PGC-1 beta Antibody [Janelia Fluor® 585]

Product Discontinued

PGC-1 beta Antibody [Janelia Fluor® 585] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 50 and 100 of human peroxisome proliferator-activated receptor gamma coactivator 1 beta using the numbering given in entry NP_573570.2 (GeneID 133522).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PPARGC1B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PGC-1 beta Antibody [Janelia Fluor® 585]

• DKFZp686C1790
• ERRL1
• PERCFLJ14284
• peroxisome proliferator-activated receptor gamma, coactivator 1 beta
• PGC1
• PGC1Bgamma, coactivator 1, beta
• PPARGC1

Background

PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. PGC-1 beta is also involved in activation of nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. Ectopic expression of this protein has been shown to lead to increased mitochondrial numbers and basal oxygen consumption.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPARGC1B