Radixin Antibody

Images

 
Western Blot: Radixin Antibody [NBP1-31553] - Sample (30 ug of whole cell lysate) A: 293T 7. 5% SDS PAGE; antibody diluted at 1:5000.
Immunocytochemistry/ Immunofluorescence: Radixin Antibody [NBP1-31553] - Analysis of HeLa, using NBP1-31553 at 1:200 dilution.
Immunohistochemistry-Paraffin: Radixin Antibody [NBP1-31553] - Paraffin-embedded RT2 xenograft, using antibody at 1:500 dilution.
Western Blot: Radixin Antibody [NBP1-31553] - 293T, with 7.5% SDS PAGE, diluted at 1:5000.
Immunohistochemistry-Paraffin: Radixin Antibody [NBP1-31553] - Paraffin-embedded U37C xenograft, using antibody at 1:500 dilution.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Radixin Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Radixin. The exact sequence is proprietary.
Localization
Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RDX
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:10000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Immunoprecipitation 1:10 - 1:500
Positive Control
Radixin Lysate (NBP2-65760)

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Purity
Immunogen affinity purified

Alternate Names for Radixin Antibody

  • deafness, autosomal recessive 24
  • DFNB24
  • radixin

Background

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin (1). The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs (2). Proteins of the ezrin-radixin-moesin family are ubiquitous constituents of the submembrane cortex, especially in epithelial cells. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the pointed ends of actin filaments to the membrane (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol RDX