Rat TNF-alpha Quantikine ELISA Kit, 2 Plate

• Reactivity: Rt
• Applications: ELISA
• Conjugate: HRP

Rat TNF-alpha Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Rat TNF-alpha Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat TNF-alpha levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant rat TNF-alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant rat TNF-alpha accurately. Results obtained using nat...ural rat TNF-alpha showed dose response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural rat TNF-alpha.
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• Specificity: Natural and recombinant rat TNF-alpha
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnf

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat TNF-alpha Quantikine ELISA Kit, 2 Plate

• APC1 protein
• Cachectin
• Cachetin
• DIF
• TNF
• TNF, monocyte-derived
• TNFA
• TNF-A
• TNFalpha
• TNF-alpha
• TNF-alphacachectin
• TNFATNF, macrophage-derived
• TNFG1F
• TNFSF1A
• TNFSF2
• TNFSF2TNF superfamily, member 2
• tumor necrosis factor (TNF superfamily, member 2)
• tumor necrosis factor alpha
• Tumor necrosis factor ligand superfamily member 2
• tumor necrosis factor
• tumor necrosis factor-alpha

Background

Tumor necrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily (1). It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (2-5). TNF-alpha is also involved in a number of pathological conditions including asthma, Crohn's disease, rheumatoid arthritis, neuropathic pain, obesity, type 2 diabetes, septic shock, autoimmunity, and cancer (5-11).  

Rat TNF-alpha is synthesized as a 26 kDa type II transmembrane protein that consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 156 aa extracellular domain (ECD) (12). Within the ECD, rat TNF-alpha shares 95% aa sequence identity with mouse, and 73% - 79% aa identity with bovine, canine, cotton rat, equine, feline, human, rhesus macaque, and porcine  TNF-alpha . It is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface (13). Cell surface TNF-alpha can both induce the lysis of tumor cells and virus infected cells, and generate its own downstream cell signaling following ligation by soluble TNF RI (14, 15). Shedding of membrane bound TNF-alpha by TACE/ADAM17 releases the bioactive cytokine, a 55 kDa soluble trimer of the TNF-alpha extracellular domain (16-18).  

TNF-alpha binds the ubiquitous 55 - 60 kDa TNF RI (19, 20) and the hematopoietic cell-restricted 78-80 kDa TNF RII (21, 22), both of which are also expressed as homotrimers (1, 23). Both type I and type II receptors bind TNF-alpha with comparable affinity and can promote NF kappa B activation (24-27). Only TNF RI, however, contains a cytoplasmic death domain which triggers the activation of apoptosis (3, 28). Soluble forms of both types of receptors are released into human serum and urine and can neutralize the biological activity of TNF-alpha (29-31).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TNF-alpha (RTA00)(256)

Publications using RTA00

• Stepanichev, MY;Onufriev, MV;Moiseeva, YV;Nedogreeva, OA;Novikova, MR;Kostryukov, PA;Lazareva, NA;Manolova, AO;Mamedova, DI;Ovchinnikova, VO;Kastberger, B;Winter, S;Gulyaeva, NV; N-Pep-Zn Improves Cognitive Functions and Acute Stress Response Affected by Chronic Social Isolation in Aged Spontaneously Hypertensive Rats (SHRs) Biomedicines 2024-10-04 [PMID: 39457574] (Rat)
• Rabelo, TK;Campos, ACP;Almeida Souza, TH;Mahmud, F;Popovic, MR;Covolan, L;Betta, VC;DaCosta, L;Lipsman, N;Diwan, M;Hamani, C; Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury Brain stimulation 2024-10-15 [PMID: 39419474] (Rat)
• Farooq, J;Sultana, R;James, JP;Fathima C, Z;Almutairy, AF;Hussain, ASM; Efficacy of Thymoquinone and Hesperidin in Attenuating Cardiotoxicity from 5-Fluorouracil: Insights from In Vivo and In Silico Studies Toxics 2024-09-23 [PMID: 39330616] (Rat)
• Edinger, F;Zajonz, T;Mayer, N;Schmidt, G;Schneck, E;Sander, M;Koch, C; A Novel Model of Venovenous Extracorporeal Membrane Oxygenation in Rats with Femoral Cannulation and Insights into Hemodynamic Changes Biomedicines 2024-08-10 [PMID: 39200283] (Rat)
• Katahira, S;Barth, M;Döpp, R;Sugimura, Y;Schmidt, V;Selig, JI;Saiki, Y;Jankowski, J;Marx, N;Jahnen-Dechent, W;Lichtenberg, A;Akhyari, P; Pioglitazone treatment mitigates cardiovascular bioprosthetic degeneration in a chronic kidney disease model Frontiers in pharmacology 2024-08-08 [PMID: 39175545] (Rat)
• Aekwattanaphol, N;Das, SC;Khadka, P;Nakpheng, T;Ali Khumaini Mudhar Bintang, M;Srichana, T; Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for combating pulmonary tuberculosis International journal of pharmaceutics 2024-08-18 [PMID: 39163929] (Rat)
• Edinger, F;Zajonz, T;Holtz, L;Schmidt, G;Schneck, E;Sander, M;Koch, C; New Insights into Hepatic and Intestinal Microcirculation and Pulmonary Inflammation in a Model of Septic Shock and Venovenous Extracorporeal Membrane Oxygenation in the Rat International journal of molecular sciences 2024-06-16 [PMID: 38928327] (Rat)
• Liu, X;Liu, Y;Su, X;Jiang, L;Tang, G;Wang, Y; Geranylgeranylacetone mitigates sepsis-associated intestinal injury through CHIP-dependent anti-inflammation and anti-oxidative effect International immunopharmacology 2024-05-23 [PMID: 38788444] (Rat)
• Lokman, MS;Kassab, R;Salem, FAM;Elshopakey, GE;Hussein, A;Aldarmahi, AA;Theyab, A;Alzahrani, KJ;Hassan, KE;Alsharif, KF;Albrakati, A;Tayyeb, JZ;El-Khadragy, MF;Alkhateeb, MA;Al-Ghamdy, AO;Althagafi, HA;Abdel Moneim, A;El-Hennamy, RE; Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis Bioscience reports 2024-05-05 [PMID: 38699907] (Rat)
• Zhou, W;Qu, H;Fu, XX;Xu, MM;Li, Q;Jiang, Y;Han, S; Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model Frontiers in pharmacology 2024-02-06 [PMID: 38384299] (Rat)
• Heald, AH;Fachim, HA;Bashir, B;Garside, B;Adam, S;Iqbal, Z;Syed, AA;Donn, R;Le Roux, CW;Abdelaal, M;White, J;Soran, H; Impact of Bariatric Surgery on ABC Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats International journal of molecular sciences 2023-11-30 [PMID: 38069302] (Rat)
• El-Hashash, SA;El-Sakhawy, MA;Eldamaty, HSE;Alqasem, AA; Experimental evidence of the neurotoxic effect of monosodium glutamate in adult female Sprague Dawley rats: The potential protective role of Zingiber officinale Rosc. rhizomes Saudi journal of biological sciences 2023-11-01 [PMID: 37869363] (Rat)
• Deng, J;Golub, LM;Lee, HM;Bhatt, HD;Johnson, F;Xu, TM;Gu, Y; A novel modified-curcumin 2.24 resolves inflammation by promoting M2 macrophage polarization Scientific reports 2023-09-19 [PMID: 37726411] (Rat)
• El Gazzar, WB;Sliem, RE;Bayoumi, H;Nasr, HE;Shabanah, M;Elalfy, A;Radwaan, SE;Gebba, MA;Mansour, HM;Badr, AM;Amer, MF;Ashour, SS;Morsi, H;Aboelkomsan, ESAF;Baioumy, B;Sayed, AEH;Farag, AA; Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats International journal of molecular sciences 2023-09-03 [PMID: 37686424] (Rat)
• Abu-Elfotuh, K;Selim, HMRM;Riad, OKM;Hamdan, AME;Hassanin, SO;Sharif, AF;Moustafa, NM;Gowifel, AMH;Mohamed, MYA;Atwa, AM;Zaghlool, SS;El-Din, MN; The protective effects of sesamol and/or the probiotic, Lactobacillus rhamnosus, against aluminum chloride-induced neurotoxicity and hepatotoxicity in rats: Modulation of Wnt/?-catenin/GSK-3?, JAK-2/STAT-3, PPAR-?, inflammatory, and apoptotic pathways Frontiers in pharmacology 2023-08-02 [PMID: 37601053] (Rat)
• Sun, F;Xu, K;Zhou, J;Zhang, W;Duan, G;Lei, M; Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways BMC cardiovascular disorders 2023-08-18 [PMID: 37596540] (Rat)
• Kim, HR;Lee, SH;Noh, EM;Choi, B;Seo, HY;Jang, H;Kim, SY;Park, MH; Therapeutic Effect of Enzymatically Hydrolyzed Cervi Cornu Collagen NP-2007 and Potential for Application in Osteoarthritis Treatment International journal of molecular sciences 2023-07-19 [PMID: 37511425] (Rat)
• Mechelinck, M;Hein, M;Kupp, C;Braunschweig, T;Helmedag, MJ;Klinkenberg, A;Habigt, MA;Klinge, U;Tolba, RH;Uhlig, M; Experimental Liver Cirrhosis Inhibits Restenosis after Balloon Angioplasty International journal of molecular sciences 2023-07-12 [PMID: 37511114] (Rat)
• Bai, Y;Mi, W;Meng, X;Dong, B;Jiang, Y;Lu, Y;Yu, Y; Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPAR alpha -dependent manner BMC neuroscience 2023-07-20 [PMID: 37474902] (Mouse)
• Elwany, NE;Abdelhamid, AM;Mohamed, NM;Khalil, SS;Elsayed Orabi, EE;Abdelfattah, AM; Vinpocetine alleviates intestinal ischemia/reperfusion injury and enhances M2 macrophage polarization in rats: Role of SIRT1/SOCS3/STAT3 signaling pathway International immunopharmacology 2023-07-15 [PMID: 37459783] (Rat)
• Queiroz, JLC;Medeiros, I;Lima, MSR;Carvalho, FMC;Camillo, CS;Santos, PPA;Guerra, GCB;da Silva, VC;Schroeder, HT;Krause, M;Morais, AHA;Passos, TS; Efficacy of Carotenoid-Loaded Gelatin Nanoparticles in Reducing Plasma Cytokines and Adipocyte Hypertrophy in Wistar Rats International journal of molecular sciences 2023-06-26 [PMID: 37445834] (Rat)
• Atta, IS;Elnady, MR;Alghamdi, AG;Alghamdi, AH;Aboulata, AA;Shatla, IM; Assessing the hepatoprotective effects of hesperidin on liver-associated disorders in albino rats with experimentally induced obesity and type II diabetes: A histological and biochemical study Heliyon 2023-05-01 [PMID: 37215885] (Rat)
• Kirkland, JM;Patel, I;Ardeshna, MS;Kopec, AM; Microglial synaptic pruning in the nucleus accumbens during adolescence sex-specifically influences splenic immune outcomes bioRxiv : the preprint server for biology 2023-05-05 [PMID: 37205376] (Rat)
• Changsan, N;Sawatdee, S;Suedee, R;Chunhachaichana, C;Srichana, T; Aqueous cannabidiol ?-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms International journal of pharmaceutics 2023-05-12 [PMID: 37182795] (Mouse)
• Uhlig, M;Hein, M;Habigt, MA;Tolba, RH;Braunschweig, T;Helmedag, MJ;Arici, M;Thei�en, A;Klinkenberg, A;Klinge, U;Mechelinck, M; Cirrhotic Cardiomyopathy Following Bile Duct Ligation in Rats-A Matter of Time? International journal of molecular sciences 2023-05-02 [PMID: 37175858] (Rat)
• Zeng, W;Takashima, K;Tang, Q;Zou, X;Ojiro, R;Ozawa, S;Jin, M;Ando, Y;Yoshida, T;Shibutani, M; Natural antioxidant formula ameliorates lipopolysaccharide-induced impairment of hippocampal neurogenesis and contextual fear memory through suppression of neuroinflammation in rats Journal of chemical neuroanatomy 2023-05-05 [PMID: 37150363] (Rat)
• J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023-04-11;9(4):e15333. 2023-04-11 [PMID: 37123969] (Rat)
• J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023;9(4):e15333. 2023 [PMID: 37123969] (Rat)
• MFP Gomes, EOC de Moura, NM Cardoso, GA da Silva, ACC Dos Santos, FS de Souza, D Estadella, RH Lambertucc, JHG Lago, A Medeiros Supplementation with okra�combined or not with exercise training is able to protect the heart of animals with metabolic syndrome Scientific Reports, 2023-01-26;13(1):1468. 2023-01-26 [PMID: 36702820] (Rat)
• J Yang, L Miao, Y Xue, X Wang Yiyi Fuzi Baijiang Powder Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats via Inhibiting the TLR4/NF-kappaB/NLRP3 Inflammasome Signaling Pathway to Repair the Intestinal Epithelial Barrier, and Modulating Intestinal Microbiota Oxidative Medicine and Cellular Longevity, 2023-01-14;2023(0):3071610. 2023-01-14 [PMID: 36691639] (Rat)
• J Xu, T Ji, G Li, H Zhang, Y Zheng, M Li, J Ma, Y Li, G Chi Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions Journal of Neuroinflammation, 2022-12-26;19(1):314. 2022-12-26 [PMID: 36572898] (Rat)
• MV Onufriev, MY Stepaniche, YV Moiseeva, MY Zhanina, OA Nedogreeva, PA Kostryukov, NA Lazareva, NV Gulyaeva A Comparative Study of Two Models of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Long-Lasting Accumulation of Corticosterone and Interleukins in the Hippocampus and Frontal Cortex in Koizumi Model Biomedicines, 2022-12-02;10(12):. 2022-12-02 [PMID: 36551875] (Rat)
• FJ Redondo-Ca, N Bejarano-R, V Baladrón, O Montenegro, LA Gómez, R Velasco, N Villasanti, S Illescas, MT Franco-Ser, I Gracia, JF Rodríguez, JR Muñoz-Rodr, JM Pérez-Orti Black Garlic and Thiosulfinate-Enriched Extracts as Adjuvants to Ceftriaxone Treatment in a Rat Peritonitis Model of Sepsis Biomedicines, 2022-12-01;10(12):. 2022-12-01 [PMID: 36551850] (Rat)
• DE Komatsu, SMZ Uddin, C Gordon, MP Kanjiya, D Bogdan, J Achonu, A DiBua, H Iftikhar, A Ackermann, RJ Shah, J Shieh, AB Bialkowska, M Kaczocha Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study PLoS ONE, 2022-12-06;17(12):e0278632. 2022-12-06 [PMID: 36473007] (Rat)
• Y Yu, B Xue, NM Irfan, T Beltz, RM Weiss, AK Johnson, RB Felder, SG Wei Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats Frontiers in Physiology, 2022-11-09;13(0):1052304. 2022-11-09 [PMID: 36439267] (Rat)
• MSR Lima, C Gonçalves, MD Neto, MH Macedo, JLC Queiroz, VC da Silva, IS Costa, CDS Camillo, PPA Santos, AAM Lima, L Pastrana, BLL Maciel, AHA Morais Anti-Inflammatory Protein Isolated from Tamarind Promotes Better Histological Aspects in the Intestine Regardless of the Improvement of Intestinal Permeability in a Preclinical Study of Diet-Induced Obesity Nutrients, 2022-11-04;14(21):. 2022-11-04 [PMID: 36364929] (Rat)
• Mahmoud Abdelbary, Riyaz Mohamed, Ellen E. Gillis, Karl Diaz-Sanders, Babak Baban, Michael W. Brands et al. Sex differences in apoptosis do not contribute to sex differences in blood pressure or renal T cells in spontaneously hypertensive rats Frontiers in Physiology 2022-10-11 [PMID: 36304583] (Rat)
• J Wang, Z Ye, Y Chen, X Qiao, Y Jin MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide Scientific Reports, 2022-10-26;12(1):17915. 2022-10-26 [PMID: 36289253] (Rat)
• C Liao, H Zhou, H Chen, G Cheng, S Li, F Ma, X Yang, B Xie, W Zhang DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model International immunopharmacology, 2022-10-21;113(0):109284. 2022-10-21 [PMID: 36279673] (Rat)
• T Khamis, AE Alsemeh, DM Abdullah Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways Scientific Reports, 2022-08-27;12(1):14654. 2022-08-27 [PMID: 36030321] (Rat)
• SN Chang, M Haroon, DK Dey, SC Kang Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate The Journal of nutritional biochemistry, 2022-08-24;0(0):109134. 2022-08-24 [PMID: 36028100] (Rat)
• H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim, S Kim, Y Lee, KH Han, WS Chung, CH Kim Anti-inflammatory clearance of amyloid-beta by a chimeric Gas6 fusion protein Nature Medicine, 2022-08-04;0(0):. 2022-08-04 [PMID: 35927581] (Rat)
• B Chen, G Qin, J Xiao, X Deng, A Lin, H Liu Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor Journal of Neuroinflammation, 2022-07-13;19(1):181. 2022-07-13 [PMID: 35831873] (Rat)
• SY Park, JS Han Neuroprotective Effect of Bcl-2 on Lipopolysaccharide-Induced Neuroinflammation in Cortical Neural Stem Cells International Journal of Molecular Sciences, 2022-06-07;23(12):. 2022-06-07 [PMID: 35742844] (Rat)
• MM da Silva, MFP Gomes, EOC de Moura, MM Veras, MC Kubota, AP Takano, ACC Dos Santos, CGDR José, GADS Souza, NM Cardoso, D Estadella, RH Lambertucc, A Medeiros Aerobic exercise training combined or not with okra consumption as a strategy to prevent kidney changes caused by metabolic syndrome in Zucker rats PLoS ONE, 2022-06-03;17(6):e0269418. 2022-06-03 [PMID: 35657982] (Rat)
• K Abu-Elfotu, FH Hussein, AN Abbas, MD Al-Rekabi, SS Barghash, SS Zaghlool, SZ El-Emam Melatonin and zinc supplements with physical and mental activities subside neurodegeneration and hepatorenal injury induced by aluminum chloride in rats: Inclusion of GSK-3beta-Wnt/beta-catenin signaling pathway Neurotoxicology, 2022-05-05;91(0):69-83. 2022-05-05 [PMID: 35526705] (Rat)
• F Yan, Z Chen, W Cui H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure BMC cardiovascular disorders, 2022-04-19;22(1):182. 2022-04-19 [PMID: 35439934] (Rat)
• Y Bai, Q Han, B Dong, H Lin, Y Jiang, X Zhang, H Chen, Y Yu PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression Brain research bulletin, 2022-03-30;184(0):56-67. 2022-03-30 [PMID: 35367313] (Mouse)
• X Gao, X Kang, H Lu, E Xue, R Chen, J Pan, J Ma Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis?fibroblast?like synoviocytes by inhibiting the NF?kappaB and MAPK signaling pathways Molecular Medicine Reports, 2022-03-24;25(5):. 2022-03-24 [PMID: 35322865] (Rat)
• Y Xiao, C Su, G Zhang, L Liang, T Jin, J Bradley, JP Ornato, W Tang Vitamin C Improves the Outcomes of Cardiopulmonary Resuscitation and Alters Shedding of Syndecan-1 and p38/MAPK Phosphorylation in a Rat Model Journal of the American Heart Association, 2022-03-15;0(0):e023787. 2022-03-15 [PMID: 35289183] (Rat)
• K Ogiso, SC Shayo, S Kawade, H Hashiguchi, T Deguchi, Y Nishio Repeated glucose spikes and insulin resistance synergistically deteriorate endothelial function and bardoxolone methyl ameliorates endothelial dysfunction PLoS ONE, 2022-01-24;17(1):e0263080. 2022-01-24 [PMID: 35073378] (Rat)
• HH Arab, SA Abd El-Aal, AH Eid, EA Arafa, AM Mahmoud, AM Ashour Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats International immunopharmacology, 2021-12-23;103(0):108284. 2021-12-23 [PMID: 34953450] (Rat)
• MV Onufriev, YV Moiseeva, MY Zhanina, NA Lazareva, NV Gulyaeva A Comparative Study of Koizumi and Longa Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Early Corticosterone and Inflammatory Response in the Hippocampus and Frontal Cortex International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948340] (Rat)
• UN Das Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution Biomolecules, 2021-12-14;11(12):. 2021-12-14 [PMID: 34944517] (Rat)
• T Pelé, S Giraud, S Joffrion, V Ameteau, A Delwail, JM Goujon, L Macchi, T Hauet, F Dkhissi, O Benzakour Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats International Journal of Molecular Sciences, 2021-11-09;22(22):. 2021-11-09 [PMID: 34829984] (Rat)
• Y Song, Z Bai, Y Zhang, J Chen, M Chen, Y Zhang, X Zhang, H Mai, B Wang, Y Lin, S Gu Protective effects of endothelial progenitor cell microvesicles on Ang�II?induced rat kidney cell injury Molecular Medicine Reports, 2021-11-05;25(1):. 2021-11-05 [PMID: 34738620] (Rat)
• YC Cheng, YM Chiu, ZK Dai, BN Wu Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats Cells, 2021-10-08;10(10):. 2021-10-08 [PMID: 34685668] (Rat)
• B Sun, Z Chen, Q Chi, Y Zhang, B Gao Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP) Journal of Cellular and Molecular Medicine, 2021-10-13;0(0):. 2021-10-13 [PMID: 34643045] (Rat)
• RVP Neves, HL Corrêa, IV de Sousa N, MK Souza, F Costa, AS Haro, LA Deus, AL Reis, HG Simões, RV Andrade, CO Assumpção, W Stone, J Prestes, EC Vieira, R de Cássia, V Cruzat, TS Rosa Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats Oxidative Medicine and Cellular Longevity, 2021-09-28;2021(0):3683796. 2021-09-28 [PMID: 34621463] (Rat)
• Y Fujihara, Y Kodo, SI Miyoshi, R Watanabe, H Toyoda, M Mankura, H Kabuto, F Takayama Spirulina platensis and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model Journal of Clinical Biochemistry and Nutrition, 2021-03-25;69(2):151-157. 2021-03-25 [PMID: 34616107] (Rat)
• Y Bai, K Mo, G Wang, W Chen, W Zhang, Y Guo, Z Sun Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism Frontiers in Pharmacology, 2021-09-16;12(0):710722. 2021-09-16 [PMID: 34603025] (Rat)
• S Scheid, M Goeller, W Baar, J Wollborn, H Buerkle, G Schlunck, W Lagrèze, U Goebel, F Ulbrich Hydrogen Sulfide Reduces Ischemia and Reperfusion Injury in Neuronal Cells in a Dose- and Time-Dependent Manner International Journal of Molecular Sciences, 2021-09-18;22(18):. 2021-09-18 [PMID: 34576259] (Rat)
• M Minami, H Otake, Y Nakazawa, N Okamoto, N Yamamoto, H Sasaki, N Nagai Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles Pharmaceutics, 2021-09-08;13(9):. 2021-09-08 [PMID: 34575501] (Rat)
• ZR Du, Y Gu, XM Xie, M Zhang, GY Jiang, WF Chen GPER and IGF-1R mediate the anti-inflammatory effect of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in rats The Journal of steroid biochemistry and molecular biology, 2021-08-31;214(0):105989. 2021-08-31 [PMID: 34478828] (Rat)
• M Uhlig, M Hein, MA Habigt, RH Tolba, T Braunschwe, MJ Helmedag, U Klinge, A Koch, C Trautwein, M Mechelinck Acute myocardial injury secondary to severe acute liver failure: A retrospective analysis supported by animal data PLoS ONE, 2021-08-30;16(8):e0256790. 2021-08-30 [PMID: 34460845] (Rat)
• SKH Chow, C Cui, KYK Cheng, YN Chim, J Wang, CHW Wong, KW Ng, RMY Wong, WH Cheung Acute Inflammatory Response in Osteoporotic Fracture Healing Augmented with Mechanical Stimulation is Regulated In Vivo through the p38-MAPK Pathway International Journal of Molecular Sciences, 2021-08-13;22(16):. 2021-08-13 [PMID: 34445423] (Rat)
• TR Goesch, NA Wilson, W Zeng, BM Verhoven, W Zhong, MM Coumbe Git, WE Fahl Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats Biomolecules, 2021-07-19;11(7):. 2021-07-19 [PMID: 34356678] (Rat)
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FAQs for TNF-alpha (RTA00). (Showing 1 - 4 of 4 FAQs).

1. I need to know about TNF-alpha antibody kits for mice.
   • We currently have two TNFalpha ELISA kits specific for mouse: catalog numbers KA0257 and NBP1-92670.
2. I would like to ask you for help. I need an antibody for Elisa to detect human TNF alpha in a supernatant from a cell culture (meaning supernatant after centrifugation of collected cell suspension from a plate well). Which of your antibodies against human tnf alpha would be suitable? I would like to buy only the primary antibody.
   • I would recommend catalog number NBP1-67821 or NB600-587; however, a full list of our anti-human TNF alpha antibodies suitable for use in ELISA can be found using this link.
3. I am interested in a TNF alpha antibody, cross reactive for human, rat and mouse (host species: rabbit). Could your product NBP1-19532 be used in western blotting applications? Or do you have a similar product in your catalog which could fit with my request?
   • The antibody you mention, NBP1-19532, has not yet been validated in Western blot. I would instead recommend either NBP1-67821 or NB600-587. These are both rabbit polyclonal antibodies that cross-reacts with human, mouse and rat and have been used in Western blotting.
4. Can your TNF-alpha products be used to treat TBI victims and therefore avoid the perispinal injections with Enbrel?
   • I am very sorry, but all of our products are for scientific research use only, and none are intended or approved for use in humans.

Bioinformatics

• Gene Symbol: Tnf