PRAT4A/TNRC5 Antibody [Alexa Fluor® 488]

• Reactivity: Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 488

PRAT4A/TNRC5 Antibody [Alexa Fluor® 488] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse PRAT4A isoform 1
  Glu38-Leu276
  Accession # Q9DAU1
• Specificity: Detects mouse PRAT4A in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse PRAT4B is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PRAT4A/TNRC5 Antibody [Alexa Fluor® 488]

• CAG4A
• canopy 3 homolog (zebrafish)
• CNPY3
• CTG4A
• ERDA5
• ERDA5CTG repeat protein 4a
• Expanded repeat-domain protein CAG/CTG 5
• PRAT4A
• PRAT4ACAG repeat containing
• Protein associated with TLR4
• protein associated with Toll-like receptor 4A
• protein canopy homolog 3
• TNRC5
• TNRC5expanded repeat domain, CAG/CTG 5
• trinucleotide repeat containing 5
• Trinucleotide repeat-containing gene 5 protein

Background

PRAT4A (Protein associated with TLR4-A) is a ubiquitously expressed, 40 kDa protein that participates in Toll receptor expression. Mouse PRAT4A is 276 amino acids (aa) in length. It contains a putative signal sequence of 37 aa, followed by a 239 aa mature region. Although the presence of a signal sequence suggests it is secreted, its best known activity involves an intracellular association with TLR4. PRAT4A appears to facilitate the maturation and expression of TLR4 on the cell surface. Studies suggest this involves the C-terminal 60 amino acids. Mature mouse PRAT4A shares 90% and 96% aa identity with human and rat PRAT4A, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.