Map17 Antibody

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Map17 Antibody Summary

Immunogen
A synthetic peptide made to the C-terminus of mouse Map17. [UniProt# Q9CQH0]
Localization
Membrane-associated
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PDZK1IP1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Application Notes
This Map17 antibody is useful for Western blot, where a major band of ~14 kDa is detected. Minor cross-reacting bands are visible at higher molecular weights. This antibody is not applicable for ICC/IF.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NB400-151 in the following applications:

  • WB
    1 publication

Reactivity Notes

Mouse, human, and rat.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for Map17 Antibody

  • 17 kDa membrane-associated protein
  • DD96
  • MAP17epithelial protein up-regulated in carcinoma, membrane associated protein 17
  • membrane-associated protein 17
  • PDZK1 interacting protein 1
  • PDZK1-interacting protein 1
  • Protein DD96
  • RP1-18D14.5
  • SPAP

Background

MAP17 (17 kD membrane-associated protein) is a small non-glycosylated protein which localize to plasma membrane as well as Golgi apparatus, and interacts with several PDZ domain-containing proteins such as NHeRF proteins, NaPi-IIa, and NHe3. Overexpression of MAP17 in OK cells (opossum kidney epithelial cells) participates in NaPi-IIa internalization to the trans-Golgi network. In mouse, MAP17 overexpression in liver resulted in PDZK1 (NHeRF3) hepatic deficiency, suggesting MAP17's role in endogenous regulation of PDZK1 turnover. MAP17 acts as an atypical anchoring site for PDZK1 and interacts with NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells, wherein its physiological role is not well known, but it does stimulate specific Na-dependent transport of mannose and glucose in Xenopus oocytes as well as in human cancer cells. MAP17 is overexpressed in a variety of human carcinomas and its overexpression strongly correlates with ROS overproduction as well as tumoral progression characterized by decreased apoptotic sensitivity with enhanced proliferation and migration in prostate, breast, ovarian cancer etc. This increase in ROS as well as tumor aggressiveness relies largely on its PDZ-binding domain as disruption of this sequence by point mutations has been shown to abolish MAP17's ability to enhance ROS production and tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Map17 Antibody (NB400-151)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Blogs on Map17.

One MAP to Navigate the Oxidative Stress, Tumorigenesis and Apoptosis Pathways?
Reactive oxygen species, ROS, are beneficially involved in many signaling pathways that control development and maintain cellular homeostasis. In physiological conditions, a tightly regulated redox balance protects cells from injurious ROS activity, a...  Read full blog post.

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Bioinformatics

Gene Symbol PDZK1IP1
Entrez
Uniprot