RAIDD/CRADD Products

Antibodies
RAIDD/CRADD Antibody
RAIDD/CRADD Antibody
AF4680
Species: Hu, Mu, Rt
Applications: WB
Host: Goat Polyclonal
RAIDD/CRADD Antibody
RAIDD/CRADD Antibody
NBP1-77048
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
RAIDD/CRADD Antibody
RAIDD/CRADD Antibody
NBP1-77061
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Lysates
RAIDD/CRADD Overexpression Ly ...
RAIDD/CRADD Overexpression Lysate ...
NBL1-09459
Applications: WB
Proteins
RAIDD/CRADD Recombinant Prote ...
RAIDD/CRADD Recombinant Protein
NBC1-18519
Species: Hu
Applications: PAGE
RAIDD/CRADD Peptide
RAIDD/CRADD Peptide
NBP1-77061PEP
Species: Hu
Applications: AC
RAIDD/CRADD Peptide
RAIDD/CRADD Peptide
NBP1-77048PEP
Species: Hu
Applications: AC
RNAi
RAIDD/CRADD RNAi
RAIDD/CRADD RNAi
H00008738-R01
Species: Hu

Description

Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. Activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD (1). RAIDD has a dual-domain structure similar to that of FADD. It has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. RAIDD is constitutively expressed in many tissues and thus could play a role in regulating apoptosis in mammalian cells (2). In metazoan cells there exists inactive polypeptide precursors (zymogens), each composed of a prodomain, which is cleaved to activate the protease, and a large and small catalytic subunit. The coupling of these proteases to signaling pathways is probably mediated by adaptor molecules that contain protein-protein interaction motifs such as the death domain (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 8738
Alternate Names
  • RIP-associated ICH1/CED3-homologous protein with death domain
  • MGC9163
  • death domain-containing protein CRADD
  • RIP-associated protein with a death domain
  • death domain containing protein CRADD
  • Caspase and RIP adapter with death domain
  • RAIDDdeath adaptor molecule RAIDD
  • caspase and RIP adaptor with death domain
  • CASP2 and RIPK1 domain containing adaptor with death domain

Research Areas for RAIDD/CRADD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Tumor Suppressors

PTMs for RAIDD/CRADD

Learn more about PTMs related to RAIDD/CRADD.

Cleavage
Sumoylation
Biotinylation
Ubiquitination

Bioinformatics Tool for RAIDD/CRADD

Discover related pathways, diseases and genes to RAIDD/CRADD. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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