PRDC/GREM2 Antibody [DyLight 405]

• Reactivity: Mu
• Applications: WB, ELISA, ELISA(Cap), ELISA(Det)
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 405

PRDC/GREM2 Antibody [DyLight 405] Summary

• Immunogen: E. coli-derived recombinant mouse PRDC
  Arg22-Gln168
  Accession # O88273
• Specificity: Detects mouse PRDC in ELISAs and Western blots. In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse (rm) Cerberus, rmGremlin, rmDAN, recombinant human (rh) COCO, rhGremlin, and rmBMP-4 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: GREM2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PRDC/GREM2 Antibody [DyLight 405]

• CKTSF1B2
• CKTSF1B2FLJ21195
• Cysteine knot superfamily 1, BMP antagonist 2
• DAN domain family member 3
• DAND3
• DAND3Prdc
• GREM2
• gremlin 2
• gremlin 2, cysteine knot superfamily, homolog
• gremlin-2
• PRDC
• PRDCgremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
• Protein related to DAN and cerberus

Background

GREM2, also known as Gremlin-2, is a 168 amino acid that is 19 kDa, belongs to the DAN family, plays a role in the inhibition of the activity of BMP2 and BMP4 in a dose-dependent manner, and as an antagonist of BMP, it may play a role in regulating organogenesis, body patterning, and tissue differentiation. Current research is being performed on several diseases and disorders including astigmatism, myopia, accommodative esotropia, keratoconus, intraocular retinoblastoma, scimitar syndrome, swine influenza, influenza, norrie disease, and multiple sclerosis. The GREM2 protein is known to have an interaction with BMP4, BMP2, CER1, NOG, and FSTL1 in signal transduction and signaling by BMP pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GREM2