PTP epsilon Antibody

Immunohistochemistry-Paraffin: PTP epsilon Antibody [NLS6802] - Anti-PTPRE antibody IHC of human colon, submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: PTP epsilon Antibody [NLS6802] - Analysis of anti-PTPRE / PTP Epsilon antibody with brains, neurons and glia.

Immunohistochemistry-Paraffin: PTP epsilon Antibody [NLS6802] - Analysis of anti-PTPRE / PTP Epsilon antibody with human skin, melanoma.

Product Discontinued

PTP epsilon Antibody Summary

• Immunogen: Synthetic 20 amino acid peptide from cytoplasmic domain of human PTPRE.
• Epitope: cytoplasmic domain of human
• Specificity: Human PTPRE. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AMT (50%).
• Predicted Species: Mouse (90%), Bovine (90%), Canine (90%), Hamster (90%), Equine (90%), Primate (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPRE
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin assay dependent

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Marmoset (95%), Panda (90%), Rat (85%), Xenopus (85%), Elephant (80%), Turkey (80%), Chicken (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PTP epsilon Antibody

• DKFZp313F1310
• EC 3.1.3.48
• FLJ57799
• FLJ58245
• HPTPE
• protein tyrosine phosphatase epsilon
• protein tyrosine phosphatase, receptor type, E
• protein tyrosine phosphatase, receptor type, epsilon polypeptide
• Protein-tyrosine phosphatase epsilon
• PTPE
• receptor-type tyrosine-protein phosphatase epsilon
• R-PTP-EPSILON

Background

PTP epsilon, an R4 receptor protein tyrosine phosphatase, is composed of a short extracellular and two cyplasmic protein phosphatase domains and has been shown to affect neuronal differentiation, endothelial cell growth, vascular development, and possibly mammary tumor development. It has been shown that the cytosolic form of PTP epsilon can be induced by IL-1 and TNF alpha in humans and is a negative regulator of IL-6- and LIF-induced Jak-STAT kinase signaling in rats. Four alternatively spliced protein isoforms have been documented for PTP epsilon: a membrane form, a cytosolic form, the p65 form, which results from translation using an internal initiation codon, and the p67 form, which results from a specific proteolytic cleavage of wild-type PTP epsilon. PTP epsilon expression has been documented in human vascular endothelial cells, astrocytoma cells, and in IW32 erythroleukemia overexpressing p53. PTP epsilon expression has been documented in animal brain, breast, ganglion, heart, kidney, liver, lung, nerve, spinal cord, spleen, testis, and vessel. The membrane and cytosolic forms of PTP epsilon show different tissue expression patterns. ESTs have been isolated from numerous human tissue libraries, including normal human blood, brain, testis, and thyroid, and cancerous human blood, brain, breast, colon, embryo, head/neck, pancreas, and skin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRE
• Entrez:
  • 5791(Human)