QPRT Antibody (OTI1C10) [DyLight 650]

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF, IHC
• Clone: OTI1C10
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

QPRT Antibody (OTI1C10) [DyLight 650] Summary

• Immunogen: Full length recombinant protein of human QPRT (NP_055113) produced in HEK293T cells.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: QPRT
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for QPRT Antibody (OTI1C10) [DyLight 650]

• EC 2.4.2.19
• nicotinate-nucleotide pyrophosphorylase (carboxylating)
• QAPRTase
• QPRTasenicotinate-nucleotide pyrophosphorylase [carboxylating]
• Quinolinate phosphoribosyltransferase [decarboxylating]
• quinolinate phosphoribosyltransferase

Background

QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: QPRT