PDZK1 Antibody (1A2)

Product Discontinued

PDZK1 Antibody (1A2) Summary

• Immunogen: Recombinant human PDZK1 (1-519aa) purified from E. coli
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PDZK1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence 1:100
  • Western Blot 1:1000
• Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 10% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for PDZK1 Antibody (1A2)

• CAP70
• CFTR-associated protein of 70 kDa
• CLAMP
• Na(+)/H(+) exchanger regulatory factor 3
• Na/Pi cotransporter C-terminal-associated protein 1
• NaPi-Cap1
• NHERF3
• NHERF-3
• NHERF3PDZD1Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• PDZ domain containing 1
• PDZ domain-containing protein 1
• PDZ-containing kidney protein 1
• PDZD1
• PDZK1
• Sodium-hydrogen exchanger regulatory factor 3

Background

PDZK1 is PDZ domain-containing scaffolding protein with a 519 amino acid protein. PDZK1 mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. This protein is expressed in the kidney, pancreas, liver, gastrointestinal tract, and adrenal cortex. In situ hybridization experiments showed that the expression of PDZK1 was limited to epithelial cells. In addition, PDZK1 was overexpressed in selected tumors of epithelial origin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PDZK1 Antibody (NBP2-22568)(1)

Publication using NBP2-22568

• Collum SD, Molina JG, Hanmandlu A et al. Rat OATP1A1 Interacts Directly With OATP1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane Hepatology 2019-05-18 [PMID: 31102415] (Single Cell Western, Rat, Human)

Bioinformatics

• Gene Symbol: PDZK1
• Uniprot:
  • NP_001188254(Human)