NLRP2/NALP2 Antibody (443625) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 443625
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

NLRP2/NALP2 Antibody (443625) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human NLRP2/NALP2
  Met1-Thr208
  Accession # Q9NX02
• Specificity: Detects human NLRP2/NALP2 in Western blots.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NLRP2/NALP2 Antibody (443625) [Alexa Fluor® 750]

• CLR19.9
• FLJ20510
• NACHT, leucine rich repeat and PYD containing 2
• NACHT, LRR and PYD domains-containing protein 2
• NALP2
• NALP2NACHT, LRR and PYD containing protein 2
• NBS1
• NBS1PYRIN-containing APAF1-like protein 2
• NLR family, pyrin domain containing 2
• NLRP2
• nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 2
• PAN1
• PAN1Nucleotide-binding site protein 1
• PYPAF2
• PYPAF2PYRIN domain and NACHT domain-containing protein 1

Background

NLRP2, also known as NALP2, is a cytosolic 121 kDa member of the NLRP family of proteins. It is expressed in macrophages and exhibits divergent effects on inflammation. Via NF kappa B, it suppresses TNF‑ alpha production in response to LPS; via procaspase‑1, it promotes proIL‑1 beta cleavage and release. Human NLRP2 is 1062 amino acids (aa) in length. It contains an N‑terminal Pyrin domain (aa 9‑90), followed by a Nacht region and nine LRRs (aa 467‑1033). Four alternate isoforms exist. Three show deletions of aa 109‑132, aa 133‑154 and aa 847‑1062, respectively; a fourth shows a 38 aa substitution for aa 1‑903. No close rodent counterparts have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q9NX02()