Endostatin (1098-ES)

View related products by pathway.

PTMs for Endostatin (1098-ES)

Learn more about PTMs related to Endostatin (1098-ES).

Blogs on Endostatin

There are no specific blogs for Endostatin, but you can read our latest blog posts.
Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Human Endostatin Protein, CF and receive a gift card or discount.


Gene Symbol COL18A1