RCC2 Antibody

Western Blot: RCC2 Antibody [NB110-40618] - Detection of Human and Mouse RCC2 on HeLa whole cell lysate using NB110-40618.

• Reactivity: Hu, Mu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

RCC2 Antibody Summary

• Description: Novus Biologicals Rabbit RCC2 Antibody (NB110-40618) is a polyclonal antibody validated for use in WB and IP. Anti-RCC2 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The immunogen this antibody was made to, maps to a region between residue 1 and 50 of human Regulator of Chromosome Condensation 2 using the numbering given in entry NP_061185.1 (GeneID 55920).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RCC2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 2-5 ug/mg lysate
  • Western Blot 1:2000-10000
• Application Notes: Western blot of lysates performed using standard western blot reagents and 4-20% SDS-PAGE.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for RCC2 Antibody

• DKFZp762N0610
• KIAA1470
• protein RCC2
• RCC1-like protein TD-60
• regulator of chromosome condensation 2
• TD60
• TD-60
• Telophase disk protein of 60 kDa

Background

RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. There are five human homologues of RAD51; XRCC2, XRCC3, RAD51B, RAD51C, RAD51D, and they interact among themselves to form one big complex or several smaller complexes. XRCC2 (X Ray Repair Cross Complementing 2), a component of the homologous recombination pathway, is essential for repairing the double strand DNA breaks by homologous recombination between sister chromatids.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for RCC2 Antibody (NB110-40618)(1)

Publication using NB110-40618

• Bruun J, Kolberg M et al. Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer. Clin Cancer Res 2015-08-15 [PMID: 25910952] (WB, Human)

Bioinformatics

• Gene Symbol: RCC2
• Entrez:
  • 55920(Human)
  • 108911(Mouse)
• Uniprot:
  • NP_061185.1(Human)