PSAP Antibody (PASE/4LJ)

Product Discontinued

PSAP Antibody (PASE/4LJ) Summary

• Immunogen: BALB/C mice were injected with purified prostatic acid phosphatase from human seminal plasma.
• Localization: Cytoplasm
• Specificity: This is specific to human prostatic acid phosphatase. It reacts with the glandular epithelium of normal and hyperplastic prostate and with prostate adenocarcinoma.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PSAP
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:25-1:100
  • Immunohistochemistry-Paraffin 1:25-1:100

Reactivity Notes

Human. Does not react with Dog, Rabbit or Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: No buffer
• Preservative: Sodium Azide
• Purity: Protein A or G purified

Alternate Names for PSAP Antibody (PASE/4LJ)

• FLJ00245
• GLBA
• proactivator polypeptide
• prosaposin
• PSAP
• SAP1
• SAP1MGC110993
• sphingolipid activator protein-1

Background

PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in PSAP gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSAP
• Entrez:
  • 5660(Human)
• Uniprot:
  • P07602()