NLRP2/NALP2 Products

Description

NLRP2/NALP2, aka PAN1 and PYPAF2, belongs to a cytoplasmic proteins family containing a NACHT domain, leucine rich repeat (NLR) and N-terminal pyrin-containing domain (PYD). As an intracellular pathogen-recognition receptors (PRRs), NLRP2/NALP2 is a 1062 amino acid protein associated in cell responses to apoptotic and inflammatory stimuli. PRRs are key components of immune systems involving in an innate effector mechanisms and activation of adaptive immunity. By interacting with ASC in addition to CARD8 and caspase 1, NLRP2/NALP2 forms an inflammasome functioning as a modulator of NF-kB and procaspase-1 activation in macrophages. Similar to TLRs, activation of the inflammasome by NLRs occurs through the recognition of pathogen-associated molecular patterns (PAMPs) through their LRR domains. NLRP2/NALP2 expressions varies in several human tumor cell lines though the highest were found in MDA-MB-435 and MCF-7 breast cancer, UACC62 melanoma, and Caco2 colon cancer cells.

Bioinformatics

Uniprot	AAH01039 Human AAH39269 Human NP_060322 Human NP_060322.1 Human Q9NX02 Human
Product By Gene ID	55655
Alternate Names	CLR19.9 FLJ20510 NACHT, leucine rich repeat and PYD containing 2 NACHT, LRR and PYD domains-containing protein 2 NALP2NACHT, LRR and PYD containing protein 2 NBS1PYRIN-containing APAF1-like protein 2 NLR family, pyrin domain containing 2 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 2 PAN1Nucleotide-binding site protein 1 PYPAF2PYRIN domain and NACHT domain-containing protein 1

Research Areas for NLRP2/NALP2

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Apoptosis