This antibody works in ELISA and Western Blot. Approx 55kDa band observed in lysates of cell line A431 and 50kDa in lysates of cell line NIH3T3 (calculated MW of 47.1kDa according to Human NP_000305 and Mouse NP_032986.1). Recommended concentration: 1-3ug/ml.
Expected from sequence similarity: Rat, Dog, Pig and Cow.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
0.02% Sodium Azide
Immunogen affinity purified
On restricted sale due to demands of patent holder. Not for sale in USA, if you are outside the USA then please contact Novus to see if we can sell into your territory.
Alternate Names for PTEN Antibody
MMAC1 phosphatase and tensin homolog deleted on chromosome 10
Mutated in multiple advanced cancers 1
phosphatase and tensin homologDEC
phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN
PTEN functions primarily as a lipid phosphatase to regulate crucial signal transduction pathways; a key target is phosphatidylinositol 3,4,5 trisphosphate. In addition, it displays weak tyrosine phosphatase activity, which may down modulate signaling pathways that involve focal adhesion kinase or Shc. PTEN negatively regulates Akt activation by preventing its phosphorylation. PTEN therefore inhibits the PI 3 kinase/Akt signaling pathway, which is important for cell growth and survival. Mutations of PTEN occur in 60 to 80% of prostate cancers.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Getting SHIP-shape Over Tumour Suppression PTEN antibodies have shown PTEN to be an important tumor suppressor and, in mutated form, a factor in cancer development. However, a recent study, led by Robert Rickert, shows that the SHIP gene may also be an important tumor suppressor in B-cell lymp... Read full blog post.
PTEN Antibodies and Cancer Research Phosphatase and tensin homologue (PTEN) antibodies are important tools for cancer research. PTEN is an important tumor suppressor but, in mutated form, is also expressed in a high number of cancers. We at Novus Biologicals have a wide PTEN antibody da... Read full blog post.
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