Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free [NBP2-21614] - Human placenta tissue.

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free [NBP2-21614] - staining of a formalin-fixed, paraffin-embedded placental tissue with pappalysin-1/PAPP-A Antibody.

• Reactivity: Hu
• Applications: WB, ELISA, IHC
• Clone: PAPP A 1-1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free Summary

• Immunogen: Purified human PAPP-A
• Epitope: The epitope is located on the PAPP-A subunit of the heterotetramer.
• Specificity: Specific for native human PAPP-A.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PAPPA
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: ELISA: In sandwich ELISA with a polyclonal antibody in coat, NBP2-21614 only reacts poorly with PAPP-A in third trimester serum. WB: NBP2-21614 only detects unreduced PAPP-A in Western blotting. IHC: NBP2-21614 can be used in IHC. Please consult www.proteinatlas.org

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 10mM Phosphate (pH 7.4) and 0.5M NaCl
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free

• ASBABP2
• DIPLA1
• EC 3.4.24.79
• IGFBP-4ase
• IGFBP-4aseaspecific BCL2 ARE-binding protein 2
• IGF-dependent IGFBP-4 protease
• insulin-like growth factor-dependent IGF binding protein-4 protease
• Insulin-like growth factor-dependent IGF-binding protein 4 protease
• PAPA
• PAPPA
• PAPPA1
• PAPP-A1
• PAPP-Adifferentially placenta 1 expressed protein
• Pappalysin1
• Pappalysin-1
• pregnacy-associated plasma protein A
• Pregnancy-associated plasma protein A
• pregnancy-associated plasma protein A, pappalysin 1

Background

Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Pappalysin-1/PAPP-A Antibody (NBP2-21614). (Showing 1 - 1 of 1 FAQ).

1. I am highly interested to use couple of Anti-PAPP-A antibodies from your reputed companies for my research work. I have got the information regarding the immunogen used to generate these antibodies, however could not get any information regarding the specific amino acids/epitope to which your Anti-PAPP-A Antibodies binds with the antigen (PAPP-A).
   • Unfortunately, none of our PAPP A antibodies have been epitope mapped. Many of them have also been generated against full-length PAPP A, so there are many potential binding sites.

Bioinformatics

• Gene Symbol: PAPPA