Reactivity | HuSpecies Glossary |
Applications | WB |
Description | Transient overexpression lysate of BCL2 binding component 3 (BBC3), transcript variant 4 The lysate was created in HEK293T cells, using Plasmid ID RC213203 and based on accession number NM_014417. The protein contains a C-MYC/DDK Tag. |
Gene | BBC3 |
Application Notes | This product is intended for use as a positive control in Western Blot. You will receive 1 vial of lysate (100ug), 1 vial of empty vector negative control (100ug), and 1 vial of 2xSDS sample buffer (250ul). |
Theoretical MW | 20.4 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Storage | Store at -80C. Avoid freeze-thaw cycles. |
Buffer | RIPA buffer |
Diseases for PUMA Lysate (NBL1-07925)Discover more about diseases related to PUMA Lysate (NBL1-07925).
| Pathways for PUMA Lysate (NBL1-07925)View related products by pathway.
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PTMs for PUMA Lysate (NBL1-07925)Learn more about PTMs related to PUMA Lysate (NBL1-07925).
| Research Areas for PUMA Lysate (NBL1-07925)Find related products by research area.
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A link between Autophagy and Apoptosis: Chat with First Author Brent E. Fitzwalter By Christina Towers, PhD. Autophagy is a cellular recycling process and most often a pro-survival mechanism that regulates cellular homeostasis. On the contrary, apoptosis is an extensively conserved and elaborate pr... Read full blog post. |
Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis? Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death. Novus Biologicals offers a variet... Read full blog post. |
Altered expression of BCL2 in cancer Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease. For example, too little cell death can promote cell overgrowth a... Read full blog post. |
IRE1 alpha dependent apoptotic-signaling pathway Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg... Read full blog post. |
Understanding Noxa Regulation of Apoptosis Noxa is a pro-apoptotic gene belonging to the Bcl2 protein family that is unique in that it contains only BH3 domain. The BH3-only subclass of proteins, including proteins like PUMA and Bim in addition to Noxa, regulate the remaining Bcl-2 family memb... Read full blog post. |
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Gene Symbol | BBC3 |