RAIDD/CRADD Antibody

Images

 
Western Blot: RAIDD/CRADD Antibody [NBP1-77048] - Analysis of RAIDD in MCF7 total cell lysate with RAIDD antibody at 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: RAIDD/CRADD Antibody [NBP1-77048] - Staining of RAIDD in HeLa cells with RAIDD antibody at 5 ug/ml.
Immunohistochemistry-Paraffin: RAIDD/CRADD Antibody [NBP1-77048] - Human kidney tissue with RAIDD antibody at 10 ug/ml.
Western Blot: RAIDD/CRADD Antibody [NBP1-77048] - HeLa total cell lysate with RAIDD antibody at 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: RAIDD/CRADD Antibody [NBP1-77048] - HeLa cells with RAIDD antibody at 5 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

RAIDD/CRADD Antibody Summary

Immunogen
Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human RAIDD. The immunogen is located within the last 50 amino acids of RAIDD.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CRADD
Purity
Ion exchange chromatography
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 5 ug/mL
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
RAIDD antibody can be used for detection of RAIDD by Western blot at 2ug/mL. A 22 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 ug/mL.
Theoretical MW
18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
RAIDD Peptide (NBP1-77048PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Ion exchange chromatography

Alternate Names for RAIDD/CRADD Antibody

  • CASP2 and RIPK1 domain containing adaptor with death domain
  • Caspase and RIP adapter with death domain
  • caspase and RIP adaptor with death domain
  • CRADD
  • death domain containing protein CRADD
  • death domain-containing protein CRADD
  • MGC9163
  • RAIDD
  • RAIDDdeath adaptor molecule RAIDD
  • RIP-associated ICH1/CED3-homologous protein with death domain
  • RIP-associated protein with a death domain

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1,RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CRADD
Entrez
Uniprot