Podoplanin Antibody (pmab-1)

Images

 
Western Blot: Podoplanin Antibody (pmab-1) [NBP2-03955] - Analysis using the Azide Free version of NBP2-03955. Analysis using podoplanin antibody. Lysate from mouse A) Brain, B) Heart, C) Small Intestine, D) Kidney, E) ...read more
Flow Cytometry: Podoplanin Antibody (pmab-1) [NBP2-03955] - Analysis using the PE conjugate of NBP2-03955. Staining using podoplanin antibody. Mouse F9 tumor cell line probed using 0.5 ug of podoplanin antibody (red) ...read more
Western Blot: Podoplanin Antibody (pmab-1) [NBP2-03955] - Analysis using the Azide Free version of NBP2-03955. Detection of mouse fetal lung tissue using Podoplanin antibody at a conentration of 1 ug/ml.
Flow Cytometry: Podoplanin Antibody (pmab-1) [NBP2-03955] - Analysis using podoplanin antibody. Mouse LLC1 cells were probed using 0.5 ug of podoplanin antibody (red) and 0.5 ug of isotype control antibody (green). ...read more
Flow Cytometry: Podoplanin Antibody (pmab-1) [NBP2-03955] - Analysis using the Alexa Fluor (R) 488 conjugate of NBP2-03955. Staining using podoplanin antibody. Mouse LLC1 cells were probed using 0.5 ug of podoplanin ...read more
Flow Cytometry: Podoplanin Antibody (pmab-1) [NBP2-03955] - Analysis using the Alexa Fluor (R) 647 conjugate of NBP2-03955. Staining using podoplanin antibody. Mouse LLC1 cells were probed using 0.5 ug of podoplanin ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
pmab-1
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Podoplanin Antibody (pmab-1) Summary

Immunogen
The immunogen is Podoplanin.
Marker
Lymphatic Endothelium Marker
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
PDPN
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 3-5 ug/ml
  • Flow Cytometry 0.5 ug/10^5 cells
  • CyTOF-ready
Positive Control
Podoplanin Lysate (NBP2-65884)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.1 ml PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Podoplanin Antibody (pmab-1)

  • 36-KD
  • Aggrus
  • Gp36
  • Gp38
  • GP40
  • HT1A-1
  • hT1alpha-1
  • hT1alpha-2
  • lung type I cell membrane associated glycoprotein
  • lung type-I cell membrane-associated glycoprotein (T1A-2)
  • OTS 8
  • OTS8
  • PA2.26 antigen
  • PDPN
  • Podoplanin
  • RANDAM-2
  • T1A
  • T1A-2
  • T1-alpha

Background

Podoplanin, also known as gp38, is a 43kD type 1 transmembrane glycoprotein found on many tissues. Podoplanin appears to be differentially expressed by lymphatic endothelial cells but not blood vessel endothelial cells (Schacht, 2005). Podoplanin has also been found to be expressed on a wide variety of tumors. It appears to be involved in lymphangioigenesis and promoting cell migration (Farr, 1992). Recently, there are indications of podoplanin presence on Th17 cells (Bettelli, 2011). In a murine EAE model for autoimmune disease it has been shown that Th17 cells migrate quickly to the CNS at EAE onset. Injection of antibody to podoplanin in mice also immunized with myelin antigen to induce EAE results in elevated numbers of Th17 cells in the CNS. Thus as in effecting migration of tumor cells, podoplanin may also promote migration of committed Th17 cells to sites of inflammation in autoimmune diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-03955AF405
Alexa Fluor 488 Labeled NBP2-03955AF488
Alexa Fluor 647 Labeled NBP2-03955AF647
Alexa Fluor 700 Labeled NBP2-03955AF700
Allophycocyanin Labeled NBP2-03955APC
Biotin Labeled NBP2-03955B
DyLight 350 Labeled NBP2-03955UV
DyLight 405 Labeled NBP2-03955V
DyLight 488 Labeled NBP2-03955G
DyLight 550 Labeled NBP2-03955R
DyLight 650 Labeled NBP2-03955C
DyLight 680 Labeled NBP2-03955FR
DyLight 755 Labeled NBP2-03955IR
HRP Labeled NBP2-03955H
PerCP Labeled NBP2-03955PCP

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Bioinformatics Tool for Podoplanin Antibody (NBP2-03955)

Discover related pathways, diseases and genes to Podoplanin Antibody (NBP2-03955). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Podoplanin Antibody (NBP2-03955)

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PTMs for Podoplanin Antibody (NBP2-03955)

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Research Areas for Podoplanin Antibody (NBP2-03955)

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Blogs on Podoplanin.

Podoplanin (OST8, Glycoprotein (Gp) 36 or 38, Lung Type I Cell Membrane Associated Glycoprotein)
Podoplanin is a mucin-type 1 transmembrane glycoprotein found in a wide range of tissues. It appears to be differentially expressed in endothelial cells of lymphatic but not blood vessel origin. In normal skin and kidney, podoplanin co-localizes with...  Read full blog post.

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Bioinformatics

Gene Symbol PDPN
Entrez
Uniprot