OATP1B3/SLCO1B3/OATP8 Antibody (1E6.2F9) [PE/Atto594]

Product Discontinued

OATP1B3/SLCO1B3/OATP8 Antibody (1E6.2F9) [PE/Atto594] Summary

• Immunogen: Two synthetic peptides made to the human OATP8 protein sequence (between residues 648-700). [Swiss-Prot Q9NPD5]
• Localization: Basolateral cell membrane
• Predicted Species: Primate (98%). Backed by our 100% Guarantee.
• Isotype: IgG3 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: SLCO1B3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for OATP1B3/SLCO1B3/OATP8 Antibody (1E6.2F9) [PE/Atto594]

• Liver-specific organic anion transporter 2
• liver-specific organic anion transporter 3TM13
• LST2
• LST-2
• LST3
• OATP1B3
• OATP1B3LST-3TM13
• OATP8
• OATP-8
• Organic anion transporter 8
• organic anion transporter LST-3c
• Organic anion-transporting polypeptide 8
• SLC21A8
• SLCO1B3
• solute carrier family 21 (organic anion transporter), member 8
• Solute carrier family 21 member 8
• solute carrier organic anion transporter family member 1B3
• solute carrier organic anion transporter family, member 1B3

Background

The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLCO1B3