Recombinant Human CD36/SR-B3 Fc Chimera Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

Recombinant Human CD36/SR-B3 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized rhCD36/Fc Chimera at 2 µg/mL (100 µL/well) can bind rhTSP-2/His with a linear range of 0.05-2 µg/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human CD36/SR-B3 protein
Human CD36
(Gly30 - Asn439)
Accession # P16671
IEGRMD Human IgG1
(Pro100 - Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Gly30
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
CD36
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
73 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
93 kDa, reducing conditions
Publications
Read Publications using
1955-CD in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human CD36/SR-B3 Fc Chimera Protein, CF

  • CD36 antigen
  • CD36 molecule (thrombospondin receptor)
  • CD36
  • Collagen R
  • FA6-152
  • FAT
  • FATCHDS7
  • Fatty acid translocase
  • Glycoprotein IIIb
  • GP3Bthrombospondin receptor)
  • GPIIIb
  • GPIV
  • Leukocyte differentiation antigen CD36
  • PAS IV
  • PAS-4
  • Platelet collagen receptor
  • platelet glycoprotein 4
  • Platelet glycoprotein IV
  • SCARB3
  • scavenger receptor class B, member 3
  • SRB3
  • SR-B3
  • Thrombospondin R
  • Thrombospondin receptor

Background

CD36, alternatively known as platelet membrane glycoprotein IV (GPIV), GPIIIb, thrombospondin receptor, collagen receptor, fatty acid translocase (FAT), and scavenger receptor class B, member 3 (SR-B3), is an integral membrane glycoprotein that has multiple physiological functions (1). It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia (1, 2). As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta -amyloid fibrils (fA beta ), collagens I and IV, and Plasmodium falciparum-infected erythrocytes (3). CD36 is required for the anti-angiogenic effects of thrombospondin-1 in the corneal neovascularization assay (4). It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues (5). CD36 has been implicated in the clearance of apoptotic cells and cell debris and has also been shown to mediate the internalization and degradation of a variety of its ligands such as oxLDL, AGE and fA beta (3). Upon ligand binding, CD36 transduces signals that mediate a wide range of pro-inflammatory cellular responses (2). CD36 plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimer’s disease and atherosclerosis (2, 3). The human CD36 gene encodes a single-chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.

  1. Febbraio, M. et al. (2001) J. Clin. Invest. 108:785. 
  2. Khoury, J. et al. (2003) J. Exp. Med. 197:1657. 
  3. Husemann, J. et al. (2002) Glia 40:195.
  4. Armstrong, L and P. Bornstein (2003) Matrix. Biol. 22:63.
  5. Febbraio M. et al. (1999) J. Biol. Chem. 274:19055.

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1955-CD
Species: Hu
Applications: Binding Activity

Publications for CD36/SR-B3 (1955-CD)(9)

We have publications tested in 3 confirmed species: Human, N/A, Parasite - Plasmodium falciparum.

We have publications tested in 3 applications: Bioassay, Cell Selection, ELISA Developmet.


Filter By Application
Bioassay
(7)
Cell Selection
(1)
ELISA Developmet
(1)
All Applications
Filter By Species
Human
(7)
N/A
(1)
Parasite - Plasmodium falciparum
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using 1955-CD Applications Species
A Chêne, S Gangnard, A Guadall, H Ginisty, O Leroy, N Havelange, NK Viebig, B Gamain Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC EBioMedicine, 2019;0(0):. 2019 [PMID: 30885725] (Cell Selection, Parasite - Plasmodium falciparum) Cell Selection Parasite - Plasmodium falciparum
Y Zhao, X Wu, X Li, LL Jiang, X Gui, Y Liu, Y Sun, B Zhu, JC Piña-Cresp, M Zhang, N Zhang, X Chen, G Bu, Z An, TY Huang, H Xu TREM2 Is a Receptor for ?-Amyloid that Mediates Microglial Function Neuron, 2018;97(5):1023-1031.e7. 2018 [PMID: 29518356] (Bioassay, Human) Bioassay Human
Nunes-Silva S, Dechavanne S, Moussiliou A, Pstrag N, Semblat J, Gangnard S, Tuikue-Ndam N, Deloron P, Chene A, Gamain B Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding. Malar J, 2015;14(1):493. 2015 [PMID: 26646943] (Bioassay, Human) Bioassay Human
Doritchamou J, Sossou-tchatcha S, Cottrell G, Moussiliou A, Hounton Houngbeme C, Massougbodji A, Deloron P, Ndam N Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy. PLoS ONE, 2014;9(6):e98577. 2014 [PMID: 24905223] (Bioassay, Human) Bioassay Human
Baur S, Rautenberg M, Faulstich M, Grau T, Severin Y, Unger C, Hoffmann W, Rudel T, Autenrieth I, Weidenmaier C A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization. PLoS Pathog, 2014;10(5):e1004089. 2014 [PMID: 24788600] (Bioassay, N/A) Bioassay N/A
Mo M, Lee HC, Kotaka M, Niang M, Gao X, Iyer JK, Lescar J, Preiser P The C-terminal segment of the cysteine-rich interdomain of Plasmodium falciparum erythrocyte membrane protein 1 determines CD36 binding and elicits antibodies that inhibit adhesion of parasite-infected erythrocytes. Infect. Immun., 2008;76(5):1837-47. 2008 [PMID: 18299339] (ELISA Developmet, Human) ELISA Developmet Human
Ikenoya M, Doi T, Miura T, Sawanobori K, Nishio M, Hidaka H Investigation of binding proteins for anti-platelet agent K-134 by Drug-Western method. Biochem. Biophys. Res. Commun., 2007;353(4):1111-4. 2007 [PMID: 17207464] (Bioassay, Human) Bioassay Human
Urban BC, Cordery D, Shafi MJ, Bull PC, Newbold CI, Williams TN, Marsh K The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria. Infect. Immun., 2006;74(12):6700-6. 2006 [PMID: 17000725] (Bioassay, Human) Bioassay Human
Pettersson F, Vogt AM, Jonsson C, Mok BW, Shamaei-Tousi A, Bergstrom S, Chen Q, Wahlgren M Whole-body imaging of sequestration of Plasmodium falciparum in the rat. Infect. Immun., 2005;73(11):7736-46. 2005 [PMID: 16239578] (Bioassay, Human) Bioassay Human

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Bioinformatics

Gene Symbol CD36
Uniprot