PUMA Products

Antibodies
PUMA Antibody
PUMA Antibody
NB100-56370
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
PUMA Antibody
PUMA Antibody
NBP1-76639
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
PUMA Overexpression Lysate (N ...
PUMA Overexpression Lysate (Native)
NBP2-11377
Applications: WB
PUMA Overexpression Lysate (N ...
PUMA Overexpression Lysate (Native)
NBL1-07925
Applications: WB
Proteins
PUMA Peptide
PUMA Peptide
NB500-261PEP
Species: Hu
PUMA Peptide
PUMA Peptide
NBP1-76639PEP
Species: Hu
Applications: AC
PUMA Peptide
PUMA Peptide
NBP1-76654PEP
Species: Hu
Applications: AC

Description

p53 upregulated modulator of apoptosis (PUMA), also called BBC3, is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 27113
Alternate Names
  • JFY-1
  • bcl-2-binding component 3
  • JFY1
  • PUMAFLJ42994
  • p53 up-regulated modulator of apoptosis
  • BCL2 binding component 3

Research Areas for PUMA

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cellular Markers
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Mitochondrial Markers
Protein Phosphatase
Signal Transduction
Tumor Suppressors

Bioinformatics Tool for PUMA

Discover related pathways, diseases and genes to PUMA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related PUMA Blog Posts

Check out the latest blog posts on PUMA.
IRE1 alpha dependent apoptotic-signaling pathway
Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...    Read more.
Understanding Noxa Regulation of Apoptosis
Noxa is a pro-apoptotic gene belonging to the Bcl2 protein family that is unique in that it contains only BH3 domain. The BH3-only subclass of proteins, including proteins like PUMA and Bim in addition to Noxa, regulate the remaining Bcl-2 family memb...    Read more.
Read more PUMA related blogs.