NLRP2/NALP2 Products

Antibodies
NLRP2/NALP2 Antibody
NLRP2/NALP2 Antibody
NB100-56155
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
NLRP2/NALP2 Antibody
NLRP2/NALP2 Antibody
NBP2-24667
Species: Hu
Applications: WB, IHC-P
Host: Rabbit Polyclonal
NLRP2/NALP2 Antibody
NLRP2/NALP2 Antibody
NB100-56154
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Antibody Pairs
NLRP2/NALP2 Antibody Pair
NLRP2/NALP2 Antibody Pair
H00055655-PW1
Species: Hu
Applications: WB, IP
Lysates
NLRP2/NALP2 Overexpression Ly ...
NLRP2/NALP2 Overexpression Lysate ...
NBP2-06894
Applications: WB
NLRP2/NALP2 Overexpression Ly ...
NLRP2/NALP2 Overexpression Lysate ...
H00055655-T01
Applications: WB
Proteins
NLRP2/NALP2 Recombinant Prote ...
NLRP2/NALP2 Recombinant Protein
H00055655-P01
Species: Hu
Applications: WB, ELISA, PA
NLRP2/NALP2 Partial Recombina ...
NLRP2/NALP2 Partial Recombinant Pr...
H00055655-Q01
Species: Hu
Applications: WB, ELISA, PA
NLRP2/NALP2 Recombinant Prote ...
NLRP2/NALP2 Recombinant Protein An...
NBP1-85553PEP
Species: Hu
Applications: AC

Description

NLRP2/NALP2, aka PAN1 and PYPAF2, belongs to a cytoplasmic proteins family containing a NACHT domain, leucine rich repeat (NLR) and N-terminal pyrin-containing domain (PYD). As an intracellular pathogen-recognition receptors (PRRs), NLRP2/NALP2 is a 1062 amino acid protein associated in cell responses to apoptotic and inflammatory stimuli. PRRs are key components of immune systems involving in an innate effector mechanisms and activation of adaptive immunity. By interacting with ASC in addition to CARD8 and caspase 1, NLRP2/NALP2 forms an inflammasome functioning as a modulator of NF-kB and procaspase-1 activation in macrophages. Similar to TLRs, activation of the inflammasome by NLRs occurs through the recognition of pathogen-associated molecular patterns (PAMPs) through their LRR domains. NLRP2/NALP2 expressions varies in several human tumor cell lines though the highest were found in MDA-MB-435 and MCF-7 breast cancer, UACC62 melanoma, and Caco2 colon cancer cells.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Product By Gene ID 55655
Alternate Names
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 2
  • FLJ20510
  • NACHT, LRR and PYD domains-containing protein 2
  • CLR19.9
  • NALP2NACHT, LRR and PYD containing protein 2
  • NBS1PYRIN-containing APAF1-like protein 2
  • PYPAF2PYRIN domain and NACHT domain-containing protein 1
  • PAN1Nucleotide-binding site protein 1
  • NACHT, leucine rich repeat and PYD containing 2
  • NLR family, pyrin domain containing 2

Research Areas for NLRP2/NALP2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for NLRP2/NALP2

Learn more about PTMs related to NLRP2/NALP2.

Phosphorylation
Cleavage

Bioinformatics Tool for NLRP2/NALP2

Discover related pathways, diseases and genes to NLRP2/NALP2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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