Recombinant Human EGF Protein, CF

Recombinant Human EGF Protein (Catalog # 236-EG) has a molecular weight (MW) of 6.7 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED50 for this effect is 20‑100 pg/mL.

1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa.

iPSC-derived human intestinal organoids were cultured using Cultrex™ UltiMatrix RGF Basement Membrane Extract (BME001-05) and intestinal organoid culture medium, which includes Recombinant Human EGF (Catalog # 236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Human intestinal organoids were stained using a Rat Anti-Human/Mouse/Rat Vimentin Monoclonal Antibody (MAB2105; green) and a Goat Anti-Human/Mouse Desmin Antigen Affinity-purified Polyclonal Antibody (AF3844; red) to visualize myofibroblast cells and counterstained with DAPI (5748; blue). (B) Human intestinal organoids were stained using a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; green) and a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-44431; red) and counterstained with DAPI (5748; blue).

Adult stem cells isolated from human descending colon were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 30 days in intestinal organoid culture medium, which includes Recombinant Human EGF (Catalog # 236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Organoids were fixed and stained with a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals; Catalog # NBP2-44431; green) to visualize intestinal goblet cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 10x magnification. (B) Organoids were fixed and stained with a Mouse Anti-Human Chromogranin A Monoclonal Antibody (MAB90981; green) to visualize enteroendocrine cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 20x magnification.

D3 mouse embryonic stem cells were expanded in KO-ES Media supplemented with Bovine Fibronectin Protein (1030-FN) to support cell attachment and spreading, the ITS and N-2 Plus Media Supplements (AR013 and AR003), and a panel of growth factors for effective oligodendrocyte differentiation, including Recombinant Human FGF-basic, Recombinant Human EGF (Catalog # 236-EG), and Recombinant Human PDGF-AA (221-AA). Oligodendrocytes were detected using a Mouse Anti-Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Monoclonal Antibody (MAB1326). The cells were stained with the NorthernLights™-557 Affinity-purified Goat Anti-Mouse IgM Secondary Antibody (NL019; red). The nuclei were counterstained with DAPI (5748;blue).

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human EGF Protein, CF Summary

• Additional Information: Analyzed by SEC-MALS
• Details of Functionality: Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:415. The ED₅₀ for this effect is 20-100 pg/mL.
• Source: E. coli-derived human EGF protein
  Asn971-Arg1023, with an N-terminal Met
• Accession #: P01133
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: EGF
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 6 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 500 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human EGF Protein, CF

• beta-urogastrone
• EGF
• epidermal growth factor (beta-urogastrone)
• epidermal growth factor
• hEGF
• HOMG4
• pro-epidermal growth factor
• URG
• Urogastrone

Background

Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin‑binding EGF‑like growth factor (HB‑EGF), epigen, and the neuregulins (NRG)-1 through -6 (1). Members of The EGF family are characterized by a shared structural motif, the EGF‑like domain, which contains three intramolecular disulfide bonds that are formed by six similarly spaced, conserved cysteine residues (2). These disulfide bonds are essential for proper protein conformation and receptor binding. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis (1). The full length EGF protein is 1207 amino acids (aa) (EGF precursor) containing nine EGF domains and nine LDLR class B repeats. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region (3). EGF is well conserved across mammals with mature human EGF 70% identical to mature mouse and rat EGF. Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). EGF is a high affinity ligand of the EGF receptor (ErbB). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members (5). EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. These receptors undergo a complex pattern of ligand-induced homo- or hetero-dimerization to transduce EGF family signals (6, 7). EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules (5, 8). Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.

1. Harris, R.C. et al. (2003) Exp. Cell Res. 284:2.
2. Carpenter, G. and Cohen, S. (1990) J. Biol. Chem. 265:7709.
3. Bell, G.I. et al. (1986) Nucl. Acids Res. 14:8427.
4. Carpenter, G. and Zendegui, J.G. (1986) Exp. Cell Res. 164:1.
5. Jorissen, R.N. et al. (2003) Exp. Cell Res. 284:31.
6. Gamett, D.C. et al. (1997) J. Biol. Chem. 272:12052.
7. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. 91:1500.
8. Qian, X. et al. (1999) J. Biol. Chem. 274:574.

Publications for EGF (236-EG)(910)

Publications using 236-EG

• Xie, X;Tong, W;Xie, Y;Jiang, H;Jiang, A;Huang, J;Liu, Z;Yu, J; Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC Cell death & disease 2025-08-28 [PMID: 40877231] (Bioassay, Human)
• Zhang, Y;Wang, R;Li, Y;Zhu, W;Liu, Y;Zhang, Z;Qi, X;Chen, H;Zhou, Q;Xie, L; Hyperglycemia-Reduced Platelet-Derived Growth Factor-BB Expression Impairs Corneal Wound Healing in Diabetic Mice Investigative ophthalmology & visual science 2025-08-01 [PMID: 40856651] (Bioassay, Human)
• Huang, M;Chen, M;Yuan, G;Cui, Y;Shen, B;Liu, Z;Zhang, B;Chen, J;Chen, D;Qiu, S;Zhang, Y;Liu, L;Qin, L;Zhu, Y;Liu, J;Zhang, H;Wu, J;Yuan, Y;Sha, J; Establishment of human gastrulating stem cells with the capacity of stable differentiation into multiple gastrulating cell types Cell research 2025-08-06 [PMID: 40770543] (Bioassay, Human)
• Seo, S;Park, MJ;Park, MG;Gwak, M;Kim, Y;Jang, J;Hong, N;Lee, BS;Kim, C;Jo, S;Shim, HB;Kim, HJ;Kim, MH;Yoo, SH;Yoon, S;Kim, S;Lee, JH;Choi, SH;Lee, SY;Yeon, GB;Park, SH;Kim, SH;Lee, H;Lee, JY;Kim, DS;Lee, BC;Park, JW;Kim, H; DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species Nature communications 2025-07-30 [PMID: 40739132] (Bioassay, Human)
• Lu, Z;Yao, X;Jiang, J;Hou, G; ERCC6L-mediated stabilization of HIF-1? enhances glycolysis and stemness properties of lung adenocarcinoma cells Cell death & disease 2025-07-21 [PMID: 40691138] (Bioassay, Human)
• Papatheodorou, I;Blažková, G;Bosáková, V;Tomášiková, Z;Spearing, E;Klieber, R;Ostašov, P;Štíchová, J;Dvon?ová, M;Mýtniková, A;Emmer, J;Bendí?ková, K;Tomáš, T;Šrámek, V;Kolovos, P;Holubová, M;Helán, M;Vlková, M;Fri?, J;Hortová-Kohoutková, M; Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution Journal of translational medicine 2025-07-02 [PMID: 40604830] (Bioassay, Human)
• Liu, Z;Wang, H;Zhang, C;Qi, H;Li, Z;Sun, Y;Wang, B;Shen, F;Hong, Z;Zhu, J;Li, X;Ding, Y;Li, K; The interplay between oxytocin receptor and YAP in regulating gastric cancer progression Oncogene 2025-07-02 [PMID: 40604321] (Bioassay, Human)
• Liu, Q;Ma, H;Liao, J;Zhu, Z;Chen, H;Sun, D;Wang, L;Lu, L;Chen, X;Zhang, X;Wang, F; MiR-125a-5p in extracellular vesicles of neural stem cells acts as a crosstalk signal modulating neuroinflammatory microenvironment to alleviate cerebral ischemia-reperfusion injury Theranostics 2025-06-12 [PMID: 40585973] (Bioassay, Human)
• Min, PX;Feng, LL;Zhang, YX;Jiang, CC;Zhang, HZ;Chen, Y;Fukunaga, K;Liu, F;Zhang, YJ;Sasaki, T;Qian, X;Horimoto, K;Jiang, JD;Lu, YM;Han, F; Endothelial cells-derived SEMA3G suppresses glioblastoma stem cells by inducing c-Myc degradation Cell death and differentiation 2025-06-18 [PMID: 40533501] (Bioassay, Human)
• Pan, T;Lin, G;Li, X;VanHeyningen, D;Walker, JC;Kohli, S;Saravanan, A;Kondur, A;Jaklic, DC;Pantoja-Gutierrez, S;Vaid, S;Sturza, J;Inoki, K;Imamichi, T;Chang, W;Dang, LT; Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity bioRxiv : the preprint server for biology 2025-05-14 [PMID: 40462897] (Bioassay, Human)
• Nonaka, T;Nakamura, A;Murata, D;Yoshizato, H;Kashimoto, S;Nagaishi, Y;Itoh, M;Zujur, D;Zhao, C;Inada, Y;Ikeya, M;Toguchida, J;Mawatari, M;Nakayama, K; Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs Regenerative therapy 2025-06-01 [PMID: 40453698] (Bioassay, Human)
• Zhang, J;Gu, Y;Tong, L;Feng, B;Dong, S;Shao, Q;Chen, Y;Tu, H;Wang, Z;Wang, Y;Li, X;Yu, H;Lin, Z;Wang, X;Li, Z;Ai, Z;Xiang, Y;Jiang, Z;Jin, Z;Li, Z;Chen, Y;Shen, Z;Huang, C;Liu, J;Liu, J;Xu, P;Yu, Y;Xia, P;Liang, H;Huang, H;Chen, D; IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner Cell stem cell 2025-05-21 [PMID: 40436019] (Bioassay, Human)
• Zhao, Y;Xiao, C;Li, S;Huang, A;Li, H;Dong, J;Qu, Q;Liu, X;Gao, B;Shao, N; CD71-Mediated Effects of Soluble Vasorin on Tumor Progression, Angiogenesis and Immunosuppression International journal of molecular sciences 2025-05-20 [PMID: 40430053] (Bioassay, Human)
• Perez-Stable, C;de Las Pozas, A;Wangpaichitr, M;Sha, W;Wang, H;Cai, R;Schally, AV; Growth Hormone-Releasing Hormone (GHRH) Antagonist Peptides Combined with PI3K Isoform Inhibitors Enhance Cell Death in Prostate Cancer Cancers 2025-05-13 [PMID: 40427140] (Bioassay, Human)
• Wang, Z;Yu, H;Gu, Z;Shi, X;Ma, J;Shao, Q;Yao, Y;Yao, S;Xu, Y;Gu, Y;Dai, J;Liu, Q;Shi, J;Qi, R;Jin, Y;Liu, Y;Shen, X;Huang, W;Liu, HJ;Jin, M;Liu, W;Brook, M;Chen, D; RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage Nature communications 2025-05-23 [PMID: 40410171] (Bioassay, Human)
• Saito, S;Kato, S;Arai, U;En, A;Tsunezumi, J;Mizushima, T;Tateishi, K;Adachi, N; HR eye &amp; MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy Nature communications 2025-05-12 [PMID: 40355434] (Bioassay, Human)
• Navarro-Traxler, AJ;Ghisolfi, L;Lien, EC;Toker, A; The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation bioRxiv : the preprint server for biology 2025-04-03 [PMID: 40236010] (Bioassay, Human)
• Zhu, Y;Abedini, A;Rodriguez, GM;McCloskey, CW;Abou-Hamad, J;Salah, OS;Larocque, J;Tsoi, MF;Boerboom, D;Cook, D;Vanderhyden, B; Loss of LATS1 and LATS2 promotes ovarian tumor formation by enhancing AKT activity and PD-L1 expression Oncogene 2025-04-12 [PMID: 40221530] (Bioassay, Transgenic Mouse)
• Wu, L;Weng, Z;Yang, X;Huang, Y;Lin, Y;Li, S;Fu, L;Yun, J; ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma Scientific reports 2025-04-10 [PMID: 40210693] (Bioassay, Human)
• Li, TL;Blair, JD;Yoo, T;Grant, GA;Hockemeyer, D;Porter, BE;Bateup, HS; mTORC1 activation drives astrocyte reactivity in cortical tubers and brain organoid models of TSC bioRxiv : the preprint server for biology 2025-03-18 [PMID: 40093155] (Bioassay, Human)
• Hei Yu, KK;Abou-Mrad, Z;Törkenczy, K;Schulze, I;Gantchev, J;Baquer, G;Hopland, K;Bander, ED;Tosi, U;Brennan, C;Moss, NS;Hamard, PJ;Koche, R;Lareau, C;Agar, NYR;Merghoub, T;Tabar, V; A pathogenic subpopulation of human glioma associated macrophages linked to glioma progression bioRxiv : the preprint server for biology 2025-02-17 [PMID: 40027797] (Bioassay, Human)
• Zhu, D;Chen, Z;Guo, K;Xie, Q;Zou, Y;Mou, Q;Zhou, Z;Jin, G; Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds Cell stem cell 2025-02-15 [PMID: 39999846] (Bioassay, Human)
• Hasel, P;Cooper, ML;Marchildon, AE;Rufen-Blanchette, U;Kim, RD;Ma, TC;Groh, AMR;Hill, EJ;Lewis, EM;Januszewski, M;Light, SEW;Smith, CJ;Stratton, JA;Sloan, SA;Kang, UJ;Chao, MV;Liddelow, SA; Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates Cell reports 2025-02-20 [PMID: 39982817] (Bioassay, Human)
• Bhattacharya, S;Tei, G;Singh, PNP;Malagola, E;Eskiocak, O;He, R;Kraiczy, J;Gu, W;Perlov, Y;Beyaz, S;Wang, TC;Zhou, Q;Shivdasani, RA; Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation bioRxiv : the preprint server for biology 2025-02-08 [PMID: 39975049] (Bioassay, Human)
• Urbanska, M;Ge, Y;Winzi, M;Abuhattum, S;Ali, SS;Herbig, M;Kräter, M;Toepfner, N;Durgan, J;Florey, O;Dori, M;Calegari, F;Lolo, FN;del Pozo, MÁ;Taubenberger, A;Cannistraci, CV;Guck, J; De novo identification of universal cell mechanics gene signatures eLife 2025-02-17 [PMID: 39960760] (Bioassay, Human)
• Xiao, H;Yao, Z;Li, T;Fang, X;Xu, X;Hu, S;Yang, Y;Jin, C;Fei, Y;Liu, C;Du, Q; SERPINH1 secretion by cancer-associated fibroblasts promotes hepatocellular carcinoma malignancy through SENP3-mediated SP1/SQLE pathway International immunopharmacology 2025-02-12 [PMID: 39946769] (Bioassay, Human)
• Mima, A;Kimura, A;Ito, R;Hatano, Y;Tsujimoto, H;Mae, SI;Yamane, J;Fujibuchi, W;Uza, N;Toyoda, T;Seno, H;Osafune, K; Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model Scientific reports 2025-02-07 [PMID: 39920294] (Bioassay, Human)
• Arthurs, AL;Dietrich, B;Knöfler, M;Lushington, CJ;Thomas, PQ;Adikusuma, F;Williamson, JM;Babikha, S;Damhuis, T;Jankovic-Karasoulos, T;Smith, MD;Pringle, KG;Roberts, CT; Genetically edited human placental organoids cast new light on the role of ACE2 Cell death & disease 2025-02-07 [PMID: 39920116] (Bioassay, Human)
• Goswami, Y;Baghel, A;Sharma, G;Sharma, PK;Biswas, S;Yadav, R;Garg, PK;Shalimar, ;Tandon, R; Liver Organoids From Hepatocytes of Healthy Humans and Non-alcoholic Fatty Liver Disease (NAFLD) Patients Display Multilineage Architecture and can be Used to Develop an In Vitro Model of Steatohepatitis Journal of clinical and experimental hepatology 2024-12-03 [PMID: 39872219] (Bioassay, Human)
• Liao, Y;Chen, J;Yao, H;Zheng, T;Tu, J;Chen, W;Guo, Z;Zou, Y;Wen, L;Xie, X; Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma Journal of translational medicine 2025-01-22 [PMID: 39844299] (Bioassay, Human)
• Lee, SM;Smela, MP;Surani, MA; The role of KLF4 in human primordial germ cell development Open biology 2025-01-01 [PMID: 39837498] (Bioassay, Human)
• Sojka, C;Wang, HV;Bhatia, TN;Li, Y;Chopra, P;Sing, A;Voss, A;King, A;Wang, F;Joseph, K;Ravi, VM;Olson, J;Hoang, K;Nduom, E;Corces, VG;Yao, B;Sloan, SA; Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma Nature cell biology 2025-01-08 [PMID: 39779941] (Bioassay, Human)
• Ruffilli, C;Röth, S;Zelcer, N;Moreau, K; Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET Scientific reports 2025-01-02 [PMID: 39748066] (Bioassay, Human)
• Tang, M;Dirks, K;Kim, SY;Qiu, Z;Gao, Y;Sun, D;Peruggia, G;Sallavanti, J;Li, W; Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis Cell death and differentiation 2024-12-23 [PMID: 39715824] (Bioassay, Human)
• Stefanski, KM;Huang, H;Luu, DD;Hutchison, JM;Saksena, N;Fisch, AJ;Hasaka, TP;Bauer, JA;Kenworthy, AK;Van Horn, WD;Sanders, CR; Small-Molecule Modulators of Lipid Raft Stability and Protein-Raft Partitioning bioRxiv : the preprint server for biology 2024-12-11 [PMID: 39713458] (Bioassay, Human)
• Hammond, T;Choi, JB;Membreño, MW;Demeter, J;Ng, R;Bhattacharya, D;Nguyen, TN;Hartmann, GG;Bossard, C;Skotheim, JM;Jackson, PK;Pasca, A;Rubin, SM;Sage, J; THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle bioRxiv : the preprint server for biology 2024-12-11 [PMID: 39713326] (Bioassay, Human)
• Harel, K;Czamanski-Cohen, J;Cohen, M;Lane, RD;Dines, M;Caspi, O;Weihs, KL; Differences in Emotional Awareness Moderate Cytokine-Symptom Associations Among Breast Cancer Survivors Brain, behavior, and immunity 2024-12-12 [PMID: 39674559] (Bioassay, Human)
• Zhao, C;Inada, Y;Motoike, S;Kamiya, D;Hino, K;Ikeya, M; BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-? signaling EMBO molecular medicine 2024-12-03 [PMID: 39627568] (Bioassay, Human)
• Shan, H;Chen, M;Zhao, S;Wei, X;Zheng, M;Li, Y;Lin, Q;Jiang, Z;Chen, Z;Fei, C;Li, Z;Chen, Z;Chen, X; Acoustic virtual 3D scaffold for direct-interacting tumor organoid-immune cell coculture systems Science advances 2024-11-22 [PMID: 39576870] (Bioassay, Human)
• Ounadjela, JR;Zhang, K;Kobayashi-Kirschvink, KJ;Jin, K;J C Russell, A;Lackner, AI;Callahan, C;Viggiani, F;Dey, KK;Jagadeesh, K;Maxian, T;Prandstetter, AM;Nadaf, N;Gong, Q;Raichur, R;Zvezdov, ML;Hui, M;Simpson, M;Liu, X;Min, W;Knöfler, M;Chen, F;Haider, S;Shu, J; Spatial multiomic landscape of the human placenta at molecular resolution Nature medicine 2024-11-20 [PMID: 39567716] (Bioassay, Human)
• He, C;Chen, Y;Zhang, X;Feng, H;Rao, Y;Ji, T;Wang, W; Down-regulation of ESRP2 inhibits breast cancer cell proliferation via inhibiting cyclinD1 Scientific reports 2024-11-18 [PMID: 39557898] (Bioassay, Human)
• Popova, LV;Garfinkle, EAR;Chopyk, DM;Navarro, JB;Rivaldi, A;Shu, Y;Lomonosova, E;Phay, JE;Miller, BS;Sattuwar, S;Mullen, M;Mardis, ER;Miller, KE;Dedhia, PH; Single Nuclei Sequencing Reveals Intratumoral Cellular Heterogeneity and Replication Stress in Adrenocortical Carcinoma bioRxiv : the preprint server for biology 2024-10-28 [PMID: 39554059] (Bioassay, Human)
• Jun, I;Choi, YJ;Kim, BR;Lee, HK;Seo, KY;Kim, TI; Activation of the mTOR pathway enhances PPAR?/SREBP-mediated lipid synthesis in human meibomian gland epithelial cells Scientific reports 2024-11-15 [PMID: 39548144] (Bioassay, Human)
• Sánchez-Castillo, A;Savelkouls, KG;Baldini, A;Hounjet, J;Sonveaux, P;Verstraete, P;De Keersmaecker, K;Dewaele, B;Björkblom, B;Melin, B;Wu, WY;Sjöberg, RL;Rouschop, KMA;Broen, MPG;Vooijs, M;Kampen, KR; Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas Oncogenesis 2024-11-13 [PMID: 39537592] (Bioassay, Human)
• Hillis, AL;Tamir, T;Perry, GE;Asara, JM;Johnson, JL;Yaron, TM;Cantley, LC;White, FM;Toker, A; Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome Proceedings of the National Academy of Sciences of the United States of America 2024-11-19 [PMID: 39536083] (Bioassay, Human)
• Mokhtaridoost, M;Chalmers, JJ;Soleimanpoor, M;McMurray, BJ;Lato, DF;Nguyen, SC;Musienko, V;Nash, JO;Espeso-Gil, S;Ahmed, S;Delfosse, K;Browning, JWL;Barutcu, AR;Wilson, MD;Liehr, T;Shlien, A;Aref, S;Joyce, EF;Weise, A;Maass, PG; Inter-chromosomal contacts demarcate genome topology along a spatial gradient Nature communications 2024-11-13 [PMID: 39532865] (Bioassay, Human)
• Rahimov, F;Nieminen, P;Kumari, P;Juuri, E;Nikopensius, T;Paraiso, K;German, J;Karvanen, A;Kals, M;Elnahas, AG;Karjalainen, J;Kurki, M;Palotie, A;FinnGen, ;Estonian Biobank Research Team, ;Heliövaara, A;Esko, T;Jukarainen, S;Palta, P;Ganna, A;Patni, AP;Mar, D;Bomsztyk, K;Mathieu, J;Ruohola-Baker, H;Visel, A;Fakhouri, WD;Schutte, BC;Cornell, RA;Rice, DP; High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene Nature communications 2024-11-06 [PMID: 39500877] (Bioassay, Human)
• Kim, S;Jung, BK;Kim, J;Jeon, JH;Kim, M;Jang, SH;Kim, CS;Jang, H; Anticancer effect of the oncolytic Newcastle disease virus harboring the PTEN gene on glioblastoma Oncology letters 2025-01-01 [PMID: 39492938] (Bioassay, Human)
• Soares De Oliveira, L;Kaserman, JE;Van Der Spek, AH;Lee, NJ;Undeutsch, HJ;Werder, RB;Wilson, AA;Hollenberg, AN; Thyroid hormone receptor beta (THR?1) is the major regulator of T3 action in human iPSC-derived hepatocytes Molecular metabolism 2024-10-29 [PMID: 39481850] (Bioassay, Human)
• Rezvani, M;Lewis, K;Quach, S;Iwasawa, K;Weihs, J;Reza, H;Cai, Y;Kimura, M;Zhang, R;Milton, Y;Chaturvedi, P;Thorner, K;Nayak, RC;Munera, JO;Kramer, P;Davis, B;Balamurugan, A;Ait Ahmed, Y;Finke, M;Behncke, RY;Guillot, A;Haegerling, R;Polansky, J;Bufler, P;Cancelas, J;Wells, J;Yoshimoto, M;Takebe, T; Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells bioRxiv : the preprint server for biology 2024-10-12 [PMID: 39416072] (Bioassay, Human)
• Zhen, X;Kim, J;Kang, JS;Choi, BJ;Park, KH;Lee, DS;Hong, SH;Lee, JH; Homology-independent targeted insertion-mediated derivation of M1-biased macrophages harbouring Megf10 and CD3? from human pluripotent stem cells EBioMedicine 2024-10-08 [PMID: 39383607] (Bioassay, Human)
• Doyle, K;Hassan, AE;Sutter, M;Rodriguez, M;Kumar, P;Brown, E; A Comparison of in vivo Tumor-Homing Abilities of Placental-Derived and Bone Marrow-Derived Mesenchymal Stromal Cells in High-Risk Neuroblastoma Journal of pediatric surgery 2024-09-21 [PMID: 39379183] (Bioassay, Human)
• Chan, P;Nagai, Y;Wu, Q;Hovsepyan, A;Mkhitaryan, S;Wang, J;Karapetyan, G;Kamenecka, T;Solt, LA;Cope, J;Moats, RA;Hirota, T;Rich, JN;Kay, SA; Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials bioRxiv : the preprint server for biology 2024-09-21 [PMID: 39345648] (Bioassay, Human)
• Beazer, JD;Sillars, A;Beck, S;Christoffersen, C;Ferraz, MJ;Mulder, MT;Graham, D;Karlsson, H;Ljunggren, S;Gill, J;Freeman, DJ; Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function Bioscience reports 2024-10-30 [PMID: 39344511] (Bioassay, Human)
• Lucendo-Villarin, B;Wang, Y;Mallanna, SK;Kimbrel, EA;Hay, DC; Screening a Compound Library to Identify Additives That Boost Cytochrome P450 Enzyme Function in Vascularised Liver Spheres Cells 2024-09-22 [PMID: 39329775] (Bioassay, Human)
• Zeger, L;Barasa, P;Han, Y;Hellgren, J;Redwan, IN;Reiche, ME;Florin, G;Christoffersson, G;Kozlova, EN; Microgravity Effect on Pancreatic Islets Cells 2024-09-21 [PMID: 39329769] (Bioassay, Mouse)
• Cinkornpumin, JK;Kwon, SY;Prandstetter, AM;Maxian, T;Sirois, J;Goldberg, J;Zhang, J;Saini, D;Dasgupta, P;Jeyarajah, MJ;Renaud, SJ;Paul, S;Haider, S;Pastor, WA; Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells bioRxiv : the preprint server for biology 2024-09-10 [PMID: 39314437] (Bioassay, Human)
• Zhang, F;Cui, X;Yang, K;Guo, R;Zhu, L;Zhao, W;Liu, Z;Liu, B; Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF International immunopharmacology 2024-09-16 [PMID: 39288626] (Bioassay, Human)
• Wang, X;Yang, S;Zheng, C;Huang, C;Yao, H;Guo, Z;Wu, Y;Wang, Z;Wu, Z;Ge, R;Cheng, W;Yan, Y;Jiang, S;Sun, J;Li, X;Xie, Q;Wang, H; Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations Nutrients 2024-09-02 [PMID: 39275267] (Bioassay, Human)
• Kent, MR;Jay, AN;Kendall, GC; New dual inducible cellular model to investigate temporal control of oncogenic cooperating genes Scientific reports 2024-09-05 [PMID: 39237585] (Bioassay, Human)
• Fernandez Garcia, M;Retallick-Townsley, K;Pruitt, A;Davidson, E;Dai, Y;Fitzpatrick, SE;Sen, A;Cohen, S;Livoti, O;Khan, S;Dossou, G;Cheung, J;Deans, PJM;Wang, Z;Huckins, L;Hoffman, E;Brennand, K; Dynamic convergence of autism disorder risk genes across neurodevelopment bioRxiv : the preprint server for biology 2024-08-24 [PMID: 39229156] (Bioassay, Human)
• MacArthur, IC;Ma, L;Huang, CY;Bhavsar, H;Suzuki, M;Dawlaty, MM; Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence Science advances 2024-08-30 [PMID: 39196941] (Bioassay, Transgenic Mouse)
• Nakakido, M;Kinoshita, S;Tsumoto, K; Development of novel humanized VHH synthetic libraries based on physicochemical analyses Scientific reports 2024-08-22 [PMID: 39174623] (Surface Plasmon Resonance (SPR), Human)
• Lisowski, P;Lickfett, S;Rybak-Wolf, A;Menacho, C;Le, S;Pentimalli, TM;Notopoulou, S;Dykstra, W;Oehler, D;López-Calcerrada, S;Mlody, B;Otto, M;Wu, H;Richter, Y;Roth, P;Anand, R;Kulka, LAM;Meierhofer, D;Glazar, P;Legnini, I;Telugu, NS;Hahn, T;Neuendorf, N;Miller, DC;Böddrich, A;Polzin, A;Mayatepek, E;Diecke, S;Olzscha, H;Kirstein, J;Ugalde, C;Petrakis, S;Cambridge, S;Rajewsky, N;Kühn, R;Wanker, EE;Priller, J;Metzger, JJ;Prigione, A; Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure Nature communications 2024-08-22 [PMID: 39174523] (Bioassay, Human)
• Lailler, C;Didelot, A;Garinet, S;Berthou, H;Sroussi, M;de Reyniès, A;Dedhar, S;Martin-Lannerée, S;Fabre, E;Le Pimpec-Barthes, F;Perrier, A;Poindessous, V;Mansuet-Lupo, A;Djouadi, F;Launay, JM;Laurent-Puig, P;Blons, H;Mouillet-Richard, S; PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up Oncogene 2024-08-15 [PMID: 39147880] (Bioassay, Human)
• Barrero, M;Lazarenkov, A;Blanco, E;Palma, LG;López-Rubio, AV;Bauer, M;Bigas, A;Di Croce, L;Sardina, JL;Payer, B; The interferon ? pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming Science advances 2024-08-09 [PMID: 39110794] (Bioassay, Mouse)
• Wilson, ZS;Raya-Sandino, A;Miranda, J;Fan, S;Brazil, JC;Quiros, M;Garcia-Hernandez, V;Liu, Q;Kim, CH;Hankenson, KD;Nusrat, A;Parkos, CA; Critical role of thrombospondin-1 in promoting intestinal mucosal wound repair JCI insight 2024-07-30 [PMID: 39078701] (Bioassay, Mouse)
• Zhang, R;Chen, Y;Feng, Z;Cai, B;Cheng, Y;Du, Y;Ou, S;Chen, H;Pan, M;Liu, H;Pei, D;Cao, S; Reprogramming human urine cells into intestinal organoids with long-term expansion ability and barrier function Heliyon 2024-07-15 [PMID: 39040281] (Bioassay, Human)
• Hillis, AL;Martin, TD;Manchester, HE;Högström, J;Zhang, N;Lecky, E;Kozlova, N;Lee, J;Persky, NS;Root, DE;Brown, M;Cichowski, K;Elledge, SJ;Muranen, T;Fruman, DA;Barry, ST;Clohessy, JG;Madsen, RR;Toker, A; Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer Cancer research 2024-07-18 [PMID: 39024548] (Bioassay, Human)
• Kang, NW;Seo, YA;Jackson, KJ;Jang, K;Song, E;Han, U;Chen, F;Heilshorn, SC;Myung, D; Photoactivated growth factor release from bio-orthogonally crosslinked hydrogels for the regeneration of corneal defects Bioactive materials 2024-10-01 [PMID: 39022184] (Bioassay, Human)
• Gao, H;Huang, X;Cai, Z;Cai, B;Wang, K;Li, J;Kuang, J;Wang, B;Zhai, Z;Ming, J;Cao, S;Qin, Y;Pei, D; Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells Cell & bioscience 2024-07-15 [PMID: 39010176] (Bioassay, Human)
• Warner, KA;Herzog, AE;Sahara, S;Nör, F;Castilho, RM;Demirci, H;Chepeha, DB;Polverini, PJ;Nör, JE; Establishment and characterization of cMYB-expressing human salivary adenoid cystic carcinoma cell lines (UM-HACC-14, UM-HACC-6) and matching patient-derived xenograft model (UM-PDX-HACC-14) Oral surgery, oral medicine, oral pathology and oral radiology 2024-06-11 [PMID: 38971694] (Bioassay, Human)
• Donahue, KL;Watkoske, HR;Kadiyala, P;Du, W;Brown, K;Scales, MK;Elhossiny, AM;Espinoza, CE;Lasse Opsahl, EL;Griffith, BD;Wen, Y;Sun, L;Velez-Delgado, A;Renollet, NM;Morales, J;Nedzesky, NM;Baliira, RK;Menjivar, RE;Medina-Cabrera, PI;Rao, A;Allen, B;Shi, J;Frankel, TL;Carpenter, ES;Bednar, F;Zhang, Y;Pasca di Magliano, M; Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth Cancer discovery 2024-07-03 [PMID: 38958646] (Bioassay, Human)
• Demeter, F;Németh, Z;Kajdácsi, E;Bihari, G;Dobó, J;Gál, P;Cervenak, L; Detrimental interactions of hypoxia and complement MASP-1 in endothelial cells as a model for atherosclerosis-related diseases Scientific reports 2024-06-27 [PMID: 38937560] (Bioassay, Human)
• Pallasch, FB;Freytag, V;Kriegs, M;Gatzemeier, D;Mair, T;Voss, H;Riecken, K;Dawood, M;Fehse, B;Efferth, T;Schlüter, H;Schumacher, U; The Histogenetic Origin of Malignant Cells Predicts Their Susceptibility towards Synthetic Lethality Utilizing the TK.007 System Cancers 2024-06-19 [PMID: 38927982] (Bioassay, Human)
• Felgendreff, P;Hosseiniasl, SM;Minshew, A;Amiot, BP;Wilken, S;Ahmadzada, B;Huebert, RC;Sakrikar, NJ;Engles, NG;Halsten, P;Mariakis, K;Barry, J;Riesgraf, S;Fecteau, C;Ross, JJ;Nyberg, SL; First Application of a Mixed Porcine-Human Repopulated Bioengineered Liver in a Preclinical Model of Post-Resection Liver Failure Biomedicines 2024-06-07 [PMID: 38927479] (Bioassay, Human, Porcine)
• Moerkens, R;Mooiweer, J;Ramírez-Sánchez, AD;Oelen, R;Franke, L;Wijmenga, C;Barrett, RJ;Jonkers, IH;Withoff, S; An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells Cell reports 2024-06-20 [PMID: 38907996] (Bioassay, Human)
• Lungova, V;Gowda, M;Fernandez, JM;Bartley, S;Venkatraman, A;Rey, FE;Thibeault, SL; Contribution of Streptococcus pseudopneumoniae and Streptococcus salivarius to vocal fold mucosal integrity and function Disease models & mechanisms 2024-07-01 [PMID: 38903015] (Cell Culture, Human)
• Choi, EK;Rajendiran, TM;Soni, T;Park, JH;Aring, L;Muraleedharan, CK;Garcia-Hernandez, V;Kamada, N;Samuelson, LC;Nusrat, A;Iwase, S;Seo, YA; The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease Nature communications 2024-06-05 [PMID: 38839750] (Bioassay, Mouse)
• Siddiqi, U;Lunnemann, HM;Childress, KO;Shupe, JA;Rutherford, SA;Farrow, MA;Washington, MK;Coffey, RJ;Lacy, DB;Markham, NO; Inhibition of EGFR/ErbB does not protect against C. difficile toxin B bioRxiv : the preprint server for biology 2024-05-14 [PMID: 38798529] (Bioassay, Human)
• O'Reilly, ME;Ho, S;Coronel, J;Zhu, L;Liu, W;Xue, C;Kim, E;Cynn, E;Matias, CV;Soni, RK;Wang, C;Ionita-Laza, I;Bauer, RC;Ross, L;Zhang, Y;Corvera, S;Fried, SK;Reilly, MP; linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability Cell reports 2024-05-14 [PMID: 38753486] (Bioassay, Human)
• Chesnokova, V;Zonis, S;Apaydin, T;Barrett, R;Melmed, S; Non-pituitary growth hormone enables colon cell senescence evasion Aging cell 2024-05-09 [PMID: 38724466] (Bioassay, Human)
• Zhang, J;Lim, SM;Yu, MR;Chen, C;Wang, J;Wang, W;Rui, H;Lu, J;Lu, S;Mok, T;Chen, ZJ;Cho, BC; D3S-001, a KRAS G12C inhibitor with rapid target engagement kinetics, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities Cancer discovery 2024-05-08 [PMID: 38717075] (Bioassay, Human)
• Loffredo, LF;Surpur, A;Ringham, OR;Li, F;de Los Santos-Alexis, K;Arpaia, N; Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection bioRxiv : the preprint server for biology 2024-04-28 [PMID: 38712053] (Bioassay, Human)
• O'Connell, AE;Raveenthiraraj, S;Oliveira, LFS;Adegboye, C;Dasuri, VS;Qi, W;Khetani, RS;Singh, A;Sundaram, N;Lin, J;Nandivada, P;Rincón-Cruz, L;Goldsmith, JD;Thiagarajah, JR;Carlone, DL;Turner, JR;Agrawal, PB;Helmrath, M;Breault, DT; WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production Cellular and molecular gastroenterology and hepatology 2024-04-30 [PMID: 38697357] (Bioassay, Human)
• Kanemura, Y;Yamamoto, A;Katsuma, A;Fukusumi, H;Shofuda, T;Kanematsu, D;Handa, Y;Sumida, M;Yoshioka, E;Mine, Y;Yamaguchi, R;Okada, M;Igarashi, M;Sekino, Y;Shirao, T;Nakamura, M;Okano, H; Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains Cells 2024-04-12 [PMID: 38667286] (Bioassay, Human)
• Chen, X;Birey, F;Li, MY;Revah, O;Levy, R;Thete, MV;Reis, N;Kaganovsky, K;Onesto, M;Sakai, N;Hudacova, Z;Hao, J;Meng, X;Nishino, S;Huguenard, J;Pa?ca, SP; Antisense oligonucleotide therapeutic approach for Timothy syndrome Nature 2024-04-01 [PMID: 38658687] (Bioassay, Human)
• Kasetsuwan, N;Reinprayoon, U;Uthaithammarat, L;Sereemaspun, A;Sae-Liang, N;Chaichompoo, W;Suksamrarn, A; Anti-inflammatory effect of curcuminoids and their analogs in hyperosmotic human corneal limbus epithelial cells BMC complementary medicine and therapies 2024-04-23 [PMID: 38654265] (Bioassay, Human)
• Lång, E;Lång, A;Blicher, P;Rognes, T;Dommersnes, PG;Bøe, SO; Topology-guided polar ordering of collective cell migration Science advances 2024-04-19 [PMID: 38630812] (Bioassay, Human)
• Carvalho, EM;Ding, EA;Saha, A;Weldy, A;Zushin, PH;Stahl, A;Aghi, MK;Kumar, S; Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics bioRxiv : the preprint server for biology 2024-04-06 [PMID: 38617333] (Bioassay, Human)
• Chen, H;Lee, LJ;Vincent, KM;Xu, Z;Liu, J;Zhang, G;Nakevska, Z;Smith, D;Lee, CH;Postovit, LM;Fu, Y; Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer Oncogene 2024-04-09 [PMID: 38594503] (Bioassay, Human)
• Shrestha, S;Acharya, P;Kang, SY;Vanga, MG;Lekkala, VKR;Liu, J;Yang, Y;Joshi, P;Lee, MY; Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assays bioRxiv : the preprint server for biology 2024-03-29 [PMID: 38586058] (Human)
• Kang, EJ;Kim, JH;Kim, YE;Lee, H;Jung, KB;Chang, DH;Lee, Y;Park, S;Lee, EY;Lee, EJ;Kang, HB;Rhyoo, MY;Seo, S;Park, S;Huh, Y;Go, J;Choi, JH;Choi, YK;Lee, IB;Choi, DH;Seo, YJ;Noh, JR;Kim, KS;Hwang, JH;Jeong, JS;Kwon, HJ;Yoo, HM;Son, MY;Kim, YG;Lee, DH;Kim, TY;Kwon, HJ;Kim, MH;Kim, BC;Kim, YH;Kang, D;Lee, CH; The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation Nature communications 2024-04-06 [PMID: 38582860] (Bioassay, Human)
• Kim, JI;Imaizumi, K;Thete, MV;Hudacova, Z;Jurju?, O;Amin, ND;Scherrer, G;Pa?ca, SP; Human assembloid model of the ascending neural sensory pathway bioRxiv : the preprint server for biology 2024-03-12 [PMID: 38559133] (Bioassay, Human)
• Hong, ES;Wang, SZ;Ponti, AK;Hajdari, N;Lee, J;Mulkearns-Hubert, EE;Volovetz, J;Kay, KE;Lathia, JD;Dhawan, A; miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma bioRxiv : the preprint server for biology 2024-03-12 [PMID: 38559056] (Bioassay, Human)
• Hu, Z;Chen, PH;Li, W;Krone, M;Zheng, S;Saarbach, J;Velasco, IU;Hines, J;Liu, Y;Crews, CM; EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling Science advances 2024-03-29 [PMID: 38536914] (Bioassay, Human)
• Nicholson, JG;Cirigliano, S;Singhania, R;Haywood, C;Shahidi Dadras, M;Yoshimura, M;Vanderbilt, D;Liechty, B;Fine, HA; Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth Acta neuropathologica communications 2024-03-25 [PMID: 38528608] (Bioassay, Human)
• Lin, P;Chen, W;Long, Z;Yu, J;Yang, J;Xia, Z;Wu, Q;Min, X;Tang, J;Cui, Y;Liu, F;Wang, C;Zheng, J;Li, W;Rich, JN;Li, L;Xie, Q; RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation Cell discovery 2024-03-19 [PMID: 38503731] (Bioassay, Xenograft)
• Qu, N;Daoud, A;Kechele, DO;Múnera, JO; Human Pluripotent Stem Cell Derived Organoids Reveal a Role for WNT Signaling in Dorsal-Ventral Patterning of the Hindgut bioRxiv : the preprint server for biology 2024-03-06 [PMID: 38496665] (Bioassay, Human)
• Bugara, B;Durbas, M;Kudrycka, M;Malinowska, A;Horwacik, I;Rokita, H; Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells Frontiers in pharmacology 2024-03-01 [PMID: 38495105] (Bioassay, Human)
• Doyle, K;Sutter, M;Rodriguez, M;Hassan, AE;Kumar, P;Brown, E; Proliferative Effects of Mesenchymal Stromal Cells on Neuroblastoma Cell Lines: Are They Tumor Promoting or Tumor Inhibiting? Journal of pediatric surgery 2024-02-26 [PMID: 38490883] (Bioassay, Human)
• Rio-Vilariño, A;Cenigaonandia-Campillo, A;García-Bautista, A;Mateos-Gómez, PA;Schlaepfer, MI;Del Puerto-Nevado, L;Aguilera, O;García-García, L;Galeano, C;de Miguel, I;Serrano-López, J;Baños, N;Fernández-Aceñero, MJ;Lacal, JC;Medico, E;García-Foncillas, J;Cebrián, A; Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells British journal of cancer 2024-03-11 [PMID: 38467828] (Bioassay, Human)
• Joshi, IV;Chan, EC;Lack, JB;Liu, C;Druey, KM; RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms The Journal of biological chemistry 2024-03-01 [PMID: 38432633] (Bioassay, Human)
• Fu, Z;Chen, Z;Ye, J;Ji, J;Ni, W;Lin, W;Lin, H;Lu, L;Zhu, G;Xie, Q;Yan, F;Chen, G;Liu, F; Identifying PLAUR as a Pivotal Gene of Tumor Microenvironment and Regulating Mesenchymal Phenotype of Glioblastoma Cancers 2024-02-19 [PMID: 38398231] (Bioassay, Human)
• Jurickova, I;Dreskin, BW;Angerman, E;Bonkowski, E;Tominaga, K;Iwasawa, K;Braun, T;Takebe, T;Helmrath, MA;Haberman, Y;Wells, JM;Denson, LA; Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn's Disease bioRxiv : the preprint server for biology 2024-01-30 [PMID: 38352573] (Bioassay, Human)
• Madsen, O;Rikkers, RSC;Wells, JM;Bergsma, R;Kar, SK;Taverne, N;Taverne-Thiele, AJ;Ellen, ED;Woelders, H; Transcriptomic analysis of intestinal organoids, derived from pigs divergent in feed efficiency, and their response to Escherichia coli BMC genomics 2024-02-13 [PMID: 38350904] (Bioassay, Porcine)
• Tanner, G;Barrow, R;Ajaib, S;Al-Jabri, M;Ahmed, N;Pollock, S;Finetti, M;Rippaus, N;Bruns, AF;Syed, K;Poulter, JA;Matthews, L;Hughes, T;Wilson, E;Johnson, C;Varn, FS;Brüning-Richardson, A;Hogg, C;Droop, A;Gusnanto, A;Care, MA;Cutillo, L;Westhead, DR;Short, SC;Jenkinson, MD;Brodbelt, A;Chakrabarty, A;Ismail, A;Verhaak, RGW;Stead, LF; IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy Genome biology 2024-02-07 [PMID: 38326875] (Bioassay, Human)
• Company, C;Schmitt, MJ;Dramaretska, Y;Serresi, M;Kertalli, S;Jiang, B;Yin, JA;Aguzzi, A;Barozzi, I;Gargiulo, G; Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes Nature communications 2024-02-05 [PMID: 38316783] (Bioassay, Human)
• Yan, Y;Li, X;Gao, Y;Mathivanan, S;Kong, L;Tao, Y;Dong, Y;Li, X;Bhattacharyya, A;Zhao, X;Zhang, SC; 3D bioprinting of human neural tissues with functional connectivity Cell Stem Cell 2024-02-01 [PMID: 38306994] (Bioassay, Human)
• Chen, HH;Nguyen, TV;Shih, YH;Chang, KC;Chiu, KC;Hsia, SM;Fuh, LJ;Shieh, TM; Combining microfluidic chip and low-attachment culture devices to isolate oral cancer stem cells Journal of dental sciences 2024-01-01 [PMID: 38303836] (Bioassay, Human)
• Rashidi, AS;Tran, DN;Peelen, CR;van Gent, M;Ouwendijk, WJD;Verjans, GMGM; Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures Journal of neuroinflammation 2024-02-01 [PMID: 38302975] (Bioassay, Human)
• Kwon, O;Lee, H;Jung, J;Son, YS;Jeon, S;Yoo, WD;Son, N;Jung, KB;Choi, E;Lee, IC;Kwon, HJ;Kim, C;Lee, MO;Cho, HS;Kim, DS;Son, MY; Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids Nature communications 2024-01-27 [PMID: 38280855] (Differentiation, Human)
• Rylaarsdam, L;Rakotomamonjy, J;Pope, E;Guemez-Gamboa, A; iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity Nature communications 2024-01-27 [PMID: 38280846] (Bioassay, Human)
• Morimoto, A;Takasugi, N;Pan, Y;Kubota, S;Dohmae, N;Abiko, Y;Uchida, K;Kumagai, Y;Uehara, T; Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling The Journal of biological chemistry 2024-01-23 [PMID: 38272219] (Bioassay, Human)
• Puri, S;Maachi, H;Nair, G;Russ, HA;Chen, R;Pulimeno, P;Cutts, Z;Ntranos, V;Hebrok, M; Sox9 regulates alternative splicing and pancreatic beta cell function Nature communications 2024-01-18 [PMID: 38238288] (Bioassay, Human)
• Liu, S;Qin, Z;Mao, Y;Wang, N;Zhang, W;Wang, Y;Chen, Y;Jia, L;Peng, X; Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma Theranostics 2024-01-01 [PMID: 38169606] (Bioassay, Human)
• Hao, XL;Lv, YF;Li, DF;Bai, FH;Gong, J;Pan, GQ;Su, LX;Wang, YL;Fu, WL;Liu, B;Huang, L;Yan, D;Tan, QL;Liu, JY;Guo, QN; TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis Journal of translational medicine 2024-01-02 [PMID: 38167440] (Bioassay, Human)
• Wang, Y;Qin, Z;Chen, Y;Zheng, Y;Jia, L; A Novel LncRNA MASCC1 Regulates the Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Sponging miR-195 Cancers 2023-12-11 [PMID: 38136338] (Cell Culture, Human)
• Calheiros, J;Raimundo, L;Morais, J;Matos, AC;Minuzzo, SA;Indraccolo, S;Sousa, E;Silva, MCD;Saraiva, L; Antitumor Activity of the Xanthonoside XGAc in Triple-Negative Breast, Ovarian and Pancreatic Cancer by Inhibiting DNA Repair Cancers 2023-12-06 [PMID: 38136266] (Bioassay, Human)
• Yuan, M;Mahmud, I;Katsushima, K;Joshi, K;Saulnier, O;Pokhrel, R;Lee, B;Liyanage, W;Kunhiraman, H;Stapleton, S;Gonzalez-Gomez, I;Kannan, RM;Eisemann, T;Kolanthai, E;Seal, S;Garrett, TJ;Abbasi, S;Bockley, K;Hanes, J;Chapagain, P;Jallo, G;Wechsler-Reya, RJ;Taylor, MD;Eberhart, CG;Ray, A;Perera, RJ; miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4 Acta neuropathologica communications 2023-12-19 [PMID: 38115140] (Bioassay, Human)
• van de Weijer, LL;Ercolano, E;Zhang, T;Shah, M;Banton, MC;Na, J;Adams, CL;Hilton, D;Kurian, KM;Hanemann, CO; A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas Acta neuropathologica communications 2023-12-15 [PMID: 38102708] (Bioassay, Human)
• Hwang, YS;Seita, Y;Blanco, MA;Sasaki, K; CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development PLoS genetics 2023-12-01 [PMID: 38091369] (Cell Culture, Human)
• Ferreira, GA;Thomé, CH;Izumi, C;Grassi, ML;Lanfredi, GP;Smolka, M;Faça, VM;Candido Dos Reis, FJ; Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma Journal of ovarian research 2023-11-29 [PMID: 38031074] (Bioassay, Human)
• Bapat, J;Yamamoto, TM;Woodruff, ER;Qamar, L;Mikeska, RG;Aird, KM;Watson, ZL;Brubaker, LW;Bitler, BG; CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR Cancer gene therapy 2023-11-29 [PMID: 38030811] (Bioassay, Human)
• Fernando, MB;Fan, Y;Zhang, Y;Kammourh, S;Murphy, AN;Ghorbani, S;Onatzevitch, R;Pero, A;Padilla, C;Cao, L;Williams, S;Fang, G;Slesinger, PA;Brennand, KJ; Precise Therapeutic Targeting of Distinct NRXN1+/- Mutations bioRxiv : the preprint server for biology 2023-10-28 [PMID: 37961635] (Bioassay, Human)
• Yang, Y;McCullough, CG;Seninge, L;Guo, L;Kwon, WJ;Zhang, Y;Li, NY;Gaddam, S;Pan, C;Zhen, H;Torkelson, J;Glass, IA;Birth Defects Research Laboratory, ;Charville, G;Que, J;Stuart, J;Ding, H;Oro, A; A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa bioRxiv : the preprint server for biology 2023-10-26 [PMID: 37961271] (Bioassay, Human)
• Teixeira, RG;Mészáros, JP;Matos, B;Côrte-Real, L;Xavier, CPR;Fontrodona, X;Garcia, MH;Romero, I;Spengler, G;Vasconcelos, MH;Tomaz, AI;Enyedy, ÉA;Valente, A; Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies European journal of medicinal chemistry 2023-10-31 [PMID: 37944388] (Cell Culture, Human)
• Harmange, G;Hueros, RAR;Schaff, DL;Emert, B;Saint-Antoine, M;Kim, LC;Niu, Z;Nellore, S;Fane, ME;Alicea, GM;Weeraratna, AT;Simon, MC;Singh, A;Shaffer, SM; Disrupting cellular memory to overcome drug resistance Nature communications 2023-11-06 [PMID: 37932277] (Bioassay, Human)
• Que, Z;Luo, B;Yu, P;Qi, D;Shangguan, W;Wang, P;Liu, J;Li, Y;Li, H;Ke, R;Wu, E;Tian, J; Polyphyllin VII induces CTC anoikis to inhibit lung cancer metastasis through EGFR pathway regulation International journal of biological sciences 2023-10-16 [PMID: 37928267] (Cell Culture, Human)
• Espinosa-Gil, S;Ivanova, S;Alari-Pahissa, E;Denizli, M;Villafranca-Magdalena, B;Viñas-Casas, M;Bolinaga-Ayala, I;Gámez-García, A;Faundez-Vidiella, C;Colas, E;Lopez-Botet, M;Zorzano, A;Lizcano, JM; MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists Cell death & disease 2023-11-02 [PMID: 37919293] (Bioassay, Xenograft)
• Wu, Q;Berglund, AE;Macaulay, RJ;Etame, AB; Epigenetic Activation of TUSC3 Sensitizes Glioblastoma to Temozolomide Independent of MGMT Promoter Methylation Status International journal of molecular sciences 2023-10-14 [PMID: 37894860] (Bioassay, Human)
• Menjivar, NG;Gad, A;Thompson, RE;Meyers, MA;Hollinshead, FK;Tesfaye, D; Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress BMC genomics 2023-10-27 [PMID: 37891479] (Bioassay, Bovine)
• Yang, Y;Yang, R;Kang, B;Qian, S;He, X;Zhang, X; Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons Cell reports 2023-10-26 [PMID: 37889749] (Bioassay, Human)
• Wu, X;Chen, CW;Jaiswal, S;Chang, TS;Zhang, R;Dame, MK;Duan, Y;Jiang, H;Spence, JR;Hsieh, SY;Wang, TD; Near-Infrared Imaging of Colonic Adenomas In Vivo Using Orthotopic Human Organoids for Early Cancer Detection Cancers 2023-09-29 [PMID: 37835489] (Bioassay, Human)
• Ham, SW;Kim, JY;Seo, S;Hong, N;Park, MJ;Kim, Y;Jang, J;Park, S;Lee, SJ;Kim, JK;Kim, EJ;Kim, SO;Kim, SC;Park, JW;Kim, H; Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells International journal of molecular sciences 2023-09-30 [PMID: 37834227] (Bioassay, Human)
• Johnstone, BH;Gu, D;Lin, CH;Du, J;Woods, EJ; Identification of a fundamental cryoinjury mechanism in MSCs and its mitigation through cell-cycle synchronization prior to freezing Cryobiology 2023-10-11 [PMID: 37827209] (Bioassay, Human)
• Batara, DC;Park, SW;Kim, HJ;Choi, SY;Ohn, T;Choi, MC;Park, SI;Kim, SH; Targeting the multidrug and toxin extrusion 1 gene (SLC47A1) sensitizes glioma stem cells to temozolomide American journal of cancer research 2023-09-15 [PMID: 37818053] (Bioassay, Human)
• Benton, A;Terwilliger, E;Moriarty, NM;Liu, B;Murphy, A;Maluvac, H;Shu, M;Gartenhaus, LE;Janson, ND;Pfeffer, CM;Utturkar, SM;Parkinson, EI;Lanman, NA;Hanna, JA; Target gene regulatory network of miR-497 in angiosarcoma bioRxiv : the preprint server for biology 2023-09-25 [PMID: 37808715] (Bioassay, Human)
• Chiaradia, I;Imaz-Rosshandler, I;Nilges, BS;Boulanger, J;Pellegrini, L;Das, R;Kashikar, ND;Lancaster, MA; Tissue morphology influences the temporal program of human brain organoid development Cell stem cell 2023-10-05 [PMID: 37802039] (Bioassay, Human)
• Raya-Sandino, A;Lozada-Soto, KM;Rajagopal, N;Garcia-Hernandez, V;Luissint, AC;Brazil, JC;Cui, G;Koval, M;Parkos, CA;Nangia, S;Nusrat, A; Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function Nature communications 2023-10-05 [PMID: 37798277] (Bioassay, Transgenic Mouse)
• Yang, X;Forró, C;Li, TL;Miura, Y;Zaluska, TJ;Tsai, CT;Kanton, S;McQueen, JP;Chen, X;Mollo, V;Santoro, F;Pa?ca, SP;Cui, B; Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids bioRxiv : the preprint server for biology 2023-09-22 [PMID: 37790529] (Bioassay, Human)
• Xia, L;Nie, T;Lu, F;Huang, L;Shi, X;Ren, D;Lu, J;Li, X;Xu, T;Cui, B;Wang, Q;Gao, G;Yang, Q; Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer Autophagy 2023-09-29 [PMID: 37772772] (Bioassay, Human)
• Hsu, WH;LaBella, KA;Lin, Y;Xu, P;Lee, R;Hsieh, CE;Yang, L;Zhou, A;Blecher, JM;Wu, CJ;Lin, K;Shang, X;Jiang, S;Spring, DJ;Xia, Y;Chen, P;Shen, JP;Kopetz, S;DePinho, RA; Oncogenic KRAS drives lipo-fibrogenesis to promote angiogenesis and colon cancer progression Cancer discovery 2023-09-28 [PMID: 37768068] (Bioassay, Xenograft)
• Pap, D;Pajtók, C;Veres-Székely, A;Szebeni, B;Szász, C;Bokrossy, P;Zrufkó, R;Vannay, Á;Tulassay, T;Szabó, AJ; High Salt Promotes Inflammatory and Fibrotic Response in Peritoneal Cells International journal of molecular sciences 2023-09-06 [PMID: 37762068] (Bioassay, Human)
• Bardag Gorce, F;Al Dahan, M;Narwani, K;Terrazas, J;Ferrini, M;Calhoun, CC;Uyanne, J;Royce-Flores, J;Crum, E;Niihara, Y; Human Oral Mucosa as a Potentially Effective Source of Neural Crest Stem Cells for Clinical Practice Cells 2023-09-06 [PMID: 37759439] (Bioassay, Human)
• Das, ND;Chang, JC;Hon, CC;Kelly, ST;Ito, S;Lizio, M;Kaczkowski, B;Watanabe, H;Katsushima, K;Natsume, A;Koseki, H;Kondo, Y;Minoda, A;Umehara, T; Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties BMC genomics 2023-09-27 [PMID: 37759202] (Bioassay, Human)
• Yin, J;Seo, Y;Rhim, J;Jin, X;Kim, TH;Kim, SS;Hong, JH;Gwak, HS;Yoo, H;Park, JB;Kim, JH; Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells Cancer research 2023-09-25 [PMID: 37747775] (Bioassay, Human)
• De Hoyos, M;Yu, X;Gonzalez-Suarez, A;Mercado-Perez, A;Krueger, E;Hernandez, J;Druliner, B;Linden, DR;Beyder, A;Chen, S;Fedyshyn, Y;Revzin, A; Modeling Gut Neuro-Epithelial Connections in a Novel Microfluidic Device Research square 2023-09-07 [PMID: 37720014] (Bioassay, Human)
• Wang, T;Zhu, Y;Chen, L;Zhang, W;Qi, H;Shi, X;Zhong, M;Chen, H;Li, Q; ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy Journal of translational medicine 2023-09-07 [PMID: 37679788] (Bioassay, Human)
• Kim, EJ;Chen, C;Gologorsky, R;Santandreu, A;Torres, A;Wright, N;Goodin, MS;Moyer, J;Chui, BW;Blaha, C;Brakeman, P;Vartanian, S;Tang, Q;David Humes, H;Fissell, WH;Roy, S; Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes Nature communications 2023-08-29 [PMID: 37644033] (Bioassay, Human)
• Doucet, EJ;Cortez Ghio, S;Barbier, MA;Savard, É;Magne, B;Safoine, M;Larouche, D;Fradette, J;Germain, L; Production of Tissue-Engineered Skin Substitutes for Clinical Applications: Elimination of Serum International journal of molecular sciences 2023-08-08 [PMID: 37628718] (Bioassay, Human)
• Purcell, RH;Sefik, E;Werner, E;King, AT;Mosley, TJ;Merritt-Garza, ME;Chopra, P;McEachin, ZT;Karne, S;Raj, N;Vaglio, BJ;Sullivan, D;Firestein, BL;Tilahun, K;Robinette, MI;Warren, ST;Wen, Z;Faundez, V;Sloan, SA;Bassell, GJ;Mulle, JG; Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion Science advances 2023-08-18 [PMID: 37585521] (Bioassay, Human)
• Chen, J;Xu, Z;Huang, H;Tang, Y;Shan, H;Xiao, F; SETD1A drives stemness by reprograming epigenetic landscape in hepatocellular carcinoma stem cells JCI insight 2023-08-15 [PMID: 37581938] (Bioassay, Human)
• Tsutsumi, R;Ueberheide, B;Liang, FX;Neel, BG;Sakai, R;Saito, Y; Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation bioRxiv : the preprint server for biology 2023-07-24 [PMID: 37546742] (Bioassay, Mouse)
• Singh, K;Han, C;Fleming, JL;Becker, AP;McElroy, J;Cui, T;Johnson, B;Kumar, A;Sebastian, E;Showalter, CA;Schrock, MS;Summers, MK;Becker, V;Tong, ZY;Meng, X;Manring, HR;Venere, M;Bell, EH;Robe, PA;Grosu, AL;Haque, SJ;Chakravarti, A; TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways Scientific reports 2023-08-01 [PMID: 37528172] (Bioassay, Human)
• Hayashi, Y;Matsuo, Y;Denda, Y;Nonoyama, K;Murase, H;Ueda, G;Aoyama, Y;Kato, T;Omi, K;Imafuji, H;Saito, K;Morimoto, M;Ogawa, R;Takahashi, H;Mitsui, A;Kimura, M;Takiguchi, S; Girdin regulates both migration and angiogenesis in pancreatic cancer cell lines Oncology reports 2023-09-01 [PMID: 37503752] (Bioassay, Human)
• Zhong, J;Wu, X;Gao, Y;Chen, J;Zhang, M;Zhou, H;Yang, J;Xiao, F;Yang, X;Huang, N;Qi, H;Wang, X;Bai, F;Shi, Y;Zhang, N; Circular RNA encoded MET variant promotes glioblastoma tumorigenesis Nature communications 2023-07-25 [PMID: 37491377] (Bioassay, Human)
• Pissas, K;Schilling, M;Tian, Y;Gründer, S; Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons Research Square 2023-01-01 [PMID: 37474775] (Bioassay, Human)
• Voss, AJ;Lanjewar, SN;Sampson, MM;King, A;Hill, EJ;Sing, A;Sojka, C;Bhatia, TN;Spangle, JM;Sloan, SA; Identification of ligand-receptor pairs that drive human astrocyte development Nature neuroscience 2023-07-17 [PMID: 37460808] (Bioassay, Human)
• Ai, Z;Niu, B;Yin, Y;Xiang, L;Shi, G;Duan, K;Wang, S;Hu, Y;Zhang, C;Zhang, C;Rong, L;Kong, R;Chen, T;Guo, Y;Liu, W;Li, N;Zhao, S;Zhu, X;Mai, X;Li, Y;Wu, Z;Zheng, Y;Fu, J;Ji, W;Li, T; Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids Cell research 2023-07-17 [PMID: 37460804] (Bioassay, Human)
• Fei-Man Hsu, Qiu Ya Wu, Emily B. Fabyanic, Alex Wei, Hao Wu, Amander T. Clark TET1 facilitates specification of early human lineages including germ cells iScience 2023-07-21 [PMID: 37456839] (Bioassay, Human)
• Ahluwalia, K;Martinez-Camarillo, JC;Thomas, BB;Naik, A;Gonzalez-Calle, A;Pollalis, D;Lebkowski, J;Lee, SY;Mitra, D;Louie, SG;Humayun, MS; Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats Cells 2023-06-22 [PMID: 37443724] (Bioassay, Human)
• Yin, J;Ding, F;Cheng, Z;Ge, X;Li, Y;Zeng, A;Zhang, J;Yan, W;Shi, Z;Qian, X;You, Y;Ding, Z;Ji, J;Wang, X; METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/ beta -catenin signaling Cell death & disease 2023-07-12 [PMID: 37438359] (Bioassay, Human)
• Arend W. Overeem, Yolanda W. Chang, Ioannis Moustakas, Celine M. Roelse, Sanne Hillenius, Talia Van Der Helm et al. Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay Cell Reports Methods 2023-06-26 [PMID: 37426764] (Bioassay, Human)
• Huycke, TR;Miyazaki, H;Häkkinen, TJ;Srivastava, V;Barruet, E;McGinnis, CS;Kalantari, A;Cornwall-Scoones, J;Vaka, D;Zhu, Q;Jo, H;DeGrado, WF;Thomson, M;Garikipati, K;Boffelli, D;Klein, OD;Gartner, ZJ; Patterning and folding of intestinal villi by active mesenchymal dewetting bioRxiv : the preprint server for biology 2023-06-26 [PMID: 37425793] (Bioassay, Human)
• Zhang, H;Du, Y;Qi, L;Xiao, S;Braun, FK;Kogiso, M;Huang, Y;Huang, F;Abdallah, A;Suarez, M;Karthick, S;Ahmed, NM;Salsman, VS;Baxter, PA;Su, JM;Brat, DJ;Hellenbeck, PL;Teo, WY;Patel, AJ;Li, XN; Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models Journal of translational medicine 2023-07-06 [PMID: 37415222] (Bioassay, Human)
• Erdem, C;Gross, SM;Heiser, LM;Birtwistle, MR; MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms Nature communications 2023-07-06 [PMID: 37414767] (Bioassay, Human)
• Ankenbauer, KE;Rao, TC;Mattheyses, AL;Bellis, SL; Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics bioRxiv : the preprint server for biology 2023-06-04 [PMID: 37398202] (Bioassay, Human)
• Fan, Y;Gao, Z;Xu, J;Wang, H;Guo, Q;Li, B;Li, M;Xu, H;Qi, Y;Zhao, S;Qiu, W;Pan, Z;Wang, Q;Xue, H;Zhao, R;Guo, X;Li, G; SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of macrophages Theranostics 2023-05-27 [PMID: 37351164] (Bioassay, Human)
• Miyamoto, S;Hirohashi, Y;Morita, R;Miyazaki, A;Ogi, K;Kanaseki, T;Ide, K;Shirakawa, J;Tsukahara, T;Murai, A;Sasaya, T;Koike, K;Kina, S;Kawano, T;Goto, T;Ntege, EH;Shimizu, Y;Torigoe, T; Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy Cancer science 2023-06-21 [PMID: 37344992] (Bioassay, Human)
• Németh, Z;Debreczeni, ML;Kajdácsi, E;Dobó, J;Gál, P;Cervenak, L; Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells International journal of molecular sciences 2023-05-24 [PMID: 37298134] (Bioassay, Human)
• Lucas, CH;Mirchia, K;Seo, K;Najem, H;Chen, W;Zakimi, N;Choudhury, A;Liu, SJ;Phillips, J;Magill, S;Horbinski, C;Solomon, D;Perry, A;Vasudevan, H;Heimberger, A;Raleigh, D; Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution Research square 2023-05-15 [PMID: 37292686] (Bioassay, Human)
• Martínez-Mármol, R;Giordano-Santini, R;Kaulich, E;Cho, AN;Przybyla, M;Riyadh, MA;Robinson, E;Chew, KY;Amor, R;Meunier, FA;Balistreri, G;Short, KR;Ke, YD;Ittner, LM;Hilliard, MA; SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity Science advances 2023-06-09 [PMID: 37285437] (Bioassay, Human)
• Mizuno, K;Ohnishi, H;Yoshimatsu, M;Zhao, C;Hayashi, Y;Kuwata, F;Kaba, S;Okuyama, H;Kawai, Y;Hiwatashi, N;Kishimoto, Y;Sakamoto, T;Ikeya, M;Omori, K; Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells Cell transplantation 2023-06-06 [PMID: 37278405] (Bioassay, Human)
• Gwon, K;Choi, D;de Hoyos-Vega, JM;Baskaran, H;Gonzalez-Suarez, AM;Lee, S;Hong, HJ;Nguyen, KM;Dharmesh, E;Sugahara, G;Ishida, Y;Saito, T;Stybayeva, G;Revzin, A; Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor Bioactive materials 2023-10-01 [PMID: 37266448] (Bioassay, N/A)
• Ito, R;Kimura, A;Hirose, Y;Hatano, Y;Mima, A;Mae, SI;Keidai, Y;Nakamura, T;Fujikura, J;Nishi, Y;Ohta, A;Toyoda, T;Inagaki, N;Osafune, K; Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model Scientific reports 2023-05-29 [PMID: 37248264] (Bioassay, Human)
• Bates, EA;Lovatt, C;Plein, AR;Davies, JA;Siebzehnrubl, FA;Parker, AL; Engineering Adenoviral Vectors with Improved GBM Selectivity Viruses 2023-04-28 [PMID: 37243172] (Bioassay, Human)
• Aracely Castillo-Venzor, Christopher A Penfold, Michael D Morgan, Walfred WC Tang, Toshihiro Kobayashi, Frederick CK Wong et al. Origin and segregation of the human germline Life Science Alliance 2023-08-01 [PMID: 37217306] (Bioassay, Human)
• Farahani, PE;Yang, X;Mesev, EV;Fomby, KA;Brumbaugh-Reed, EH;Bashor, CJ;Nelson, CM;Toettcher, JE; pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells eLife 2023-05-22 [PMID: 37212240] (Bioassay, Mouse, Human)
• Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR; Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung bioRxiv : the preprint server for biology 2023-05-05 [PMID: 37205521] (Bioassay, Human)
• Kuo, C;Choi, S;van Unen, V;Zhang, H;Rustagi, A;Alwahabi, S;Santos, A;Chan, J;Lam, B;Solis, D;Mah, J;R�ltgen, K;Trope, W;Guh-Siesel, A;Lin, Z;Beck, A;Edwards, C;Mallajosyula, V;Martin, B;Dunn, J;Shrager, J;Baric, R;Pinsky, B;Boyd, S;Blish, C;Davis, M; Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection Research square 2023-05-05 [PMID: 37205380] (Bioassay, Human)
• Yamakawa, K;Koyanagi-Aoi, M;Machinaga, A;Kakiuchi, N;Hirano, T;Kodama, Y;Aoi, T; Blockage of retinoic acid signaling via RAR? suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase Cancer cell international 2023-05-17 [PMID: 37198667] (Cell Culture, Human)
• Yuan, H;Wu, X;Wu, Q;Chatoff, A;Megill, E;Gao, J;Huang, T;Duan, T;Yang, K;Jin, C;Yuan, F;Wang, S;Zhao, L;Zinn, PO;Abdullah, KG;Zhao, Y;Snyder, NW;Rich, JN; Lysine catabolism reprograms tumour immunity through histone crotonylation Nature 2023-05-17 [PMID: 37198486] (Bioassay, Human)
• Omar, FA;Brown, TC;Gillanders, WE;Fleming, TP;Smith, MA;Bremner, RM;Sankpal, NV; Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1 PloS one 2023-05-16 [PMID: 37192201] (Bioassay, Human)
• Pedrosa, L;Bedia, C;Diao, D;Mosteiro, A;Ferr�s, A;Stanzani, E;Mart�nez-Soler, F;Tortosa, A;Pineda, E;Aldecoa, I;Centellas, M;Mu�oz-Tudur�, M;Sevilla, A;Sierra, �;Gonz�lez S�nchez, JJ; Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy Cells 2023-04-10 [PMID: 37190034] (Bioassay, Human)
• Maylem, ERS;Spicer, LJ;Batalha, IM;Sch�tz, LF; Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells Domestic animal endocrinology 2023-04-25 [PMID: 37167929] (Bioassay, Bovine)
• Perez-Pepe, M;Desotell, AW;Li, H;Li, W;Han, B;Lin, Q;Klein, DE;Liu, Y;Goodarzi, H;Alarc�n, CR; 7SK methylation by METTL3 promotes transcriptional activity Science advances 2023-05-10 [PMID: 37163588] (Bioassay, Human)
• Huang, X;Zhou, Q; Generation of gastirc insulin-secreting organoids from human stomach sample Research square 2023-04-27 [PMID: 37163124] (Bioassay, Human)
• Zaid Taha, Mathieu J.F. Crupi, Nouf Alluqmani, Faiha Fareez, Kristy Ng, Judy Sobh et al. Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus Frontiers in Immunology 2023-04-19 [PMID: 37153626] (Bioassay, Human)
• Mahr, RM;Jena, S;Nashif, SK;Nelson, AB;Rauckhorst, AJ;Rome, FI;Sheldon, RD;Hughey, CC;Puchalska, P;Gearhart, MD;Taylor, EB;Crawford, PA;Wernimont, SA; Mitochondrial citrate metabolism and efflux regulate BeWo differentiation Scientific reports 2023-05-06 [PMID: 37149697] (Bioassay, Human)
• Katabami, M;Kinoshita, I;Ariga, S;Shimizu, Y;Dosaka-Akita, H; Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners PloS one 2023-05-05 [PMID: 37146018] (Bioassay, Human)
• F Hermans, L Hemeryck, C Bueds, M Torres Per, S Hasevoets, H Kobayashi, D Lambrechts, I Lambrichts, A Bronckaers, H Vankelecom Organoids from mouse molar and incisor as new tools to study tooth-specific biology and development Stem Cell Reports, 2023-04-20;18(5):1166-1181. 2023-04-20 [PMID: 37084723] (Bioassay, Mouse)
• Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz et al. PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice Cellular and Molecular Gastroenterology and Hepatology 2023-04-07 [PMID: 37030630] (Bioassay, Transgenic Mouse)
• SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons Cell Reports, 2023-04-04;42(4):112344. 2023-04-04 [PMID: 37018073] (Bioassay, Human)
• Y Liu, Y Zhang, S Chen, X Zhong, Q Liu Effect of LGR4/EGFR signaling on cell growth and cancer stem cell-like characteristics in liver cancer Cytokine, 2023-03-29;165(0):156185. 2023-03-29 [PMID: 37001327] (Bioassay, In Vivo, Human, Xenograft)
• J Vigna, D Sighel, EF Rosatti, A Defant, M Pancher, V Sidarovich, A Quattrone, I Mancini Expanding the Chemical Space of Arsenicin A-C Related Polyarsenicals and Evaluation of Some Analogs as Inhibitors of Glioblastoma Stem Cell Growth Marine Drugs, 2023-03-17;21(3):. 2023-03-17 [PMID: 36976235] (Bioassay, Human)
• W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis Nature Communications, 2023-03-22;14(1):1578. 2023-03-22 [PMID: 36949068] (Bioassay, Human)
• TT Lemmetyine, EW Viitala, L Wartiovaar, T Kaprio, J Hagström, C Haglund, P Katajisto, TC Wang, E Domènech-M, S Ollila Fibroblast-derived EGF ligand Neuregulin-1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth Disease Models & Mechanisms, 2023-04-03;0(0):. 2023-04-03 [PMID: 36912192] (Bioassay, Mouse)
• M Priedols, G Paidere, CB Santos, A Miscenko, RG Bergmanis, A Spule, B Bekere, G Mozolevski, A Abols, R Rimsa Bifurcated Asymmetric Field Flow Fractionation of Nanoparticles in PDMS-Free Microfluidic Devices for Applications in Label-Free Extracellular Vesicle Separation Polymers, 2023-02-04;15(4):. 2023-02-04 [PMID: 36850073] (Bioassay, Human)
• NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome International Journal of Molecular Sciences, 2023-02-09;24(4):. 2023-02-09 [PMID: 36834891] (Bioassay, Human)
• M Shono, K Kishimoto, O Hikabe, M Hayashi, K Semi, Y Takashima, E Sasaki, K Kato, K Hayashi Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling Scientific Reports, 2023-02-23;13(1):3186. 2023-02-23 [PMID: 36823310] (Bioassay, Human)
• E Domènech-M, A Brandt, TT Lemmetyine, L Wartiovaar, TP Mäkelä, S Ollila Tellu: an object detector algorithm for automatic classification of intestinal organoids Disease Models & Mechanisms, 2023-03-13;0(0):. 2023-03-13 [PMID: 36804687] (Bioassay, Mouse)
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Human)
• MF Wells, J Nemesh, S Ghosh, JM Mitchell, MR Salick, CJ Mello, D Meyer, O Pietilaine, F Piccioni, EJ Guss, K Raghunatha, M Tegtmeyer, D Hawes, A Neumann, KA Worringer, D Ho, S Kommineni, K Chan, BK Peterson, JJ Raymond, JT Gold, MT Siekmann, E Zuccaro, R Nehme, A Kaykas, K Eggan, SA McCarroll Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages Cell Stem Cell, 2023-02-15;0(0):. 2023-02-15 [PMID: 36796362] (Bioassay, Human)
• L Pang, M Dunterman, W Xuan, A Gonzalez, Y Lin, WH Hsu, F Khan, RS Hagan, WA Muller, AB Heimberger, P Chen Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma Cell Reports, 2023-02-14;42(2):112127. 2023-02-14 [PMID: 36795563] (Bioassay, Human)
• RC Gimple, G Zhang, S Wang, T Huang, J Lee, S Taori, D Lv, D Dixit, ME Halbert, AR Morton, RL Kidwell, Z Dong, BC Prager, L Kim, Z Qiu, L Zhao, Q Xie, Q Wu, S Agnihotri, JN Rich Sorting-nexin-10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting JCI Insight, 2023-03-22;0(0):. 2023-03-22 [PMID: 36795488] (Bioassay, Human)
• AH Ghobashi, TT Vuong, JW Kimani, HM O'Hagan Activation of AKT induces EZH2-mediated beta-catenin trimethylation in colorectal cancer bioRxiv : the preprint server for biology, 2023-02-04;0(0):. 2023-02-04 [PMID: 36778289] (Bioassay, Human)
• RH Purcell, E Sefik, E Werner, AT King, TJ Mosley, ME Merritt-Ga, P Chopra, ZT McEachin, S Karne, N Raj, K Tilahun, M Robinette, ST Warren, Z Wen, V Faundez, SA Sloan, GJ Bassell, JG Mulle Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion bioRxiv : the preprint server for biology, 2023-05-26;0(0):. 2023-05-26 [PMID: 36747819] (Bioassay, Human)
• J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, V Jorgji, P Sindurakar, J Braverman, A Mehta, T Oka, M Huang, D Lieb, M Spurrell, JN Allen, TA Abrams, JW Clark, AC Enzinger, PC Enzinger, SJ Klempner, NJ McCleary, JA Meyerhardt, DP Ryan, MB Yurgelun, K Kanter, EE Van Sevent, I Baiev, G Chi, J Jarnagin, WB Bradford, E Wong, AG Michel, IJ Fetter, G Siravegna, AJ Gemma, A Sharpe, S Demehri, R Leary, CD Campbell, O Yilmaz, GA Getz, AR Parikh, N Hacohen, RB Corcoran Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Nature Medicine, 2023-01-26;0(0):. 2023-01-26 [PMID: 36702949] (Bioassay, Human)
• P Kakni, B Jutten, D Teixeira O, J Penders, R Truckenmül, P Habibovic, S Giselbrech Hypoxia-tolerant apical-out intestinal organoids to model host-microbiome interactions Journal of tissue engineering, 2023-01-18;14(0):2041731422114. 2023-01-18 [PMID: 36699634] (Bioassay, Human)
• M Zhao, Y Li, C Lu, F Ding, M Xu, X Ge, M Li, Z Wang, J Yin, J Zhang, X Wang, Z Ge, H Xiao, Y Xiao, H Liu, W Liu, Y Cao, Q Wang, Y You, X Wang, K Yang, Z Shi, X Qian PGC-1alpha degradation suppresses mitochondrial biogenesis to confer radiation resistance in glioma Cancer Research, 2023-04-04;0(0):. 2023-04-04 [PMID: 36696363] (Bioassay, Human)
• V Zayat, Z Kuczynska, M Liput, E Metin, S Rzonca-Nie, M Smyk, T Mazurczak, A Goszczansk, P Leszczynsk, D Hoffman-Za, L Buzanska The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model Cells, 2023-01-16;12(2):. 2023-01-16 [PMID: 36672274] (Bioassay, Human)
• T Fujimori, Y Shibayama, T Kanda, K Suzuki, D Ogawa, R Ishikawa, K Kadota, T Matsunaga, T Tamiya, A Nishiyama, K Miyake Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis Scientific Reports, 2023-01-16;13(1):808. 2023-01-16 [PMID: 36646875] (Cell Culture, Human)
• J Sun, S Osenberg, A Irwin, LH Ma, N Lee, Y Xiang, F Li, YW Wan, IH Park, M Maletic-Sa, N Ballas Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation Cell Reports, 2023-01-05;42(1):111942. 2023-01-05 [PMID: 36640327] (Bioassay, Human)
• Y Sun, OY Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, EJ Robitschek, TGR Davis, S Kim, A Fu, X Ma, J Gwee, P Tiwari, PP Du, P Sindurakar, J Tian, A Mehta, AM Schneider, K Yizhak, M Sade-Feldm, T LaSalle, T Sharova, H Xie, S Liu, WA Michaud, R Saad-Beret, KB Yates, A Iracheta-V, JKE Spetz, X Qin, KA Sarosiek, G Zhang, JW Kim, MY Su, AM Cicerchia, MQ Rasmussen, SJ Klempner, D Juric, SI Pai, DM Miller, A Giobbie-Hu, JH Chen, K Pelka, DT Frederick, S Stinson, E Ivanova, AR Aref, CP Paweletz, DA Barbie, DR Sen, DE Fisher, RB Corcoran, N Hacohen, PK Sorger, KT Flaherty, GM Boland, RT Manguso, RW Jenkins Targeting TBK1 to overcome resistance to cancer immunotherapy Nature, 2023-01-12;0(0):. 2023-01-12 [PMID: 36634707] (Bioassay, Human)
• L Liu, S Han, X Xiao, X An, J Gladkich, U Hinz, S Hillmer, T Hoppe-Tich, Y Xu, M Schaefer, O Strobel, I Herr Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy Cell Death & Disease, 2022-12-19;13(12):1052. 2022-12-19 [PMID: 36535942] (Bioassay, Human)
• E Cuevas, A Guzman, SM Burks, A Ramirez-Le, SF Ali, SZ Imam Autophagy and protein aggregation as a mechanism of dopaminergic degeneration in a primary human dopaminergic neuronal model Toxicology reports, 2022-04-01;9(0):806-813. 2022-04-01 [PMID: 36518412] (Bioassay, Human)
• TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity Cells, 2022-11-30;11(23):. 2022-11-30 [PMID: 36497105] (Differentiation, Differentiation, Human)
• D Sighel, G Battistini, EF Rosatti, J Vigna, M Pavan, R Belli, D Peroni, F Alessandri, S Longhi, M Pancher, J Rorbach, S Moro, A Quattrone, I Mancini Streptogramin A derivatives as mitochondrial translation inhibitors to suppress glioblastoma stem cell growth European Journal of Medicinal Chemistry, 2022-11-30;246(0):114979. 2022-11-30 [PMID: 36495628] (Bioassay, Human)
• C Degorre, IC Sutton, SL Lehman, UT Shankavara, K Camphausen, PJ Tofilon Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb Cancer Cell International, 2022-12-08;22(1):389. 2022-12-08 [PMID: 36482431] (Cell Culture, Human)
• JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)
• RE Thompson, MA Meyers, C Premananda, FK Hollinshea Generation and cryopreservation of feline oviductal organoids Theriogenology, 2022-11-17;196(0):167-173. 2022-11-17 [PMID: 36423511] (Bioassay, Feline)
• EJ Kim, JY Kim, SO Kim, N Hong, SH Choi, MG Park, J Jang, SW Ham, S Seo, SY Lee, K Lee, HJ Jeong, SJ Kim, S Jeong, K Min, SC Kim, X Jin, SH Kim, SH Kim, H Kim The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2 Cell Reports, 2022-11-22;41(8):111626. 2022-11-22 [PMID: 36417870] (Bioassay, Human, Transgenic Mouse)
• HJ Kim, SS Suh, J Park, MJ Shin, MH Koo, SJ Lee, YJ Jeon, S Lee, UJ Youn, SH Kim 7beta-22 Dihydroxyhopane, Isolated from the Sub-Antarctic Lichen, Inhibits the Viability and Stemness in Glioma Stem Like Cells OncoTargets and Therapy, 2022-11-15;15(0):1375-1383. 2022-11-15 [PMID: 36411942] (Bioassay, Human)
• HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling Journal of Biomedical Science, 2022-11-21;29(1):99. 2022-11-21 [PMID: 36411463] (Bioassay, Human)
• Rodrigo M. Florentino, Kazutoyo Morita, Nils Haep, Takashi Motomura, Ricardo Diaz-Aragon, Lanuza A.P. Faccioli et al. Biofabrication of synthetic human liver tissue with advanced programmable functions iScience 2022-12-22 [PMID: 36404924] (Bioassay, Human)
• R Qureshi, M Picon-Ruiz, M Sho, D Van Booven, V Nunes de P, AB Diaz-Ruano, TA Ince, J Slingerlan Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis Cell Reports, 2022-11-15;41(7):111672. 2022-11-15 [PMID: 36384125]
• K Madden-Hen, D Gupta, AA Radecki, C Guild, A Rath, CD Heinen Loss of mismatch repair promotes a direct selective advantage in human stem cells Stem Cell Reports, 2022-11-10;0(0):. 2022-11-10 [PMID: 36368329] (Bioassay, Human)
• W Otsu, T Yako, E Sugisawa, S Nakamura, H Tsusaki, N Umigai, M Shimazawa, H Hara Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells Journal of pharmacological sciences, 2022-10-14;150(4):279-288. 2022-10-14 [PMID: 36344051] (Bioassay, Human)
• M Ishibane, H Hashimoto, M Kaneko, S Saito, S Pae, S Saito, Y Reien, Y Hirayama, N Higashi-Ku, H Mitsuya, N Anzai Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters Journal of pharmacological sciences, 2022-09-16;150(4):201-203. 2022-09-16 [PMID: 36344041] (Bioassay, Transgenic Mouse)
• Z Li, F Fang, Y Long, Q Zhao, X Wang, Z Ye, T Meng, X Gu, W Xiang, C Xiong, H Li The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate Cell & bioscience, 2022-11-04;12(1):181. 2022-11-04 [PMID: 36333732] (Bioassay, Human)
• AN Cho, F Bright, N Morey, C Au, LM Ittner, YD Ke Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus Cells, 2022-10-11;11(20):. 2022-10-11 [PMID: 36291062] (Bioassay, Human)
• Z Tu, Y Hu, D Raizada, MA Bassal, DG Tenen, AE Karnoub Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in�triple-negative breast cancer Proceedings of the National Academy of Sciences of the United States of America, 2022-10-21;119(43):e2203180119. 2022-10-21 [PMID: 36269860] (Bioassay, Human)
• W He, X Zhu, A Xin, H Zhang, Y Sun, H Xu, H Li, T Yang, D Zhou, H Yan, X Sun Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion Cell & bioscience, 2022-10-18;12(1):175. 2022-10-18 [PMID: 36258228] (Bioassay, Human)
• O Revah, F Gore, KW Kelley, J Andersen, N Sakai, X Chen, MY Li, F Birey, X Yang, NL Saw, SW Baker, ND Amin, S Kulkarni, R Mudipalli, B Cui, S Nishino, GA Grant, JK Knowles, M Shamloo, JR Huguenard, K Deisseroth, SP Pa?ca Maturation and circuit integration of transplanted human cortical organoids Nature, 2022-10-12;610(7931):319-326. 2022-10-12 [PMID: 36224417] (Bioassay, Human)
• DS Lee, YJ Song, HR Gug, JH Lee, HS Bae, JC Park Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells Stem Cells International, 2022-09-27;2022(0):1092184. 2022-09-27 [PMID: 36213683] (Cell Culture, Mouse)
• H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)
• A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Nature Cell Biology, 2022-10-06;0(0):. 2022-10-06 [PMID: 36202974] (Bioassay, Human)
• PC Kinnunen, GD Luker, KE Luker, JJ Linderman Computational modeling implicates protein scaffolding in p38 regulation of Akt Journal of theoretical biology, 2022-10-01;555(0):111294. 2022-10-01 [PMID: 36195198] (Bioassay, Human)
• H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E Antibody targeting of E3 ubiquitin ligases for receptor degradation Nature, 2022-09-21;610(7930):182-189. 2022-09-21 [PMID: 36131013] (Bioassay, Human)
• G Le-Bel, P Desjardins, C Gross, S Cortez Ghi, C Couture, L Germain, SL Guérin Influence of the Postmortem/Storage Time of Human Corneas on the Properties of Cultured Limbal Epithelial Cells Cells, 2022-08-31;11(17):. 2022-08-31 [PMID: 36078126] (Bioassay, Human)
• GM Jowett, E Read, LB Roberts, D Coman, M Vilà Gonzá, T Zabinski, U Niazi, R Reis, TJ Trieu, D Danovi, E Gentleman, L Vallier, MA Curtis, GM Lord, JF Neves Organoids capture tissue-specific innate lymphoid cell development in mice and humans Cell Reports, 2022-08-30;40(9):111281. 2022-08-30 [PMID: 36044863] (Bioassay, Mouse)
• I Jun, YJ Choi, BR Kim, KY Seo, TI Kim Activation of ADRB2/PKA Signaling Pathway Facilitates Lipid Synthesis in Meibocytes, and Beta-Blocker Glaucoma Drug Impedes PKA-Induced Lipid Synthesis by Inhibiting ADRB2 International Journal of Molecular Sciences, 2022-08-22;23(16):. 2022-08-22 [PMID: 36012741] (Cell Culture, Human)
• Y Hattori, K Kurozumi, Y Otani, A Uneda, N Tsuboi, K Makino, S Hirano, K Fujii, Y Tomita, T Oka, Y Matsumoto, Y Shimazu, H Michiue, H Kumon, I Date Combination of Ad-SGE-REIC and bevacizumab modulates glioma progression by suppressing tumor invasion and angiogenesis PLoS ONE, 2022-08-25;17(8):e0273242. 2022-08-25 [PMID: 36006934] (Bioassay, Human)
• Shibnath Ghatak, Vincent C. Hascall, Nikos Karamanos, Roger R. Markwald, Suniti Misra Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance Frontiers in Oncology 2022-08-02 [PMID: 35982950] (Flow Cytometry, Human)
• EJ Sohn Differentially expression and function of circular RNAs in ovarian cancer stem cells Journal of ovarian research, 2022-08-17;15(1):97. 2022-08-17 [PMID: 35978436] (Cell Culture, Human)
• M Grouls, AWF Janssen, LPM Duivenvoor, GJEJ Hooiveld, H Bouwmeeste, M van der Za Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate Scientific Reports, 2022-08-17;12(1):13988. 2022-08-17 [PMID: 35977967] (Bioassay, Human)
• D Hao, L Lu, H Song, Y Duan, J Chen, R Carney, JJ Li, P Zhou, J Nolta, KS Lam, JK Leach, DL Farmer, A Panitch, A Wang Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair Theranostics, 2022-08-08;12(13):6021-6037. 2022-08-08 [PMID: 35966577] (Cell Culture, Human)
• S Fan, K Boerner, CK Muraleedha, A Nusrat, M Quiros, CA Parkos Epithelial JAM-A is fundamental for intestinal wound repair in-vivo JCI Insight, 2022-09-08;0(0):. 2022-09-08 [PMID: 35943805] (Bioassay, Mouse)
• S Jeising, G Geerling, R Guthoff, D Hänggi, M Sabel, M Rapp, AC Nickel In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma Photodiagnosis and photodynamic therapy, 2022-08-04;0(0):103049. 2022-08-04 [PMID: 35932958] (Bioassay, Human)
• K Wang, Z Li, Y Li, X Liu, Y Sun, J Hong, Y Ding, W Zheng, L Qian, D Xu Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy Mechanisms of Ageing and Development, 2022-08-03;207(0):111714. 2022-08-03 [PMID: 35931242] (In Vivo, Mouse)
• Y Wang, H Shu, J Liu, X Jin, L Wang, Y Qu, M Xia, P Peng, Y Feng, M Wei EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association The Journal of Biological Chemistry, 2022-08-03;0(0):102340. 2022-08-03 [PMID: 35931120] (Bioassay, Human)
• CC Dibble, SA Barritt, GE Perry, EC Lien, RC Geck, SE DuBois-Coy, D Bartee, TT Zengeya, EB Cohen, M Yuan, BD Hopkins, JL Meier, JG Clohessy, JM Asara, LC Cantley, A Toker PI3K drives the de novo synthesis of coenzyme A from vitamin B5 Nature, 2022-07-27;608(7921):192-198. 2022-07-27 [PMID: 35896750] (Bioassay, Human)
• T Tabata, M Petitt, J Li, X Chi, W Chen, I Yurgelonis, S Wellnitz, S Bredl, T Vicente, X Yang, PR Dormitzer, L Pereira Neutralizing Antibodies to Human Cytomegalovirus Recombinant Proteins Reduce Infection in an Ex Vivo Model of Developing Human Placentas Vaccines, 2022-07-04;10(7):. 2022-07-04 [PMID: 35891239] (Bioassay, Human)
• D Sardar, HC Chen, A Reyes, S Varadharaj, A Jain, C Mohila, R Curry, B Lozzi, K Rajendran, A Cervantes, K Yu, A Jalali, G Rao, SC Mack, B Deneen Sox9 directs divergent epigenomic states in brain tumor subtypes Oncogene, 2022-07-15;119(29):e2202015119. 2022-07-15 [PMID: 35858326] (Bioassay, Mouse)
• M Cecchi, A Mannini, A Lapucci, A Silvano, M Lulli, C Luceri, M D'Ambrosio, A Chiarugi, AH Eid, A Parenti Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase Frontiers in Pharmacology, 2022-06-30;13(0):911019. 2022-06-30 [PMID: 35847038] (Bioassay, Human)
• D Li, Q Zhang, L Li, K Chen, J Yang, D Dixit, RC Gimple, S Ci, C Lu, L Hu, J Gao, D Shan, Y Li, J Zhang, ZM Shi, D Gu, W Yuan, Q Wu, K Yang, L Zhao, Z Qiu, D Lv, W Gao, H Yang, F Lin, Q Wang, J Man, C Li, W Tao, S Agnihotri, X Qian, Y Shi, Y You, N Zhang, JN Rich, X Wang beta2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages Oncogene, 2022-09-16;0(0):. 2022-09-16 [PMID: 35841593] (Bioassay, Human)
• R Moser, J Annis, O Nikolova, CJ Whatcott, KE Gurley, E Mendez, K Moran-Jone, C Dorrell, RC Sears, CJ Kuo, H Han, AV Biankin, C Grandori, DD Von Hoff, CJ Kemp Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL Cancer Research, 2022-09-16;0(0):. 2022-09-16 [PMID: 35819261] (Bioassay, Human)
• CG Park, SH Choi, SY Lee, K Eun, MG Park, J Jang, HJ Jeong, SJ Kim, S Jeong, K Lee, H Kim Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells Cells, 2022-06-26;11(13):. 2022-06-26 [PMID: 35805116] (Bioassay, Human)
• JI Takahashi, S Nakamura, I Onuma, Y Zhou, S Yokoyama, H Sakurai Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis Scientific Reports, 2022-07-07;12(1):11561. 2022-07-07 [PMID: 35798841] (Bioassay, Human)
• HY Chen, SJ Chan, X Liu, AC Wei, RI Jian, KW Huang, YD Lang, JH Shih, CC Liao, CL Luan, YT Kao, SY Chiang, PW Hsiao, YS Jou, Y Chen, RH Chen Long noncoding RNA Smyca coactivates TGF-beta/Smad and Myc pathways to drive tumor progression Journal of hematology & oncology, 2022-07-06;15(1):85. 2022-07-06 [PMID: 35794621] (Bioassay, Human)
• D Guo, J Xiao, J Liang, J Fan, P Hou, X Li, H Zhang, K Li, L Bu, P Li, M He, Y Zhong, L Guo, P Jia, Q Xiao, J Wu, H Peng, C Li, F Xing CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T cell activation in refractory glioblastoma Cancer Research, 2022-09-16;0(0):. 2022-09-16 [PMID: 35792620] (Bioassay, Human)
• V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)
• Marie O. Pohl, Laura Martin-Sancho, Ranjala Ratnayake, Kris M. White, Laura Riva, Qi-Yin Chen et al. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity ACS Infectious Diseases 2022-07-08 [PMID: 35766385] (Bioassay, Human)
• EJ Sohn PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis BMC Cancer, 2022-06-27;22(1):708. 2022-06-27 [PMID: 35761259] (Bioassay, Human)
• M Ratliff, H Kim, H Qi, M Kim, B Ku, DD Azorin, D Hausmann, RK Khajuria, A Patel, E Maier, L Cousin, A Ogier, F Sahm, N Etminan, L Bunse, F Winkler, V El-Khoury, M Platten, YJ Kwon Patient-Derived Tumor Organoids for Guidance of Personalized Drug Therapies in Recurrent Glioblastoma International Journal of Molecular Sciences, 2022-06-12;23(12):. 2022-06-12 [PMID: 35743016] (Bioassay, Human)
• MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor Biomolecules, 2022-06-18;12(6):. 2022-06-18 [PMID: 35740973] (Bioassay, Human)
• RE Thompson, MA Meyers, DNR Veeramacha, BS Pukazhenth, FK Hollinshea Equine Oviductal Organoid Generation and Cryopreservation Methods and protocols, 2022-06-15;5(3):. 2022-06-15 [PMID: 35736552] (Bioassay, Equine)
• Y Chen, J Mei, P Zhang, J Liu, L Chen, L Wu, Y Zhang IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation Oncogene, 2022-05-31;108(0):108897. 2022-05-31 [PMID: 35729832] (Bioassay, Human)
• U Mala, TK Baral, K Somasundar Integrative analysis of cell adhesion molecules in glioblastoma identified prostaglandin F2 receptor inhibitor (PTGFRN) as an essential gene BMC Cancer, 2022-06-11;22(1):642. 2022-06-11 [PMID: 35690717] (Bioassay, Human)
• M Wang, W Li, J Hao, A Gonzales, Z Zhao, RS Flores, X Kuang, X Mu, T Ching, G Tang, Z Luo, CE Garciamend, JK Sahoo, MF Wells, G Niu, P Agrawal, A Quiñones-H, K Eggan, YS Zhang Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues Nature Communications, 2022-06-09;13(1):3317. 2022-06-09 [PMID: 35680907] (Bioassay, Human)
• M Vicioso-Ma, R Fueyo, C Navarro, S Cruz-Molin, WFJ van Ijcken, E Rebollo, Á Rada-Igles, MA Martínez-B JMJD3 intrinsically disordered region links the 3D-genome structure to TGFbeta-dependent transcription activation Nature Communications, 2022-06-07;13(1):3263. 2022-06-07 [PMID: 35672304] (Bioassay, Mouse)
• AK Nair, M Traurig, JR Sutherland, YL Muller, ED Grellinger, L Saporito, RG Nelson, C Bogardus, LJ Baier Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians Cells, 2022-04-25;11(9):. 2022-04-25 [PMID: 35563754] (Bioassay, Human)
• V Semkova, S Haupt, M Segschneid, C Bell, M Ingelman-S, M Hajo, B Weykopf, P Muthukotti, A Till, O Brüstle Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation Cells, 2022-04-20;11(9):. 2022-04-20 [PMID: 35563695] (Bioassay, Human)
• K Li, X Sun, R Zha, S Liu, Y Feng, T Sano, UK Aryal, A Sudo, BY Li, H Yokota Counterintuitive production of tumor-suppressive secretomes from Oct4- and c-Myc-overexpressing tumor cells and MSCs Theranostics, 2022-03-28;12(7):3084-3103. 2022-03-28 [PMID: 35547745] (Bioassay, Mouse)
• H Sun, J Zheng, J Xiao, J Yue, Z Shi, Z Xuan, C Chen, Y Zhao, W Tang, S Ye, J Li, Q Deng, L Zhang, F Zhu, C Shao TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC Cell Death & Disease, 2022-05-11;13(5):450. 2022-05-11 [PMID: 35546143] (Bioassay, Human)
• EQX Mulcahy, Y Zhang, RR Col?n, SR Cain, MK Gibert, CJ Dube, M Hafner, R Abounader MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53 International Journal of Molecular Sciences, 2022-04-01;23(7):. 2022-04-01 [PMID: 35409289] (Bioassay, Human)
• D Bernareggi, Q Xie, BC Prager, J Yun, LS Cruz, TV Pham, W Kim, X Lee, M Coffey, C Zalfa, P Azmoon, H Zhu, P Tamayo, JN Rich, DS Kaufman CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity Nature Communications, 2022-04-07;13(1):1899. 2022-04-07 [PMID: 35393416] (Bioassay, Human)
• H Han, Y Wang, J Curto, S Gurrapu, S Laudato, A Rumandla, G Chakrabort, X Wang, H Chen, Y Jiang, D Kumar, EG Caggiano, M Capogiri, B Zhang, Y Ji, SN Maity, M Hu, S Bai, AM Aparicio, E Efstathiou, CJ Logothetis, N Navin, NM Navone, Y Chen, FG Giancotti Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis Cell Reports, 2022-04-05;39(1):110595. 2022-04-05 [PMID: 35385726] (Bioassay, Human)
• Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)
• S Kim, S Min, YS Choi, SH Jo, JH Jung, K Han, J Kim, S An, YW Ji, YG Kim, SW Cho Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids Nature Communications, 2022-03-30;13(1):1692. 2022-03-30 [PMID: 35354790] (Bioassay, Human)
• R Suenaga, S Konagaya, J Yamaura, R Ito, S Tanaka, Y Ishizaki, T Toyoda Microwell bag culture for large-scale production of homogeneous islet-like clusters Scientific Reports, 2022-03-25;12(1):5221. 2022-03-25 [PMID: 35338209] (Bioassay, Human)
• V De Re, L Alessandri, G Brisotto, L Caggiari, M De Zorzi, M Casarotto, G Miolo, F Puglisi, SK Garattini, S Lonardi, R Cannizzaro, V Canzonieri, M Fassan, A Steffan HER2-CDH1 Interaction via Wnt/B-Catenin Is Associated with Patients&#039; Survival in HER2-Positive Metastatic Gastric Adenocarcinoma Cancers, 2022-02-28;14(5):. 2022-02-28 [PMID: 35267574] (Cell Culture, Human)
• K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 2022-03-03;0(0):. 2022-03-03 [PMID: 35245440] (Bioassay, Human)
• K Pang, J Lee, J Kim, J Park, Y Park, E Hong, H An, A Ooshima, M Son, KS Park, JH Cho, C Lee, YS Song, KM Yang, SJ Kim Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells Cell Death & Disease, 2022-02-22;13(2):169. 2022-02-22 [PMID: 35194034] (Bioassay, Human)
• MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-02-15;38(7):110379. 2022-02-15 [PMID: 35172130] (Bioassay, Human)
• D Liu, G Rychkov, P Hurtado, HY Luo, T Zhang, L Bobrovskay, XF Zhou Conversion of Human Fibroblasts into Induced Neural Stem Cells by Small Molecules International Journal of Molecular Sciences, 2022-02-03;23(3):. 2022-02-03 [PMID: 35163660] (Cell Culture, Human, Mouse)
• SY Zhao, Z Wang, XB Wu, S Zhang, Q Chen, DD Wang, QF Tan CERS6-AS1 contributes to the malignant phenotypes of colorectal cancer cells by interacting with miR-15b-5p to regulate SPTBN2 The Kaohsiung journal of medical sciences, 2022-02-11;0(0):. 2022-02-11 [PMID: 35146902] (Bioassay, Human)
• C Hu, CA Leche, A Kiyatkin, Z Yu, SE Stayrook, KM Ferguson, MA Lemmon Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias Nature, 2022-02-09;602(7897):518-522. 2022-02-09 [PMID: 35140400] (Bioassay, Human)
• DA Eagles, NJ Saez, B Krishnarju, JJ Bradford, YK Chin, H Starobova, A Mueller, ME Reichelt, EAB Undheim, RS Norton, WG Thomas, I Vetter, GF King, SD Robinson A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals Proceedings of the National Academy of Sciences of the United States of America, 2022-02-15;119(7):. 2022-02-15 [PMID: 35131940] (Bioassay, Human)
• C Fu, A Arora, W Engl, M Sheetz, V Viasnoff Cooperative regulation of adherens junction expansion through Epidermal Growth Factor Receptor (EGFR) activation Journal of Cell Science, 2022-02-22;0(0):. 2022-02-22 [PMID: 35099018] (Bioassay, Mouse)
• A Hunziker, I Glas, MO Pohl, S Stertz Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation Cell Reports, 2022-01-25;38(4):110306. 2022-01-25 [PMID: 35081340] (Bioassay, Human)
• L Yu, M Toriseva, S Afshan, M Cangiano, V Fey, A Erickson, H Seikkula, K Alanen, P Taimen, O Ettala, M Nurmi, PJ Boström, M Kallajoki, J Tuomela, T Mirtti, IJ Beumer, M Nees, P Härkönen Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression Cancers, 2022-01-07;14(2):. 2022-01-07 [PMID: 35053442] (Bioassay, Human)
• Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang, S Zhao, H Xu, M Li, Z Gao, Y Fan, J Xu, H Wang, S Wang, J Qiu, Q Wang, X Guo, L Deng, P Zhang, H Xue, G Li EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3 Molecular Cancer, 2022-01-14;21(1):16. 2022-01-14 [PMID: 35031058] (Bioassay, Human)
• SH Gao, GZ Wang, LP Wang, L Feng, YC Zhou, XJ Yu, F Liang, FY Yang, Z Wang, BB Sun, D Wang, LJ Liang, DW Xie, S Zhao, HP Feng, X Li, KK Li, TS Tang, YC Huang, SQ Wang, GB Zhou Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer Cell Calcium, 2022-01-06;102(0):102527. 2022-01-06 [PMID: 35026540] (Bioassay, Human)
• Y Miura, MY Li, O Revah, SJ Yoon, G Narazaki, SP Pa?ca Engineering brain assembloids to interrogate human neural circuits Nature Protocols, 2022-01-06;17(1):15-35. 2022-01-06 [PMID: 34992269] (Bioassay, Human)
• PE Farahani, SB Lemke, E Dine, G Uribe, JE Toettcher, CM Nelson Substratum stiffness regulates Erk signaling dynamics through receptor-level control Cell Reports, 2021-12-28;37(13):110181. 2021-12-28 [PMID: 34965432] (Bioassay, Human)
• N Jalali Mot, C Wang, EG Kuellenber, GR Wojtkiewic, S Schmidt, JW Chen D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity Cancers, 2021-12-18;13(24):. 2021-12-18 [PMID: 34944979] (Bioassay, Human)
• K Dokladny, JK Crane, AJ Kassicieh, JB Kaper, O Kovbasnjuk Cross-Talk between Probiotic Nissle 1917 and Human Colonic Epithelium Affects the Metabolite Composition and Demonstrates Host Antibacterial Effect Metabolites, 2021-12-05;11(12):. 2021-12-05 [PMID: 34940599] (Bioassay, Human)
• V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 2021-12-14;37(11):110068. 2021-12-14 [PMID: 34910915] (Bioassay, Human)
• S Siddharth, S Parida, N Muniraj, S Hercules, D Lim, A Nagalingam, C Wang, B Gyorffy, JM Daniel, D Sharma Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression Elife, 2021-12-10;10(0):. 2021-12-10 [PMID: 34889737] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)
• KX Li, X Sun, BY Li, H Yokota Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells Cancers, 2021-11-09;13(22):. 2021-11-09 [PMID: 34830748] (Bioassay, Human)
• Y Gu, Y Chen, L Wei, S Wu, K Shen, C Liu, Y Dong, Y Zhao, Y Zhang, C Zhang, W Zheng, J He, Y Wang, Y Li, X Zhao, H Wang, J Tan, L Wang, Q Zhou, G Xie, H Liang, J Ou ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation Nature Communications, 2021-11-18;12(1):6711. 2021-11-18 [PMID: 34795238] (Bioassay, Human)
• RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors Nature Communications, 2021-11-17;12(1):6636. 2021-11-17 [PMID: 34789735] (Bioassay, Human)
• RR Madsen, EC Erickson, OM Rueda, X Robin, C Caldas, A Toker, RK Semple, B Vanhaesebr Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype PloS Genetics, 2021-11-11;17(11):e1009876. 2021-11-11 [PMID: 34762647] (Bioassay, Human)
• T Gebregiwor, Y Kano, J St-Germain, N Radulovich, ML Udaskin, A Mentes, R Huang, BPK Poon, W He, I Valencia-S, CM Robinson, M Huestis, J Miao, JJ Yeh, ZY Zhang, MS Irwin, JE Lee, MS Tsao, B Raught, CB Marshall, M Ohh, M Ikura The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors Nature Communications, 2021-11-01;12(1):6274. 2021-11-01 [PMID: 34725361] (Bioassay, Human)
• A De Zutter, H Crijns, N Berghmans, M García-Cab, L Vanbrabant, N Pörtner, V Vanheule, P Verscheure, MM Siddiquei, AM Abu El-Asr, P Carmeliet, P Van Wielen, I De Meester, J Van Damme, P Proost, S Struyf The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors Cancers, 2021-10-12;13(20):. 2021-10-12 [PMID: 34680238] (Cell Culture, Human)
• X Morales, R Peláez, S Garasa, C Ortiz de S, A Rouzaut CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration Biomolecules, 2021-10-18;11(10):. 2021-10-18 [PMID: 34680167] (Bioassay, Human)
• T Kobayashi, A Castillo-V, CA Penfold, M Morgan, N Mizuno, WWC Tang, Y Osada, M Hirao, F Yoshida, H Sato, H Nakauchi, M Hirabayash, MA Surani Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells Cell Reports, 2021-10-12;37(2):109812. 2021-10-12 [PMID: 34644585] (Bioassay, Rabbit)
• G Belthier, Z Homayed, F Grillet, C Duperray, J Vendrell, I Krol, S Bravo, JC Boyer, O Villeronce, J Vitre-Boub, D Heaug-Wane, F Macari-Fin, J Smith, M Merlot, G Lossaint, T Mazard, F Portales, J Solassol, M Ychou, N Aceto, E Mamessier, F Bertucci, JM Pascussi, E Samalin, F Hollande, J Pannequin CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM Cancers, 2021-10-02;13(19):. 2021-10-02 [PMID: 34638450] (Cell Culture, Human)
• M Niu, J Xu, Y Liu, Y Li, T He, L Ding, Y He, Y Yi, F Li, R Guo, Y Gao, R Li, L Li, M Fu, Q Hu, Y Luo, C Zhang, K Qin, J Yi, S Yu, J Yang, H Chen, L Wang, Z Li, B Dong, S Qi, L Ouyang, Y Zhang, Y Cao, ZJ Xiao FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth Nature Communications, 2021-10-11;12(1):5919. 2021-10-11 [PMID: 34635651] (Cell Culture, Human)
• T Arad, N Fainstein, S Goldfarb, M Lachish, T Ganz, T Ben-Hur CD200 -dependent and -independent immune-modulatory functions of neural stem cells Stem Cell Research, 2021-10-07;56(0):102559. 2021-10-07 [PMID: 34634761] (Cell Culture, Mouse)
• Kim Y, Kim H, Jung D, Kang D, Nam D, Nam H, Cho H Glioblastoma patient-derived cell-based phenotypic drug screening and identification of possible action mechanisms through proteomic analysis. STAR Protoc, 2021-09-24;2(4):100849. 2021-09-24 [PMID: 34611628] (Bioassay, Human)
• A Tarallo, C Damiano, S Strollo, N Minopoli, A Indrieri, E Polishchuk, F Zappa, E Nusco, S Fecarotta, C Porto, M Coletta, R Iacono, M Moracci, R Polishchuk, DL Medina, P Imbimbo, DM Monti, MA De Matteis, G Parenti Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease Embo Molecular Medicine, 2021-10-04;0(0):e14434. 2021-10-04 [PMID: 34606154] (Bioassay, Human)
• X Dolde, C Karreman, M Wiechers, S Schildknec, M Leist Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays International Journal of Molecular Sciences, 2021-09-18;22(18):. 2021-09-18 [PMID: 34576243] (Bioassay, Human)
• X Feng, A Cao, T Qin, Q Zhang, S Fan, B Wang, B Song, X Yu, L Li Abnormally elevated ubiquilin?1 expression in breast cancer regulates metastasis and stemness via AKT signaling Oncology reports, 2021-09-16;46(5):. 2021-09-16 [PMID: 34528694] (Bioassay, Human)
• Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)
• T Miyake, M Kuge, Y Matsumoto, M Shimada alpha-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells Stem Cell Research, 2021-08-20;56(0):102511. 2021-08-20 [PMID: 34455240] (Bioassay, Human)
• AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (Bioassay, Human)
• C Lin, Å Ekblad-Nor, J Michaëlsso, C Götherströ, CC Hsu, H Ye, J Johansson, A Rising, E Sundström, E Åkesson In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair Cells, 2021-07-06;10(7):. 2021-07-06 [PMID: 34359882] (Bioassay, Human)
• A Ulman, M Kot, K Skrzypek, B Szewczyk, M Majka Myogenic Differentiation of iPS Cells Shows Different Efficiency in Simultaneous Comparison of Protocols Cells, 2021-07-02;10(7):. 2021-07-02 [PMID: 34359837] (Bioassay, Human)
• BM Larsen, M Kannan, LF Langer, BD Leibowitz, A Bentaieb, A Cancino, I Dolgalev, BE Drummond, JR Dry, CS Ho, G Khullar, BA Krantz, B Mapes, KE McKinnon, J Metti, JF Perera, TA Rand, V Sanchez-Fr, JM Shaxted, MM Stein, MA Streit, YC Tan, Y Zhang, E Zhao, J Venkataram, MC Stumpe, JA Borgia, A Masood, DVT Catenacci, JV Mathews, DB Gursel, JJ Wei, TH Welling, DM Simeone, KP White, AA Khan, C Igartua, AA Salahudeen A pan-cancer organoid platform for precision medicine Cell Reports, 2021-07-27;36(4):109429. 2021-07-27 [PMID: 34320344] (Bioassay, Human)
• IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional Nature Communications, 2021-07-27;12(1):4566. 2021-07-27 [PMID: 34315881] (Bioassay, Human)
• MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells Nature Communications, 2021-07-23;12(1):4492. 2021-07-23 [PMID: 34301945] (Bioassay, Human)
• J Barra, J Cerda-Infa, L Sandoval, P Gajardo-Me, JF Henriquez, M Labarca, C Metz, J Venegas, C Retamal, C Oyanadel, J Cancino, A Soza, MA Cuello, JC Roa, VP Montecinos, A Gonzalez D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy Cancers, 2021-07-20;13(14):. 2021-07-20 [PMID: 34298835] (Bioassay, Human)
• SM Dieter, C Siegl, PL Codó, M Huerta, AL Ostermann-, E Schulz, MK Zowada, S Martin, K Laaber, A Nowrouzi, M Blatter, S Kreth, F Westermann, A Benner, U Uhrig, K Putzker, J Lewis, A Haegebarth, D Mumberg, SJ Holton, J Weiske, LM Toepper, U Scheib, G Siemeister, CR Ball, B Kuster, G Stoehr, H Hahne, S Johannes, M Lange, F Herbst, H Glimm Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer Cell Reports, 2021-07-20;36(3):109394. 2021-07-20 [PMID: 34289372] (Bioassay, Human)
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• KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nat Commun, 2017-08-24;8(1):331. 2017-08-24 [PMID: 28835709] (Bioassay, Human)
• KJ Yoon, G Song, X Qian, J Pan, D Xu, HS Rho, NS Kim, C Habela, L Zheng, F Jacob, F Zhang, EM Lee, WK Huang, FR Ringeling, C Vissers, C Li, L Yuan, K Kang, S Kim, J Yeo, Y Cheng, S Liu, Z Wen, CF Qin, Q Wu, KM Christian, H Tang, P Jin, Z Xu, J Qian, H Zhu, H Song, GL Ming Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins Cell Stem Cell, 2017-08-17;0(0):. 2017-08-17 [PMID: 28826723] (Bioassay, Mouse)
• FM Khan, S Marquardt, SK Gupta, S Knoll, U Schmitz, A Spitschak, D Engelmann, J Vera, O Wolkenhaue, BM Pützer Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures Nat Commun, 2017-08-04;8(1):198. 2017-08-04 [PMID: 28775339] (Bioassay, Human)
• E Zanini, LS Louis, J Antony, E Karali, IS Okon, AB McKie, S Vaughan, M El-Bahrawy, J Stebbing, C Recchi, H Gabra The tumor suppressor protein OPCML potentiates anti-EGFR and anti-HER2 targeted therapy in HER2-positive ovarian and breast cancer Mol. Cancer Ther., 2017-08-03;0(0):. 2017-08-03 [PMID: 28775148] (Bioassay, Human)
• K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva J. Clin. Invest., 2017-07-31;0(0):. 2017-07-31 [PMID: 28758906] (Bioassay, Human)
• J Yin, YT Oh, JY Kim, SS Kim, E Choi, TH Kim, JH Hong, N Chang, HJ Cho, JK Sa, JC Kim, HJ Kwon, S Park, W Lin, I Nakano, HS Gwak, H Yoo, SH Lee, J Lee, JH Kim, SY Kim, DH Nam, MJ Park, JB Park Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBP? signaling Cancer Res., 2017-07-28;0(0):. 2017-07-28 [PMID: 28754668] (Bioassay, Human)
• E Martínez-S, S Montori, C Gil-Recio, R Núñez-Told, D Costamagna, A Rotini, M Atari, A Luttun, M Sampaolesi Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration Stem Cell Res Ther, 2017-07-27;8(1):175. 2017-07-27 [PMID: 28750661] (Bioassay, Human)
• X Wang, Z Huang, Q Wu, BC Prager, SC Mack, K Yang, LJY Kim, RC Gimple, Y Shi, S Lai, Q Xie, TE Miller, CG Hubert, A Song, Z Dong, W Zhou, X Fang, Z Zhu, V Mahadev, S Bao, JN Rich MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells Cancer Res., 2017-07-20;0(0):. 2017-07-20 [PMID: 28729418] (Bioassay, Human)
• EK Kim, JH Cho, E Kim, YJ Kim Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth PLoS ONE, 2017-07-14;12(7):e0181183. 2017-07-14 [PMID: 28708871] (Bioassay, Human)
• D Yu, OF Khan, ML Suvà, B Dong, WK Panek, T Xiao, M Wu, Y Han, AU Ahmed, IV Balyasniko, HF Zhang, C Sun, R Langer, DG Anderson, MS Lesniak Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression Proc. Natl. Acad. Sci. U.S.A., 2017-07-10;0(0):. 2017-07-10 [PMID: 28696296] (Bioassay, Human)
• M Morrison J, MM Williams, DJ Hicks, B Jones, V Sanchez, CD Young, DD Sarbassov, WJ Muller, D Brantley-S, RS Cook Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis Breast Cancer Res., 2017-06-30;19(1):74. 2017-06-30 [PMID: 28666462] (Bioassay, Human)
• CT Kuo, JY Wang, YF Lin, AM Wo, BPC Chen, H Lee Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array Sci Rep, 2017-06-29;7(1):4363. 2017-06-29 [PMID: 28663555] (Bioassay, Human)
• S Mahati, D Bolati, Y Yang, R Mao, H Zhang, Y Bao TMPRSS4 promotes cancer stem cell traits by regulating CLDN1 in hepatocellular carcinoma Biochem. Biophys. Res. Commun., 2017-06-23;0(0):. 2017-06-23 [PMID: 28651932] (Bioassay, Human)
• JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Cell Stem Cell, 2017-06-22;0(0):. 2017-06-22 [PMID: 28648364] (Bioassay, Human)
• CN Im Combination Treatment with PPAR? Ligand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells Biomed Res Int, 2017-05-31;2017(0):5832824. 2017-05-31 [PMID: 28642874] (Bioassay, Human)
• Y Hao, J Lyu, R Qu, D Sun, Z Zhao, Z Chen, J Ding, H Xie, Y Xu, H Li Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors Sci Rep, 2017-06-19;7(1):3830. 2017-06-19 [PMID: 28630494] (Bioassay, Human)
• M Crespo, E Vilar, SY Tsai, K Chang, S Amin, T Srinivasan, T Zhang, NH Pipalia, HJ Chen, M Witherspoo, M Gordillo, JZ Xiang, FR Maxfield, S Lipkin, T Evans, S Chen Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing Nat. Med., 2017-06-19;0(0):. 2017-06-19 [PMID: 28628110] (Bioassay, Human)
• AI Sagredo, EA Sagredo, C Cappelli, P Báez, AM Rodrigo, C Blanco, JC Tapia, C Echeverría, O Cerda, A Stutzin, F Simon, K Marcelain, R Armisén TRPM4 regulates Akt/GSK3-? activity and enhances ?-catenin signaling and cell proliferation in prostate cancer cells Mol Oncol, 2017-12-30;0(0):. 2017-12-30 [PMID: 28614631] (Bioassay, Human)
• SS Karve, S Pradhan, DV Ward, AA Weiss Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli PLoS ONE, 2017-06-14;12(6):e0178966. 2017-06-14 [PMID: 28614372] (Bioassay, Human)
• R Chijimatsu, M Ikeya, Y Yasui, Y Ikeda, K Ebina, Y Moriguchi, K Shimomura, DA Hart, Y Hideki, N Norimasa Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair Stem Cells Int, 2017-05-10;2017(0):1960965. 2017-05-10 [PMID: 28607560] (Bioassay, Human)
• E Jung, M Osswald, J Blaes, B Wiestler, F Sahm, T Schmenger, G Solecki, K Deumelandt, FT Kurz, R Xie, S Weil, O Heil, C Thomé, M Gömmel, M Syed, P Häring, PE Huber, S Heiland, M Platten, A von Deimli, W Wick, F Winkler Tweety-homologue 1 drives brain colonization of gliomas J. Neurosci., 2017-06-12;0(0):. 2017-06-12 [PMID: 28607172] (Bioassay, Human)
• MJ Son, JS Ryu, JY Kim, Y Kwon, KS Chung, SJ Mun, YS Cho Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells Exp. Mol. Med., 2017-06-09;49(6):e344. 2017-06-09 [PMID: 28604662] (Bioassay, Human)
• D Jung, J Xiong, M Ye, X Qin, L Li, S Cheng, M Luo, J Peng, J Dong, F Tang, W Shen, MM Matzuk, K Kee In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells Nat Commun, 2017-06-12;8(0):15680. 2017-06-12 [PMID: 28604658] (Bioassay, Human)
• A Prieur, M Cappellini, G Habif, MP Lefranc, T Mazard, E Morency, JM Pascussi, M Flaceliere, N Cahuzac, B Vire, B Dubuc, A Durochat, P Liaud, J Ollier, C Pfeiffer, S Poupeau, V Saywell, C Planque, E Assenat, F Bibeau, JF Bourgaux, P Pujol, A Sézeur, M Ychou, D Joubert Targeting the Wnt pathway and cancer stem cells with anti-progastrin humanized antibodies: a major breakthrough for K-RAS mutated colorectal cancer treatment Clin. Cancer Res., 2017-06-09;0(0):. 2017-06-09 [PMID: 28600477] (Bioassay, Human)
• K Kajiwara, T Tanemoto, S Wada, J Karibe, N Ihara, Y Ikemoto, T Kawasaki, Y Oishi, O Samura, K Okamura, S Takada, H Akutsu, H Sago, A Okamoto, A Umezawa Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1701-1713. 2017-06-06 [PMID: 28591652] (Bioassay, Human)
• J Trott, EK Tan, S Ong, DM Titmarsh, SLIJ Denil, M Giam, CK Wong, J Wang, M Shboul, M Eio, J Cooper-Whi, SM Cool, G Rancati, LW Stanton, B Reversade, NR Dunn Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1675-1688. 2017-06-06 [PMID: 28591650] (Bioassay, Human)
• M Yoshihara, Y Sasamoto, R Hayashi, Y Ishikawa, M Tsujikawa, Y Hayashizak, M Itoh, H Kawaji, K Nishida High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor Sci Rep, 2017-06-06;7(1):2845. 2017-06-06 [PMID: 28588247] (Bioassay, Human)
• C Zou, Y Lu, X Teng, S Wang, X Sun, F Huang, G Shu, X Huang, H Guo, Z Chen, J Zhang, YA Zhang MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys Sci Rep, 2017-05-31;7(1):2505. 2017-05-31 [PMID: 28566744] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura Establishment of a refined culture method for rat colon organoids Biochem. Biophys. Res. Commun., 2017-05-27;0(0):. 2017-05-27 [PMID: 28559141] (Bioassay, Rat)
• DA Casolari, T Nguyen, CM Butcher, DG Iarossi, CN Hahn, SC Bray, P Neufing, WT Parker, J Feng, KZY Maung, A Wee, L Vidovic, CH Kok, PG Bardy, S Branford, ID Lewis, SW Lane, HS Scott, DM Ross, RJ D'Andrea A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm Sci Rep, 2017-05-26;7(1):2467. 2017-05-26 [PMID: 28550306] (Bioassay, Mouse)
• LJ Fulcher, LD Hutchinson, TJ Macartney, C Turnbull, GP Sapkota Targeting endogenous proteins for degradation through the affinity-directed protein missile system Open Biol, 2017-05-01;7(5):. 2017-05-01 [PMID: 28490657] (Bioassay, Human)
• J Zhou, C Zhang, J Pan, L Chen, ST Qi Interleukin?6 induces an epithelial?mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration Mol Med Rep, 2017-05-02;15(6):4123-4131. 2017-05-02 [PMID: 28487953] (Bioassay, Human)
• N Sahoo, M Gu, X Zhang, N Raval, J Yang, M Bekier, R Calvo, S Patnaik, W Wang, G King, M Samie, Q Gao, S Sahoo, S Sundaresan, TM Keeley, Y Wang, J Marugan, M Ferrer, LC Samuelson, JL Merchant, H Xu Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca(2+) Efflux Channel in the Tubulovesicle Dev. Cell, 2017-05-08;41(3):262-273.e6. 2017-05-08 [PMID: 28486130] (Bioassay, Mouse)
• YJ Chen, L Lankford, S Kabagambe, Z Saenz, P Kumar, D Farmer, A Wang Effect of 2-octylcyanoacrylate on placenta derived mesenchymal stromal cells on extracellular matrix Placenta, 2017-04-02;0(0):. 2017-04-02 [PMID: 28465002] (Bioassay, Human)
• R Chen, G Jin, TM McIntyre The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-EGF to active high molecular weight EGF J. Biol. Chem., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455445] (Bioassay, Human)
• F Birey, J Andersen, CD Makinson, S Islam, W Wei, N Huber, HC Fan, KRC Metzler, G Panagiotak, N Thom, NA O'Rourke, LM Steinmetz, JA Bernstein, J Hallmayer, JR Huguenard, SP Pa?ca Assembly of functionally integrated human forebrain spheroids Nature, 2017-04-26;545(7652):54-59. 2017-04-26 [PMID: 28445465] (Bioassay, Human)
• S Lugert, T Kremer, R Jagasia, A Herrmann, S Aigner, C Giachino, I Mendez-Dav, AM Gardier, JP Carralot, H Meisterman, A Augustin, MD Saxe, J Lamerz, G Duran-Pach, A Ducret, V Taylor, DJ David, C Czech Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis Sci Rep, 2017-04-25;7(0):46543. 2017-04-25 [PMID: 28440309] (Bioassay, Human)
• J Li, B Yu, P Deng, Y Cheng, Y Yu, K Kevork, S Ramadoss, X Ding, X Li, CY Wang KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/?-catenin signalling Nat Commun, 2017-04-25;8(0):15146. 2017-04-25 [PMID: 28440295] (Bioassay, Human)
• JRW Conway, SC Warren, P Timpson Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors Methods, 2017-04-19;0(0):. 2017-04-19 [PMID: 28435000] (Bioassay, Human)
• R Núñez-Told, E Martínez-S, C Gil-Recio, MÁ Carrasco, A Al Madhoun, S Montori, M Atari Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation BMC Cell Biol., 2017-04-21;18(1):21. 2017-04-21 [PMID: 28427322] (Bioassay, Human)
• DH Lee, S Cheul Oh, AJ Giles, J Jung, MR Gilbert, DM Park Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1? in human glioma stem cells Oncotarget, 2017-06-20;8(25):40233-40245. 2017-06-20 [PMID: 28410215] (Bioassay, Human)
• YC Xu, X Wang, Y Chen, SM Chen, XY Yang, YM Sun, MY Geng, J Ding, LH Meng Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K?-selective Inhibitors in Breast Cancer Theranostics, 2017-02-23;7(4):974-986. 2017-02-23 [PMID: 28382169] (Bioassay, Human)
• Y Wan, X Fei, Z Wang, D Jiang, H Chen, M Wang, S Zhou miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway Tumour Biol., 2017-04-01;39(4):1010428317695. 2017-04-01 [PMID: 28381178] (Bioassay, Human)
• NA Guadagno, C Moriconi, V Licursi, E D'Acunto, PS Nisi, N Carucci, A De Jaco, E Cacci, R Negri, G Lupo, E Miranda Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB Neurobiol. Dis., 2017-03-28;103(0):32-44. 2017-03-28 [PMID: 28363799] (Bioassay, Human)
• PH Vincent, E Benedikz, P Uhlen, O Hovatta, E Sundström Expression of Pluripotency Markers in Non-pluripotent Human Neural Stem and Progenitor Cells Stem Cells Dev., 2017-03-27;0(0):. 2017-03-27 [PMID: 28351210] (Bioassay, Human)
• X Wang, K Yang, Q Xie, Q Wu, SC Mack, Y Shi, LJ Kim, BC Prager, WA Flavahan, X Liu, M Singer, CG Hubert, TE Miller, W Zhou, Z Huang, X Fang, A Regev, ML Suvà, TH Hwang, JW Locasale, S Bao, JN Rich Purine synthesis promotes maintenance of brain tumor initiating cells in glioma Nat. Neurosci, 2017-03-27;0(0):. 2017-03-27 [PMID: 28346452] (Bioassay, Human)
• L Xue, Y Li, J Chen Duration of simulated microgravity affects the differentiation of mesenchymal stem cells Mol Med Rep, 2017-03-22;15(5):3011-3018. 2017-03-22 [PMID: 28339035] (Bioassay, Rat)
• F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells Nat Protoc, 2017-03-23;12(4):814-827. 2017-03-23 [PMID: 28333915] (Bioassay, Human)
• K Eun, HM Jeon, SO Kim, SH Choi, SY Lee, X Jin, SC Kim, H Kim A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells Biochem. Biophys. Res. Commun, 2017-03-19;0(0):. 2017-03-19 [PMID: 28327358] (Bioassay, Human)
• M Imaizumi, NY Li-Jessen, Y Sato, DT Yang, SL Thibeault Retention of Human-Induced Pluripotent Stem Cells (hiPS) With Injectable HA Hydrogels for Vocal Fold Engineering Ann. Otol. Rhinol. Laryngol., 2017-02-12;126(4):304-314. 2017-02-12 [PMID: 28290232]
• D Chen, M Wu, Y Li, I Chang, Q Yuan, M Ekimyan-Sa, P Deng, B Yu, Y Yu, J Dong, JM Szymanski, S Ramadoss, J Li, CY Wang Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma Cell Stem Cell, 2017-03-09;0(0):. 2017-03-09 [PMID: 28285905] (Bioassay, Human)
• G Riddick, S Kotliarova, V Rodriguez, HS Kim, A Linkous, AJ Storaska, S Ahn, J Walling, G Belova, HA Fine A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity Sci Rep, 2017-03-03;7(0):43605. 2017-03-03 [PMID: 28256619] (Bioassay, Human)
• S Fu, H Xu, M Gu, C Liu, Q Wang, X Wan, Y Chen, Q Chen, Y Peng, Z Cai, J Zhou, Z Wang Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity Sci Rep, 2017-03-03;7(0):43771. 2017-03-03 [PMID: 28256562] (Bioassay, Human)
• H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3 Sci Rep, 2017-03-02;7(0):43736. 2017-03-02 [PMID: 28252047] (Bioassay, Human)
• R Horibe, Y Hirohashi, T Asano, T Mariya, T Suzuki, A Takaya, H Saijo, Y Shionoya, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, K Watanabe, E Atsuyama, S Toji, H Hirano, T Hasegawa, H Takahashi, N Sato, T Torigoe Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy PLoS ONE, 2017-03-01;12(3):e0171460. 2017-03-01 [PMID: 28248963] (Bioassay, Human)
• J Liao, PP Liu, G Hou, J Shao, J Yang, K Liu, W Lu, S Wen, Y Hu, P Huang Regulation of stem-like cancer cells by glutamine through ?-catenin pathway mediated by redox signaling Mol. Cancer, 2017-02-28;16(1):51. 2017-02-28 [PMID: 28245869] (Bioassay, Human)
• A Almazán-Mo, P Zarzosa, I Vidal, C Molist, I Giralt, N Navarro, A Soriano, MF Segura, A Alfranca, J Garcia-Cas, J Sánchez de, J Roma, S Gallego Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma Stem Cells Int, 2017-01-24;2017(0):7507380. 2017-01-24 [PMID: 28243259] (Bioassay, Human)
• CN Im, HH Yun, JH Lee Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties Int J Mol Sci, 2017-02-22;18(2):. 2017-02-22 [PMID: 28241425] (Bioassay, Human)
• L Wang, Y Hirohashi, T Ogawa, M Shen, R Takeda, A Murai, E Yamamoto, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Nishidate, K Okita, G Kutomi, N Sato, I Takemasa, T Torigoe LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells Biochem. Biophys. Res. Commun, 2017-02-24;0(0):. 2017-02-24 [PMID: 28238780] (Bioassay, Human)
• CA Valle Oseg, JV Spencer Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells Cancer Cell Int, 2017-02-13;17(0):24. 2017-02-13 [PMID: 28228690] (Bioassay, Human)
• R Takeda, Y Hirohashi, M Shen, L Wang, T Ogawa, A Murai, E Yamamoto, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Nishidate, K Okita, G Kutomi, N Sato, I Takemasa, T Torigoe Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells Biochem. Biophys. Res. Commun, 2017-02-20;0(0):. 2017-02-20 [PMID: 28219643] (Bioassay, Human)
• E Kassianido, CA Brand, US Schwarz, S Kumar Geometry and network connectivity govern the mechanics of stress fibers Proc. Natl. Acad. Sci. U.S.A, 2017-02-17;0(0):. 2017-02-17 [PMID: 28213499] (Bioassay, Human)
• PH Lakner, MG Monaghan, Y Möller, MA Olayioye, K Schenke-La Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models Sci Rep, 2017-02-13;7(0):42730. 2017-02-13 [PMID: 28211922] (Bioassay, Human)
• JC Niclis, C Turner, J Durnall, S McDougal, JA Kauhausen, B Leaw, M Dottori, CL Parish, LH Thompson Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived From Human Induced Pluripotent Stem Cells After Intracerebral Transplantation Stem Cells Transl Med, 2017-02-15;0(0):. 2017-02-15 [PMID: 28198124] (Bioassay, Human)
• NV Sankpal, TP Fleming, PK Sharma, HJ Wiedner, WE Gillanders A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer Oncogene, 2017-02-13;0(0):. 2017-02-13 [PMID: 28192403] (Bioassay, Human)
• N Arora, J Imran Also, JW Guggenheim, M Mak, J Munera, JM Wells, RD Kamm, HH Asada, SY Shvartsman, LG Griffith A process engineering approach to increase organoid yield Development, 2017-02-07;144(6):1128-1136. 2017-02-07 [PMID: 28174251] (Bioassay, Human)
• J Worthingto, G Spain, JF Timms Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells Mol. Cell Proteomics, 2017-02-07;16(4):608-621. 2017-02-07 [PMID: 28174229] (Bioassay, Human)
• J Wang, K Nikhil, K Viccaro, L Chang, M Jacobsen, G Sandusky, K Shah Aurora A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma J. Cell. Sci, 2017-02-06;0(0):. 2017-02-06 [PMID: 28167680] (Bioassay, Human)
• HO King, T Brend, HL Payne, A Wright, TA Ward, K Patel, T Egnuni, LF Stead, A Patel, H Wurdak, SC Short RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells Stem Cell Reports, 2017-01-10;8(1):125-139. 2017-01-10 [PMID: 28076755] (Bioassay, Human)
• DH Heiland, R Ferrarese, R Claus, F Dai, AP Masilamani, E Kling, A Weyerbrock, T Kling, S Nelander, MS Carro c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas Oncotarget, 2017-01-24;0(0):. 2017-01-24 [PMID: 28036297] (Bioassay, Human)
• Xinfang Yu Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production Mol. Carcinog, 2017-05-01;0(0):. 2017-05-01 [PMID: 27996164] (Bioassay, Human)
• Young Dong Yoo Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition EMBO Rep, 2016-12-19;0(0):. 2016-12-19 [PMID: 27993939] (Bioassay, Human)
• Brain tissue banking for stem cells for our future Sci Rep, 2016-12-19;6(0):39394. 2016-12-19 [PMID: 27991551] (Bioassay, Human)
• SW Lee, JU Chong, SO Min, SY Bak, KS Kim Are Adipose-Derived Stem Cells From Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells? Cell Transplant, 2016-11-24;26(5):855-866. 2016-11-24 [PMID: 27938473] (Bioassay, Human)
• Xiaoguang Fang Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination J. Exp. Med, 2016-12-06;0(0):. 2016-12-06 [PMID: 27923907] (Bioassay, Human)
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• Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. Stem Cells, 2012-07-01;30(7):1455-64. 2012-07-01 [PMID: 22495904] (Bioassay, Human)
• Goel S, Chin EN, Fakhraldeen SA Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J. Biol. Chem., 2012-03-20;287(20):16454-66. 2012-03-20 [PMID: 22433869] (Bioassay, Mouse)
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• Walter D, Satheesha S, Albrecht P, Bornhauser BC, D'Alessandro V, Oesch SM, Rehrauer H, Leuschner I, Koscielniak E, Gengler C, Moch H, Bernasconi M, Niggli FK, Schafer BW CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres. PLoS ONE, 2011-05-13;6(5):e19506. 2011-05-13 [PMID: 21602936] (Bioassay, Human)
• Brave SR, Odedra R, James NH Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer. Int. J. Oncol., 2011-04-29;39(1):271-8. 2011-04-29 [PMID: 21537841] (Bioassay, Human)
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• Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina. PLoS ONE, 2010-08-26;5(8):e12425. 2010-08-26 [PMID: 20865053] (Bioassay, Mouse)
• Yang MH, Hsu DS, Wang HW Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol., 2010-09-05;12(10):982-92. 2010-09-05 [PMID: 20818389] (Bioassay, Human)
• Park JA, Drazen JM, Tschumperlin DJ The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J. Biol. Chem., 2010-07-22;285(39):29817-25. 2010-07-22 [PMID: 20650887] (Bioassay, Human)
• Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors. Oncogene, 2010-03-08;29(20):2938-49. 2010-03-08 [PMID: 20208561] (Bioassay, Human)
• Hickinson DM, Klinowska T, Speake G AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin. Cancer Res., 2010-02-09;16(4):1159-69. 2010-02-09 [PMID: 20145185] (Bioassay, Human)
• Morizane S, Yamasaki K, Kabigting FD, Gallo RL Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid. J. Invest. Dermatol., 2010-01-21;130(5):1297-306. 2010-01-21 [PMID: 20090765] (Bioassay, Human)
• Lee HS, Myers A, Kim J Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis. Am. J. Respir. Crit. Care Med., 2009-09-17;180(11):1056-67. 2009-09-17 [PMID: 19762561] (Bioassay, Human)
• Switzer CH, Ridnour LA, Cheng RY, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD, Wink DA Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity. Oncogene, 2009-08-24;28(43):3837-46. 2009-08-24 [PMID: 19701246] (Bioassay, Human)
• Fischer AJ, Scott MA, Ritchey ER, Sherwood P Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Glia, 2009-11-01;57(14):1538-52. 2009-11-01 [PMID: 19306360] (In Vivo, Chicken)
• Katakura M, Hashimoto M, Shahdat HM, Gamoh S, Okui T, Matsuzaki K, Shido O Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. Neuroscience, 2009-03-09;160(3):651-60. 2009-03-09 [PMID: 19272428] (Bioassay, Rat)
• Li JJ, Liu DP, Liu GT, Xie D EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene, 2009-03-09;28(15):1759-68. 2009-03-09 [PMID: 19270726] (Bioassay, Human)
• Riento K, Frick M, Schafer I, Nichols BJ Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. J. Cell. Sci., 2009-03-03;122(0):912-8. 2009-03-03 [PMID: 19258392] (Bioassay, Human, Mouse)
• Riekstina U, Muceniece R, Cakstina I, Muiznieks I, Ancans J Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions. Cytotechnology, 2009-02-14;58(3):153-62. 2009-02-14 [PMID: 19219561] (Bioassay, Human)
• Chang CJ, Hsu CC, Yung MC, Chen KY, Tzao C, Wu WF, Chou HY, Lee YY, Lu KH, Chiou SH, Ma HI Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. Biochem. Biophys. Res. Commun., 2009-01-21;380(2):236-42. 2009-01-21 [PMID: 19166820] (Bioassay, Human)
• Ueda Y, Karasawa Y, Satoh Y, Nishikawa S, Imaki J, Ito M Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture. Invest. Ophthalmol. Vis. Sci., 2008-12-20;50(5):1978-87. 2008-12-20 [PMID: 19098316] (Bioassay, Mouse)
• Sarup J, Jin P, Turin L, Bai X, Beryt M, Brdlik C, Higaki JN, Jorgensen B, Lau FW, Lindley P, Liu J, Ni I, Rozzelle J, Kumari R, Watson SA, Zhang J, Shepard HM Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. Mol. Cancer Ther., 2008-10-01;7(10):3223-36. 2008-10-01 [PMID: 18852126] (Bioassay, Human)
• Bergin DA, Greene CM, Sterchi EE, Kenna C, Geraghty P, Belaaouaj A, Taggart CC, O'Neill SJ, McElvaney NG Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. J. Biol. Chem., 2008-09-04;283(46):31736-44. 2008-09-04 [PMID: 18772136] (Bioassay, Human)
• Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. Biochem. Biophys. Res. Commun., 2008-07-26;374(4):683-7. 2008-07-26 [PMID: 18662673] (Bioassay, Mouse)
• Ren W, Korchin B, Zhu QS, Wei C, Dicker A, Heymach J, Lazar A, Pollock RE, Lev D Epidermal Growth Factor Receptor Blockade in Combination with Conventional Chemotherapy Inhibits Soft Tissue Sarcoma Cell Growth In vitro and In vivo. Clin. Cancer Res., 2008-05-01;14(9):2785-2795. 2008-05-01 [PMID: 18451246] (Bioassay, Human)
• Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells, 2008-04-17;26(7):1705-12. 2008-04-17 [PMID: 18420830] (Bioassay, Human)
• Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 2008-01-15;22(2):152-65. 2008-01-15 [PMID: 18198334] (Bioassay, Human)
• Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside. Biochem. Biophys. Res. Commun., 2007-09-04;363(3):472-8. 2007-09-04 [PMID: 17888881] (Bioassay, Human)
• Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 2007-08-24;282(43):31643-55. 2007-08-24 [PMID: 17720976] (Bioassay, Human)
• Inagaki A, Soeda A, Oka N, Kitajima H, Nakagawa J, Motohashi T, Kunisada T, Iwama T Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions. Biochem. Biophys. Res. Commun., 2007-07-18;361(3):586-92. 2007-07-18 [PMID: 17673180] (Bioassay, Human)
• Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J. Biol. Chem., 2007-07-17;282(37):26656-64. 2007-07-17 [PMID: 17636266] (Bioassay, Mouse)
• Schweizer PA, Krause U, Becker R, Seckinger A, Bauer A, Hardt C, Eckstein V, Ho AD, Koenen M, Katus HA, Zehelein J Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells. Stem Cells, 2007-06-01;25(6):1546-51. 2007-06-01 [PMID: 17548531] (Bioassay, Human)
• Wolff GS, Chiang PJ, Smith SM, Romero R, Armant DR Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Biol. Reprod., 2007-03-28;77(1):53-60. 2007-03-28 [PMID: 17392498] (Bioassay, Human)
• Sa SM, Valdez PA, Wu J The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol., 2007-02-15;178(4):2229-40. 2007-02-15 [PMID: 17277128] (Bioassay, Human)
• Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats. Stroke, 2006-07-27;37(9):2361-7. 2006-07-27 [PMID: 16873711] (Bioassay, Rat)
• Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P, Damas JK Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes. Blood, 2006-08-01;108(3):928-35. 2006-08-01 [PMID: 16861346] (Bioassay, Human)
• Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell, 2006-07-01;10(1):39-50. 2006-07-01 [PMID: 16843264] (Bioassay, Human)
• Close JL, Liu J, Gumuscu B, Reh TA Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina. Glia, 2006-08-01;54(2):94-104. 2006-08-01 [PMID: 16710850] (In Vivo, Rat)
• Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat)
• Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development, 2006-01-11;133(4):751-9. 2006-01-11 [PMID: 16407398] (Bioassay, Human)
• Close JL, Gumuscu B, Reh TA Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling. Development, 2005-07-01;132(13):3015-26. 2005-07-01 [PMID: 15944186] (In Vivo, Rat)
• Collombet JM, Four E, Burckhart MF, Masqueliez C, Bernabe D, Baubichon D, Herodin F, Lallement G Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice. Toxicology, 2005-05-15;210(1):9-23. 2005-05-15 [PMID: 15804454] (In Vivo, Mouse)
• Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. Mol. Vis., 2004-12-22;10(0):973-86. 2004-12-22 [PMID: 15623987] (In Vivo, Chicken)
• Lavigne MC, Thakker P, Gunn J, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW Human bronchial epithelial cells express and secrete MMP-12. Biochem. Biophys. Res. Commun., 2004-11-12;324(2):534-46. 2004-11-12 [PMID: 15474460] (Bioassay, Human)
• Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm. Genome, 2004-07-01;15(7):525-36. 2004-07-01 [PMID: 15366372] (In Vivo, Mouse)
• Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res. Dev. Brain Res., 2004-09-17;152(2):159-69. 2004-09-17 [PMID: 15351504] (Bioassay, Human)
• Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood, 2004-03-25;104(2):314-20. 2004-03-25 [PMID: 15044249] (Bioassay, Human)
• Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev. Biol., 2004-02-15;266(2):223-37. 2004-02-15 [PMID: 14738873] (Bioassay, Human)
• Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22. 2004-01-12 [PMID: 14722222] (Bioassay, Human)
• Viti J, Gulacsi A, Lillien L Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci., 2003-07-02;23(13):5919-27. 2003-07-02 [PMID: 12843296] (Bioassay, Mouse)
• Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Bioassay, Human)
• Huaux F, 107322, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-09-01;169(5):2653-61. 2002-09-01 [PMID: 12193738] (Bioassay, Mouse)
• Jeschke B, Meyer J, Jonczyk A, Kessler H, Adamietz P, Meenen NM, Kantlehner M, Goepfert C, Nies B RGD-peptides for tissue engineering of articular cartilage. Biomaterials, 2002-08-01;23(16):3455-63. 2002-08-01 [PMID: 12099289] (Bioassay, Porcine)
• Humes HD, Fissell WH, Weitzel WF, Buffington DA, Westover AJ, MacKay SM, Gutierrez JM Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells. Am. J. Kidney Dis., 2002-05-01;39(5):1078-87. 2002-05-01 [PMID: 11979353] (Bioassay, Human, Porcine)
• Chen MC, Goliger J, Bunnett N, Soll AH Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability. Am. J. Physiol. Gastrointest. Liver Physiol., 2001-02-01;280(2):G264-72. 2001-02-01 [PMID: 11208549] (Bioassay, Canine)
• Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human)

Bioinformatics

• Gene Symbol: EGF
• Uniprot:
  • P01133()