NMDAR3B Antibody

Western Blot: NMDAR3B Antibody [NBP1-52062] - NBP1-52062 (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

NMDAR3B Antibody Summary

• Description: Novus Biologicals Goat NMDAR3B Antibody (NBP1-52062) is a polyclonal antibody validated for use in WB and ELISA. Anti-NMDAR3B Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-EAPPHSGRPGSQ corresponding to C-Terminus according to NP_619635.1.
• Epitope: C-EAPPHSGRPGSQ
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: GRIN3B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
  • Western Blot 0.5 - 1.5 ug/ml
• Application Notes: WB: Approx. 110 kDa band observed in human brain (cerebellum and cerebral cortex) lysates (calculated MW of 113 kDa band according to NP_619635.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for NMDAR3B Antibody

• GluN3B
• glutamate [NMDA] receptor subunit 3B
• glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
• GRIN3B
• NMDA receptor subunit 3B
• NMDA type glutamate receptor subunit NR3B
• NMDAR3B
• N-methyl-D-aspartate receptor subtype 3B
• NR3B

Background

The GRIN3B (NMDAR3B) gene encodes a 1,043 amino acid long, nearly 113 kDA glutamate receptor iontrophic, NMDA 3B that is a glycine controlled receptor that functions in glutamate-gated ion channels with reduced single-channel conductance, calcium, and voltage-sensitivity to magnesium. GRIN3B functions in glutamic acid signaling, the pathogenesis of ALS, the neuroactive ligand-receptor interaction, and the dopamine DARPP32 feedback onto cAMP pathway. This gene has been linked to HIV type 1, neuroblastoma, pain syndrome, opiod abuse, immunodeficiency, and alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NMDAR3B Antibody (NBP1-52062)(1)

Publication using NBP1-52062

• Need AC, Keefe RS, Ge D et al. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet 2009-07-01 [PMID: 19156168]

Bioinformatics

• Gene Symbol: GRIN3B
• Entrez:
  • 116444(Human)
• Uniprot:
  • NP_619635.1(Human)