Human P-Selectin/CD62P ELISA Kit (Colorimetric) Summary
The cross reactivity and interference of circulating factors of the immune system was evaluated by spiking these proteins at physiologically relevant concentrations into a human P-selectin positive sample. There was no cross reactivity or interference detected, notably not with human E-selectin and human L-selectin.
|Standard Curve Range
0.63 - 40.00 ng/mL
For recovery data see the manual.
ELISA Kit (Colorimetric)
This kit is an enzyme-linked immunosorbent assay for quantitative detection.
Packaging, Storage & Formulations
Storage of components varies. See protocol for specific instructions.
- Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to GLP-1
Alternate Names for Human P-Selectin/CD62P ELISA Kit (Colorimetric)
- CD62P antigen
- PADGEMantigen CD62)
- selectin P (granule membrane protein 140kDa, antigen CD62)
P-selectin belongs to the selectin family of adhesion molecules. P-selectin acts as a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin is a 140 kDa protein that is highly glycosylated. The cDNA derived amino acid sequence predicts a molecule with a series of cysteine-rich domains. P-selectin is located in membranes of a granules in unstimulated platelets and redistributed to the cell surface upon platelet activation. P-selectin is also present in endothelial cells in membranes of Weibel-Palade bodies and megakaryocytes. The physiologic role of P-selectin might be the mediation of initial leukocyte adhesion to activated endothelium during acute inflammation. It may work in concert with E-selectin to direct early, regionally specific adherence of neutrophils and monocytes at sites of acute inflammation. A soluble form of P-selectin found in serum and plasma has been described which might represent a proteolytic fragment or more likely a soluble splice variant lacking the transmembrane domain. Excessive accumulation of neutrophils on the endothelial surface accompanied by high exposure of P-selectin has been implicated in a number of inflammatory disorders, including adult respiratory distress syndrome, acute lung injury, ischemia-reperfusion injury, Gram-negative septic shock, thrombotic diseases and rheumatoid arthritis. Malignant cells were shown to express receptors for P-selectin suggesting an important role for P-selectin in tumor formation and metastasis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed
for 6 months from date of receipt.
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