Recombinant Human CXCL13/BLC/BCA-1 Protein


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Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human CXCL13/BLC/BCA-1 Protein Summary

Details of Functionality
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR5. The ED50 for this effect is 0.005‑0.02 µg/mL.
E. coli-derived human CXCL13/BLC/BCA-1 protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
8.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
9 kDa, reducing conditions
Read Publications using
801-CX in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human CXCL13/BLC/BCA-1 Protein

  • Angie
  • ANGIE2
  • B cell-attracting chemokine 1
  • B lymphocyte chemoattractant
  • BCA1
  • BCA-1
  • BCA1B-cell chemoattractant
  • BCA-1CXC chemokine BLC
  • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
  • BLC
  • BLCSmall-inducible cytokine B13
  • BLR1L
  • B-lymphocyte chemoattractant
  • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
  • chemokine (C-X-C motif) ligand 13
  • C-X-C motif chemokine 13
  • CXCL13
  • SCYB13
  • SCYB13B-cell-attracting chemokine 1
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)


CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA-1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23-34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.

  1. Gunn, M.D. et al. (1998) Nature, 391:799.
  2. Legler, D.F. et al. (1998) J. Exp. Med. 187:655.
  3. Forster, R. et al. (1996) Cell 87:1037.

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Publications for CXCL13/BLC/BCA-1 (801-CX)(18)

We have publications tested in 3 confirmed species: Human, N/A, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 3 applications: Antibody Absorption, Bioassay, ELISA (Standard).

Filter By Application
Antibody Absorption
ELISA (Standard)
All Applications
Filter By Species
Primate - Macaca mulatta (Rhesus Macaque)
All Species
Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using 801-CX Applications Species
A Ardain, R Domingo-Go, S Das, SW Kazer, NC Howard, A Singh, M Ahmed, S Nhamoyebon, J Rangel-Mor, P Ogongo, L Lu, D Ramsuran, M de la Luz, T K Ulland, M Darby, E Park, F Karim, L Melocchi, R Madansein, KJ Dullabh, M Dunlap, N Marin-Agud, T Ebihara, T Ndung'u, D Kaushal, AS Pym, JK Kolls, A Steyn, J Zúñiga, W Horsnell, WM Yokoyama, AK Shalek, HN Kløverpris, M Colonna, A Leslie, SA Khader Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis Nature, 2019;570(7762):528-532. 2019 [PMID: 31168092] (Bioassay, Human) Bioassay Human
LW Middleton, Z Shen, S Varma, AS Pollack, X Gong, S Zhu, C Zhu, JW Foley, S Vennam, RT Sweeney, K Tu, J Biscocho, O Eminaga, R Nolley, R Tibshirani, JD Brooks, RB West, JR Pollack Genomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis JCI Insight, 2019;5(0):. 2019 [PMID: 31094703] (Bioassay, Human) Bioassay Human
SD Reiff, R Mantel, LL Smith, JT Greene, EM Muhowski, CA Fabian, VM Goettl, M Tran, B Harrington, KA Rogers, FT Awan, K Maddocks, L Andritsos, AM Lehman, D Sampath, R Lapalombel, S Eathiraj, G Abbadessa, B Schwartz, A Johnson, JC Byrd, JA Woyach The BTK Inhibitor ARQ 531 Targets Ibrutinib Resistant CLL and Richter&#039;s Transformation Cancer Discov, 2018;0(0):. 2018 [PMID: 30093506] (Bioassay, Human) Bioassay Human
E Armas-Gonz, MJ Domínguez-, A Díaz-Martí, M Arce-Franc, J Castro-Her, G Danelon, V Hernández-, S Bustabad-R, A Cantabrana, M Uguccioni, F Díaz-Gonzá Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis Arthritis Res. Ther., 2018;20(1):114. 2018 [PMID: 29880013] (Bioassay, Human) Bioassay Human
JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism Blood, 2018;0(0):. 2018 [PMID: 29496671] (Bioassay, Human) Bioassay Human
Blackburn M, Zhong-Min M, Caccuri F, McKinnon K, Schifanella L, Guan Y, Gorini G, Venzon D, Fenizia C, Binello N, Gordon S, Miller C, Franchini G, Vaccari M Regulatory and Helper Follicular T Cells and Antibody Avidity to Simian Immunodeficiency Virus Glycoprotein 120. J Immunol, 2015;195(7):3227-36. 2015 [PMID: 26297759] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque)) Bioassay Primate - Macaca mulatta (Rhesus Macaque)
Boswell K, Paris R, Boritz E, Ambrozak D, Yamamoto T, Darko S, Wloka K, Wheatley A, Narpala S, McDermott A, Roederer M, Haubrich R, Connors M, Ake J, Douek D, Kim J, Petrovas C, Koup R Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog, 2014;10(1):e1003853. 2014 [PMID: 24497824] (Bioassay, Human) Bioassay Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012;487(7408):505-9. 2012 [PMID: 22763448] (Bioassay, Human) Bioassay Human
Ponader S, Chen SS, Buggy JJ The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood, 2012;119(5):1182-9. 2012 [PMID: 22180443] (Bioassay, Human) Bioassay Human
Weiss N, Deboux C, Chaverot N, Miller F, Baron-Van Evercooren A, Couraud P, Cazaubon S IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells. J Neuroimmunol, 0;223(1):131-4. 0 [PMID: 20400187] (Bioassay, Human) Bioassay Human
Show All 18 Publications.

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Gene Symbol CXCL13