PTEN [p Ser382, p Thr383, p Ser380] Antibody


Western Blot: PTEN Antibody [NB100-92618] - analysis of p-PTEN (S380+T382+T383) antibody in extracts from HT29 cells treated with calycalinA
Immunohistochemistry: PTEN Antibody [NB100-92618] - analyzes of PTEN (E2) antibody in paraffin-embedded human muscle tissue.

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PTEN [p Ser382, p Thr383, p Ser380] Antibody Summary

Synthetic phosphopeptide derived from human PTEN around the phosphorylation site of Serine 380 and 382 and Threonine 383.
p Ser380, p Ser382, p Thr383
Immunogen affinity purified
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  • Western Blot 1:500-1:1000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot analysis of p-PTEN (S380+T382+T383) Antibody in extracts from HT29 cell treated with calycalinA Immunohistochemistry analysis of p-PTEN (S380+T382+T383) Antibody in paraffin-embedded human breast carcinoma tissue
Theoretical MW
47 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

This antibody is reactive against Human, Mouse,.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for PTEN [p Ser382, p Thr383, p Ser380] Antibody

  • BZS
  • EC,10q23del
  • EC
  • EC
  • GLM2
  • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
  • MMAC1
  • MMAC1MGC11227
  • Mutated in multiple advanced cancers 1
  • phosphatase and tensin homologDEC
  • phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN
  • PTEN
  • PTEN1


As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm, and it shares extensive homology with the cytoskeletal proteins Tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells. PTEN contains five major phosphorylation sites and these are all located in the C-terminal 50 amino acid tail region (Ser 370, Ser 380, Thr 382, Thr 383 and Ser 385) and have been implicated in controlling PTEN activity.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol PTEN